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Protein

Netrin-3

Gene

Ntn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons.By similarity

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-3
Alternative name(s):
Netrin-2-like protein
Gene namesi
Name:Ntn3
Synonyms:Ntn2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341188. Ntn3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001708618 – 580Netrin-3Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi92 ↔ 125By similarity
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 264By similarity
Disulfide bondi257 ↔ 274By similarity
Disulfide bondi276 ↔ 285By similarity
Disulfide bondi288 ↔ 308By similarity
Disulfide bondi311 ↔ 320By similarity
Disulfide bondi313 ↔ 338By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi353 ↔ 371By similarity
Disulfide bondi374 ↔ 386By similarity
Disulfide bondi376 ↔ 393By similarity
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi395 ↔ 404By similarity
Disulfide bondi407 ↔ 421By similarity
Disulfide bondi441 ↔ 514By similarity
Disulfide bondi460 ↔ 577By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1A3.
PaxDbiQ9R1A3.
PRIDEiQ9R1A3.

PTM databases

PhosphoSitePlusiQ9R1A3.

Expressioni

Tissue specificityi

Very low levels at E10.5 to E12.5 in dorsal root ganglia. High levels in motor neurons at E13.5, E14.5 and E15.5. At E11.5 also expressed in the developing limb buds.2 Publications

Gene expression databases

BgeeiENSMUSG00000036473.
ExpressionAtlasiQ9R1A3. baseline and differential.
GenevisibleiQ9R1A3. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi201867. 1 interactor.
STRINGi10090.ENSMUSP00000024931.

Structurei

3D structure databases

ProteinModelPortaliQ9R1A3.
SMRiQ9R1A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 254Laminin N-terminalPROSITE-ProRule annotationAdd BLAST219
Domaini255 – 310Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini311 – 373Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini374 – 423Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50
Domaini441 – 577NTRPROSITE-ProRule annotationAdd BLAST137

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi500 – 502Cell attachment site; atypicalSequence analysis3

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512. Eukaryota.
ENOG410XS7U. LUCA.
GeneTreeiENSGT00890000139348.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiQ9R1A3.
KOiK06844.
OMAiLRFCSAP.
OrthoDBiEOG091G005L.
PhylomeDBiQ9R1A3.
TreeFamiTF352481.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
PfamiView protein in Pfam
PF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTWLWGLLL TAGTLSAALS PGLPASADPC YDEAREPRSC IPGLVNAALG
60 70 80 90 100
REVLASSTCG RSANRVCDSS DPQRAHSADL LTSAPGTASP LCWRSDLLQQ
110 120 130 140 150
APFNVTLTVP LGKAFELVFV SLRFCSAPPT SVALLKSQDH GRSWVPLGFF
160 170 180 190 200
SSSCTLDYGR LPAPADGPSG PGPEALCFPA PQAQPDGGGL LAFSVQDGSP
210 220 230 240 250
QGLDLDNSPV LQDWVTATDI RIVLTRPAIQ GDTRDGGVTV PYSYSATELQ
260 270 280 290 300
VGGRCKCNGH ASRCLLDTHG HLVCDCQHGT EGPDCSRCKP FYCDRPWQRA
310 320 330 340 350
TGQEAHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC
360 370 380 390 400
HYCREGFYRD PGRVLSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT
410 420 430 440 450
GLTCNRCAPG FQQSRSPVAP CVKTPVPGPT EESSPVEPQD CESHCRPARG
460 470 480 490 500
SYRISLKKFC RKDYAVQVAV GARGEARGSW TRFPVAVLAV FRSGEERARR
510 520 530 540 550
GSSALWVPTL DAACGCPRLL PGRRYLLLGG GPGAAAGSTA GRGQGLSAAR
560 570 580
GSLVLPWRDA WTRRLRRLQR RERRGRCGTA
Length:580
Mass (Da):62,023
Last modified:May 1, 2000 - v1
Checksum:iE1D7BFBADD10629D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → P in AAD42078 (Ref. 2) Curated1
Sequence conflicti215V → M in AAD42078 (Ref. 2) Curated1
Sequence conflicti370A → G in AAD28603 (PubMed:10381568).Curated1
Sequence conflicti580A → P in AAD28603 (PubMed:10381568).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152418 mRNA. Translation: AAD40063.1.
AK031199 mRNA. Translation: BAC27297.1.
AF149094 mRNA. Translation: AAD42078.1.
AF128866 mRNA. Translation: AAD28603.1.
CCDSiCCDS28478.1.
RefSeqiNP_035077.1. NM_010947.3.
UniGeneiMm.259542.

Genome annotation databases

EnsembliENSMUST00000024931; ENSMUSP00000024931; ENSMUSG00000036473.
GeneIDi18209.
KEGGimmu:18209.
UCSCiuc008auy.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiNET3_MOUSE
AccessioniPrimary (citable) accession number: Q9R1A3
Secondary accession number(s): Q9QY49, Q9WVA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot