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Protein

Protein ATP1B4

Gene

Atp1b4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:Atp1b4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620994. Atp1b4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 109109NuclearSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini131 – 356226Perinuclear spaceSequence analysisAdd
BLAST

GO - Cellular componenti

  • chromatin Source: RGD
  • nuclear inner membrane Source: UniProtKB
  • sodium:potassium-exchanging ATPase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Protein ATP1B4PRO_0000219125Add
BLAST

Proteomic databases

PaxDbiQ9R193.
PRIDEiQ9R193.

Expressioni

Tissue specificityi

Expressed in perinatal myocytes (at protein level). Expressed during postnatal development in skeletal muscle and heart.1 Publication

Interactioni

Subunit structurei

Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-60962N.
STRINGi10116.ENSRNOP00000009329.

Structurei

3D structure databases

ProteinModelPortaliQ9R193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 7137Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ9R193.
KOiK01540.
PhylomeDBiQ9R193.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9R193-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRQLRSRRA PAFPYGYRYR LDDQDEMNHN YLADEEEEAE EEAQVMMVPG
60 70 80 90 100
LEEEEEEEEG KEEEEEREEE EGQGQSTGNA WWRKLQIVNE YLWDPEKRMS
110 120 130 140 150
LARTGQSRSL ILVIYFFFYA SLAAVITLFI YMLFLAISPY MPTFTEQVKP
160 170 180 190 200
PGVMIRPFAH SLNFNFNVSE PETWQRYVIS LNGFLQGYND SLQEEMNIDC
210 220 230 240 250
PPGQYFIQDG DEDEDKKACQ FKRSFLKNCS GLEDPTFGYS TGQPCILLKM
260 270 280 290 300
NRIVGFRPEF GDPVKVSCKV QKGDENDIRS INYYPESASF DLRYYPYYGK
310 320 330 340 350
LTHVNYTSPL VAMHFTDVVK NQEVPVQCQL KGKGIVNDVI NDRFVGRIIF

TLNIET
Length:356
Mass (Da):41,518
Last modified:May 1, 2000 - v1
Checksum:iC4B6A378B65BABFA
GO
Isoform B (identifier: Q9R193-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-109: Missing.

Show »
Length:352
Mass (Da):41,059
Checksum:i9A596D79B32248EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1094Missing in isoform B. 1 PublicationVSP_000354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158385 mRNA. Translation: AAD49694.1.
AF158386 mRNA. Translation: AAD49695.1.
RefSeqiNP_445833.1. NM_053381.1. [Q9R193-1]
UniGeneiRn.160581.

Genome annotation databases

GeneIDi84396.
KEGGirno:84396.
UCSCiRGD:620994. rat. [Q9R193-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158385 mRNA. Translation: AAD49694.1.
AF158386 mRNA. Translation: AAD49695.1.
RefSeqiNP_445833.1. NM_053381.1. [Q9R193-1]
UniGeneiRn.160581.

3D structure databases

ProteinModelPortaliQ9R193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60962N.
STRINGi10116.ENSRNOP00000009329.

Proteomic databases

PaxDbiQ9R193.
PRIDEiQ9R193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84396.
KEGGirno:84396.
UCSCiRGD:620994. rat. [Q9R193-1]

Organism-specific databases

CTDi23439.
RGDi620994. Atp1b4.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ9R193.
KOiK01540.
PhylomeDBiQ9R193.

Miscellaneous databases

NextBioi616809.
PROiQ9R193.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles."
    Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N.
    FEBS Lett. 456:243-248(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    Strain: Sprague-Dawley.
    Tissue: Skeletal muscle.
  2. "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
    Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
    Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
    Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D., Roy S., Bibert S., Geering K., Modyanov N.N.
    Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNW1 AND TOR1AIP1.

Entry informationi

Entry nameiAT1B4_RAT
AccessioniPrimary (citable) accession number: Q9R193
Secondary accession number(s): Q9R192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: December 9, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.