ID   ANGL3_MOUSE             Reviewed;         455 AA.
AC   Q9R182;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   21-SEP-2011, entry version 81.
DE   RecName: Full=Angiopoietin-related protein 3;
DE   AltName: Full=Angiopoietin-like protein 3;
DE   Flags: Precursor;
GN   Name=Angptl3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20112762; PubMed=10644446; DOI=10.1006/geno.1999.6041;
RA   Conklin D., Gilbertson D., Taft D.W., Maurer M.F., Whitmore T.E.,
RA   Smith D.L., Walker K.M., Chen L.H., Wattler S., Nehls M., Lewis K.B.;
RT   "Identification of a mammalian angiopoietin-related protein expressed
RT   specifically in liver.";
RL   Genomics 62:477-482(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
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DR   EMBL; AF162224; AAD45920.1; -; mRNA.
DR   EMBL; BC019491; AAH19491.1; -; mRNA.
DR   IPI; IPI00128206; -.
DR   RefSeq; NP_038941.1; NM_013913.3.
DR   UniGene; Mm.28341; -.
DR   ProteinModelPortal; Q9R182; -.
DR   SMR; Q9R182; 243-454.
DR   STRING; Q9R182; -.
DR   PhosphoSite; Q9R182; -.
DR   PRIDE; Q9R182; -.
DR   Ensembl; ENSMUST00000030280; ENSMUSP00000030280; ENSMUSG00000028553.
DR   GeneID; 30924; -.
DR   KEGG; mmu:30924; -.
DR   CTD; 27329; -.
DR   MGI; MGI:1353627; Angptl3.
DR   GeneTree; ENSGT00560000076679; -.
DR   HOGENOM; HBG713975; -.
DR   HOVERGEN; HBG001644; -.
DR   InParanoid; Q9R182; -.
DR   OMA; RGEHTSG; -.
DR   OrthoDB; EOG4G1MGS; -.
DR   PhylomeDB; Q9R182; -.
DR   NextBio; 307316; -.
DR   ArrayExpress; Q9R182; -.
DR   Bgee; Q9R182; -.
DR   CleanEx; MM_ANGPTL3; -.
DR   Genevestigator; Q9R182; -.
DR   GermOnline; ENSMUSG00000028553; Mus musculus.
DR   GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR   GO; GO:0055090; P:acylglycerol homeostasis; IMP:BHF-UCL.
DR   GO; GO:0048844; P:artery morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0007160; P:cell-matrix adhesion; ISS:UniProtKB.
DR   GO; GO:0042632; P:cholesterol homeostasis; IMP:BHF-UCL.
DR   GO; GO:0010519; P:negative regulation of phospholipase activity; IMP:BHF-UCL.
DR   GO; GO:0055091; P:phospholipid homeostasis; IMP:BHF-UCL.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL.
DR   GO; GO:0006641; P:triglyceride metabolic process; NAS:UniProtKB.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR014715; Fibrinogen_a/b/g_C_2.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Gene3D; G3DSA:4.10.530.10; Fibrinogen_a/b/g_C_2; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen_a/b/g_C; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; FALSE_NEG.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     16       Potential.
FT   CHAIN        17    455       Angiopoietin-related protein 3.
FT                                /FTId=PRO_0000009123.
FT   DOMAIN      237    455       Fibrinogen C-terminal.
FT   COILED       85    206       Potential.
FT   CARBOHYD    115    115       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    232    232       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    296    296       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    357    357       N-linked (GlcNAc...) (Potential).
FT   DISULFID    246    274       By similarity.
FT   DISULFID    394    408       By similarity.
SQ   SEQUENCE   455 AA;  52543 MW;  31609D3700D3F33D CRC64;
     MHTIKLFLFV VPLVIASRVD PDLSSFDSAP SEPKSRFAML DDVKILANGL LQLGHGLKDF
     VHKTKGQIND IFQKLNIFDQ SFYDLSLRTN EIKEEEKELR RTTSTLQVKN EEVKNMSVEL
     NSKLESLLEE KTALQHKVRA LEEQLTNLIL SPAGAQEHPE VTSLKSFVEQ QDNSIRELLQ
     SVEEQYKQLS QQHMQIKEIE KQLRKTGIQE PSENSLSSKS RAPRTTPPLQ LNETENTEQD
     DLPADCSAVY NRGEHTSGVY TIKPRNSQGF NVYCDTQSGS PWTLIQHRKD GSQDFNETWE
     NYEKGFGRLD GEFWLGLEKI YAIVQQSNYI LRLELQDWKD SKHYVEYSFH LGSHETNYTL
     HVAEIAGNIP GALPEHTDLM FSTWNHRAKG QLYCPESYSG GWWWNDICGE NNLNGKYNKP
     RTKSRPERRR GIYWRPQSRK LYAIKSSKMM LQPTT
//