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Q9R155 (S26A4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pendrin
Alternative name(s):
Sodium-independent chloride/iodide transporter
Solute carrier family 26 member 4
Gene names
Name:Slc26a4
Synonyms:Pds
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length780 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-independent transporter of chloride and iodide.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea. Ref.1

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 780780Pendrin
PRO_0000080165

Regions

Topological domain1 – 8787Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain1091Extracellular Potential
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 1355Cytoplasmic Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 19135Extracellular Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 2186Cytoplasmic Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 26324Extracellular Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 29511Cytoplasmic Potential
Transmembrane296 – 31621Helical; Potential
Topological domain317 – 34428Extracellular Potential
Transmembrane345 – 36521Helical; Potential
Topological domain366 – 38419Cytoplasmic Potential
Transmembrane385 – 40521Helical; Potential
Topological domain406 – 42116Extracellular Potential
Transmembrane422 – 44221Helical; Potential
Topological domain443 – 4486Cytoplasmic Potential
Transmembrane449 – 46921Helical; Potential
Topological domain470 – 48617Extracellular Potential
Transmembrane487 – 50721Helical; Potential
Topological domain508 – 780273Cytoplasmic Potential
Domain535 – 729195STAS

Sequences

Sequence LengthMass (Da)Tools
Q9R155 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4988BB48F057BF38

FASTA78085,687
        10         20         30         40         50         60 
MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL ARSCSCSRKR 

        70         80         90        100        110        120 
AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL QGMAYALLAA VPVQFGLYSA 

       130        140        150        160        170        180 
FFPILTYFVF GTSRHISVGP FPVVSLMVGS VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT 

       190        200        210        220        230        240 
RDAARVLLAS TLTLLVGIIQ LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL 

       250        260        270        280        290        300 
NVSTKNYNGI LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI 

       310        320        330        340        350        360 
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML AASFSIAVVA 

       370        380        390        400        410        420 
YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC FVATTALSRT AVQESTGGKT 

       430        440        450        460        470        480 
QVAGLISAVI VMVAIVALGR LLEPLQKSVL AAVVIANLKG MFMQVCDVPR LWKQNKTDAV 

       490        500        510        520        530        540 
IWVFTCIMSI ILGLDLGLLA GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE 

       550        560        570        580        590        600 
EPEGVKILRF SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 

       610        620        630        640        650        660 
KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL 

       670        680        690        700        710        720 
DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL EKMEQCGFFD DNIRKDRFFL 

       730        740        750        760        770        780 
TVHDAILHLQ NQVKSREGQD SLLETVARIR DCKDPLDLME AEMNAEELDV QDEAMRRLAS

« Hide

References

[1]"Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
Everett L.A., Morsli H., Wu D.K., Green E.D.
Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF167411 mRNA. Translation: AAD51617.1.
IPIIPI00128141.
RefSeqNP_035997.1. NM_011867.3.
UniGeneMm.100187.

3D structure databases

ProteinModelPortalQ9R155.
SMRQ9R155. Positions 516-577, 617-730.
ModBaseSearch...

Protein family/group databases

TCDB2.A.53.2.4. sulfate permease (SulP) family.

PTM databases

PhosphoSiteQ9R155.

Proteomic databases

PaxDbQ9R155.
PRIDEQ9R155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
GeneID23985.
KEGGmmu:23985.
UCSCuc007nho.1. mouse.

Organism-specific databases

CTD5172.
MGIMGI:1346029. Slc26a4.

Phylogenomic databases

eggNOGCOG0659.
GeneTreeENSGT00670000097702.
HOGENOMHOG000006546.
HOVERGENHBG000639.
InParanoidQ9R155.
KOK14702.
OMAPSWNGLG.
OrthoDBEOG4DFPN2.

Gene expression databases

BgeeQ9R155.
CleanExMM_SLC26A4.
GenevestigatorQ9R155.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. STAS. 1 hit.
TIGRFAMsTIGR00815. sulP. 1 hit.
PROSITEPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303877.
SOURCESearch...

Entry information

Entry nameS26A4_MOUSE
AccessionPrimary (citable) accession number: Q9R155
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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