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Q9R190

- MTA2_MOUSE

UniProt

Q9R190 - MTA2_MOUSE

Protein

Metastasis-associated protein MTA2

Gene

Mta2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri367 – 39428GATA-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone deacetylase activity Source: MGI
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: InterPro
    6. transcription factor binding transcription factor activity Source: UniProtKB
    7. transcription regulatory region DNA binding Source: UniProtKB
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chromatin remodeling Source: MGI
    2. DNA methylation Source: MGI
    3. DNA packaging Source: MGI
    4. histone deacetylation Source: GOC
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis-associated protein MTA2
    Alternative name(s):
    Metastasis-associated 1-like 1
    Gene namesi
    Name:Mta2
    Synonyms:Mta1l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1346340. Mta2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. histone deacetylase complex Source: MGI
    2. nucleus Source: MGI
    3. NuRD complex Source: MGI
    4. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 668668Metastasis-associated protein MTA2PRO_0000083497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei152 – 1521N6-acetyllysineBy similarity
    Modified residuei433 – 4331PhosphoserineBy similarity
    Modified residuei435 – 4351PhosphoserineBy similarity
    Modified residuei460 – 4601N6-acetyllysine1 Publication
    Cross-linki492 – 492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity
    Modified residuei522 – 5221N6-acetyllysine1 Publication
    Modified residuei531 – 5311N6-acetyllysine1 Publication
    Modified residuei534 – 5341PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9R190.
    PaxDbiQ9R190.
    PRIDEiQ9R190.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00128230.

    PTM databases

    PhosphoSiteiQ9R190.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R190.
    BgeeiQ9R190.
    CleanExiMM_MTA2.
    GenevestigatoriQ9R190.

    Interactioni

    Subunit structurei

    Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 By similarity. Interacts with FAM64A By similarity. Interacts with NACC2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EsrrbQ615392EBI-904134,EBI-2312731
    Pou5f1P202636EBI-904134,EBI-1606219
    Sall4Q8BX223EBI-904134,EBI-2312582

    Protein-protein interaction databases

    BioGridi204807. 23 interactions.
    DIPiDIP-36630N.
    IntActiQ9R190. 18 interactions.
    MINTiMINT-1866896.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R190.
    SMRiQ9R190. Positions 145-321, 365-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 144144BAHPROSITE-ProRule annotationAdd
    BLAST
    Domaini145 – 256112ELM2PROSITE-ProRule annotationAdd
    BLAST
    Domaini263 – 31553SANTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 ELM2 domain.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.Curated
    Contains 1 SANT domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri367 – 39428GATA-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252834.
    GeneTreeiENSGT00580000081398.
    HOGENOMiHOG000045387.
    HOVERGENiHBG002598.
    InParanoidiQ9R190.
    KOiK11660.
    OMAiNAVKAEC.
    OrthoDBiEOG780RM1.
    PhylomeDBiQ9R190.
    TreeFamiTF106444.

    Family and domain databases

    InterProiIPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view]
    SMARTiSM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD    50
    ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT 100
    HIRGKCSVTL LNETDILNQY LDKEDCFFYS LVFDPVQKTL LADQGEIRVG 150
    CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV 200
    GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS 250
    TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 300
    ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV 350
    GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK 400
    YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN 450
    RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP 500
    KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN 550
    RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 600
    APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP 650
    LPASSHPAST NEPIVLED 668
    Length:668
    Mass (Da):75,030
    Last modified:May 1, 2000 - v1
    Checksum:i88996F779BA6F4D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti489 – 4891N → I in BAC40180. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159259 mRNA. Translation: AAD51281.1.
    AF348083 Genomic DNA. Translation: AAL30174.1.
    AB047977 Genomic DNA. Translation: BAB79231.1.
    AK088158 mRNA. Translation: BAC40180.1.
    AK147099 mRNA. Translation: BAE27675.1.
    AK159979 mRNA. Translation: BAE35530.1.
    BC079847 mRNA. Translation: AAH79847.1.
    CCDSiCCDS29561.1.
    RefSeqiNP_035972.3. NM_011842.3.
    UniGeneiMm.25339.

    Genome annotation databases

    EnsembliENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646.
    GeneIDi23942.
    KEGGimmu:23942.
    UCSCiuc008gof.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159259 mRNA. Translation: AAD51281.1 .
    AF348083 Genomic DNA. Translation: AAL30174.1 .
    AB047977 Genomic DNA. Translation: BAB79231.1 .
    AK088158 mRNA. Translation: BAC40180.1 .
    AK147099 mRNA. Translation: BAE27675.1 .
    AK159979 mRNA. Translation: BAE35530.1 .
    BC079847 mRNA. Translation: AAH79847.1 .
    CCDSi CCDS29561.1.
    RefSeqi NP_035972.3. NM_011842.3.
    UniGenei Mm.25339.

    3D structure databases

    ProteinModelPortali Q9R190.
    SMRi Q9R190. Positions 145-321, 365-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204807. 23 interactions.
    DIPi DIP-36630N.
    IntActi Q9R190. 18 interactions.
    MINTi MINT-1866896.

    PTM databases

    PhosphoSitei Q9R190.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00128230.

    Proteomic databases

    MaxQBi Q9R190.
    PaxDbi Q9R190.
    PRIDEi Q9R190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000096240 ; ENSMUSP00000093959 ; ENSMUSG00000071646 .
    GeneIDi 23942.
    KEGGi mmu:23942.
    UCSCi uc008gof.1. mouse.

    Organism-specific databases

    CTDi 9219.
    MGIi MGI:1346340. Mta2.

    Phylogenomic databases

    eggNOGi NOG252834.
    GeneTreei ENSGT00580000081398.
    HOGENOMi HOG000045387.
    HOVERGENi HBG002598.
    InParanoidi Q9R190.
    KOi K11660.
    OMAi NAVKAEC.
    OrthoDBi EOG780RM1.
    PhylomeDBi Q9R190.
    TreeFami TF106444.

    Miscellaneous databases

    ChiTaRSi MTA2. mouse.
    NextBioi 303749.
    PROi Q9R190.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R190.
    Bgeei Q9R190.
    CleanExi MM_MTA2.
    Genevestigatori Q9R190.

    Family and domain databases

    InterProi IPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view ]
    SMARTi SM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation."
      Zhang Y., Ng H.-H., Erdjument-Bromage H., Tempst P., Bird A., Reinberg D.
      Genes Dev. 13:1924-1935(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression."
      Xia L., Zhang Y.
      Gene 268:77-85(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor."
      Matsusue K., Takiguchi S., Toh Y., Kono A.
      DNA Cell Biol. 20:603-611(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, SUBCELLULAR LOCATION.
      Strain: 129/SvJ.
      Tissue: Liver.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Amnion and Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    6. Cited for: INTERACTION WITH HDAC7.
    7. "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2."
      Saito M., Ishikawa F.
      J. Biol. Chem. 277:35434-35439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MBD3.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-460; LYS-522 AND LYS-531, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiMTA2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R190
    Secondary accession number(s): Q3TVT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3