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Q9R154

- S26A4_RAT

UniProt

Q9R154 - S26A4_RAT

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Protein

Pendrin

Gene

Slc26a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium-independent transporter of chloride and iodide.

GO - Molecular functioni

  1. chloride transmembrane transporter activity Source: RGD
  2. iodide transmembrane transporter activity Source: RGD
  3. secondary active sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: GOC
  3. inorganic anion transport Source: RGD
  4. iodide transport Source: GOC
  5. regulation of pH Source: UniProtKB
  6. regulation of protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_237370. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Pendrin
Alternative name(s):
Sodium-independent chloride/iodide transporter
Solute carrier family 26 member 4
Gene namesi
Name:Slc26a4
Synonyms:Pds
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3293. Slc26a4.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Cell membrane; Multi-pass membrane protein
Note: Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Topological domaini109 – 1091ExtracellularSequence Analysis
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 1355CytoplasmicSequence Analysis
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Topological domaini157 – 19135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 2186CytoplasmicSequence Analysis
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 26324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 29511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 34428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 38419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Topological domaini406 – 42116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Topological domaini443 – 4486CytoplasmicSequence Analysis
Transmembranei449 – 46921HelicalSequence AnalysisAdd
BLAST
Topological domaini470 – 48617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence AnalysisAdd
BLAST
Topological domaini508 – 780273CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780PendrinPRO_0000080166Add
BLAST

Proteomic databases

PaxDbiQ9R154.
PRIDEiQ9R154.

Expressioni

Gene expression databases

GenevestigatoriQ9R154.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010350.

Structurei

3D structure databases

ProteinModelPortaliQ9R154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 729195STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ9R154.
KOiK14702.
OMAiPSWNGLG.
OrthoDBiEOG76T9QT.
PhylomeDBiQ9R154.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R154-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARDRRSEP PQLAEYSCSY AVSRPVYSEL AFQQQRERRL PERRTLRDSL
60 70 80 90 100
ARSCSCSRKR AFGALKALLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL
110 120 130 140 150
QGMAYALLAA VPVQYGLYSA FFPILTYFVF GTSRHISVGP FPVVSLMVGS
160 170 180 190 200
VVLSMAPDDH FLVPSGNGST LNTTTLDTGT RDAARVLLAS TLTLLVGIIQ
210 220 230 240 250
LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGV
260 270 280 290 300
LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHKIPVPI
310 320 330 340 350
PIEVIVTIIA TAISYGANLE ANYNAGIVKS IPSGFLPPVL PSVGLFSDML
360 370 380 390 400
AASFSIAVVA YAIAVSVGKV YATKHDYIID GNQEFIAFGI SNVFSGFFSC
410 420 430 440 450
FVATTALSRT AVQESTGGKT QVAGLISAVI VMVAIVALGK LLEPLQKSVL
460 470 480 490 500
AAVVIANLKG MFMQVCDVPR LWKQNKTDAV IWVFTCIMSI ILGLDLGLLA
510 520 530 540 550
GLLFGLLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE EPEGVKILRF
560 570 580 590 600
SSPIFYGNVD GFKKCVKSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT
610 620 630 640 650
KNGIISDVGS SNNAFEPDED VEEPEELDIP TKEIEIQVDW NSELPVKVNV
660 670 680 690 700
PKVPIHSLVL DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL
710 720 730 740 750
EKMEQCGFFD DNIRKDRFFL TVHDAILYLQ NQAKSREGQD SLLETITLIQ
760 770 780
DCKDPLELME AEINEEELDV QDEAMRRLAS
Length:780
Mass (Da):85,715
Last modified:May 1, 2000 - v1
Checksum:iDA0CDB7496B8D535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167412 mRNA. Translation: AAD51618.1.
RefSeqiNP_062087.1. NM_019214.1.
XP_008762798.1. XM_008764576.1.
UniGeneiRn.11792.

Genome annotation databases

EnsembliENSRNOT00000010350; ENSRNOP00000010350; ENSRNOG00000007314.
GeneIDi29440.
KEGGirno:29440.
UCSCiRGD:3293. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167412 mRNA. Translation: AAD51618.1 .
RefSeqi NP_062087.1. NM_019214.1.
XP_008762798.1. XM_008764576.1.
UniGenei Rn.11792.

3D structure databases

ProteinModelPortali Q9R154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010350.

Proteomic databases

PaxDbi Q9R154.
PRIDEi Q9R154.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010350 ; ENSRNOP00000010350 ; ENSRNOG00000007314 .
GeneIDi 29440.
KEGGi rno:29440.
UCSCi RGD:3293. rat.

Organism-specific databases

CTDi 5172.
RGDi 3293. Slc26a4.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00760000119026.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi Q9R154.
KOi K14702.
OMAi PSWNGLG.
OrthoDBi EOG76T9QT.
PhylomeDBi Q9R154.
TreeFami TF313784.

Enzyme and pathway databases

Reactomei REACT_237370. Multifunctional anion exchangers.

Miscellaneous databases

NextBioi 609189.
PROi Q9R154.

Gene expression databases

Genevestigatori Q9R154.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear."
    Everett L.A., Morsli H., Wu D.K., Green E.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:9727-9732(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiS26A4_RAT
AccessioniPrimary (citable) accession number: Q9R154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3