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Q9R154

- S26A4_RAT

UniProt

Q9R154 - S26A4_RAT

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Protein

Pendrin

Gene
Slc26a4, Pds
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-independent transporter of chloride and iodide.

GO - Molecular functioni

  1. chloride transmembrane transporter activity Source: RGD
  2. iodide transmembrane transporter activity Source: RGD
  3. secondary active sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: GOC
  3. inorganic anion transport Source: RGD
  4. iodide transport Source: GOC
  5. regulation of pH Source: UniProtKB
  6. regulation of protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Pendrin
Alternative name(s):
Sodium-independent chloride/iodide transporter
Solute carrier family 26 member 4
Gene namesi
Name:Slc26a4
Synonyms:Pds
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3293. Slc26a4.

Subcellular locationi

Membrane; Multi-pass membrane protein Inferred. Cell membrane; Multi-pass membrane protein
Note: Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Reviewed predictionAdd
BLAST
Topological domaini109 – 1091Extracellular Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Topological domaini131 – 1355Cytoplasmic Reviewed prediction
Transmembranei136 – 15621Helical; Reviewed predictionAdd
BLAST
Topological domaini157 – 19135Extracellular Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Topological domaini213 – 2186Cytoplasmic Reviewed prediction
Transmembranei219 – 23921Helical; Reviewed predictionAdd
BLAST
Topological domaini240 – 26324Extracellular Reviewed predictionAdd
BLAST
Transmembranei264 – 28421Helical; Reviewed predictionAdd
BLAST
Topological domaini285 – 29511Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei296 – 31621Helical; Reviewed predictionAdd
BLAST
Topological domaini317 – 34428Extracellular Reviewed predictionAdd
BLAST
Transmembranei345 – 36521Helical; Reviewed predictionAdd
BLAST
Topological domaini366 – 38419Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei385 – 40521Helical; Reviewed predictionAdd
BLAST
Topological domaini406 – 42116Extracellular Reviewed predictionAdd
BLAST
Transmembranei422 – 44221Helical; Reviewed predictionAdd
BLAST
Topological domaini443 – 4486Cytoplasmic Reviewed prediction
Transmembranei449 – 46921Helical; Reviewed predictionAdd
BLAST
Topological domaini470 – 48617Extracellular Reviewed predictionAdd
BLAST
Transmembranei487 – 50721Helical; Reviewed predictionAdd
BLAST
Topological domaini508 – 780273Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780PendrinPRO_0000080166Add
BLAST

Proteomic databases

PaxDbiQ9R154.
PRIDEiQ9R154.

Expressioni

Gene expression databases

GenevestigatoriQ9R154.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010350.

Structurei

3D structure databases

ProteinModelPortaliQ9R154.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 729195STASAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00750000117367.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R154.
KOiK14702.
OMAiPSWNGLG.
OrthoDBiEOG76T9QT.
PhylomeDBiQ9R154.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R154-1 [UniParc]FASTAAdd to Basket

« Hide

MAARDRRSEP PQLAEYSCSY AVSRPVYSEL AFQQQRERRL PERRTLRDSL    50
ARSCSCSRKR AFGALKALLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL 100
QGMAYALLAA VPVQYGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS 150
VVLSMAPDDH FLVPSGNGST LNTTTLDTGT RDAARVLLAS TLTLLVGIIQ 200
LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGV 250
LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHKIPVPI 300
PIEVIVTIIA TAISYGANLE ANYNAGIVKS IPSGFLPPVL PSVGLFSDML 350
AASFSIAVVA YAIAVSVGKV YATKHDYIID GNQEFIAFGI SNVFSGFFSC 400
FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGK LLEPLQKSVL 450
AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA 500
GLLFGLLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF 550
SSPIFYGNVD GFKKCVKSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 600
KNGIISDVGS SNNAFEPDED VEEPEELDIP TKEIEIQVDW NSELPVKVNV 650
PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL 700
EKMEQCGFFD DNIRKDRFFL TVHDAILYLQ NQAKSREGQD SLLETITLIQ 750
DCKDPLELME AEINEEELDV QDEAMRRLAS 780
Length:780
Mass (Da):85,715
Last modified:May 1, 2000 - v1
Checksum:iDA0CDB7496B8D535
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167412 mRNA. Translation: AAD51618.1.
RefSeqiNP_062087.1. NM_019214.1.
XP_006240038.1. XM_006239976.1.
XP_006240039.1. XM_006239977.1.
UniGeneiRn.11792.

Genome annotation databases

EnsembliENSRNOT00000010350; ENSRNOP00000010350; ENSRNOG00000007314.
GeneIDi29440.
KEGGirno:29440.
UCSCiRGD:3293. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167412 mRNA. Translation: AAD51618.1 .
RefSeqi NP_062087.1. NM_019214.1.
XP_006240038.1. XM_006239976.1.
XP_006240039.1. XM_006239977.1.
UniGenei Rn.11792.

3D structure databases

ProteinModelPortali Q9R154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010350.

Proteomic databases

PaxDbi Q9R154.
PRIDEi Q9R154.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010350 ; ENSRNOP00000010350 ; ENSRNOG00000007314 .
GeneIDi 29440.
KEGGi rno:29440.
UCSCi RGD:3293. rat.

Organism-specific databases

CTDi 5172.
RGDi 3293. Slc26a4.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00750000117367.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi Q9R154.
KOi K14702.
OMAi PSWNGLG.
OrthoDBi EOG76T9QT.
PhylomeDBi Q9R154.
TreeFami TF313784.

Miscellaneous databases

NextBioi 609189.
PROi Q9R154.

Gene expression databases

Genevestigatori Q9R154.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
    Everett L.A., Morsli H., Wu D.K., Green E.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiS26A4_RAT
AccessioniPrimary (citable) accession number: Q9R154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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