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Protein

Nuclear receptor subfamily 1 group I member 2

Gene

Nr1i2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441AgonistBy similarity
Binding sitei285 – 2851AgonistBy similarity
Binding sitei296 – 2961AgonistBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 10467Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri38 – 5821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri74 – 9926NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 2
Alternative name(s):
Orphan nuclear receptor PXR
Pregnane X receptor
Gene namesi
Name:Nr1i2
Synonyms:Pxr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi69057. Nr1i2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2146315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Nuclear receptor subfamily 1 group I member 2PRO_0000053550Add
BLAST

Proteomic databases

PaxDbiQ9R1A7.

PTM databases

PhosphoSiteiQ9R1A7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002906.
GenevisibleiQ9R1A7. RN.

Interactioni

Subunit structurei

Heterodimer with RXRA. Interacts with NCOA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003934.

Structurei

3D structure databases

ProteinModelPortaliQ9R1A7.
SMRiQ9R1A7. Positions 139-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 20197HingeAdd
BLAST
Regioni202 – 431230Ligand-bindingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 8927Bipartite nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 5821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri74 – 9926NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129681.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ9R1A7.
KOiK08540.
OMAiYIECNRP.
OrthoDBiEOG091G05X3.
PhylomeDBiQ9R1A7.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEERWNHV GLVQREEADS VLEEPINVDE EDGGLQICRV CGDKANGYHF
60 70 80 90 100
NVMTCEGCKG FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL
110 120 130 140 150
ESGMKKEMIM SDAAVEQRRA LIKRKKREKI EAPPPGGQGL TEEQQALIQE
160 170 180 190 200
LMDAQMQTFD TTFSHFKDFR LPAVFHSDCE LPEVLQASLL EDPATWSQIM
210 220 230 240 250
KDSVPMKISV QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL ADVSTYMFKG
260 270 280 290 300
VINFAKVISH FRELPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR
310 320 330 340 350
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLREEEYVLM QAISLFSPDR
360 370 380 390 400
PGVVQRSVVD QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI
410 420 430
NAQQTQQLLR IQDTHPFATP LMQELFSSTD G
Length:431
Mass (Da):49,660
Last modified:May 1, 2000 - v1
Checksum:i4B545F21F9439697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151377 mRNA. Translation: AAD47214.1.
RefSeqiNP_443212.1. NM_052980.2.
UniGeneiRn.207164.

Genome annotation databases

EnsembliENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906.
GeneIDi84385.
KEGGirno:84385.
UCSCiRGD:69057. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151377 mRNA. Translation: AAD47214.1.
RefSeqiNP_443212.1. NM_052980.2.
UniGeneiRn.207164.

3D structure databases

ProteinModelPortaliQ9R1A7.
SMRiQ9R1A7. Positions 139-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003934.

Chemistry

ChEMBLiCHEMBL2146315.

PTM databases

PhosphoSiteiQ9R1A7.

Proteomic databases

PaxDbiQ9R1A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906.
GeneIDi84385.
KEGGirno:84385.
UCSCiRGD:69057. rat.

Organism-specific databases

CTDi8856.
RGDi69057. Nr1i2.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129681.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ9R1A7.
KOiK08540.
OMAiYIECNRP.
OrthoDBiEOG091G05X3.
PhylomeDBiQ9R1A7.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

PROiQ9R1A7.

Gene expression databases

BgeeiENSRNOG00000002906.
GenevisibleiQ9R1A7. RN.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR1I2_RAT
AccessioniPrimary (citable) accession number: Q9R1A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.