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Q9R157

- ADA18_MOUSE

UniProt

Q9R157 - ADA18_MOUSE

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Protein
Disintegrin and metalloproteinase domain-containing protein 18
Gene
Adam18, Adam27, Dtgn3, Tmdc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. integrin binding Source: MGI
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Protein family/group databases

MEROPSiM12.958.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 18
Short name:
ADAM 18
Alternative name(s):
Disintegrin and metalloproteinase domain-containing protein 27
Short name:
ADAM 27
Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Short name:
tMDC III
Gene namesi
Name:Adam18
Synonyms:Adam27, Dtgn3, Tmdc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:105986. Adam18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini173 – 683511Extracellular Reviewed prediction
Add
BLAST
Transmembranei684 – 70421Helical; Reviewed prediction
Add
BLAST
Topological domaini705 – 71915Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 179160 Reviewed prediction
PRO_0000029100Add
BLAST
Chaini180 – 719540Disintegrin and metalloproteinase domain-containing protein 18
PRO_0000029101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi289 ↔ 373 By similarity
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi332 ↔ 357 By similarity
Disulfide bondi334 ↔ 339 By similarity
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi405 – 4051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi447 ↔ 468 By similarity
Glycosylationi607 – 6071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi614 – 6141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi620 ↔ 632 By similarity
Glycosylationi621 – 6211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi626 ↔ 638 By similarity
Disulfide bondi640 ↔ 649 By similarity

Post-translational modificationi

The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R157.
PRIDEiQ9R157.

PTM databases

PhosphoSiteiQ9R157.

Expressioni

Tissue specificityi

Expressed specifically in testis.

Developmental stagei

Adult levels are reached by day 16 after birth.

Gene expression databases

BgeeiQ9R157.
CleanExiMM_ADAM18.
GenevestigatoriQ9R157.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033957.

Structurei

3D structure databases

ProteinModelPortaliQ9R157.
SMRiQ9R157. Positions 182-650.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini180 – 378199Peptidase M12B
Add
BLAST
Domaini387 – 47690Disintegrin
Add
BLAST
Domaini616 – 65035EGF-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi477 – 615139Cys-rich
Add
BLAST

Domaini

A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329803.
GeneTreeiENSGT00750000117474.
HOGENOMiHOG000230883.
HOVERGENiHBG103628.
InParanoidiQ80Y08.
KOiK16909.
OMAiDYMGSEM.
OrthoDBiEOG7W1537.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR000742. EG-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R157-1 [UniParc]FASTAAdd to Basket

« Hide

MPLLFILAEL AMLFARLDSE GICLHITVPQ KIEPRKGGDA EGKVTYVITI    50
DGKPYSLHLR NHSFLSQNFL VYTYNETGSL YSDSSHFLAH CHYRGYVDEV 100
PNSIVTLSIC SGLRGFLQLE NVSYGIEPLE SSARFEHIVY QVKSDSSMLA 150
GNDSHVWQID QLDKGHFNEQ DKNHSQLLPQ SLKLHIIVGK FLFDYMGSDI 200
MAITQKIFQI IGLVNAMLTQ LKLSVVLASL ELWSDKNHIS TDGNATDILQ 250
RLLDWKRDYL TLQSNEITHL LIYRRRPKYI GAASPGEICS KSYVAGVGMY 300
PEDIGLEGFS VVITQLIGLH IGLTYDDNIR NCSCPSAPCI MQQGALSSSG 350
KKTFSNCSLH DYMHYVSNFD TQCLGDLSNV HVLQPNQAVC GNGIMEAGEE 400
CDCGNETECQ FKECCDHETC RLKGSAQCGS GACCMPTCEL SASGTPCRKA 450
VDPECDFTEY CDGSSSHCVP DTFALNGHLC RLGSAYCYNG RCQALNDQCV 500
SLFGKGSQGA SYACFEKVNS PRENLANCDS KDSYSVPCGQ QDVLCGKLAC 550
FRPPKNYKSP SQSVVYSYVH DSVCLSILPG LSMRSDGRDS AYVADGTVCG 600
PQMYCINGTC KEVNFTGNDC NATKKCKGNG ICNNFGNCQC FPDYRPPDCN 650
LQIGSPGGSI DDGNTLRTES AFATKRLSKN EDSWVILGFF IFLPFIVTFL 700
VGIMKRNERK IVPQGEHKI 719
Length:719
Mass (Da):79,210
Last modified:July 27, 2011 - v2
Checksum:i9CD092E12625DA6D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451D → N in AAD48844. 1 Publication
Sequence conflicti159 – 1591I → T in AAD48844. 1 Publication
Sequence conflicti169 – 1691E → D in AAD48844. 1 Publication
Sequence conflicti276 – 2761R → H in AAD48844. 1 Publication
Sequence conflicti386 – 3861N → K in AAD48844. 1 Publication
Sequence conflicti577 – 5771I → V in AAD48844. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167405 mRNA. Translation: AAD48844.1.
BC051136 mRNA. Translation: AAH51136.2.
U06148 mRNA. Translation: AAA18427.1.
CCDSiCCDS22195.1.
PIRiI48946.
RefSeqiNP_034214.2. NM_010084.2.
UniGeneiMm.89943.

Genome annotation databases

EnsembliENSMUST00000033957; ENSMUSP00000033957; ENSMUSG00000031552.
GeneIDi13524.
KEGGimmu:13524.
UCSCiuc009lfb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167405 mRNA. Translation: AAD48844.1 .
BC051136 mRNA. Translation: AAH51136.2 .
U06148 mRNA. Translation: AAA18427.1 .
CCDSi CCDS22195.1.
PIRi I48946.
RefSeqi NP_034214.2. NM_010084.2.
UniGenei Mm.89943.

3D structure databases

ProteinModelPortali Q9R157.
SMRi Q9R157. Positions 182-650.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033957.

Protein family/group databases

MEROPSi M12.958.

PTM databases

PhosphoSitei Q9R157.

Proteomic databases

PaxDbi Q9R157.
PRIDEi Q9R157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033957 ; ENSMUSP00000033957 ; ENSMUSG00000031552 .
GeneIDi 13524.
KEGGi mmu:13524.
UCSCi uc009lfb.2. mouse.

Organism-specific databases

CTDi 8749.
MGIi MGI:105986. Adam18.

Phylogenomic databases

eggNOGi NOG329803.
GeneTreei ENSGT00750000117474.
HOGENOMi HOG000230883.
HOVERGENi HBG103628.
InParanoidi Q80Y08.
KOi K16909.
OMAi DYMGSEM.
OrthoDBi EOG7W1537.
TreeFami TF314733.

Miscellaneous databases

NextBioi 284100.
PROi Q9R157.
SOURCEi Search...

Gene expression databases

Bgeei Q9R157.
CleanExi MM_ADAM18.
Genevestigatori Q9R157.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR000742. EG-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization."
    Zhu G.-Z., Lin Y., Myles D.G., Primakoff P.
    Gene 234:227-237(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "A family of cellular proteins related to snake venom disintegrins."
    Weskamp G., Blobel C.P.
    Proc. Natl. Acad. Sci. U.S.A. 91:2748-2751(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-453.
    Strain: BALB/c.

Entry informationi

Entry nameiADA18_MOUSE
AccessioniPrimary (citable) accession number: Q9R157
Secondary accession number(s): Q60621, Q80Y08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi