Q9R179 (Q9R179_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sonic hedgehog protein EMBL AAD45373.1

Gene names

Name:

Shh RGD 3673

Organism

Rattus norvegicus (Rat) EMBL AAD45373.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	161 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Cell membrane SAAS SAAS000320 Membrane Secreted SAAS SAAS000320
Molecular function	Developmental protein SAAS SAAS000320 Hydrolase Protease SAAS SAAS000320
Gene Ontology (GO)
Biological_process	Bergmann glial cell differentiation Inferred from electronic annotation. Source: Compara CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Inferred from electronic annotation. Source: Compara androgen metabolic process Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara apoptotic process Inferred from electronic annotation. Source: Compara artery development Inferred from electronic annotation. Source: Compara axon guidance Inferred from electronic annotation. Source: Compara blood coagulation Inferred from electronic annotation. Source: Compara branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara bud outgrowth involved in lung branching Inferred from electronic annotation. Source: Compara camera-type eye development Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cell fate specification Inferred from electronic annotation. Source: Compara cellular response to lithium ion Inferred from electronic annotation. Source: Compara determination of left/right asymmetry in lateral mesoderm Inferred from electronic annotation. Source: Compara dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara ectoderm development Inferred from electronic annotation. Source: Compara embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic foregut morphogenesis Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara endocytosis Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara establishment of cell polarity Inferred from electronic annotation. Source: Compara formation of anatomical boundary Inferred from electronic annotation. Source: Compara hair follicle morphogenesis Inferred from electronic annotation. Source: Compara heart looping Inferred from electronic annotation. Source: Compara hindbrain development Inferred from electronic annotation. Source: Compara hindgut morphogenesis Inferred from electronic annotation. Source: Compara inner ear development Inferred from electronic annotation. Source: Compara intermediate filament organization Inferred from electronic annotation. Source: Compara left lung development Inferred from electronic annotation. Source: Compara limb bud formation Inferred from electronic annotation. Source: Compara lung epithelium development Inferred from electronic annotation. Source: Compara lung lobe morphogenesis Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara lymphoid progenitor cell differentiation Inferred from electronic annotation. Source: Compara male genitalia development Inferred from electronic annotation. Source: Compara mesenchymal cell proliferation involved in lung development Inferred from electronic annotation. Source: Compara mesenchymal smoothened signaling pathway involved in prostate gland development Inferred from electronic annotation. Source: Compara metanephric mesenchymal cell proliferation involved in metanephros development Inferred from electronic annotation. Source: Compara midbrain development Inferred from electronic annotation. Source: Compara multicellular structure septum development Inferred from electronic annotation. Source: Compara myoblast differentiation Inferred from electronic annotation. Source: Compara myotube differentiation Inferred from electronic annotation. Source: Compara negative regulation of T cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cholesterol efflux Inferred from electronic annotation. Source: Compara negative regulation of kidney smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of transcription elongation from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of ureter smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara negative thymic T cell selection Inferred from electronic annotation. Source: Compara neural crest cell migration Inferred from electronic annotation. Source: Compara neuroblast proliferation Inferred from electronic annotation. Source: Compara neuron fate commitment Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara oligodendrocyte development Inferred from electronic annotation. Source: Compara organ formation Inferred from electronic annotation. Source: Compara osteoblast development Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara pancreas development Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara positive regulation of T cell differentiation in thymus Inferred from electronic annotation. Source: Compara positive regulation of Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation involved in prostate gland development Inferred from electronic annotation. Source: Compara positive regulation of hh target transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of immature T cell proliferation in thymus Inferred from electronic annotation. Source: Compara positive regulation of kidney smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation involved in ureter development Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of sclerotome development Inferred from electronic annotation. Source: Compara positive regulation of skeletal muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of skeletal muscle tissue development Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of striated muscle cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of ureter smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara positive thymic T cell selection Inferred from electronic annotation. Source: Compara primary prostatic bud elongation Inferred from electronic annotation. Source: Compara prostate epithelial cord elongation Inferred from electronic annotation. Source: Compara protein localization to nucleus Inferred from electronic annotation. Source: Compara proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: Compara regulation of mesenchymal cell proliferation involved in prostate gland development Inferred from electronic annotation. Source: Compara regulation of prostatic bud formation Inferred from electronic annotation. Source: Compara right lung development Inferred from electronic annotation. Source: Compara salivary gland cavitation Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Inferred from electronic annotation. Source: Compara somite development Inferred from electronic annotation. Source: Compara spinal cord dorsal/ventral patterning Inferred from electronic annotation. Source: Compara stem cell development Inferred from electronic annotation. Source: Compara telencephalon regionalization Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara thyroid gland development Inferred from electronic annotation. Source: Compara trachea morphogenesis Inferred from electronic annotation. Source: Compara vasculogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: Compara glycosaminoglycan binding Inferred from electronic annotation. Source: Compara peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAD45373.1
	Non-terminal residue	161	1	EMBL AAD45373.1

Sequences

	Sequence		Length	Mass (Da)
	Q9R179 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: DF06D85FD45AE4DB	FASTA	161	17,906
	10 20 30 40 50 60 IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH HSEESLHYEG 70 80 90 100 110 120 RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC SVKAENSVAA KSGGCFPGSA 130 140 150 160 TVHLEQGGTK LVKDLSPGDR VLAADDQGRL LYSDFLTFLD R

References

[1]	"Sonic hedgehog in the rat." Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAD45373.1. Tissue: Kidney EMBL AAD45373.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF162915 mRNA. Translation: AAD45373.1.
IPI	IPI00211101.
UniGene	Rn.10432.
3D structure databases
HSSP	HSSP built from PDB template 1VHH based on UniProtKB Q62226.
ProteinModelPortal	Q9R179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9R179.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	3673. Shh.
Phylogenomic databases
HOVERGEN	HBG005480.
InParanoid	Q9R179.
Gene expression databases
ArrayExpress	Q9R179.
Genevestigator	Q9R179.
Family and domain databases
Gene3D	3.30.1380.10. 1 hit.
InterPro	IPR001657. Hedgehog. IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom. IPR000320. Hedgehog_signaling_dom. IPR001767. Hint_dom. [Graphical view]
Pfam	PF01085. HH_signal. 1 hit. PF01079. Hint. 1 hit. [Graphical view]
PRINTS	PR00632. SONICHHOG.
SUPFAM	SSF55166. Hedgehog_sig_N. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q9R179.

Entry information

Entry name

Q9R179_RAT

Accession

Primary (citable) accession number: Q9R179

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	March 6, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)