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Q9R179

- Q9R179_RAT

UniProt

Q9R179 - Q9R179_RAT

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Protein
Submitted name:

Sonic hedgehog protein

Gene
Shh
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. glycosaminoglycan binding Source: Ensembl
  3. peptidase activity Source: UniProtKB-KW
  4. signal transducer activity Source: Ensembl
  5. zinc ion binding Source: Ensembl

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. apoptotic process Source: Ensembl
  4. artery development Source: Ensembl
  5. axon guidance Source: Ensembl
  6. Bergmann glial cell differentiation Source: Ensembl
  7. blood coagulation Source: Ensembl
  8. branching involved in salivary gland morphogenesis Source: Ensembl
  9. branching involved in ureteric bud morphogenesis Source: Ensembl
  10. bud outgrowth involved in lung branching Source: Ensembl
  11. camera-type eye development Source: Ensembl
  12. canonical Wnt signaling pathway Source: Ensembl
  13. CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Source: Ensembl
  14. cell fate specification Source: Ensembl
  15. cellular response to lithium ion Source: Ensembl
  16. determination of left/right asymmetry in lateral mesoderm Source: Ensembl
  17. dorsal/ventral neural tube patterning Source: Ensembl
  18. ectoderm development Source: Ensembl
  19. embryonic digestive tract morphogenesis Source: Ensembl
  20. embryonic digit morphogenesis Source: Ensembl
  21. embryonic foregut morphogenesis Source: Ensembl
  22. embryonic forelimb morphogenesis Source: Ensembl
  23. embryonic hindlimb morphogenesis Source: Ensembl
  24. embryonic skeletal system development Source: Ensembl
  25. endocytosis Source: Ensembl
  26. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  27. establishment of cell polarity Source: Ensembl
  28. formation of anatomical boundary Source: Ensembl
  29. hair follicle morphogenesis Source: Ensembl
  30. heart looping Source: Ensembl
  31. hindbrain development Source: Ensembl
  32. hindgut morphogenesis Source: Ensembl
  33. inner ear development Source: Ensembl
  34. intermediate filament organization Source: Ensembl
  35. left lung development Source: Ensembl
  36. limb bud formation Source: Ensembl
  37. lung-associated mesenchyme development Source: Ensembl
  38. lung epithelium development Source: Ensembl
  39. lung lobe morphogenesis Source: Ensembl
  40. lymphoid progenitor cell differentiation Source: Ensembl
  41. male genitalia development Source: Ensembl
  42. mesenchymal cell proliferation involved in lung development Source: Ensembl
  43. mesenchymal smoothened signaling pathway involved in prostate gland development Source: Ensembl
  44. metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
  45. midbrain development Source: Ensembl
  46. multicellular structure septum development Source: Ensembl
  47. myoblast differentiation Source: Ensembl
  48. myotube differentiation Source: Ensembl
  49. negative regulation of alpha-beta T cell differentiation Source: Ensembl
  50. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  51. negative regulation of cell migration Source: Ensembl
  52. negative regulation of cholesterol efflux Source: Ensembl
  53. negative regulation of kidney smooth muscle cell differentiation Source: Ensembl
  54. negative regulation of mesenchymal cell apoptotic process Source: Ensembl
  55. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  56. negative regulation of T cell proliferation Source: Ensembl
  57. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  58. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  59. negative regulation of ureter smooth muscle cell differentiation Source: Ensembl
  60. negative thymic T cell selection Source: Ensembl
  61. neural crest cell migration Source: Ensembl
  62. neuroblast proliferation Source: Ensembl
  63. neuron fate commitment Source: Ensembl
  64. odontogenesis of dentin-containing tooth Source: Ensembl
  65. oligodendrocyte development Source: Ensembl
  66. organ formation Source: Ensembl
  67. osteoblast development Source: Ensembl
  68. palate development Source: Ensembl
  69. pancreas development Source: Ensembl
  70. patterning of blood vessels Source: Ensembl
  71. positive regulation of alpha-beta T cell differentiation Source: Ensembl
  72. positive regulation of cell division Source: Ensembl
  73. positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  74. positive regulation of hh target transcription factor activity Source: Ensembl
  75. positive regulation of immature T cell proliferation in thymus Source: Ensembl
  76. positive regulation of kidney smooth muscle cell differentiation Source: Ensembl
  77. positive regulation of mesenchymal cell proliferation involved in ureter development Source: Ensembl
  78. positive regulation of neuroblast proliferation Source: Ensembl
  79. positive regulation of oligodendrocyte differentiation Source: Ensembl
  80. positive regulation of protein import into nucleus Source: Ensembl
  81. positive regulation of sclerotome development Source: Ensembl
  82. positive regulation of skeletal muscle cell proliferation Source: Ensembl
  83. positive regulation of skeletal muscle tissue development Source: Ensembl
  84. positive regulation of smoothened signaling pathway Source: Ensembl
  85. positive regulation of striated muscle cell differentiation Source: Ensembl
  86. positive regulation of T cell differentiation in thymus Source: Ensembl
  87. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  88. positive regulation of ureter smooth muscle cell differentiation Source: Ensembl
  89. positive regulation of Wnt signaling pathway Source: Ensembl
  90. positive thymic T cell selection Source: Ensembl
  91. primary prostatic bud elongation Source: Ensembl
  92. prostate epithelial cord elongation Source: Ensembl
  93. protein localization to nucleus Source: Ensembl
  94. regulation of mesenchymal cell proliferation involved in prostate gland development Source: Ensembl
  95. regulation of odontogenesis Source: Ensembl
  96. regulation of prostatic bud formation Source: Ensembl
  97. right lung development Source: Ensembl
  98. salivary gland cavitation Source: Ensembl
  99. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
  100. somite development Source: Ensembl
  101. spinal cord dorsal/ventral patterning Source: Ensembl
  102. spinal cord motor neuron differentiation Source: Ensembl
  103. striated muscle tissue development Source: Ensembl
  104. telencephalon regionalization Source: Ensembl
  105. thalamus development Source: Ensembl
  106. thymus development Source: Ensembl
  107. thyroid gland development Source: Ensembl
  108. trachea morphogenesis Source: Ensembl
  109. vasculogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sonic hedgehog proteinImported
Gene namesi
Name:ShhImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3673. Shh.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: Ensembl
  4. membrane raft Source: Ensembl
  5. nucleus Source: Ensembl
  6. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9R179.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9R179.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005480.
InParanoidiQ9R179.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
[Graphical view]
PfamiPF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SUPFAMiSSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9R179-1 [UniParc]FASTAAdd to Basket

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IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH    50
HSEESLHYEG RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC 100
SVKAENSVAA KSGGCFPGSA TVHLEQGGTK LVKDLSPGDR VLAADDQGRL 150
LYSDFLTFLD R 161
Length:161
Mass (Da):17,906
Last modified:May 1, 2000 - v1
Checksum:iDF06D85FD45AE4DB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei161 – 1611Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162915 mRNA. Translation: AAD45373.1.
UniGeneiRn.10432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162915 mRNA. Translation: AAD45373.1 .
UniGenei Rn.10432.

3D structure databases

ProteinModelPortali Q9R179.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9R179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 3673. Shh.

Phylogenomic databases

HOVERGENi HBG005480.
InParanoidi Q9R179.

Gene expression databases

Genevestigatori Q9R179.

Family and domain databases

Gene3Di 2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProi IPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
[Graphical view ]
Pfami PF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view ]
PRINTSi PR00632. SONICHHOG.
SUPFAMi SSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sonic hedgehog in the rat."
    Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9R179_RAT
AccessioniPrimary (citable) accession number: Q9R179
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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