Reviewed, UniProtKB/Swiss-Prot Q9R1A9 (TREX2_MOUSE)

Names and origin

Protein names

Recommended name:
    Three prime repair exonuclease 2
    EC=3.1.11.2
Alternative name(s):
    3'-5' exonuclease TREX2

Gene names

Name:

Trex2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Ref.1
Catalytic activity	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
Cofactor	Magnesium. Required for activity. Substitution with Mn2+ results in partial activity By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the exonuclease superfamily. TREX family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Ligand	Magnesium
Molecular function	Exonuclease Hydrolase Nuclease
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exodeoxyribonuclease III activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Three prime repair exonuclease 2		PRO_0000109871

Sequences

	Sequence		Length	Mass (Da)
	Q9R1A9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 695CF4126AB06676	FASTA	236	25,955
	10 20 30 40 50 60 MSEPPRAETF VFLDLEATGL PNMDPEIAEI SLFAVHRSSL ENPERDDSGS LVLPRVLDKL 70 80 90 100 110 120 TLCMCPERPF TAKASEITGL SSESLMHCGK AGFNGAVVRT LQGFLSRQEG PICLVAHNGF 130 140 150 160 170 180 DYDFPLLCTE LQRLGAHLPQ DTVCLDTLPA LRGLDRAHSH GTRAQGRKSY SLASLFHRYF 190 200 210 220 230 QAEPSAAHSA EGDVHTLLLI FLHRAPELLA WADEQARSWA HIEPMYVPPD GPSLEA

References

[1]	"Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases." Mazur D.J., Perrino F.W. J. Biol. Chem. 274:19655-19660(1999) [PubMed: 10391904] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF151108 mRNA. Translation: AAD48777.1.
IPI	IPI00128388.
RefSeq	NP_036037.1.
UniGene	Mm.23312
3D structure databases
SMR	Q9R1A9. Positions 3-228.
ModBase	Search...
Proteomic databases
PRIDE	Q9R1A9.
Genome annotation databases
Ensembl	ENSMUST00000033738; ENSMUSP00000033738; ENSMUSG00000031372; Mus musculus. [Genome view]
GeneID	24102.
KEGG	mmu:24102.
UCSC	uc009tlt.2. mouse.
Organism-specific databases
CTD	24102.
MGI	MGI:1346343. Trex2.
Phylogenomic databases
HOGENOM	Q9R1A9.
HOVERGEN	Q9R1A9.
OMA	AETFVFL.
Enzyme and pathway databases
BRENDA	3.1.11.2. 244.
Gene expression databases
ArrayExpress	Q9R1A9.
Bgee	Q9R1A9.
CleanEx	MM_TREX2.
Genevestigator	Q9R1A9.
GermOnline	ENSMUSG00000031372. Mus musculus.
Family and domain databases
InterPro	IPR006055. Exonuclease. IPR013520. Exonuclease_RNaseT/DNA_pol3. [Graphical view]
Pfam	PF00929. Exonuc_X-T. 1 hit. [Graphical view]
SMART	SM00479. EXOIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	304113.
SOURCE	Search...

Entry information

Entry name

TREX2_MOUSE

Accession

Primary (citable) accession number: Q9R1A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)