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Q9R179 (Q9R179_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Shh RGD 3673
OrganismRattus norvegicus (Rat) EMBL AAD45373.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length161 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS000320
Membrane
Secreted SAAS SAAS000320
   Molecular functionDevelopmental protein SAAS SAAS000320
Hydrolase
Protease SAAS SAAS000320
Gene Ontology (GO)
   Biological_processBergmann glial cell differentiation

Inferred from electronic annotation. Source: Ensembl

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

Inferred from electronic annotation. Source: Ensembl

androgen metabolic process

Inferred from electronic annotation. Source: Ensembl

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

apoptotic process

Inferred from electronic annotation. Source: Ensembl

artery development

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Inferred from electronic annotation. Source: Ensembl

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

bud outgrowth involved in lung branching

Inferred from electronic annotation. Source: Ensembl

camera-type eye development

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cell fate specification

Inferred from electronic annotation. Source: Ensembl

cellular response to lithium ion

Inferred from electronic annotation. Source: Ensembl

determination of left/right asymmetry in lateral mesoderm

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral neural tube patterning

Inferred from electronic annotation. Source: Ensembl

ectoderm development

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic foregut morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic forelimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic hindlimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system development

Inferred from electronic annotation. Source: Ensembl

endocytosis

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

establishment of cell polarity

Inferred from electronic annotation. Source: Ensembl

formation of anatomical boundary

Inferred from electronic annotation. Source: Ensembl

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

heart looping

Inferred from electronic annotation. Source: Ensembl

hindbrain development

Inferred from electronic annotation. Source: Ensembl

hindgut morphogenesis

Inferred from electronic annotation. Source: Ensembl

inner ear development

Inferred from electronic annotation. Source: Ensembl

intermediate filament organization

Inferred from electronic annotation. Source: Ensembl

left lung development

Inferred from electronic annotation. Source: Ensembl

limb bud formation

Inferred from electronic annotation. Source: Ensembl

lung epithelium development

Inferred from electronic annotation. Source: Ensembl

lung lobe morphogenesis

Inferred from electronic annotation. Source: Ensembl

lung-associated mesenchyme development

Inferred from electronic annotation. Source: Ensembl

lymphoid progenitor cell differentiation

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

mesenchymal cell proliferation involved in lung development

Inferred from electronic annotation. Source: Ensembl

mesenchymal smoothened signaling pathway involved in prostate gland development

Inferred from electronic annotation. Source: Ensembl

metanephric mesenchymal cell proliferation involved in metanephros development

Inferred from electronic annotation. Source: Ensembl

midbrain development

Inferred from electronic annotation. Source: Ensembl

multicellular structure septum development

Inferred from electronic annotation. Source: Ensembl

myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

myotube differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cholesterol efflux

Inferred from electronic annotation. Source: Ensembl

negative regulation of kidney smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription elongation from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of ureter smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

neuron fate commitment

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte development

Inferred from electronic annotation. Source: Ensembl

organ formation

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

positive regulation of Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation involved in prostate gland development

Inferred from electronic annotation. Source: Ensembl

positive regulation of hh target transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of immature T cell proliferation in thymus

Inferred from electronic annotation. Source: Ensembl

positive regulation of kidney smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation involved in ureter development

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of sclerotome development

Inferred from electronic annotation. Source: Ensembl

positive regulation of skeletal muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of skeletal muscle tissue development

Inferred from electronic annotation. Source: Ensembl

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of striated muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of ureter smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

primary prostatic bud elongation

Inferred from electronic annotation. Source: Ensembl

prostate epithelial cord elongation

Inferred from electronic annotation. Source: Ensembl

protein localization to nucleus

Inferred from electronic annotation. Source: Ensembl

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of mesenchymal cell proliferation involved in prostate gland development

Inferred from electronic annotation. Source: Ensembl

regulation of odontogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of prostatic bud formation

Inferred from electronic annotation. Source: Ensembl

right lung development

Inferred from electronic annotation. Source: Ensembl

salivary gland cavitation

Inferred from electronic annotation. Source: Ensembl

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

Inferred from electronic annotation. Source: Ensembl

somite development

Inferred from electronic annotation. Source: Ensembl

spinal cord dorsal/ventral patterning

Inferred from electronic annotation. Source: Ensembl

spinal cord motor neuron differentiation

Inferred from electronic annotation. Source: Ensembl

striated muscle tissue development

Inferred from electronic annotation. Source: Ensembl

telencephalon regionalization

Inferred from electronic annotation. Source: Ensembl

thalamus development

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

thyroid gland development

Inferred from electronic annotation. Source: Ensembl

trachea morphogenesis

Inferred from electronic annotation. Source: Ensembl

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

membrane raft

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: Ensembl

glycosaminoglycan binding

Inferred from electronic annotation. Source: Ensembl

peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

signal transducer activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAD45373.1
Non-terminal residue1611 EMBL AAD45373.1

Sequences

Sequence LengthMass (Da)Tools
Q9R179 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: DF06D85FD45AE4DB

FASTA16117,906
        10         20         30         40         50         60 
IIFKDEENTG ADRLMTQRCK DKLNALAISV MNQWPGVKLR VTEGWDEDGH HSEESLHYEG 

        70         80         90        100        110        120 
RAVDITTSDR DRSKYGMLAR LAVEAGFDWV YYESKAHIHC SVKAENSVAA KSGGCFPGSA 

       130        140        150        160 
TVHLEQGGTK LVKDLSPGDR VLAADDQGRL LYSDFLTFLD R 

« Hide

References

[1]"Sonic hedgehog in the rat."
Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAD45373.1.
Tissue: Kidney EMBL AAD45373.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF162915 mRNA. Translation: AAD45373.1.
UniGeneRn.10432.

3D structure databases

ProteinModelPortalQ9R179.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9R179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD3673. Shh.

Phylogenomic databases

HOVERGENHBG005480.
InParanoidQ9R179.

Gene expression databases

GenevestigatorQ9R179.

Family and domain databases

Gene3D3.30.1380.10. 1 hit.
InterProIPR001657. Hedgehog.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
[Graphical view]
PfamPF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view]
PRINTSPR00632. SONICHHOG.
SUPFAMSSF55166. SSF55166. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9R179_RAT
AccessionPrimary (citable) accession number: Q9R179
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)