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Q9R155

- S26A4_MOUSE

UniProt

Q9R155 - S26A4_MOUSE

Protein

Pendrin

Gene

Slc26a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sodium-independent transporter of chloride and iodide.

    GO - Molecular functioni

    1. anion transmembrane transporter activity Source: MGI
    2. chloride transmembrane transporter activity Source: Ensembl
    3. iodide transmembrane transporter activity Source: Ensembl
    4. secondary active sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. organ morphogenesis Source: MGI
    2. regulation of pH Source: UniProtKB
    3. regulation of protein localization Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi2.A.53.2.4. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pendrin
    Alternative name(s):
    Sodium-independent chloride/iodide transporter
    Solute carrier family 26 member 4
    Gene namesi
    Name:Slc26a4
    Synonyms:Pds
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1346029. Slc26a4.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. brush border membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 780780PendrinPRO_0000080165Add
    BLAST

    Proteomic databases

    PaxDbiQ9R155.
    PRIDEiQ9R155.

    PTM databases

    PhosphoSiteiQ9R155.

    Expressioni

    Tissue specificityi

    Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea.1 Publication

    Gene expression databases

    BgeeiQ9R155.
    CleanExiMM_SLC26A4.
    GenevestigatoriQ9R155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R155.
    SMRiQ9R155. Positions 516-577, 617-730.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 1091ExtracellularSequence Analysis
    Topological domaini131 – 1355CytoplasmicSequence Analysis
    Topological domaini157 – 19135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 2186CytoplasmicSequence Analysis
    Topological domaini240 – 26324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 29511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 34428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini366 – 38419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini406 – 42116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 4486CytoplasmicSequence Analysis
    Topological domaini470 – 48617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 780273CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini535 – 729195STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117367.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiQ9R155.
    KOiK14702.
    OMAiPSWNGLG.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ9R155.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R155-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL    50
    ARSCSCSRKR AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL 100
    QGMAYALLAA VPVQFGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS 150
    VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT RDAARVLLAS TLTLLVGIIQ 200
    LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGI 250
    LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI 300
    PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML 350
    AASFSIAVVA YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC 400
    FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGR LLEPLQKSVL 450
    AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA 500
    GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF 550
    SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 600
    KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV 650
    PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL 700
    EKMEQCGFFD DNIRKDRFFL TVHDAILHLQ NQVKSREGQD SLLETVARIR 750
    DCKDPLDLME AEMNAEELDV QDEAMRRLAS 780
    Length:780
    Mass (Da):85,687
    Last modified:May 1, 2000 - v1
    Checksum:i4988BB48F057BF38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167411 mRNA. Translation: AAD51617.1.
    CCDSiCCDS36429.1.
    RefSeqiNP_035997.1. NM_011867.3.
    XP_006515154.1. XM_006515091.1.
    XP_006515155.1. XM_006515092.1.
    UniGeneiMm.100187.

    Genome annotation databases

    EnsembliENSMUST00000001253; ENSMUSP00000001253; ENSMUSG00000020651.
    GeneIDi23985.
    KEGGimmu:23985.
    UCSCiuc007nho.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167411 mRNA. Translation: AAD51617.1 .
    CCDSi CCDS36429.1.
    RefSeqi NP_035997.1. NM_011867.3.
    XP_006515154.1. XM_006515091.1.
    XP_006515155.1. XM_006515092.1.
    UniGenei Mm.100187.

    3D structure databases

    ProteinModelPortali Q9R155.
    SMRi Q9R155. Positions 516-577, 617-730.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.53.2.4. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q9R155.

    Proteomic databases

    PaxDbi Q9R155.
    PRIDEi Q9R155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001253 ; ENSMUSP00000001253 ; ENSMUSG00000020651 .
    GeneIDi 23985.
    KEGGi mmu:23985.
    UCSCi uc007nho.1. mouse.

    Organism-specific databases

    CTDi 5172.
    MGIi MGI:1346029. Slc26a4.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117367.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi Q9R155.
    KOi K14702.
    OMAi PSWNGLG.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q9R155.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 303877.
    PROi Q9R155.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R155.
    CleanExi MM_SLC26A4.
    Genevestigatori Q9R155.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
      Everett L.A., Morsli H., Wu D.K., Green E.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells."
      Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.
      Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS26A4_MOUSE
    AccessioniPrimary (citable) accession number: Q9R155
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3