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Q9R1C6

- DGKE_MOUSE

UniProt

Q9R1C6 - DGKE_MOUSE

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Protein

Diacylglycerol kinase epsilon

Gene

Dgke

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition (By similarity).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 10650Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 17454Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase epsilon (EC:2.7.1.107)
Short name:
DAG kinase epsilon
Alternative name(s):
Diglyceride kinase epsilon
Short name:
DGK-epsilon
Gene namesi
Name:Dgke
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1889276. Dgke.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm By similarity. Membrane By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Diacylglycerol kinase epsilonPRO_0000218465Add
BLAST

Proteomic databases

MaxQBiQ9R1C6.
PaxDbiQ9R1C6.
PRIDEiQ9R1C6.

PTM databases

PhosphoSiteiQ9R1C6.

Expressioni

Tissue specificityi

Expressed in platelets.1 Publication

Gene expression databases

BgeeiQ9R1C6.
CleanExiMM_DGKE.
ExpressionAtlasiQ9R1C6. baseline and differential.
GenevestigatoriQ9R1C6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000285.

Structurei

3D structure databases

ProteinModelPortaliQ9R1C6.
SMRiQ9R1C6. Positions 114-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 353142DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 10650Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 17454Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000220913.
HOVERGENiHBG051347.
InParanoidiQ9R1C6.
KOiK00901.
OMAiCMKTSLK.
OrthoDBiEOG71VSS6.
PhylomeDBiQ9R1C6.
TreeFamiTF313104.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGDQRSGPP AQSLLPDGHL VLWTLCSVLL PVFITLWCSL QRSRRQLHRR
60 70 80 90 100
DIFRKSKHCW RDTDLFSHPT YCCVCAQHIL QGAFCDCCGL RVDEGCLKKV
110 120 130 140 150
DKRFPCKEIM LKNDKAADAM PHHWIRGNVP LCSYCVFCRQ QCGSQPKLCD
160 170 180 190 200
YRCIWCQKTV HDECMRGSLR SEKCDFGEFR NLIIPPSYLT SINQMRKDKN
210 220 230 240 250
TNYEGLASKF GKQWTPLIIL ANSRSGTNMG EGLLGEFKIL LNPVQVFDVT
260 270 280 290 300
KTPPIKALQL CTLLPYYSVR VLVCGGDGTV GWVLDAIDEM KIKGQEKYIP
310 320 330 340 350
EVAVLPLGTG NDLSNTLGWG TGYAGEIPVA QVLRNVMEAD GIKLDRWKVQ
360 370 380 390 400
VTNKGYYNLR KPKEFTMNNY FSVGPDALMA LNFHAHREKA PSLFSSRILN
410 420 430 440 450
KAVYLFYGTK DCLVQECKDL NKKIELELDG ERVELPNLEG IIVLNIGYWG
460 470 480 490 500
GGCRLWEGMG DETYPLARHD DGLLEIVGVY GSFHCAQIQV KLANPFRIGQ
510 520 530 540 550
AHTVRLTLKC SMMPMQVDGE PWAQGPCTVT ITHKTHALML YFSGEQSDDD
560
ISSPSDHEDV KEAE
Length:564
Mass (Da):63,635
Last modified:May 1, 2000 - v1
Checksum:iC900BEC2CE9DD109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136744 mRNA. Translation: AAD45665.1.
AL646096 Genomic DNA. Translation: CAI24267.1.
CCDSiCCDS25234.1.
RefSeqiNP_062378.1. NM_019505.3.
UniGeneiMm.153695.

Genome annotation databases

EnsembliENSMUST00000000285; ENSMUSP00000000285; ENSMUSG00000000276.
ENSMUST00000107894; ENSMUSP00000103526; ENSMUSG00000000276.
GeneIDi56077.
KEGGimmu:56077.
UCSCiuc007kwd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136744 mRNA. Translation: AAD45665.1 .
AL646096 Genomic DNA. Translation: CAI24267.1 .
CCDSi CCDS25234.1.
RefSeqi NP_062378.1. NM_019505.3.
UniGenei Mm.153695.

3D structure databases

ProteinModelPortali Q9R1C6.
SMRi Q9R1C6. Positions 114-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000285.

PTM databases

PhosphoSitei Q9R1C6.

Proteomic databases

MaxQBi Q9R1C6.
PaxDbi Q9R1C6.
PRIDEi Q9R1C6.

Protocols and materials databases

DNASUi 56077.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000285 ; ENSMUSP00000000285 ; ENSMUSG00000000276 .
ENSMUST00000107894 ; ENSMUSP00000103526 ; ENSMUSG00000000276 .
GeneIDi 56077.
KEGGi mmu:56077.
UCSCi uc007kwd.1. mouse.

Organism-specific databases

CTDi 8526.
MGIi MGI:1889276. Dgke.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00760000119050.
HOGENOMi HOG000220913.
HOVERGENi HBG051347.
InParanoidi Q9R1C6.
KOi K00901.
OMAi CMKTSLK.
OrthoDBi EOG71VSS6.
PhylomeDBi Q9R1C6.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.

Miscellaneous databases

NextBioi 311868.
PROi Q9R1C6.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1C6.
CleanExi MM_DGKE.
ExpressionAtlasi Q9R1C6. baseline and differential.
Genevestigatori Q9R1C6.

Family and domain databases

InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling."
    Rodriguez de Turco E.B., Tang W., Topham M.K., Sakane F., Marcheselli V.L., Chen C., Taketomi A., Prescott S.M., Bazan N.G.
    Proc. Natl. Acad. Sci. U.S.A. 98:4740-4745(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDGKE_MOUSE
AccessioniPrimary (citable) accession number: Q9R1C6
Secondary accession number(s): Q5SU69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3