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Protein

Protein ATP1B4

Gene

Atp1b4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:Atp1b4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620994 Atp1b4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 109NuclearSequence analysisAdd BLAST109
Transmembranei110 – 130Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini131 – 356Perinuclear spaceSequence analysisAdd BLAST226

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191251 – 356Protein ATP1B4Add BLAST356

Proteomic databases

PaxDbiQ9R193
PRIDEiQ9R193

Expressioni

Tissue specificityi

Expressed in perinatal myocytes (at protein level). Expressed during postnatal development in skeletal muscle and heart.1 Publication

Interactioni

Subunit structurei

Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Snw1D4A8G72EBI-15644324,EBI-15644341

Protein-protein interaction databases

DIPiDIP-60962N
IntActiQ9R193, 2 interactors
STRINGi10116.ENSRNOP00000009329

Structurei

3D structure databases

ProteinModelPortaliQ9R193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 71Glu-richAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiQ9R193
KOiK01540
PhylomeDBiQ9R193

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9R193-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRQLRSRRA PAFPYGYRYR LDDQDEMNHN YLADEEEEAE EEAQVMMVPG
60 70 80 90 100
LEEEEEEEEG KEEEEEREEE EGQGQSTGNA WWRKLQIVNE YLWDPEKRMS
110 120 130 140 150
LARTGQSRSL ILVIYFFFYA SLAAVITLFI YMLFLAISPY MPTFTEQVKP
160 170 180 190 200
PGVMIRPFAH SLNFNFNVSE PETWQRYVIS LNGFLQGYND SLQEEMNIDC
210 220 230 240 250
PPGQYFIQDG DEDEDKKACQ FKRSFLKNCS GLEDPTFGYS TGQPCILLKM
260 270 280 290 300
NRIVGFRPEF GDPVKVSCKV QKGDENDIRS INYYPESASF DLRYYPYYGK
310 320 330 340 350
LTHVNYTSPL VAMHFTDVVK NQEVPVQCQL KGKGIVNDVI NDRFVGRIIF

TLNIET
Length:356
Mass (Da):41,518
Last modified:May 1, 2000 - v1
Checksum:iC4B6A378B65BABFA
GO
Isoform B (identifier: Q9R193-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-109: Missing.

Show »
Length:352
Mass (Da):41,059
Checksum:i9A596D79B32248EC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000354106 – 109Missing in isoform B. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158385 mRNA Translation: AAD49694.1
AF158386 mRNA Translation: AAD49695.1
RefSeqiNP_445833.1, NM_053381.1 [Q9R193-1]
UniGeneiRn.160581

Genome annotation databases

GeneIDi84396
KEGGirno:84396
UCSCiRGD:620994 rat [Q9R193-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAT1B4_RAT
AccessioniPrimary (citable) accession number: Q9R193
Secondary accession number(s): Q9R192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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