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Q9R179

- Q9R179_RAT

UniProt

Q9R179 - Q9R179_RAT

Protein
Submitted name:

Sonic hedgehog protein

Gene

Shh

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. glycosaminoglycan binding Source: Ensembl
    3. peptidase activity Source: InterPro
    4. signal transducer activity Source: Ensembl
    5. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. apoptotic process Source: Ensembl
    4. artery development Source: Ensembl
    5. axon guidance Source: Ensembl
    6. Bergmann glial cell differentiation Source: Ensembl
    7. blood coagulation Source: Ensembl
    8. branching involved in salivary gland morphogenesis Source: Ensembl
    9. branching involved in ureteric bud morphogenesis Source: Ensembl
    10. bud outgrowth involved in lung branching Source: Ensembl
    11. camera-type eye development Source: Ensembl
    12. canonical Wnt signaling pathway Source: Ensembl
    13. CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Source: Ensembl
    14. cell fate specification Source: Ensembl
    15. cellular response to lithium ion Source: Ensembl
    16. determination of left/right asymmetry in lateral mesoderm Source: Ensembl
    17. dorsal/ventral neural tube patterning Source: Ensembl
    18. ectoderm development Source: Ensembl
    19. embryonic digestive tract morphogenesis Source: Ensembl
    20. embryonic digit morphogenesis Source: Ensembl
    21. embryonic foregut morphogenesis Source: Ensembl
    22. embryonic forelimb morphogenesis Source: Ensembl
    23. embryonic hindlimb morphogenesis Source: Ensembl
    24. embryonic skeletal system development Source: Ensembl
    25. endocytosis Source: Ensembl
    26. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    27. establishment of cell polarity Source: Ensembl
    28. formation of anatomical boundary Source: Ensembl
    29. hair follicle morphogenesis Source: Ensembl
    30. heart looping Source: Ensembl
    31. hindbrain development Source: Ensembl
    32. hindgut morphogenesis Source: Ensembl
    33. inner ear development Source: Ensembl
    34. intermediate filament organization Source: Ensembl
    35. left lung development Source: Ensembl
    36. limb bud formation Source: Ensembl
    37. lung-associated mesenchyme development Source: Ensembl
    38. lung epithelium development Source: Ensembl
    39. lung lobe morphogenesis Source: Ensembl
    40. lymphoid progenitor cell differentiation Source: Ensembl
    41. male genitalia development Source: Ensembl
    42. mesenchymal cell proliferation involved in lung development Source: Ensembl
    43. mesenchymal smoothened signaling pathway involved in prostate gland development Source: Ensembl
    44. metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
    45. midbrain development Source: Ensembl
    46. multicellular structure septum development Source: Ensembl
    47. myoblast differentiation Source: Ensembl
    48. myotube differentiation Source: Ensembl
    49. negative regulation of alpha-beta T cell differentiation Source: Ensembl
    50. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    51. negative regulation of cell migration Source: Ensembl
    52. negative regulation of cholesterol efflux Source: Ensembl
    53. negative regulation of kidney smooth muscle cell differentiation Source: Ensembl
    54. negative regulation of mesenchymal cell apoptotic process Source: Ensembl
    55. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    56. negative regulation of T cell proliferation Source: Ensembl
    57. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
    58. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    59. negative regulation of ureter smooth muscle cell differentiation Source: Ensembl
    60. negative thymic T cell selection Source: Ensembl
    61. neural crest cell migration Source: Ensembl
    62. neuroblast proliferation Source: Ensembl
    63. neuron fate commitment Source: Ensembl
    64. odontogenesis of dentin-containing tooth Source: Ensembl
    65. oligodendrocyte development Source: Ensembl
    66. organ formation Source: Ensembl
    67. osteoblast development Source: Ensembl
    68. palate development Source: Ensembl
    69. pancreas development Source: Ensembl
    70. patterning of blood vessels Source: Ensembl
    71. positive regulation of alpha-beta T cell differentiation Source: Ensembl
    72. positive regulation of cell division Source: Ensembl
    73. positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
    74. positive regulation of hh target transcription factor activity Source: Ensembl
    75. positive regulation of immature T cell proliferation in thymus Source: Ensembl
    76. positive regulation of kidney smooth muscle cell differentiation Source: Ensembl
    77. positive regulation of mesenchymal cell proliferation involved in ureter development Source: Ensembl
    78. positive regulation of neuroblast proliferation Source: Ensembl
    79. positive regulation of oligodendrocyte differentiation Source: Ensembl
    80. positive regulation of protein import into nucleus Source: Ensembl
    81. positive regulation of sclerotome development Source: Ensembl
    82. positive regulation of skeletal muscle cell proliferation Source: Ensembl
    83. positive regulation of skeletal muscle tissue development Source: Ensembl
    84. positive regulation of smoothened signaling pathway Source: Ensembl
    85. positive regulation of striated muscle cell differentiation Source: Ensembl
    86. positive regulation of T cell differentiation in thymus Source: Ensembl
    87. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    88. positive regulation of ureter smooth muscle cell differentiation Source: Ensembl
    89. positive regulation of Wnt signaling pathway Source: Ensembl
    90. positive thymic T cell selection Source: Ensembl
    91. primary prostatic bud elongation Source: Ensembl
    92. prostate epithelial cord elongation Source: Ensembl
    93. protein localization to nucleus Source: Ensembl
    94. regulation of mesenchymal cell proliferation involved in prostate gland development Source: Ensembl
    95. regulation of odontogenesis Source: Ensembl
    96. regulation of prostatic bud formation Source: Ensembl
    97. right lung development Source: Ensembl
    98. salivary gland cavitation Source: Ensembl
    99. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
    100. somite development Source: Ensembl
    101. spinal cord dorsal/ventral patterning Source: Ensembl
    102. spinal cord motor neuron differentiation Source: Ensembl
    103. striated muscle tissue development Source: Ensembl
    104. telencephalon regionalization Source: Ensembl
    105. thalamus development Source: Ensembl
    106. thymus development Source: Ensembl
    107. thyroid gland development Source: Ensembl
    108. trachea morphogenesis Source: Ensembl
    109. vasculogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Sonic hedgehog proteinImported
    Gene namesi
    Name:ShhImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi3673. Shh.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular matrix Source: Ensembl
    3. extracellular space Source: Ensembl
    4. membrane raft Source: Ensembl
    5. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R179.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG005480.
    InParanoidiQ9R179.

    Family and domain databases

    Gene3Di2.170.16.10. 1 hit.
    3.30.1380.10. 1 hit.
    InterProiIPR001657. Hedgehog.
    IPR028992. Hedgehog/Intein_dom.
    IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
    IPR000320. Hedgehog_signalling_dom.
    IPR001767. Hint_dom.
    [Graphical view]
    PfamiPF01085. HH_signal. 1 hit.
    PF01079. Hint. 1 hit.
    [Graphical view]
    PRINTSiPR00632. SONICHHOG.
    SUPFAMiSSF51294. SSF51294. 1 hit.
    SSF55166. SSF55166. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q9R179-1 [UniParc]FASTAAdd to Basket

    « Hide

    IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH    50
    HSEESLHYEG RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC 100
    SVKAENSVAA KSGGCFPGSA TVHLEQGGTK LVKDLSPGDR VLAADDQGRL 150
    LYSDFLTFLD R 161
    Length:161
    Mass (Da):17,906
    Last modified:May 1, 2000 - v1
    Checksum:iDF06D85FD45AE4DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei161 – 1611Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162915 mRNA. Translation: AAD45373.1.
    UniGeneiRn.10432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162915 mRNA. Translation: AAD45373.1 .
    UniGenei Rn.10432.

    3D structure databases

    ProteinModelPortali Q9R179.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9R179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 3673. Shh.

    Phylogenomic databases

    HOVERGENi HBG005480.
    InParanoidi Q9R179.

    Gene expression databases

    Genevestigatori Q9R179.

    Family and domain databases

    Gene3Di 2.170.16.10. 1 hit.
    3.30.1380.10. 1 hit.
    InterProi IPR001657. Hedgehog.
    IPR028992. Hedgehog/Intein_dom.
    IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
    IPR000320. Hedgehog_signalling_dom.
    IPR001767. Hint_dom.
    [Graphical view ]
    Pfami PF01085. HH_signal. 1 hit.
    PF01079. Hint. 1 hit.
    [Graphical view ]
    PRINTSi PR00632. SONICHHOG.
    SUPFAMi SSF51294. SSF51294. 1 hit.
    SSF55166. SSF55166. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sonic hedgehog in the rat."
      Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ9R179_RAT
    AccessioniPrimary (citable) accession number: Q9R179
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)