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Protein

Metastasis-associated protein MTA2

Gene

Mta2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: MGI
  • chromatin remodeling Source: MGI
  • DNA methylation Source: MGI
  • DNA packaging Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of fibroblast migration Source: Ensembl

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6804758. Regulation of TP53 Activity through Acetylation.
R-MMU-73762. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA2
Alternative name(s):
Metastasis-associated 1-like 1
Gene namesi
Name:Mta2
Synonyms:Mta1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1346340. Mta2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • histone deacetylase complex Source: MGI
  • membrane Source: MGI
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • NuRD complex Source: MGI
  • protein complex Source: MGI
  • transcription factor complex Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834971 – 668Metastasis-associated protein MTA2Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei460N6-acetyllysineCombined sources1
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternateBy similarity
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei522N6-acetyllysineCombined sources1
Modified residuei531N6-acetyllysineCombined sources1
Modified residuei534PhosphothreonineBy similarity1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki595Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9R190.
MaxQBiQ9R190.
PaxDbiQ9R190.
PeptideAtlasiQ9R190.
PRIDEiQ9R190.

2D gel databases

REPRODUCTION-2DPAGEiIPI00128230.

PTM databases

iPTMnetiQ9R190.
PhosphoSitePlusiQ9R190.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071646.
CleanExiMM_MTA2.
GenevisibleiQ9R190. MM.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with PIMREG (By similarity). Interacts with NACC2 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204807. 49 interactors.
DIPiDIP-36630N.
IntActiQ9R190. 43 interactors.
MINTiMINT-1866896.
STRINGi10090.ENSMUSP00000093959.

Structurei

3D structure databases

ProteinModelPortaliQ9R190.
SMRiQ9R190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144BAHPROSITE-ProRule annotationAdd BLAST144
Domaini145 – 256ELM2PROSITE-ProRule annotationAdd BLAST112
Domaini263 – 315SANTPROSITE-ProRule annotationAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3554. Eukaryota.
ENOG410XSAJ. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ9R190.
KOiK11660.
OMAiGPPTPIN.
OrthoDBiEOG091G04Z4.
PhylomeDBiQ9R190.
TreeFamiTF106444.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeobox-like.
IPR035170. MTA1_R1.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
PF17226. MTA_R1. 1 hit.
SMARTiView protein in SMART
SM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILNQY LDKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN
560 570 580 590 600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP
660
LPASSHPAST NEPIVLED
Length:668
Mass (Da):75,030
Last modified:May 1, 2000 - v1
Checksum:i88996F779BA6F4D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti489N → I in BAC40180 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159259 mRNA. Translation: AAD51281.1.
AF348083 Genomic DNA. Translation: AAL30174.1.
AB047977 Genomic DNA. Translation: BAB79231.1.
AK088158 mRNA. Translation: BAC40180.1.
AK147099 mRNA. Translation: BAE27675.1.
AK159979 mRNA. Translation: BAE35530.1.
BC079847 mRNA. Translation: AAH79847.1.
CCDSiCCDS29561.1.
RefSeqiNP_035972.3. NM_011842.3.
UniGeneiMm.25339.

Genome annotation databases

EnsembliENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646.
GeneIDi23942.
KEGGimmu:23942.
UCSCiuc008gof.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMTA2_MOUSE
AccessioniPrimary (citable) accession number: Q9R190
Secondary accession number(s): Q3TVT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot