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Protein

Netrin-3

Gene

Ntn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons.By similarity

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-3
Alternative name(s):
Netrin-2-like protein
Gene namesi
Name:Ntn3
Synonyms:Ntn2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341188. Ntn3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • Golgi apparatus Source: MGI
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 580563Netrin-3PRO_0000017086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi92 ↔ 125By similarity
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 264By similarity
Disulfide bondi257 ↔ 274By similarity
Disulfide bondi276 ↔ 285By similarity
Disulfide bondi288 ↔ 308By similarity
Disulfide bondi311 ↔ 320By similarity
Disulfide bondi313 ↔ 338By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi353 ↔ 371By similarity
Disulfide bondi374 ↔ 386By similarity
Disulfide bondi376 ↔ 393By similarity
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi395 ↔ 404By similarity
Disulfide bondi407 ↔ 421By similarity
Disulfide bondi441 ↔ 514By similarity
Disulfide bondi460 ↔ 577By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R1A3.
PRIDEiQ9R1A3.

PTM databases

PhosphoSiteiQ9R1A3.

Expressioni

Tissue specificityi

Very low levels at E10.5 to E12.5 in dorsal root ganglia. High levels in motor neurons at E13.5, E14.5 and E15.5. At E11.5 also expressed in the developing limb buds.2 Publications

Gene expression databases

BgeeiQ9R1A3.
ExpressionAtlasiQ9R1A3. baseline and differential.
GenevisibleiQ9R1A3. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi201867. 1 interaction.
STRINGi10090.ENSMUSP00000024931.

Structurei

3D structure databases

ProteinModelPortaliQ9R1A3.
SMRiQ9R1A3. Positions 25-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 254219Laminin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini255 – 31056Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 37363Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 42350Laminin EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 577137NTRPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi500 – 5023Cell attachment site; atypicalSequence analysis

Sequence similaritiesi

Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512. Eukaryota.
ENOG410XS7U. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiQ9R1A3.
KOiK06844.
OMAiGFFSSHC.
OrthoDBiEOG7SR4KJ.
PhylomeDBiQ9R1A3.
TreeFamiTF352481.

Family and domain databases

InterProiIPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTWLWGLLL TAGTLSAALS PGLPASADPC YDEAREPRSC IPGLVNAALG
60 70 80 90 100
REVLASSTCG RSANRVCDSS DPQRAHSADL LTSAPGTASP LCWRSDLLQQ
110 120 130 140 150
APFNVTLTVP LGKAFELVFV SLRFCSAPPT SVALLKSQDH GRSWVPLGFF
160 170 180 190 200
SSSCTLDYGR LPAPADGPSG PGPEALCFPA PQAQPDGGGL LAFSVQDGSP
210 220 230 240 250
QGLDLDNSPV LQDWVTATDI RIVLTRPAIQ GDTRDGGVTV PYSYSATELQ
260 270 280 290 300
VGGRCKCNGH ASRCLLDTHG HLVCDCQHGT EGPDCSRCKP FYCDRPWQRA
310 320 330 340 350
TGQEAHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC
360 370 380 390 400
HYCREGFYRD PGRVLSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT
410 420 430 440 450
GLTCNRCAPG FQQSRSPVAP CVKTPVPGPT EESSPVEPQD CESHCRPARG
460 470 480 490 500
SYRISLKKFC RKDYAVQVAV GARGEARGSW TRFPVAVLAV FRSGEERARR
510 520 530 540 550
GSSALWVPTL DAACGCPRLL PGRRYLLLGG GPGAAAGSTA GRGQGLSAAR
560 570 580
GSLVLPWRDA WTRRLRRLQR RERRGRCGTA
Length:580
Mass (Da):62,023
Last modified:May 1, 2000 - v1
Checksum:iE1D7BFBADD10629D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231L → P in AAD42078 (Ref. 2) Curated
Sequence conflicti215 – 2151V → M in AAD42078 (Ref. 2) Curated
Sequence conflicti370 – 3701A → G in AAD28603 (PubMed:10381568).Curated
Sequence conflicti580 – 5801A → P in AAD28603 (PubMed:10381568).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152418 mRNA. Translation: AAD40063.1.
AK031199 mRNA. Translation: BAC27297.1.
AF149094 mRNA. Translation: AAD42078.1.
AF128866 mRNA. Translation: AAD28603.1.
CCDSiCCDS28478.1.
RefSeqiNP_035077.1. NM_010947.3.
UniGeneiMm.259542.

Genome annotation databases

EnsembliENSMUST00000024931; ENSMUSP00000024931; ENSMUSG00000036473.
GeneIDi18209.
KEGGimmu:18209.
UCSCiuc008auy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152418 mRNA. Translation: AAD40063.1.
AK031199 mRNA. Translation: BAC27297.1.
AF149094 mRNA. Translation: AAD42078.1.
AF128866 mRNA. Translation: AAD28603.1.
CCDSiCCDS28478.1.
RefSeqiNP_035077.1. NM_010947.3.
UniGeneiMm.259542.

3D structure databases

ProteinModelPortaliQ9R1A3.
SMRiQ9R1A3. Positions 25-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201867. 1 interaction.
STRINGi10090.ENSMUSP00000024931.

PTM databases

PhosphoSiteiQ9R1A3.

Proteomic databases

PaxDbiQ9R1A3.
PRIDEiQ9R1A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024931; ENSMUSP00000024931; ENSMUSG00000036473.
GeneIDi18209.
KEGGimmu:18209.
UCSCiuc008auy.2. mouse.

Organism-specific databases

CTDi4917.
MGIiMGI:1341188. Ntn3.

Phylogenomic databases

eggNOGiKOG3512. Eukaryota.
ENOG410XS7U. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiQ9R1A3.
KOiK06844.
OMAiGFFSSHC.
OrthoDBiEOG7SR4KJ.
PhylomeDBiQ9R1A3.
TreeFamiTF352481.

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Miscellaneous databases

PROiQ9R1A3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1A3.
ExpressionAtlasiQ9R1A3. baseline and differential.
GenevisibleiQ9R1A3. MM.

Family and domain databases

InterProiIPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors."
    Wang H., Copeland N.G., Gilbert D.J., Jenkins N.A., Tessier-Lavigne M.
    J. Neurosci. 19:4938-4947(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Netrin-3, a novel netrin-related axon guidance cue is associated with motor neurons within the developing vertebrate nervous system."
    Seaman C., Lackmann M., Kravets L., Anderson R.B., Cooper H.M.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Divergent properties of mouse netrins."
    Pueschel A.W.
    Mech. Dev. 83:65-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb.
  5. "Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons."
    Seaman C., Cooper H.M.
    Mech. Dev. 101:245-248(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNET3_MOUSE
AccessioniPrimary (citable) accession number: Q9R1A3
Secondary accession number(s): Q9QY49, Q9WVA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.