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Q9R1C8

- 5HT6R_MOUSE

UniProt

Q9R1C8 - 5HT6R_MOUSE

Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs By similarity.By similarity

    GO - Molecular functioni

    1. serotonin receptor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
    3. learning Source: Ensembl
    4. long-term synaptic potentiation Source: Ensembl
    5. negative regulation of acetylcholine secretion, neurotransmission Source: Ensembl
    6. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
    7. negative regulation of glutamate secretion Source: Ensembl
    8. positive regulation of dopamine secretion Source: Ensembl
    9. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
    10. response to drug Source: Ensembl
    11. response to estradiol Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 6
    Short name:
    5-HT-6
    Short name:
    5-HT6
    Alternative name(s):
    Serotonin receptor 6
    Gene namesi
    Name:Htr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1196627. Htr6.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: MGI
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4404405-hydroxytryptamine receptor 6PRO_0000068975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9R1C8.

    PTM databases

    PhosphoSiteiQ9R1C8.

    Expressioni

    Gene expression databases

    BgeeiQ9R1C8.
    CleanExiMM_HTR6.
    GenevestigatoriQ9R1C8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000101428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1C8.
    SMRiQ9R1C8. Positions 33-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularBy similarityAdd
    BLAST
    Topological domaini58 – 647CytoplasmicBy similarity
    Topological domaini86 – 10015ExtracellularBy similarityAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicBy similarityAdd
    BLAST
    Topological domaini167 – 18418ExtracellularBy similarityAdd
    BLAST
    Topological domaini209 – 26759CytoplasmicBy similarityAdd
    BLAST
    Topological domaini293 – 2975ExtracellularBy similarity
    Topological domaini323 – 440118CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5723Helical; Name=1By similarityAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2By similarityAdd
    BLAST
    Transmembranei101 – 12222Helical; Name=3By similarityAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=4By similarityAdd
    BLAST
    Transmembranei185 – 20824Helical; Name=5By similarityAdd
    BLAST
    Transmembranei268 – 29225Helical; Name=6By similarityAdd
    BLAST
    Transmembranei298 – 32225Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299437.
    GeneTreeiENSGT00750000117368.
    HOGENOMiHOG000241520.
    HOVERGENiHBG106962.
    InParanoidiQ9R1C8.
    KOiK04162.
    OMAiCLLWTAF.
    OrthoDBiEOG7XH6Q0.
    PhylomeDBiQ9R1C8.
    TreeFamiTF351753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R1C8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL    50
    ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 100
    LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA 150
    WSLAALASFL PLLLGWHELG KARTSAPGQC RLLASLPYVL VASGVTFFLP 200
    SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ VPRTPRPGME 250
    SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS 300
    PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP 350
    ASPSMWTSHS GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL 400
    PGEATRDPPP PTRAPTVVNF FVTDSVEPEI RQHPLGSPMN 440
    Length:440
    Mass (Da):46,998
    Last modified:May 1, 2000 - v1
    Checksum:i4440CDEBE01FEF0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134158 mRNA. Translation: AAD46490.1.
    CCDSiCCDS18838.1.
    RefSeqiNP_067333.1. NM_021358.2.
    UniGeneiMm.291096.

    Genome annotation databases

    EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747.
    ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
    GeneIDi15565.
    KEGGimmu:15565.
    UCSCiuc008vlr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134158 mRNA. Translation: AAD46490.1 .
    CCDSi CCDS18838.1.
    RefSeqi NP_067333.1. NM_021358.2.
    UniGenei Mm.291096.

    3D structure databases

    ProteinModelPortali Q9R1C8.
    SMRi Q9R1C8. Positions 33-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000101428.

    Chemistry

    BindingDBi Q9R1C8.
    ChEMBLi CHEMBL1075268.
    GuidetoPHARMACOLOGYi 11.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9R1C8.

    Proteomic databases

    PRIDEi Q9R1C8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068036 ; ENSMUSP00000068333 ; ENSMUSG00000028747 .
    ENSMUST00000105802 ; ENSMUSP00000101428 ; ENSMUSG00000028747 .
    GeneIDi 15565.
    KEGGi mmu:15565.
    UCSCi uc008vlr.1. mouse.

    Organism-specific databases

    CTDi 3362.
    MGIi MGI:1196627. Htr6.

    Phylogenomic databases

    eggNOGi NOG299437.
    GeneTreei ENSGT00750000117368.
    HOGENOMi HOG000241520.
    HOVERGENi HBG106962.
    InParanoidi Q9R1C8.
    KOi K04162.
    OMAi CLLWTAF.
    OrthoDBi EOG7XH6Q0.
    PhylomeDBi Q9R1C8.
    TreeFami TF351753.

    Miscellaneous databases

    NextBioi 288530.
    PROi Q9R1C8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R1C8.
    CleanExi MM_HTR6.
    Genevestigatori Q9R1C8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop."
      Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W.
      Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
      Tissue: Brain.

    Entry informationi

    Entry namei5HT6R_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3