Q9R1C8 (5HT6R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 6
Short name=5-HT-6
Short name=5-HT6

Alternative name(s):
Serotonin receptor 6

Gene names

Name:

Htr6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Inferred from electronic annotation. Source: Compara brain development Inferred from electronic annotation. Source: Compara learning Inferred from electronic annotation. Source: Compara long-term synaptic potentiation Inferred from electronic annotation. Source: Compara negative regulation of acetylcholine secretion Inferred from electronic annotation. Source: Compara negative regulation of gamma-aminobutyric acid secretion Inferred from electronic annotation. Source: Compara negative regulation of glutamate secretion Inferred from electronic annotation. Source: Compara positive regulation of cAMP metabolic process Inferred from electronic annotation. Source: InterPro positive regulation of dopamine secretion Inferred from electronic annotation. Source: Compara positive regulation of gamma-aminobutyric acid secretion Inferred from electronic annotation. Source: Compara regulation of hormone secretion Inferred from electronic annotation. Source: InterPro response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	cilium Inferred from direct assay PubMed 22179047. Source: MGI dendrite Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	serotonin receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	5-hydroxytryptamine receptor 6		PRO_0000068975
Regions
	Topological domain	1 – 34	34	Extracellular By similarity
	Transmembrane	35 – 57	23	Helical; Name=1; By similarity
	Topological domain	58 – 64	7	Cytoplasmic By similarity
	Transmembrane	65 – 85	21	Helical; Name=2; By similarity
	Topological domain	86 – 100	15	Extracellular By similarity
	Transmembrane	101 – 122	22	Helical; Name=3; By similarity
	Topological domain	123 – 144	22	Cytoplasmic By similarity
	Transmembrane	145 – 166	22	Helical; Name=4; By similarity
	Topological domain	167 – 184	18	Extracellular By similarity
	Transmembrane	185 – 208	24	Helical; Name=5; By similarity
	Topological domain	209 – 267	59	Cytoplasmic By similarity
	Transmembrane	268 – 292	25	Helical; Name=6; By similarity
	Topological domain	293 – 297	5	Extracellular By similarity
	Transmembrane	298 – 322	25	Helical; Name=7; By similarity
	Topological domain	323 – 440	118	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9R1C8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4440CDEBE01FEF0C	FASTA	440	46,998
	10 20 30 40 50 60 MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL ICTQPALRNT 70 80 90 100 110 120 SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI 130 140 150 160 170 180 SLDRYLLILS PLRYKLRMTA PRALALILGA WSLAALASFL PLLLGWHELG KARTSAPGQC 190 200 210 220 230 240 RLLASLPYVL VASGVTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ 250 260 270 280 290 300 VPRTPRPGME SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS 310 320 330 340 350 360 PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP ASPSMWTSHS 370 380 390 400 410 420 GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL PGEATRDPPP PTRAPTVVNF 430 440 FVTDSVEPEI RQHPLGSPMN

References

[1]	"Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop." Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W. Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF134158 mRNA. Translation: AAD46490.1.
IPI	IPI00128438.
RefSeq	NP_067333.1. NM_021358.2.
UniGene	Mm.291096.
3D structure databases
ProteinModelPortal	Q9R1C8.
SMR	Q9R1C8. Positions 33-339.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000101428.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9R1C8.
Proteomic databases
PRIDE	Q9R1C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747. ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
GeneID	15565.
KEGG	mmu:15565.
UCSC	uc008vlr.1. mouse.
Organism-specific databases
CTD	3362.
MGI	MGI:1196627. Htr6.
Phylogenomic databases
eggNOG	NOG299437.
GeneTree	ENSGT00700000104081.
HOGENOM	HOG000241520.
HOVERGEN	HBG106962.
InParanoid	Q9R1C8.
KO	K04162.
OMA	KLRMTPP.
OrthoDB	EOG47WNPD.
Gene expression databases
ArrayExpress	Q9R1C8.
Bgee	Q9R1C8.
CleanEx	MM_HTR6.
Genevestigator	Q9R1C8.
GermOnline	ENSMUSG00000028747. Mus musculus.
Family and domain databases
InterPro	IPR002232. 5HT6_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24247. PTHR24247. 1 hit. PTHR24247:SF4. PTHR24247:SF4. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9R1C8.
ChEMBL	CHEMBL1075268.
NextBio	288530.
SOURCE	Search...

Entry information

Entry name

5HT6R_MOUSE

Accession

Primary (citable) accession number: Q9R1C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program