Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9R190

- MTA2_MOUSE

UniProt

Q9R190 - MTA2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Metastasis-associated protein MTA2

Gene

Mta2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri367 – 39428GATA-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone deacetylase activity Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
  6. transcription factor binding transcription factor activity Source: UniProtKB
  7. transcription regulatory region DNA binding Source: UniProtKB
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: Ensembl
  2. chromatin remodeling Source: MGI
  3. DNA methylation Source: MGI
  4. DNA packaging Source: MGI
  5. histone deacetylation Source: GOC
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA2
Alternative name(s):
Metastasis-associated 1-like 1
Gene namesi
Name:Mta2
Synonyms:Mta1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1346340. Mta2.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. histone deacetylase complex Source: MGI
  2. nuclear chromatin Source: Ensembl
  3. nucleus Source: MGI
  4. NuRD complex Source: MGI
  5. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Metastasis-associated protein MTA2PRO_0000083497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521N6-acetyllysineBy similarity
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei435 – 4351PhosphoserineBy similarity
Modified residuei460 – 4601N6-acetyllysine1 Publication
Cross-linki492 – 492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity
Modified residuei522 – 5221N6-acetyllysine1 Publication
Modified residuei531 – 5311N6-acetyllysine1 Publication
Modified residuei534 – 5341PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9R190.
PaxDbiQ9R190.
PRIDEiQ9R190.

2D gel databases

REPRODUCTION-2DPAGEIPI00128230.

PTM databases

PhosphoSiteiQ9R190.

Expressioni

Gene expression databases

BgeeiQ9R190.
CleanExiMM_MTA2.
ExpressionAtlasiQ9R190. baseline and differential.
GenevestigatoriQ9R190.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with FAM64A (By similarity). Interacts with NACC2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EsrrbQ615392EBI-904134,EBI-2312731
Pou5f1P202636EBI-904134,EBI-1606219
Sall4Q8BX223EBI-904134,EBI-2312582

Protein-protein interaction databases

BioGridi204807. 23 interactions.
DIPiDIP-36630N.
IntActiQ9R190. 18 interactions.
MINTiMINT-1866896.

Structurei

3D structure databases

ProteinModelPortaliQ9R190.
SMRiQ9R190. Positions 145-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 144144BAHPROSITE-ProRule annotationAdd
BLAST
Domaini145 – 256112ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 31553SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri367 – 39428GATA-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG252834.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ9R190.
KOiK11660.
OMAiNAVKAEC.
OrthoDBiEOG780RM1.
PhylomeDBiQ9R190.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R190-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILNQY LDKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN
560 570 580 590 600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP
660
LPASSHPAST NEPIVLED
Length:668
Mass (Da):75,030
Last modified:May 1, 2000 - v1
Checksum:i88996F779BA6F4D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti489 – 4891N → I in BAC40180. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159259 mRNA. Translation: AAD51281.1.
AF348083 Genomic DNA. Translation: AAL30174.1.
AB047977 Genomic DNA. Translation: BAB79231.1.
AK088158 mRNA. Translation: BAC40180.1.
AK147099 mRNA. Translation: BAE27675.1.
AK159979 mRNA. Translation: BAE35530.1.
BC079847 mRNA. Translation: AAH79847.1.
CCDSiCCDS29561.1.
RefSeqiNP_035972.3. NM_011842.3.
UniGeneiMm.25339.

Genome annotation databases

EnsembliENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646.
GeneIDi23942.
KEGGimmu:23942.
UCSCiuc008gof.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159259 mRNA. Translation: AAD51281.1 .
AF348083 Genomic DNA. Translation: AAL30174.1 .
AB047977 Genomic DNA. Translation: BAB79231.1 .
AK088158 mRNA. Translation: BAC40180.1 .
AK147099 mRNA. Translation: BAE27675.1 .
AK159979 mRNA. Translation: BAE35530.1 .
BC079847 mRNA. Translation: AAH79847.1 .
CCDSi CCDS29561.1.
RefSeqi NP_035972.3. NM_011842.3.
UniGenei Mm.25339.

3D structure databases

ProteinModelPortali Q9R190.
SMRi Q9R190. Positions 145-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204807. 23 interactions.
DIPi DIP-36630N.
IntActi Q9R190. 18 interactions.
MINTi MINT-1866896.

PTM databases

PhosphoSitei Q9R190.

2D gel databases

REPRODUCTION-2DPAGE IPI00128230.

Proteomic databases

MaxQBi Q9R190.
PaxDbi Q9R190.
PRIDEi Q9R190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000096240 ; ENSMUSP00000093959 ; ENSMUSG00000071646 .
GeneIDi 23942.
KEGGi mmu:23942.
UCSCi uc008gof.1. mouse.

Organism-specific databases

CTDi 9219.
MGIi MGI:1346340. Mta2.

Phylogenomic databases

eggNOGi NOG252834.
GeneTreei ENSGT00580000081398.
HOGENOMi HOG000045387.
HOVERGENi HBG002598.
InParanoidi Q9R190.
KOi K11660.
OMAi NAVKAEC.
OrthoDBi EOG780RM1.
PhylomeDBi Q9R190.
TreeFami TF106444.

Miscellaneous databases

ChiTaRSi MTA2. mouse.
NextBioi 303749.
PROi Q9R190.
SOURCEi Search...

Gene expression databases

Bgeei Q9R190.
CleanExi MM_MTA2.
ExpressionAtlasi Q9R190. baseline and differential.
Genevestigatori Q9R190.

Family and domain databases

InterProi IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view ]
SMARTi SM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation."
    Zhang Y., Ng H.-H., Erdjument-Bromage H., Tempst P., Bird A., Reinberg D.
    Genes Dev. 13:1924-1935(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression."
    Xia L., Zhang Y.
    Gene 268:77-85(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor."
    Matsusue K., Takiguchi S., Toh Y., Kono A.
    DNA Cell Biol. 20:603-611(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, SUBCELLULAR LOCATION.
    Strain: 129/SvJ.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Amnion and Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. Cited for: INTERACTION WITH HDAC7.
  7. "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2."
    Saito M., Ishikawa F.
    J. Biol. Chem. 277:35434-35439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MBD3.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-460; LYS-522 AND LYS-531, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiMTA2_MOUSE
AccessioniPrimary (citable) accession number: Q9R190
Secondary accession number(s): Q3TVT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3