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Protein

Pendrin

Gene

Slc26a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent transporter of chloride and iodide.

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • bicarbonate transport Source: GO_Central
  • chloride transmembrane transport Source: GO_Central
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • regulation of pH Source: UniProtKB
  • regulation of protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.4. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pendrin
Alternative name(s):
Sodium-independent chloride/iodide transporter
Solute carrier family 26 member 4
Gene namesi
Name:Slc26a4
Synonyms:Pds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1346029. Slc26a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109ExtracellularSequence analysis1
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 135CytoplasmicSequence analysis5
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 191ExtracellularSequence analysisAdd BLAST35
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 218CytoplasmicSequence analysis6
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 263ExtracellularSequence analysisAdd BLAST24
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 295CytoplasmicSequence analysisAdd BLAST11
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 344ExtracellularSequence analysisAdd BLAST28
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 384CytoplasmicSequence analysisAdd BLAST19
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 421ExtracellularSequence analysisAdd BLAST16
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 448CytoplasmicSequence analysis6
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 486ExtracellularSequence analysisAdd BLAST17
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 780CytoplasmicSequence analysisAdd BLAST273

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • brush border membrane Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801651 – 780PendrinAdd BLAST780

Proteomic databases

MaxQBiQ9R155.
PaxDbiQ9R155.
PRIDEiQ9R155.

PTM databases

iPTMnetiQ9R155.
PhosphoSitePlusiQ9R155.

Expressioni

Tissue specificityi

Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000020651.
CleanExiMM_SLC26A4.
GenevisibleiQ9R155. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001253.

Structurei

3D structure databases

ProteinModelPortaliQ9R155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini535 – 729STASPROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R155.
KOiK14702.
OMAiPSWNGLG.
OrthoDBiEOG091G07RT.
PhylomeDBiQ9R155.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030285. Pendrin.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF33. PTHR11814:SF33. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL
60 70 80 90 100
ARSCSCSRKR AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL
110 120 130 140 150
QGMAYALLAA VPVQFGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS
160 170 180 190 200
VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT RDAARVLLAS TLTLLVGIIQ
210 220 230 240 250
LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGI
260 270 280 290 300
LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI
310 320 330 340 350
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML
360 370 380 390 400
AASFSIAVVA YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC
410 420 430 440 450
FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGR LLEPLQKSVL
460 470 480 490 500
AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA
510 520 530 540 550
GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF
560 570 580 590 600
SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT
610 620 630 640 650
KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV
660 670 680 690 700
PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL
710 720 730 740 750
EKMEQCGFFD DNIRKDRFFL TVHDAILHLQ NQVKSREGQD SLLETVARIR
760 770 780
DCKDPLDLME AEMNAEELDV QDEAMRRLAS
Length:780
Mass (Da):85,687
Last modified:May 1, 2000 - v1
Checksum:i4988BB48F057BF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167411 mRNA. Translation: AAD51617.1.
CCDSiCCDS36429.1.
RefSeqiNP_035997.1. NM_011867.3.
XP_006515154.1. XM_006515091.1.
XP_006515155.1. XM_006515092.3.
XP_017170557.1. XM_017315068.1.
UniGeneiMm.100187.

Genome annotation databases

EnsembliENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
GeneIDi23985.
KEGGimmu:23985.
UCSCiuc007nho.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167411 mRNA. Translation: AAD51617.1.
CCDSiCCDS36429.1.
RefSeqiNP_035997.1. NM_011867.3.
XP_006515154.1. XM_006515091.1.
XP_006515155.1. XM_006515092.3.
XP_017170557.1. XM_017315068.1.
UniGeneiMm.100187.

3D structure databases

ProteinModelPortaliQ9R155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001253.

Protein family/group databases

TCDBi2.A.53.2.4. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ9R155.
PhosphoSitePlusiQ9R155.

Proteomic databases

MaxQBiQ9R155.
PaxDbiQ9R155.
PRIDEiQ9R155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
GeneIDi23985.
KEGGimmu:23985.
UCSCiuc007nho.1. mouse.

Organism-specific databases

CTDi5172.
MGIiMGI:1346029. Slc26a4.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R155.
KOiK14702.
OMAiPSWNGLG.
OrthoDBiEOG091G07RT.
PhylomeDBiQ9R155.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-MMU-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiQ9R155.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020651.
CleanExiMM_SLC26A4.
GenevisibleiQ9R155. MM.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030285. Pendrin.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF33. PTHR11814:SF33. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A4_MOUSE
AccessioniPrimary (citable) accession number: Q9R155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.