Diacylglycerol kinase epsilon - Mus musculus (Mouse)

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Q9R1C6 (DGKE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Diacylglycerol kinase epsilon
Short name=DAG kinase epsilon
EC=2.7.1.107

Alternative name(s):
Diglyceride kinase epsilon
Short name=DGK-epsilon

Gene names

Name:

Dgke

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition By similarity.
Catalytic activity	ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the eukaryotic diacylglycerol kinase family. Contains 1 DAGKc domain. Contains 2 phorbol-ester/DAG-type zinc fingers.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 564

564

Diacylglycerol kinase epsilon

PRO_0000218465

Regions

Transmembrane

20 – 40

Helical; Potential

Transmembrane

433 – 453

Helical; Potential

Domain

212 – 353

142

DAGKc

Zinc finger

57 – 106

Phorbol-ester/DAG-type 1

Zinc finger

121 – 174

Phorbol-ester/DAG-type 2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9R1C6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C900BEC2CE9DD109
Show »

FASTA

564

63,635

        10         20         30         40         50         60 
MEGDQRSGPP AQSLLPDGHL VLWTLCSVLL PVFITLWCSL QRSRRQLHRR DIFRKSKHCW 

        70         80         90        100        110        120 
RDTDLFSHPT YCCVCAQHIL QGAFCDCCGL RVDEGCLKKV DKRFPCKEIM LKNDKAADAM 

       130        140        150        160        170        180 
PHHWIRGNVP LCSYCVFCRQ QCGSQPKLCD YRCIWCQKTV HDECMRGSLR SEKCDFGEFR 

       190        200        210        220        230        240 
NLIIPPSYLT SINQMRKDKN TNYEGLASKF GKQWTPLIIL ANSRSGTNMG EGLLGEFKIL 

       250        260        270        280        290        300 
LNPVQVFDVT KTPPIKALQL CTLLPYYSVR VLVCGGDGTV GWVLDAIDEM KIKGQEKYIP 

       310        320        330        340        350        360 
EVAVLPLGTG NDLSNTLGWG TGYAGEIPVA QVLRNVMEAD GIKLDRWKVQ VTNKGYYNLR 

       370        380        390        400        410        420 
KPKEFTMNNY FSVGPDALMA LNFHAHREKA PSLFSSRILN KAVYLFYGTK DCLVQECKDL 

       430        440        450        460        470        480 
NKKIELELDG ERVELPNLEG IIVLNIGYWG GGCRLWEGMG DETYPLARHD DGLLEIVGVY 

       490        500        510        520        530        540 
GSFHCAQIQV KLANPFRIGQ AHTVRLTLKC SMMPMQVDGE PWAQGPCTVT ITHKTHALML 

       550        560 
YFSGEQSDDD ISSPSDHEDV KEAE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling." Rodriguez de Turco E.B., Tang W., Topham M.K., Sakane F., Marcheselli V.L., Chen C., Taketomi A., Prescott S.M., Bazan N.G. Proc. Natl. Acad. Sci. U.S.A. 98:4740-4745(2001) [PubMed: 11287665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF136744 mRNA. Translation: AAD45665.1. AL646096 Genomic DNA. Translation: CAI24267.1.
IPI	IPI00128436.
RefSeq	NP_062378.1. NM_019505.3.
UniGene	Mm.153695.
3D structure databases
ProteinModelPortal	Q9R1C6.
SMR	Q9R1C6. Positions 57-179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9R1C6.
PTM databases
PhosphoSite	Q9R1C6.
Proteomic databases
PRIDE	Q9R1C6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000285; ENSMUSP00000000285; ENSMUSG00000000276. ENSMUST00000107894; ENSMUSP00000103526; ENSMUSG00000000276.
GeneID	56077.
KEGG	mmu:56077.
UCSC	uc007kwd.1. mouse.
Organism-specific databases
CTD	8526.
MGI	MGI:1889276. Dgke.
Phylogenomic databases
GeneTree	ENSGT00600000084245.
HOGENOM	HBG388006.
HOVERGEN	HBG051347.
InParanoid	Q9R1C6.
OMA	ASKFGKQ.
OrthoDB	EOG43N7CG.
PhylomeDB	Q9R1C6.
Gene expression databases
ArrayExpress	Q9R1C6.
Bgee	Q9R1C6.
CleanEx	MM_DGKE.
Genevestigator	Q9R1C6.
GermOnline	ENSMUSG00000000276. Mus musculus.
Family and domain databases
InterPro	IPR000756. Diacylglycerol_kin_accessory. IPR001206. Diacylglycerol_kinase_cat_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. [Graphical view]
KO	K00901.
Pfam	PF00130. C1_1. 2 hits. PF00609. DAGK_acc. 1 hit. PF00781. DAGK_cat. 1 hit. [Graphical view]
SMART	SM00109. C1. 2 hits. SM00045. DAGKa. 1 hit. SM00046. DAGKc. 1 hit. [Graphical view]
PROSITE	PS50146. DAGK. 1 hit. PS00479. ZF_DAG_PE_1. 2 hits. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	311868.
SOURCE	Search...

Entry information

Entry name

DGKE_MOUSE

Accession

Primary (citable) accession number: Q9R1C6
Secondary accession number(s): Q5SU69

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents