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Q9R1C8

- 5HT6R_MOUSE

UniProt

Q9R1C8 - 5HT6R_MOUSE

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Protein

5-hydroxytryptamine receptor 6

Gene
Htr6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs By similarity.

GO - Molecular functioni

  1. serotonin receptor activity Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
  3. learning Source: Ensembl
  4. long-term synaptic potentiation Source: Ensembl
  5. negative regulation of acetylcholine secretion, neurotransmission Source: Ensembl
  6. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
  7. negative regulation of glutamate secretion Source: Ensembl
  8. positive regulation of dopamine secretion Source: Ensembl
  9. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
  10. response to drug Source: Ensembl
  11. response to estradiol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
Serotonin receptor 6
Gene namesi
Name:Htr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1196627. Htr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular By similarityAdd
BLAST
Transmembranei35 – 5723Helical; Name=1; By similarityAdd
BLAST
Topological domaini58 – 647Cytoplasmic By similarity
Transmembranei65 – 8521Helical; Name=2; By similarityAdd
BLAST
Topological domaini86 – 10015Extracellular By similarityAdd
BLAST
Transmembranei101 – 12222Helical; Name=3; By similarityAdd
BLAST
Topological domaini123 – 14422Cytoplasmic By similarityAdd
BLAST
Transmembranei145 – 16622Helical; Name=4; By similarityAdd
BLAST
Topological domaini167 – 18418Extracellular By similarityAdd
BLAST
Transmembranei185 – 20824Helical; Name=5; By similarityAdd
BLAST
Topological domaini209 – 26759Cytoplasmic By similarityAdd
BLAST
Transmembranei268 – 29225Helical; Name=6; By similarityAdd
BLAST
Topological domaini293 – 2975Extracellular By similarity
Transmembranei298 – 32225Helical; Name=7; By similarityAdd
BLAST
Topological domaini323 – 440118Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. cilium Source: MGI
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4404405-hydroxytryptamine receptor 6PRO_0000068975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 180 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9R1C8.

PTM databases

PhosphoSiteiQ9R1C8.

Expressioni

Gene expression databases

BgeeiQ9R1C8.
CleanExiMM_HTR6.
GenevestigatoriQ9R1C8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101428.

Structurei

3D structure databases

ProteinModelPortaliQ9R1C8.
SMRiQ9R1C8. Positions 33-339.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299437.
GeneTreeiENSGT00750000117368.
HOGENOMiHOG000241520.
HOVERGENiHBG106962.
InParanoidiQ9R1C8.
KOiK04162.
OMAiCLLWTAF.
OrthoDBiEOG7XH6Q0.
PhylomeDBiQ9R1C8.
TreeFamiTF351753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1C8-1 [UniParc]FASTAAdd to Basket

« Hide

MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL    50
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 100
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA 150
WSLAALASFL PLLLGWHELG KARTSAPGQC RLLASLPYVL VASGVTFFLP 200
SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ VPRTPRPGME 250
SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS 300
PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP 350
ASPSMWTSHS GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL 400
PGEATRDPPP PTRAPTVVNF FVTDSVEPEI RQHPLGSPMN 440
Length:440
Mass (Da):46,998
Last modified:May 1, 2000 - v1
Checksum:i4440CDEBE01FEF0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134158 mRNA. Translation: AAD46490.1.
CCDSiCCDS18838.1.
RefSeqiNP_067333.1. NM_021358.2.
UniGeneiMm.291096.

Genome annotation databases

EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747.
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747.
GeneIDi15565.
KEGGimmu:15565.
UCSCiuc008vlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134158 mRNA. Translation: AAD46490.1 .
CCDSi CCDS18838.1.
RefSeqi NP_067333.1. NM_021358.2.
UniGenei Mm.291096.

3D structure databases

ProteinModelPortali Q9R1C8.
SMRi Q9R1C8. Positions 33-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000101428.

Chemistry

BindingDBi Q9R1C8.
ChEMBLi CHEMBL1075268.
GuidetoPHARMACOLOGYi 11.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9R1C8.

Proteomic databases

PRIDEi Q9R1C8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068036 ; ENSMUSP00000068333 ; ENSMUSG00000028747 .
ENSMUST00000105802 ; ENSMUSP00000101428 ; ENSMUSG00000028747 .
GeneIDi 15565.
KEGGi mmu:15565.
UCSCi uc008vlr.1. mouse.

Organism-specific databases

CTDi 3362.
MGIi MGI:1196627. Htr6.

Phylogenomic databases

eggNOGi NOG299437.
GeneTreei ENSGT00750000117368.
HOGENOMi HOG000241520.
HOVERGENi HBG106962.
InParanoidi Q9R1C8.
KOi K04162.
OMAi CLLWTAF.
OrthoDBi EOG7XH6Q0.
PhylomeDBi Q9R1C8.
TreeFami TF351753.

Miscellaneous databases

NextBioi 288530.
PROi Q9R1C8.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1C8.
CleanExi MM_HTR6.
Genevestigatori Q9R1C8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop."
    Kohen R., Fashingbauer L.A., Heidmann D.E.A., Guthrie C.R., Hamblin M.W.
    Brain Res. Mol. Brain Res. 90:110-117(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Brain.

Entry informationi

Entry namei5HT6R_MOUSE
AccessioniPrimary (citable) accession number: Q9R1C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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