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Protein

Secreted frizzled-related protein 1

Gene

Sfrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to prostaglandin E stimulus Source: RGD
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of osteoclast differentiation Source: RGD
  • negative regulation of Wnt signaling pathway Source: RGD
  • non-canonical Wnt signaling pathway Source: GO_Central
  • osteoblast differentiation Source: UniProtKB
  • regulation of ossification Source: RGD

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 1
Short name:
sFRP-1
Gene namesi
Name:Sfrp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621074. Sfrp1.

Subcellular locationi

  • Secreted By similarity

  • Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000191647‹1 – ›158Secreted frizzled-related protein 1Add BLAST›158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi51 ↔ 121By similarity
Disulfide bondi68 ↔ 123By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R168.

Expressioni

Developmental stagei

Differentially expressed in developing kidney. In 16 dpc embryos, highly expressed around the ureter and, also in all stromal elements, including the interstitial populations of the medulla and the outer layer of the cortex. In 19 dpc embryos, expression in the medulla is increased and is also found in the mesenchymal tissue surrounding the developing ureter.1 Publication

Interactioni

Subunit structurei

Interacts with WNT4, WNT1, WNT2, WNT8, MYOC and FRZD6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9R168. 1 interactor.
MINTiMINT-4574816.
STRINGi10116.ENSRNOP00000024128.

Structurei

3D structure databases

ProteinModelPortaliQ9R168.
SMRiQ9R168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 34FZPROSITE-ProRule annotationAdd BLAST›34
Domaini51 – ›158NTRPROSITE-ProRule annotationAdd BLAST›108

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ9R168.
PhylomeDBiQ9R168.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF101. PTHR11309:SF101. 1 hit.
PfamiView protein in Pfam
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9R168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VRDSCEPVMQ FFGFYWPEML KCDKFPEGDV CIAMTPPNAT EASKPQGTTV
60 70 80 90 100
CPPCDNELKS EAIIEHLCAS EFALRMKIKE VKKENGDKKI VPKKKKPLKL
110 120 130 140 150
GPIKKKELKR LVLFLKNGAD CPCHQLDNLS HNFLIMGRKV KSQYLLTAIH

KWDKKNKE
Length:158
Mass (Da):18,072
Last modified:May 1, 2000 - v1
Checksum:iABB1F13E3FB62690
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167308 mRNA. Translation: AAD49337.1.
UniGeneiRn.163333.

Genome annotation databases

UCSCiRGD:621074. rat.

Similar proteinsi

Entry informationi

Entry nameiSFRP1_RAT
AccessioniPrimary (citable) accession number: Q9R168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families