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Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_332615. Serotonin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
Serotonin receptor 6
Gene namesi
Name:Htr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1196627. Htr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5723Helical; Name=1By similarityAdd
BLAST
Topological domaini58 – 647CytoplasmicBy similarity
Transmembranei65 – 8521Helical; Name=2By similarityAdd
BLAST
Topological domaini86 – 10015ExtracellularBy similarityAdd
BLAST
Transmembranei101 – 12222Helical; Name=3By similarityAdd
BLAST
Topological domaini123 – 14422CytoplasmicBy similarityAdd
BLAST
Transmembranei145 – 16622Helical; Name=4By similarityAdd
BLAST
Topological domaini167 – 18418ExtracellularBy similarityAdd
BLAST
Transmembranei185 – 20824Helical; Name=5By similarityAdd
BLAST
Topological domaini209 – 26759CytoplasmicBy similarityAdd
BLAST
Transmembranei268 – 29225Helical; Name=6By similarityAdd
BLAST
Topological domaini293 – 2975ExtracellularBy similarity
Transmembranei298 – 32225Helical; Name=7By similarityAdd
BLAST
Topological domaini323 – 440118CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • cilium Source: MGI
  • dendrite Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4404405-hydroxytryptamine receptor 6PRO_0000068975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9R1C8.

PTM databases

PhosphoSiteiQ9R1C8.

Expressioni

Gene expression databases

BgeeiQ9R1C8.
CleanExiMM_HTR6.
ExpressionAtlasiQ9R1C8. baseline.
GenevisibleiQ9R1C8. MM.

Interactioni

Subunit structurei

Interacts with CDK5 (PubMed:25078650). Interacts with MTOR (PubMed:23027611). Interacts with RPTOR and NF1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068333.

Structurei

3D structure databases

ProteinModelPortaliQ9R1C8.
SMRiQ9R1C8. Positions 33-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299437.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000241520.
HOVERGENiHBG106962.
InParanoidiQ9R1C8.
KOiK04162.
OMAiCLLWTAF.
OrthoDBiEOG7XH6Q0.
PhylomeDBiQ9R1C8.
TreeFamiTF351753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTSAPGQC RLLASLPYVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ VPRTPRPGME
260 270 280 290 300
SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS
310 320 330 340 350
PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP
360 370 380 390 400
ASPSMWTSHS GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL
410 420 430 440
PGEATRDPPP PTRAPTVVNF FVTDSVEPEI RQHPLGSPMN
Length:440
Mass (Da):46,998
Last modified:May 1, 2000 - v1
Checksum:i4440CDEBE01FEF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134158 mRNA. Translation: AAD46490.1.
CCDSiCCDS18838.1.
RefSeqiNP_067333.1. NM_021358.2.
UniGeneiMm.291096.

Genome annotation databases

EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747.
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
GeneIDi15565.
KEGGimmu:15565.
UCSCiuc008vlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134158 mRNA. Translation: AAD46490.1.
CCDSiCCDS18838.1.
RefSeqiNP_067333.1. NM_021358.2.
UniGeneiMm.291096.

3D structure databases

ProteinModelPortaliQ9R1C8.
SMRiQ9R1C8. Positions 33-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068333.

Chemistry

BindingDBiQ9R1C8.
ChEMBLiCHEMBL1075268.
GuidetoPHARMACOLOGYi11.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9R1C8.

Proteomic databases

PRIDEiQ9R1C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747.
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
GeneIDi15565.
KEGGimmu:15565.
UCSCiuc008vlr.1. mouse.

Organism-specific databases

CTDi3362.
MGIiMGI:1196627. Htr6.

Phylogenomic databases

eggNOGiNOG299437.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000241520.
HOVERGENiHBG106962.
InParanoidiQ9R1C8.
KOiK04162.
OMAiCLLWTAF.
OrthoDBiEOG7XH6Q0.
PhylomeDBiQ9R1C8.
TreeFamiTF351753.

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_332615. Serotonin receptors.

Miscellaneous databases

NextBioi288530.
PROiQ9R1C8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1C8.
CleanExiMM_HTR6.
ExpressionAtlasiQ9R1C8. baseline.
GenevisibleiQ9R1C8. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop."
    Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W.
    Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Brain.
  2. Cited for: FUNCTION, INTERACTION WITH MTOR.
  3. "The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism."
    Jacobshagen M., Niquille M., Chaumont-Dubel S., Marin P., Dayer A.
    Development 141:3370-3377(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDK5.

Entry informationi

Entry namei5HT6R_MOUSE
AccessioniPrimary (citable) accession number: Q9R1C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.