Reviewed,
UniProtKB/Swiss-Prot Q9R1C8 (5HT6R_MOUSE)
Last modified
July 7, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 5-hydroxytryptamine receptor 6 Short name=5-HT-6 Alternative name(s): Serotonin receptor 6 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 440 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 440 | 440 | 5-hydroxytryptamine receptor 6 | PRO_0000068975 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 34 | 34 | Extracellular By similarity | ||||||||
| Transmembrane | 35 – 57 | 23 | 1 By similarity | ||||||||
| Topological domain | 58 – 64 | 7 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 65 – 85 | 21 | 2 By similarity | ||||||||
| Topological domain | 86 – 100 | 15 | Extracellular By similarity | ||||||||
| Transmembrane | 101 – 122 | 22 | 3 By similarity | ||||||||
| Topological domain | 123 – 144 | 22 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 145 – 166 | 22 | 4 By similarity | ||||||||
| Topological domain | 167 – 184 | 18 | Extracellular By similarity | ||||||||
| Transmembrane | 185 – 208 | 24 | 5 By similarity | ||||||||
| Topological domain | 209 – 267 | 59 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 268 – 292 | 25 | 6 By similarity | ||||||||
| Topological domain | 293 – 297 | 5 | Extracellular By similarity | ||||||||
| Transmembrane | 298 – 322 | 25 | 7 By similarity | ||||||||
| Topological domain | 323 – 440 | 118 | Cytoplasmic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 125 | 1 | Phosphotyrosine By similarity | ||||||||
| Glycosylation | 9 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 99 ↔ 180 | By similarity | |||||||||
Sequences
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References
| [1] | "Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop." Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W. Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed: 11406289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF134158 mRNA. Translation: AAD46490.1. | |
| IPI | IPI00128438. |
| RefSeq | NP_067333.1. |
| UniGene | Mm.425211 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | Q9R1C8. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000028747. Mus musculus. [Contig view] |
| GeneID | 15565. |
| KEGG | mmu:15565. |
Organism-specific databases | |
| MGI | MGI:1196627. Htr6. |
Phylogenomic databases | |
| HOGENOM | Q9R1C8. |
| HOVERGEN | Q9R1C8. |
| OMA | Q9R1C8. KLRMTPP. |
Gene expression databases | |
| ArrayExpress | Q9R1C8. |
| CleanEx | MM_HTR6. |
| GermOnline | ENSMUSG00000028747. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 288530. |
| SOURCE | Search... |
Entry information
| Entry name | 5HT6R_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9R1C8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


