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Q9R154

- S26A4_RAT

UniProt

Q9R154 - S26A4_RAT

Protein

Pendrin

Gene

Slc26a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sodium-independent transporter of chloride and iodide.

    GO - Molecular functioni

    1. chloride transmembrane transporter activity Source: RGD
    2. iodide transmembrane transporter activity Source: RGD
    3. secondary active sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: GOC
    3. inorganic anion transport Source: RGD
    4. iodide transport Source: GOC
    5. regulation of pH Source: UniProtKB
    6. regulation of protein localization Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pendrin
    Alternative name(s):
    Sodium-independent chloride/iodide transporter
    Solute carrier family 26 member 4
    Gene namesi
    Name:Slc26a4
    Synonyms:Pds
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi3293. Slc26a4.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Cell membrane; Multi-pass membrane protein
    Note: Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. brush border membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 780780PendrinPRO_0000080166Add
    BLAST

    Proteomic databases

    PaxDbiQ9R154.
    PRIDEiQ9R154.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R154.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R154.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 1091ExtracellularSequence Analysis
    Topological domaini131 – 1355CytoplasmicSequence Analysis
    Topological domaini157 – 19135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 2186CytoplasmicSequence Analysis
    Topological domaini240 – 26324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 29511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 34428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini366 – 38419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini406 – 42116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 4486CytoplasmicSequence Analysis
    Topological domaini470 – 48617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 780273CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini535 – 729195STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117367.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiQ9R154.
    KOiK14702.
    OMAiPSWNGLG.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ9R154.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R154-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARDRRSEP PQLAEYSCSY AVSRPVYSEL AFQQQRERRL PERRTLRDSL    50
    ARSCSCSRKR AFGALKALLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL 100
    QGMAYALLAA VPVQYGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS 150
    VVLSMAPDDH FLVPSGNGST LNTTTLDTGT RDAARVLLAS TLTLLVGIIQ 200
    LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGV 250
    LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHKIPVPI 300
    PIEVIVTIIA TAISYGANLE ANYNAGIVKS IPSGFLPPVL PSVGLFSDML 350
    AASFSIAVVA YAIAVSVGKV YATKHDYIID GNQEFIAFGI SNVFSGFFSC 400
    FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGK LLEPLQKSVL 450
    AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA 500
    GLLFGLLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF 550
    SSPIFYGNVD GFKKCVKSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 600
    KNGIISDVGS SNNAFEPDED VEEPEELDIP TKEIEIQVDW NSELPVKVNV 650
    PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL 700
    EKMEQCGFFD DNIRKDRFFL TVHDAILYLQ NQAKSREGQD SLLETITLIQ 750
    DCKDPLELME AEINEEELDV QDEAMRRLAS 780
    Length:780
    Mass (Da):85,715
    Last modified:May 1, 2000 - v1
    Checksum:iDA0CDB7496B8D535
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167412 mRNA. Translation: AAD51618.1.
    RefSeqiNP_062087.1. NM_019214.1.
    XP_006240038.1. XM_006239976.1.
    XP_006240039.1. XM_006239977.1.
    UniGeneiRn.11792.

    Genome annotation databases

    EnsembliENSRNOT00000010350; ENSRNOP00000010350; ENSRNOG00000007314.
    GeneIDi29440.
    KEGGirno:29440.
    UCSCiRGD:3293. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167412 mRNA. Translation: AAD51618.1 .
    RefSeqi NP_062087.1. NM_019214.1.
    XP_006240038.1. XM_006239976.1.
    XP_006240039.1. XM_006239977.1.
    UniGenei Rn.11792.

    3D structure databases

    ProteinModelPortali Q9R154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010350.

    Proteomic databases

    PaxDbi Q9R154.
    PRIDEi Q9R154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010350 ; ENSRNOP00000010350 ; ENSRNOG00000007314 .
    GeneIDi 29440.
    KEGGi rno:29440.
    UCSCi RGD:3293. rat.

    Organism-specific databases

    CTDi 5172.
    RGDi 3293. Slc26a4.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117367.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi Q9R154.
    KOi K14702.
    OMAi PSWNGLG.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q9R154.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 609189.
    PROi Q9R154.

    Gene expression databases

    Genevestigatori Q9R154.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
      Everett L.A., Morsli H., Wu D.K., Green E.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiS26A4_RAT
    AccessioniPrimary (citable) accession number: Q9R154
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3