ID   Q9R179_RAT              Unreviewed;       161 AA.
AC   Q9R179;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   SubName: Full=Sonic hedgehog protein {ECO:0000313|EMBL:AAD45373.1};
DE   Flags: Fragment;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAD45373.1};
RN   [1] {ECO:0000313|EMBL:AAD45373.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAD45373.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAD45373.1};
RA   Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.;
RT   "Sonic hedgehog in the rat.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Multimer. {ECO:0000256|ARBA:ARBA00034131}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC       Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Endoplasmic reticulum
CC       membrane {ECO:0000256|ARBA:ARBA00004586}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004394}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004635}.
CC   -!- SIMILARITY: Belongs to the hedgehog family.
CC       {ECO:0000256|ARBA:ARBA00010649}.
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DR   EMBL; AF162915; AAD45373.1; -; mRNA.
DR   AlphaFoldDB; Q9R179; -.
DR   MEROPS; C46.002; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0045165; P:cell fate commitment; IEA:UniProt.
DR   GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR   GO; GO:0007417; P:central nervous system development; IEA:UniProt.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:InterPro.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   CDD; cd00081; Hint; 1.
DR   Gene3D; 3.30.1380.10; -; 1.
DR   Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR   InterPro; IPR001657; Hedgehog.
DR   InterPro; IPR001767; Hedgehog_Hint.
DR   InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
DR   InterPro; IPR000320; Hedgehog_signalling_dom.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   PANTHER; PTHR11889; HEDGEHOG; 1.
DR   PANTHER; PTHR11889:SF36; SONIC HEDGEHOG PROTEIN; 1.
DR   Pfam; PF01085; HH_signal; 1.
DR   Pfam; PF01079; Hint; 1.
DR   PRINTS; PR00632; SONICHHOG.
DR   SUPFAM; SSF55166; Hedgehog/DD-peptidase; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
PE   2: Evidence at transcript level;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          1..101
FT                   /note="Hedgehog N-terminal signalling"
FT                   /evidence="ECO:0000259|Pfam:PF01085"
FT   DOMAIN          103..161
FT                   /note="Hedgehog protein Hint"
FT                   /evidence="ECO:0000259|Pfam:PF01079"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAD45373.1"
FT   NON_TER         161
FT                   /evidence="ECO:0000313|EMBL:AAD45373.1"
SQ   SEQUENCE   161 AA;  17906 MW;  DF06D85FD45AE4DB CRC64;
     IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH HSEESLHYEG
     RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC SVKAENSVAA KSGGCFPGSA
     TVHLEQGGTK LVKDLSPGDR VLAADDQGRL LYSDFLTFLD R
//