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Protein

Cyclin-H

Gene

Ccnh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-69202. Cyclin E associated events during G1/S transition.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Gene namesi
Name:Ccnh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi69419. Ccnh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Cyclin-HPRO_0000080473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Phosphoserine; by CDK8By similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei304 – 3041Phosphoserine; by CDK8By similarity
Modified residuei315 – 3151PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R1A0.
PRIDEiQ9R1A0.

Expressioni

Gene expression databases

GenevisibleiQ9R1A0. RN.

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039039.

Structurei

3D structure databases

ProteinModelPortaliQ9R1A0.
SMRiQ9R1A0. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi310 – 3134Poly-Glu

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00390000008634.
HOGENOMiHOG000232149.
HOVERGENiHBG050840.
InParanoidiQ9R1A0.
KOiK06634.
OMAiRKFKCKV.
OrthoDBiEOG70GMFX.
PhylomeDBiQ9R1A0.
TreeFamiTF101008.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R1A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHNSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPLFLEP
60 70 80 90 100
HEEMTLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH
110 120 130 140 150
PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKAL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDIKTRYPM LENPEILRKT ADDFLSRIAL
210 220 230 240 250
TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTCLSQLLD
260 270 280 290 300
IMKSMRNLVK KYEPPRSEEV AILKQKLERC HSSDLALNMV TKKRKGYEDD
310 320
DYVSKKPKQE EEEWTDDDLV DAL
Length:323
Mass (Da):37,610
Last modified:October 18, 2001 - v2
Checksum:i7993FEDE265C2A96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1262FV → KE in CAC37406 (PubMed:11252168).Curated
Sequence conflicti220 – 2201S → R in CAC37406 (PubMed:11252168).Curated
Sequence conflicti237 – 2382ML → SR in AAD46521 (PubMed:10501206).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154914 mRNA. Translation: AAD46521.1.
AJ276495 mRNA. Translation: CAC37406.1.
BC059109 mRNA. Translation: AAH59109.1.
RefSeqiNP_443213.2. NM_052981.2.
UniGeneiRn.23255.

Genome annotation databases

EnsembliENSRNOT00000049423; ENSRNOP00000039039; ENSRNOG00000031656.
GeneIDi84389.
KEGGirno:84389.
UCSCiRGD:69419. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154914 mRNA. Translation: AAD46521.1.
AJ276495 mRNA. Translation: CAC37406.1.
BC059109 mRNA. Translation: AAH59109.1.
RefSeqiNP_443213.2. NM_052981.2.
UniGeneiRn.23255.

3D structure databases

ProteinModelPortaliQ9R1A0.
SMRiQ9R1A0. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039039.

Proteomic databases

PaxDbiQ9R1A0.
PRIDEiQ9R1A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049423; ENSRNOP00000039039; ENSRNOG00000031656.
GeneIDi84389.
KEGGirno:84389.
UCSCiRGD:69419. rat.

Organism-specific databases

CTDi902.
RGDi69419. Ccnh.

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00390000008634.
HOGENOMiHOG000232149.
HOVERGENiHBG050840.
InParanoidiQ9R1A0.
KOiK06634.
OMAiRKFKCKV.
OrthoDBiEOG70GMFX.
PhylomeDBiQ9R1A0.
TreeFamiTF101008.

Enzyme and pathway databases

ReactomeiR-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-69202. Cyclin E associated events during G1/S transition.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

NextBioi616747.
PROiQ9R1A0.

Gene expression databases

GenevisibleiQ9R1A0. RN.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cell cycle regulation gene cyclin H from ischemic rat brain: expression in neurons after global cerebral ischemia."
    Jin K., Nagayama T., Chen J., Stetler A.R., Kawaguchi K., Simon R.P., Graham S.H.
    J. Neurochem. 73:1598-1608(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region."
    Laes J.-F., Quan X., Ravoet M., van Vooren P., van Reeth T., Szpirer J., Szpirer C.
    Mamm. Genome 12:199-206(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCNH_RAT
AccessioniPrimary (citable) accession number: Q9R1A0
Secondary accession number(s): Q99JE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 18, 2001
Last modified: May 11, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.