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Protein

N-acetyltransferase 6

Gene

Nat6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 6 (EC:2.3.1.-)
Alternative name(s):
Protein fusion-2
Short name:
Protein fus-2
Gene namesi
Name:Nat6
Synonyms:Fus2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1888902. Nat6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314N-acetyltransferase 6PRO_0000074537Add
BLAST

Proteomic databases

MaxQBiQ9R123.
PaxDbiQ9R123.
PRIDEiQ9R123.

PTM databases

iPTMnetiQ9R123.
PhosphoSiteiQ9R123.

Expressioni

Gene expression databases

BgeeiQ9R123.
CleanExiMM_NAT6.
ExpressionAtlasiQ9R123. baseline and differential.
GenevisibleiQ9R123. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091300.

Structurei

3D structure databases

ProteinModelPortaliQ9R123.
SMRiQ9R123. Positions 145-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 243154N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3397. Eukaryota.
ENOG41126M5. LUCA.
GeneTreeiENSGT00390000000980.
HOGENOMiHOG000113734.
HOVERGENiHBG031735.
InParanoidiQ9R123.
OMAiGCPIFWM.
OrthoDBiEOG76QFJF.
PhylomeDBiQ9R123.
TreeFamiTF106312.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELILSTSPA KLTLDPARQP ELTLRFNLSK LTLDPARQPE LSLSPRLAEL
60 70 80 90 100
TLDPTCHPEM SLSPGPAELT LDPQHQAKEL PVPKLPELIL EPVHCRPELM
110 120 130 140 150
SACADLINDQ WPRSRASRLH SLGQSSDAFP LCLMLLSPQP TPGAAPVVVG
160 170 180 190 200
HARLSRVLDQ PHSLLVETVV VARPLRGRGF GRRLMEGLEA FARARGFRRL
210 220 230 240 250
HLTTHDQLYF YAHLGYQLGE PVQGLAFTNR RLSTTVLRAF SKPPCPQPPC
260 270 280 290 300
KEPILAAQAV PRSSKGPPLP PPPPLPQSLT ASPPPSPEPL PQSPLETCYR
310
DLKGCPIFWM EKDI
Length:314
Mass (Da):34,583
Last modified:May 1, 2000 - v1
Checksum:iC10445FF34332A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172275 mRNA. Translation: AAD48062.1.
AF338323 Genomic DNA. Translation: AAL57174.1.
BC026545 mRNA. Translation: AAH26545.1.
AH009891 Genomic DNA. Translation: AAG23428.1.
AF417492 mRNA. Translation: AAM14421.1.
AF417493 mRNA. Translation: AAM14423.1.
AF417494 mRNA. Translation: AAM14425.1.
AF417495 mRNA. Translation: AAM14427.1.
AF417497 mRNA. Translation: AAM14431.1.
AF417498 mRNA. Translation: AAM14433.1.
CCDSiCCDS23498.1.
RefSeqiNP_062724.1. NM_019750.3.
UniGeneiMm.10305.
Mm.475658.

Genome annotation databases

EnsembliENSMUST00000093785; ENSMUSP00000091300; ENSMUSG00000079334.
GeneIDi56441.
KEGGimmu:56441.
UCSCiuc009rly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172275 mRNA. Translation: AAD48062.1.
AF338323 Genomic DNA. Translation: AAL57174.1.
BC026545 mRNA. Translation: AAH26545.1.
AH009891 Genomic DNA. Translation: AAG23428.1.
AF417492 mRNA. Translation: AAM14421.1.
AF417493 mRNA. Translation: AAM14423.1.
AF417494 mRNA. Translation: AAM14425.1.
AF417495 mRNA. Translation: AAM14427.1.
AF417497 mRNA. Translation: AAM14431.1.
AF417498 mRNA. Translation: AAM14433.1.
CCDSiCCDS23498.1.
RefSeqiNP_062724.1. NM_019750.3.
UniGeneiMm.10305.
Mm.475658.

3D structure databases

ProteinModelPortaliQ9R123.
SMRiQ9R123. Positions 145-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091300.

PTM databases

iPTMnetiQ9R123.
PhosphoSiteiQ9R123.

Proteomic databases

MaxQBiQ9R123.
PaxDbiQ9R123.
PRIDEiQ9R123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093785; ENSMUSP00000091300; ENSMUSG00000079334.
GeneIDi56441.
KEGGimmu:56441.
UCSCiuc009rly.1. mouse.

Organism-specific databases

CTDi24142.
MGIiMGI:1888902. Nat6.

Phylogenomic databases

eggNOGiKOG3397. Eukaryota.
ENOG41126M5. LUCA.
GeneTreeiENSGT00390000000980.
HOGENOMiHOG000113734.
HOVERGENiHBG031735.
InParanoidiQ9R123.
OMAiGCPIFWM.
OrthoDBiEOG76QFJF.
PhylomeDBiQ9R123.
TreeFamiTF106312.

Miscellaneous databases

NextBioi312634.
PROiQ9R123.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R123.
CleanExiMM_NAT6.
ExpressionAtlasiQ9R123. baseline and differential.
GenevisibleiQ9R123. MM.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse ortholog of the human Fus2 gene."
    Duh F.-M., Minna J.D., Lerman M.I.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic sequence of the mouse Hyal1 locus encoding the mouse Hyal1, Fus2, and Hyal3 genes."
    Csoka A.B.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Isolation and characterization of the murine Hyal1 gene, encoding hyaluronidase 1."
    Shuttleworth T.L., Triggs-Raine B.L., Wicklow B.A.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-231.
    Strain: 129/Sv.
  5. "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3."
    Shuttleworth T.L., Wilson M.D., Wicklow B.A., Wilkins J.A., Triggs-Raine B.L.
    J. Biol. Chem. 277:23008-23018(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-204.
    Strain: 129/Sv.

Entry informationi

Entry nameiNAT6_MOUSE
AccessioniPrimary (citable) accession number: Q9R123
Secondary accession number(s): Q8QZY5, Q8R014, Q9ERM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.