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Protein

Pendrin

Gene

Slc26a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-independent transporter of chloride and iodide.

GO - Molecular functioni

  1. anion transmembrane transporter activity Source: MGI
  2. chloride transmembrane transporter activity Source: Ensembl
  3. iodide transmembrane transporter activity Source: Ensembl
  4. secondary active sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. organ morphogenesis Source: MGI
  2. regulation of pH Source: UniProtKB
  3. regulation of protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi2.A.53.2.4. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pendrin
Alternative name(s):
Sodium-independent chloride/iodide transporter
Solute carrier family 26 member 4
Gene namesi
Name:Slc26a4
Synonyms:Pds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1346029. Slc26a4.

Subcellular locationi

  1. Membrane 1 Publication; Multi-pass membrane protein 1 Publication
  2. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

  3. Note: Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Topological domaini109 – 1091ExtracellularSequence Analysis
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 1355CytoplasmicSequence Analysis
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Topological domaini157 – 19135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 2186CytoplasmicSequence Analysis
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 26324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 29511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 34428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 38419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Topological domaini406 – 42116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Topological domaini443 – 4486CytoplasmicSequence Analysis
Transmembranei449 – 46921HelicalSequence AnalysisAdd
BLAST
Topological domaini470 – 48617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence AnalysisAdd
BLAST
Topological domaini508 – 780273CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780PendrinPRO_0000080165Add
BLAST

Proteomic databases

MaxQBiQ9R155.
PaxDbiQ9R155.
PRIDEiQ9R155.

PTM databases

PhosphoSiteiQ9R155.

Expressioni

Tissue specificityi

Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea.1 Publication

Gene expression databases

BgeeiQ9R155.
CleanExiMM_SLC26A4.
GenevestigatoriQ9R155.

Structurei

3D structure databases

ProteinModelPortaliQ9R155.
SMRiQ9R155. Positions 516-577, 617-730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 729195STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R155.
KOiK14702.
OMAiDCKDPLE.
OrthoDBiEOG76T9QT.
PhylomeDBiQ9R155.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030285. Pendrin.
IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF33. PTHR11814:SF33. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL
60 70 80 90 100
ARSCSCSRKR AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL
110 120 130 140 150
QGMAYALLAA VPVQFGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS
160 170 180 190 200
VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT RDAARVLLAS TLTLLVGIIQ
210 220 230 240 250
LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGI
260 270 280 290 300
LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI
310 320 330 340 350
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML
360 370 380 390 400
AASFSIAVVA YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC
410 420 430 440 450
FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGR LLEPLQKSVL
460 470 480 490 500
AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA
510 520 530 540 550
GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF
560 570 580 590 600
SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT
610 620 630 640 650
KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV
660 670 680 690 700
PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL
710 720 730 740 750
EKMEQCGFFD DNIRKDRFFL TVHDAILHLQ NQVKSREGQD SLLETVARIR
760 770 780
DCKDPLDLME AEMNAEELDV QDEAMRRLAS
Length:780
Mass (Da):85,687
Last modified:May 1, 2000 - v1
Checksum:i4988BB48F057BF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167411 mRNA. Translation: AAD51617.1.
CCDSiCCDS36429.1.
RefSeqiNP_035997.1. NM_011867.3.
XP_006515154.1. XM_006515091.1.
XP_006515155.1. XM_006515092.2.
UniGeneiMm.100187.

Genome annotation databases

EnsembliENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
GeneIDi23985.
KEGGimmu:23985.
UCSCiuc007nho.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167411 mRNA. Translation: AAD51617.1.
CCDSiCCDS36429.1.
RefSeqiNP_035997.1. NM_011867.3.
XP_006515154.1. XM_006515091.1.
XP_006515155.1. XM_006515092.2.
UniGeneiMm.100187.

3D structure databases

ProteinModelPortaliQ9R155.
SMRiQ9R155. Positions 516-577, 617-730.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.53.2.4. the sulfate permease (sulp) family.

PTM databases

PhosphoSiteiQ9R155.

Proteomic databases

MaxQBiQ9R155.
PaxDbiQ9R155.
PRIDEiQ9R155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
GeneIDi23985.
KEGGimmu:23985.
UCSCiuc007nho.1. mouse.

Organism-specific databases

CTDi5172.
MGIiMGI:1346029. Slc26a4.

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R155.
KOiK14702.
OMAiDCKDPLE.
OrthoDBiEOG76T9QT.
PhylomeDBiQ9R155.
TreeFamiTF313784.

Miscellaneous databases

NextBioi303877.
PROiQ9R155.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R155.
CleanExiMM_SLC26A4.
GenevestigatoriQ9R155.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030285. Pendrin.
IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF33. PTHR11814:SF33. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
    Everett L.A., Morsli H., Wu D.K., Green E.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
  2. "Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells."
    Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.
    Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS26A4_MOUSE
AccessioniPrimary (citable) accession number: Q9R155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.