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Q9R190 (MTA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metastasis-associated protein MTA2
Alternative name(s):
Metastasis-associated 1-like 1
Gene names
Name:Mta2
Synonyms:Mta1l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Subunit structure

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 By similarity. Interacts with FAM64A By similarity. Ref.6 Ref.7

Subcellular location

Nucleus Ref.3.

Sequence similarities

Contains 1 BAH domain.

Contains 1 ELM2 domain.

Contains 1 GATA-type zinc finger.

Contains 1 SANT domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA methylation

Inferred from mutant phenotype PubMed 20720167. Source: MGI

DNA packaging

Traceable author statement Ref.1. Source: MGI

chromatin remodeling

Traceable author statement PubMed 14645126. Source: MGI

histone deacetylation

Inferred from direct assay Ref.1. Source: GOC

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.3. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 20636338. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.3. Source: MGI

   Cellular_componentNuRD complex

Inferred from direct assay PubMed 14645126. Source: MGI

histone deacetylase complex

Inferred from direct assay Ref.1. Source: MGI

nucleus

Inferred from direct assay Ref.3PubMed 16462733PubMed 20720167. Source: MGI

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchromatin binding

Inferred from electronic annotation. Source: InterPro

histone deacetylase activity

Inferred from direct assay Ref.1. Source: MGI

protein binding

Inferred from physical interaction PubMed 20636338. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription factor binding transcription factor activity

Inferred from direct assay PubMed 20636338. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 20636338. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 668668Metastasis-associated protein MTA2
PRO_0000083497

Regions

Domain1 – 144144BAH
Domain145 – 256112ELM2
Domain263 – 31553SANT
Zinc finger367 – 39428GATA-type; atypical

Amino acid modifications

Modified residue1521N6-acetyllysine By similarity
Modified residue4331Phosphoserine By similarity
Modified residue4351Phosphoserine By similarity
Modified residue4601N6-acetyllysine Ref.8
Modified residue5221N6-acetyllysine Ref.8
Modified residue5311N6-acetyllysine Ref.8
Modified residue5341Phosphothreonine By similarity

Experimental info

Sequence conflict4891N → I in BAC40180. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9R190 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 88996F779BA6F4D1

FASTA66875,030
        10         20         30         40         50         60 
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD ISSSLNSLAD 

        70         80         90        100        110        120 
SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT HIRGKCSVTL LNETDILNQY 

       130        140        150        160        170        180 
LDKEDCFFYS LVFDPVQKTL LADQGEIRVG CKFQAEIPDR LAEGESDNRN QQKMEMKVWD 

       190        200        210        220        230        240 
PDNPLTDRQI DQFLVVARAV GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR 

       250        260        270        280        290        300 
NGYDLAKAMS TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 

       310        320        330        340        350        360 
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV GSKPGMNGAG 

       370        380        390        400        410        420 
FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK YGGLKTPTQL EGAARGTTEP 

       430        440        450        460        470        480 
HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN RQTFLLQTTK LTRLARRMCR DLLQPRRAAR 

       490        500        510        520        530        540 
RPYAPINANA IKAECSIRLP KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT 

       550        560        570        580        590        600 
PINRNQLTQN RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 

       610        620        630        640        650        660 
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP LPASSHPAST 


NEPIVLED 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation."
Zhang Y., Ng H.-H., Erdjument-Bromage H., Tempst P., Bird A., Reinberg D.
Genes Dev. 13:1924-1935(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression."
Xia L., Zhang Y.
Gene 268:77-85(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor."
Matsusue K., Takiguchi S., Toh Y., Kono A.
DNA Cell Biol. 20:603-611(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, SUBCELLULAR LOCATION.
Strain: 129/SvJ.
Tissue: Liver.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Amnion and Thymus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[6]"Identification of a nuclear domain with deacetylase activity."
Downes M., Ordentlich P., Kao H.-Y., Alvarez J.G.A., Evans R.M.
Proc. Natl. Acad. Sci. U.S.A. 97:10330-10335(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HDAC7.
[7]"The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2."
Saito M., Ishikawa F.
J. Biol. Chem. 277:35434-35439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MBD3.
[8]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-460; LYS-522 AND LYS-531, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF159259 mRNA. Translation: AAD51281.1.
AF348083 Genomic DNA. Translation: AAL30174.1.
AB047977 Genomic DNA. Translation: BAB79231.1.
AK088158 mRNA. Translation: BAC40180.1.
AK147099 mRNA. Translation: BAE27675.1.
AK159979 mRNA. Translation: BAE35530.1.
BC079847 mRNA. Translation: AAH79847.1.
CCDSCCDS29561.1.
RefSeqNP_035972.3. NM_011842.3.
UniGeneMm.25339.

3D structure databases

ProteinModelPortalQ9R190.
SMRQ9R190. Positions 145-321, 365-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204807. 23 interactions.
DIPDIP-36630N.
IntActQ9R190. 18 interactions.
MINTMINT-1866896.

PTM databases

PhosphoSiteQ9R190.

2D gel databases

REPRODUCTION-2DPAGEIPI00128230.

Proteomic databases

MaxQBQ9R190.
PaxDbQ9R190.
PRIDEQ9R190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646.
GeneID23942.
KEGGmmu:23942.
UCSCuc008gof.1. mouse.

Organism-specific databases

CTD9219.
MGIMGI:1346340. Mta2.

Phylogenomic databases

eggNOGNOG252834.
GeneTreeENSGT00580000081398.
HOGENOMHOG000045387.
HOVERGENHBG002598.
InParanoidQ9R190.
KOK11660.
OMANAVKAEC.
OrthoDBEOG780RM1.
PhylomeDBQ9R190.
TreeFamTF106444.

Gene expression databases

ArrayExpressQ9R190.
BgeeQ9R190.
CleanExMM_MTA2.
GenevestigatorQ9R190.

Family and domain databases

InterProIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTA2. mouse.
NextBio303749.
PROQ9R190.
SOURCESearch...

Entry information

Entry nameMTA2_MOUSE
AccessionPrimary (citable) accession number: Q9R190
Secondary accession number(s): Q3TVT8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot