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Q9R1E9

- CTGF_RAT

UniProt

Q9R1E9 - CTGF_RAT

Protein

Connective tissue growth factor

Gene

Ctgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes By similarity. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells By similarity. Enhances fibroblast growth factor-induced DNA synthesis By similarity.By similarity

    GO - Molecular functioni

    1. fibronectin binding Source: RGD
    2. growth factor activity Source: RGD
    3. heparin binding Source: RGD

    GO - Biological processi

    1. angiogenesis Source: RGD
    2. cartilage condensation Source: Ensembl
    3. cell adhesion Source: RGD
    4. cell differentiation Source: Ensembl
    5. cell-matrix adhesion Source: Ensembl
    6. cell migration Source: Ensembl
    7. chondrocyte proliferation Source: Ensembl
    8. cytosolic calcium ion transport Source: RGD
    9. DNA replication Source: UniProtKB-KW
    10. extracellular matrix constituent secretion Source: RGD
    11. fibroblast growth factor receptor signaling pathway Source: Ensembl
    12. integrin-mediated signaling pathway Source: Ensembl
    13. intracellular signal transduction Source: RGD
    14. lung development Source: RGD
    15. negative regulation of cell death Source: RGD
    16. negative regulation of gene expression Source: Ensembl
    17. organ senescence Source: RGD
    18. ossification Source: Ensembl
    19. positive regulation of cardiac muscle contraction Source: RGD
    20. positive regulation of cell activation Source: RGD
    21. positive regulation of cell death Source: RGD
    22. positive regulation of cell differentiation Source: Ensembl
    23. positive regulation of cell proliferation Source: RGD
    24. positive regulation of collagen biosynthetic process Source: RGD
    25. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    26. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    27. positive regulation of G0 to G1 transition Source: RGD
    28. positive regulation of gene expression Source: RGD
    29. positive regulation of JNK cascade Source: Ensembl
    30. positive regulation of protein phosphorylation Source: RGD
    31. positive regulation of stress fiber assembly Source: Ensembl
    32. reactive oxygen species metabolic process Source: Ensembl
    33. regulation of cell growth Source: InterPro
    34. regulation of chondrocyte differentiation Source: Ensembl
    35. response to amino acid Source: RGD
    36. response to anoxia Source: RGD
    37. response to estradiol Source: RGD
    38. response to fatty acid Source: RGD
    39. response to glucose Source: RGD
    40. response to mineralocorticoid Source: RGD
    41. response to organic cyclic compound Source: RGD
    42. response to peptide hormone Source: RGD

    Keywords - Biological processi

    Cell adhesion, DNA synthesis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196408. PPARA activates gene expression.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Connective tissue growth factor
    Alternative name(s):
    CCN family member 2
    Connective tissue growth-related protein
    Gene namesi
    Name:Ctgf
    Synonyms:Ccn2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621392. Ctgf.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: RGD
    2. cis-Golgi network Source: RGD
    3. cytosol Source: RGD
    4. extracellular space Source: RGD
    5. Golgi apparatus Source: Ensembl
    6. perinuclear region of cytoplasm Source: RGD
    7. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 347323Connective tissue growth factorPRO_0000014405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi254 ↔ 291By similarity
    Disulfide bondi271 ↔ 305By similarity
    Disulfide bondi282 ↔ 321By similarity
    Disulfide bondi285 ↔ 323By similarity
    Disulfide bondi290 ↔ 327By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9R1E9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R1E9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1E9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9672IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini99 – 16567VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 24146TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 32875CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni245 – 347103Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    GeneTreeiENSGT00750000117442.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ9R1E9.
    KOiK06827.
    OMAiKTYRAKF.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiQ9R1E9.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R1E9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLASVAGPVS LALVLLLCTR PATGQDCSAQ CQCAAEAAPR CPAGVSLVLD    50
    GCGCCRVCAK QLGELCTERD PCDPHKGLFC DFGSPANRKI GVCTAKDGAP 100
    CVFGGSVYRS GESFQSSCKY QCTCLDGAVG CVPLCSMDVR LPSPDCPFPR 150
    RVKLPGKCCE EWVCDEPKDR TVVGPALAAY RLEDTFGPDP TMMRANCLVQ 200
    TTEWSACSKT CGMGISTRVT NDNTFCRLEK QSRLCMVRPC EADLEENIKK 250
    GKKCIRTPKI AKPVKFELSG CTSVKTYRAK FCGVCTDGRC CTPHRTTTLP 300
    VEFKCPDGEI MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA 347
    Length:347
    Mass (Da):37,756
    Last modified:May 1, 2000 - v1
    Checksum:iCFBE1A19766B7B16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351A → R in BAA82125. (PubMed:10393331)Curated
    Sequence conflicti94 – 941T → P in BAA82125. (PubMed:10393331)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120275 mRNA. Translation: AAD39132.1.
    AB023068 mRNA. Translation: BAA82125.1.
    AY596447 Transcribed RNA. Translation: AAT08023.1.
    RefSeqiNP_071602.1. NM_022266.2.
    UniGeneiRn.17145.

    Genome annotation databases

    EnsembliENSRNOT00000020528; ENSRNOP00000020528; ENSRNOG00000015036.
    GeneIDi64032.
    KEGGirno:64032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120275 mRNA. Translation: AAD39132.1 .
    AB023068 mRNA. Translation: BAA82125.1 .
    AY596447 Transcribed RNA. Translation: AAT08023.1 .
    RefSeqi NP_071602.1. NM_022266.2.
    UniGenei Rn.17145.

    3D structure databases

    ProteinModelPortali Q9R1E9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9R1E9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020528 ; ENSRNOP00000020528 ; ENSRNOG00000015036 .
    GeneIDi 64032.
    KEGGi rno:64032.

    Organism-specific databases

    CTDi 1490.
    RGDi 621392. Ctgf.

    Phylogenomic databases

    eggNOGi NOG72934.
    GeneTreei ENSGT00750000117442.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q9R1E9.
    KOi K06827.
    OMAi KTYRAKF.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi Q9R1E9.
    TreeFami TF326070.

    Enzyme and pathway databases

    Reactomei REACT_196408. PPARA activates gene expression.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Miscellaneous databases

    NextBioi 612658.
    PROi Q9R1E9.

    Gene expression databases

    Genevestigatori Q9R1E9.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development."
      Xu J., Smock S.L., Safadi F.F., Rosenzweig A.B., Odgren P.R., Marks S.C. Jr., Owen T.A., Popoff S.N.
      J. Cell. Biochem. 77:103-115(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo."
      Shimo T., Nakanishi T., Nishida T., Asano M., Kanyama M., Kuboki T., Tamatani T., Tezuka K., Takemura M., Matsumura T., Takigawa M.
      J. Biochem. 126:137-145(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Connective tissue growth related gene."
      Ma L.N., Zou Y.L.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiCTGF_RAT
    AccessioniPrimary (citable) accession number: Q9R1E9
    Secondary accession number(s): Q53YJ0, Q9WVS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3