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Protein

Cyclin-H

Gene

Ccnh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-113418 Formation of the Early Elongation Complex
R-RNO-5696395 Formation of Incision Complex in GG-NER
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-69202 Cyclin E associated events during G1/S transition
R-RNO-69231 Cyclin D associated events in G1
R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-69656 Cyclin A:Cdk2-associated events at S phase entry
R-RNO-72086 mRNA Capping
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-73772 RNA Polymerase I Promoter Escape
R-RNO-73776 RNA Polymerase II Promoter Escape
R-RNO-73777 RNA Polymerase I Chain Elongation
R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-RNO-73863 RNA Polymerase I Transcription Termination
R-RNO-75953 RNA Polymerase II Transcription Initiation
R-RNO-75955 RNA Polymerase II Transcription Elongation
R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Gene namesi
Name:Ccnh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi69419 Ccnh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804731 – 323Cyclin-HAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine; by CDK8By similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei304Phosphoserine; by CDK8By similarity1
Modified residuei315PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R1A0
PRIDEiQ9R1A0

PTM databases

iPTMnetiQ9R1A0
PhosphoSitePlusiQ9R1A0

Expressioni

Gene expression databases

BgeeiENSRNOG00000031656
GenevisibleiQ9R1A0 RN

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039039

Structurei

3D structure databases

ProteinModelPortaliQ9R1A0
SMRiQ9R1A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi310 – 313Poly-Glu4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG2496 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00390000008634
HOGENOMiHOG000232149
HOVERGENiHBG050840
InParanoidiQ9R1A0
KOiK06634
OMAiNYYLTIH
OrthoDBiEOG091G0CEG
PhylomeDBiQ9R1A0
TreeFamiTF101008

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHNSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPLFLEP
60 70 80 90 100
HEEMTLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH
110 120 130 140 150
PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKAL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDIKTRYPM LENPEILRKT ADDFLSRIAL
210 220 230 240 250
TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTCLSQLLD
260 270 280 290 300
IMKSMRNLVK KYEPPRSEEV AILKQKLERC HSSDLALNMV TKKRKGYEDD
310 320
DYVSKKPKQE EEEWTDDDLV DAL
Length:323
Mass (Da):37,610
Last modified:October 18, 2001 - v2
Checksum:i7993FEDE265C2A96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125 – 126FV → KE in CAC37406 (PubMed:11252168).Curated2
Sequence conflicti220S → R in CAC37406 (PubMed:11252168).Curated1
Sequence conflicti237 – 238ML → SR in AAD46521 (PubMed:10501206).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154914 mRNA Translation: AAD46521.1
AJ276495 mRNA Translation: CAC37406.1
BC059109 mRNA Translation: AAH59109.1
RefSeqiNP_443213.2, NM_052981.2
UniGeneiRn.23255

Genome annotation databases

EnsembliENSRNOT00000049423; ENSRNOP00000039039; ENSRNOG00000031656
GeneIDi84389
KEGGirno:84389
UCSCiRGD:69419 rat

Similar proteinsi

Entry informationi

Entry nameiCCNH_RAT
AccessioniPrimary (citable) accession number: Q9R1A0
Secondary accession number(s): Q99JE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 18, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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