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Q9R179

- Q9R179_RAT

UniProt

Q9R179 - Q9R179_RAT

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Protein
Submitted name:

Sonic hedgehog protein

Gene

Shh

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. glycosaminoglycan binding Source: Ensembl
  3. peptidase activity Source: InterPro
  4. zinc ion binding Source: Ensembl

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. apoptotic signaling pathway Source: Ensembl
  3. artery development Source: Ensembl
  4. axon guidance Source: Ensembl
  5. Bergmann glial cell differentiation Source: Ensembl
  6. blood coagulation Source: Ensembl
  7. branching involved in salivary gland morphogenesis Source: Ensembl
  8. branching involved in ureteric bud morphogenesis Source: Ensembl
  9. bud outgrowth involved in lung branching Source: Ensembl
  10. camera-type eye development Source: Ensembl
  11. canonical Wnt signaling pathway Source: Ensembl
  12. CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Source: Ensembl
  13. cell fate specification Source: Ensembl
  14. cellular response to lithium ion Source: Ensembl
  15. cerebellar granule cell precursor proliferation Source: Ensembl
  16. determination of left/right asymmetry in lateral mesoderm Source: Ensembl
  17. dorsal/ventral neural tube patterning Source: Ensembl
  18. ectoderm development Source: Ensembl
  19. embryonic digestive tract morphogenesis Source: Ensembl
  20. embryonic digit morphogenesis Source: Ensembl
  21. embryonic foregut morphogenesis Source: Ensembl
  22. embryonic forelimb morphogenesis Source: Ensembl
  23. embryonic hindlimb morphogenesis Source: Ensembl
  24. embryonic skeletal system development Source: Ensembl
  25. endocytosis Source: Ensembl
  26. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  27. establishment of cell polarity Source: Ensembl
  28. formation of anatomical boundary Source: Ensembl
  29. hair follicle morphogenesis Source: Ensembl
  30. heart looping Source: Ensembl
  31. hindgut morphogenesis Source: Ensembl
  32. inner ear development Source: Ensembl
  33. intermediate filament organization Source: Ensembl
  34. left lung development Source: Ensembl
  35. limb bud formation Source: Ensembl
  36. lung-associated mesenchyme development Source: Ensembl
  37. lung epithelium development Source: Ensembl
  38. lung lobe morphogenesis Source: Ensembl
  39. lymphoid progenitor cell differentiation Source: Ensembl
  40. male genitalia development Source: Ensembl
  41. mesenchymal cell proliferation involved in lung development Source: Ensembl
  42. mesenchymal smoothened signaling pathway involved in prostate gland development Source: Ensembl
  43. metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
  44. midbrain development Source: Ensembl
  45. multicellular structure septum development Source: Ensembl
  46. myoblast differentiation Source: Ensembl
  47. myotube differentiation Source: Ensembl
  48. negative regulation of alpha-beta T cell differentiation Source: Ensembl
  49. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  50. negative regulation of cell migration Source: Ensembl
  51. negative regulation of cholesterol efflux Source: Ensembl
  52. negative regulation of kidney smooth muscle cell differentiation Source: Ensembl
  53. negative regulation of mesenchymal cell apoptotic process Source: Ensembl
  54. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  55. negative regulation of T cell proliferation Source: Ensembl
  56. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  57. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  58. negative regulation of ureter smooth muscle cell differentiation Source: Ensembl
  59. negative thymic T cell selection Source: Ensembl
  60. neural crest cell migration Source: Ensembl
  61. neuroblast proliferation Source: Ensembl
  62. neuron fate commitment Source: Ensembl
  63. odontogenesis of dentin-containing tooth Source: Ensembl
  64. oligodendrocyte development Source: Ensembl
  65. organ formation Source: Ensembl
  66. osteoblast development Source: Ensembl
  67. palate development Source: Ensembl
  68. pancreas development Source: Ensembl
  69. patterning of blood vessels Source: Ensembl
  70. polarity specification of anterior/posterior axis Source: Ensembl
  71. positive regulation of alpha-beta T cell differentiation Source: Ensembl
  72. positive regulation of cell division Source: Ensembl
  73. positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  74. positive regulation of hh target transcription factor activity Source: Ensembl
  75. positive regulation of immature T cell proliferation in thymus Source: Ensembl
  76. positive regulation of kidney smooth muscle cell differentiation Source: Ensembl
  77. positive regulation of mesenchymal cell proliferation involved in ureter development Source: Ensembl
  78. positive regulation of neuroblast proliferation Source: Ensembl
  79. positive regulation of oligodendrocyte differentiation Source: Ensembl
  80. positive regulation of protein import into nucleus Source: Ensembl
  81. positive regulation of sclerotome development Source: Ensembl
  82. positive regulation of skeletal muscle cell proliferation Source: Ensembl
  83. positive regulation of skeletal muscle tissue development Source: Ensembl
  84. positive regulation of striated muscle cell differentiation Source: Ensembl
  85. positive regulation of T cell differentiation in thymus Source: Ensembl
  86. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  87. positive regulation of ureter smooth muscle cell differentiation Source: Ensembl
  88. positive regulation of Wnt signaling pathway Source: Ensembl
  89. positive thymic T cell selection Source: Ensembl
  90. primary prostatic bud elongation Source: Ensembl
  91. prostate epithelial cord elongation Source: Ensembl
  92. protein localization to nucleus Source: Ensembl
  93. regulation of mesenchymal cell proliferation involved in prostate gland development Source: Ensembl
  94. regulation of odontogenesis Source: Ensembl
  95. regulation of prostatic bud formation Source: Ensembl
  96. right lung development Source: Ensembl
  97. salivary gland cavitation Source: Ensembl
  98. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
  99. somite development Source: Ensembl
  100. spinal cord dorsal/ventral patterning Source: Ensembl
  101. spinal cord motor neuron differentiation Source: Ensembl
  102. striated muscle tissue development Source: Ensembl
  103. telencephalon regionalization Source: Ensembl
  104. thalamus development Source: Ensembl
  105. thymus development Source: Ensembl
  106. thyroid gland development Source: Ensembl
  107. trachea morphogenesis Source: Ensembl
  108. vasculogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sonic hedgehog proteinImported
Gene namesi
Name:ShhImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3673. Shh.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: Ensembl
  4. membrane raft Source: Ensembl
  5. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9R179. baseline.
GenevestigatoriQ9R179.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9R179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005480.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
[Graphical view]
PfamiPF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SUPFAMiSSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9R179-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH
60 70 80 90 100
HSEESLHYEG RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC
110 120 130 140 150
SVKAENSVAA KSGGCFPGSA TVHLEQGGTK LVKDLSPGDR VLAADDQGRL
160
LYSDFLTFLD R
Length:161
Mass (Da):17,906
Last modified:May 1, 2000 - v1
Checksum:iDF06D85FD45AE4DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei161 – 1611Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162915 mRNA. Translation: AAD45373.1.
UniGeneiRn.10432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162915 mRNA. Translation: AAD45373.1 .
UniGenei Rn.10432.

3D structure databases

ProteinModelPortali Q9R179.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9R179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 3673. Shh.

Phylogenomic databases

HOVERGENi HBG005480.

Gene expression databases

ExpressionAtlasi Q9R179. baseline.
Genevestigatori Q9R179.

Family and domain databases

Gene3Di 2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProi IPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
[Graphical view ]
Pfami PF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view ]
PRINTSi PR00632. SONICHHOG.
SUPFAMi SSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sonic hedgehog in the rat."
    Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9R179_RAT
AccessioniPrimary (citable) accession number: Q9R179
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)