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Q9R1C8 (5HT6R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 6

Short name=5-HT-6
Short name=5-HT6
Alternative name(s):
Serotonin receptor 6
Gene names
Name:Htr6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

learning

Inferred from electronic annotation. Source: Ensembl

long-term synaptic potentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of acetylcholine secretion, neurotransmission

Inferred from electronic annotation. Source: Ensembl

negative regulation of gamma-aminobutyric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of dopamine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of gamma-aminobutyric acid secretion

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcilium

Inferred from direct assay PubMed 22179047. Source: MGI

dendrite

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserotonin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4404405-hydroxytryptamine receptor 6
PRO_0000068975

Regions

Topological domain1 – 3434Extracellular By similarity
Transmembrane35 – 5723Helical; Name=1; By similarity
Topological domain58 – 647Cytoplasmic By similarity
Transmembrane65 – 8521Helical; Name=2; By similarity
Topological domain86 – 10015Extracellular By similarity
Transmembrane101 – 12222Helical; Name=3; By similarity
Topological domain123 – 14422Cytoplasmic By similarity
Transmembrane145 – 16622Helical; Name=4; By similarity
Topological domain167 – 18418Extracellular By similarity
Transmembrane185 – 20824Helical; Name=5; By similarity
Topological domain209 – 26759Cytoplasmic By similarity
Transmembrane268 – 29225Helical; Name=6; By similarity
Topological domain293 – 2975Extracellular By similarity
Transmembrane298 – 32225Helical; Name=7; By similarity
Topological domain323 – 440118Cytoplasmic By similarity

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 180 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R1C8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4440CDEBE01FEF0C

FASTA44046,998
        10         20         30         40         50         60 
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL ICTQPALRNT 

        70         80         90        100        110        120 
SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI 

       130        140        150        160        170        180 
SLDRYLLILS PLRYKLRMTA PRALALILGA WSLAALASFL PLLLGWHELG KARTSAPGQC 

       190        200        210        220        230        240 
RLLASLPYVL VASGVTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ 

       250        260        270        280        290        300 
VPRTPRPGME SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS 

       310        320        330        340        350        360 
PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP ASPSMWTSHS 

       370        380        390        400        410        420 
GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL PGEATRDPPP PTRAPTVVNF 

       430        440 
FVTDSVEPEI RQHPLGSPMN 

« Hide

References

[1]"Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop."
Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W.
Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF134158 mRNA. Translation: AAD46490.1.
RefSeqNP_067333.1. NM_021358.2.
UniGeneMm.291096.

3D structure databases

ProteinModelPortalQ9R1C8.
SMRQ9R1C8. Positions 33-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000101428.

Chemistry

BindingDBQ9R1C8.
ChEMBLCHEMBL1075268.
GuidetoPHARMACOLOGY11.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9R1C8.

Proteomic databases

PRIDEQ9R1C8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747.
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
GeneID15565.
KEGGmmu:15565.
UCSCuc008vlr.1. mouse.

Organism-specific databases

CTD3362.
MGIMGI:1196627. Htr6.

Phylogenomic databases

eggNOGNOG299437.
GeneTreeENSGT00750000117368.
HOGENOMHOG000241520.
HOVERGENHBG106962.
InParanoidQ9R1C8.
KOK04162.
OMACLLWTAF.
OrthoDBEOG7XH6Q0.
PhylomeDBQ9R1C8.
TreeFamTF351753.

Gene expression databases

BgeeQ9R1C8.
CleanExMM_HTR6.
GenevestigatorQ9R1C8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002232. 5HT6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF4. PTHR24247:SF4. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288530.
PROQ9R1C8.
SOURCESearch...

Entry information

Entry name5HT6R_MOUSE
AccessionPrimary (citable) accession number: Q9R1C8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries