Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9R117

- TYK2_MOUSE

UniProt

Q9R117 - TYK2_MOUSE

Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

Tyk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei923 – 9231ATPPROSITE-ProRule annotation
    Active sitei1016 – 10161Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi896 – 9049ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
    Gene namesi
    Name:Tyk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1929470. Tyk2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. membrane Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11801180Non-receptor tyrosine-protein kinase TYK2PRO_0000088178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei291 – 2911PhosphotyrosineBy similarity
    Modified residuei600 – 6001Phosphotyrosine1 Publication
    Modified residuei877 – 8771PhosphoserineBy similarity
    Modified residuei1047 – 10471Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9R117.
    PRIDEiQ9R117.

    PTM databases

    PhosphoSiteiQ9R117.

    Expressioni

    Gene expression databases

    CleanExiMM_TYK2.
    GenevestigatoriQ9R117.

    Interactioni

    Subunit structurei

    Interacts with JAKMIP1.By similarity

    Protein-protein interaction databases

    MINTiMINT-1513145.

    Structurei

    Secondary structure

    1
    1180
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi887 – 8893
    Beta strandi890 – 8989
    Beta strandi900 – 90910
    Beta strandi913 – 9153
    Beta strandi918 – 9258
    Helixi931 – 94616
    Beta strandi955 – 9606
    Beta strandi967 – 9726
    Helixi979 – 9824
    Helixi983 – 9853
    Helixi990 – 100920
    Helixi1019 – 10213
    Beta strandi1022 – 10243
    Helixi1026 – 10283
    Beta strandi1030 – 10323
    Beta strandi1046 – 10494
    Beta strandi1054 – 10563
    Helixi1058 – 10603
    Helixi1063 – 10675
    Beta strandi1070 – 10723
    Helixi1073 – 108816
    Turni1089 – 10913
    Helixi1093 – 10953
    Helixi1097 – 11059
    Helixi1110 – 112314
    Helixi1135 – 114410
    Helixi1149 – 11513
    Helixi1155 – 116814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E1ZX-ray2.50A880-1170[»]
    4E20X-ray2.60A881-1170[»]
    ProteinModelPortaliQ9R117.
    SMRiQ9R117. Positions 27-562, 573-863, 880-1170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 426398FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 52581SH2; atypicalAdd
    BLAST
    Domaini585 – 862278Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini890 – 1162273Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FERM domain mediates interaction with JAKMIP1.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 SH2 domain.Curated

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG006195.
    InParanoidiQ9R117.

    Family and domain databases

    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R117-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLCGRRAIL EDSKADGTEA QPLVPTGCLM VLLHWPGPEG GEPWVTFSQT     50
    SLTAEEVCIH IAHKVGITPP CLNLFALYNA QAKVWLPPNH ILDTSQDMNL 100
    YFRMRFYFRN WHGMNPQEPA VYRCGFPGAE TSSDRAEQGV QLLDSASFEY 150
    LFEQGKHEFM NDVVSLRDLS SEEEIHHFKN ESLGMAFLHL CHLALSRGVP 200
    LEEMAREISF KNCIPHSFRQ HIRQHNVLTR LRLHRVFRRF LRAFRPGHLS 250
    QQVVMVKYLA TLERLAPRFG SERIPVCHLE VLAQPERDPC YIQNSGQTAG 300
    DPGPELPSGP PTHEVLVTGT GGIQWHPLQT QESERGNSRG NPHGSRSGKK 350
    PKAPKAGEHL TESPQEPPWT YFCDFQDISH VVLKERRVHI HLQDNKCLLL 400
    CLCSQAEALS FVALVDGYFR LTADSSHYLC HEVAPPRLVT SIQNGIHGPL 450
    MDPFVQAKLW PEDGLYLIQW STSHLHRLIL TVAHRNPAXS NGPRGLRLRK 500
    FPITQQPGAF VLDGWGRSFA SLGDLRLALQ GCSLRAGDDC FPLHXCCLPR 550
    PREISNLVIM RGSRAHTRPL NLSQLSFHRV HQDEITQLSH LGQGTRTNVY 600
    EGLLRVGGPD EGKVDNGCPP EPGGTSGQQL RVVLKVLDPS HHDIALAFYE 650
    XASLMSQVSH MHLAFLHGVC VRGSENIIVT EFVEHGPLDV WLRRQRGQVP 700
    MTWKMVVAQQ LASALSYLED KNLVHGNVCG RNILLARLGL EEGTNPFIKL 750
    SDPGVGQGAL SREERVERIP WTAPECLSGG TSSLGTATDM WGFGATLLEI 800
    CFDGEAPLQG RGPSEKERFY TKKHQLPEPS CPELATLTRQ CLTYEPAQRP 850
    SFRTILRDLT RLQPQNLVGT SAVNSDSPAS DPTVFHKRYL KKIRDLGEGH 900
    FGKVSLYCYD PTNDGTGEMV AVKALKEGCG PQLRSGWQRE IEILRTLYHE 950
    HIVKYKGCCE DQGEKSVQLV MEYVPLGSLR DYLPRHCVGL AQLLLFAQQI 1000
    CEGMAYLHAQ HYIHRDLAAR NVLLDNDRLV KIGDFGLAKA VPEGHEYYRV 1050
    REDGDSPVFW YAPECLKECK FYYASDVWSF GVTLYELLTY CDSNQSPHTK 1100
    FTELIGHTQG QMTVLRLTEL LERGERLPRP DRCPCEIYHL MKNCWETEAS 1150
    FRPTFQNLVP ILQTAQEKYQ GQVPSVFSVC 1180
    Length:1,180
    Mass (Da):132,861
    Last modified:August 15, 2003 - v2
    Checksum:i65E060079F08B1C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911C → F in AAC34580. (PubMed:11070173)Curated
    Sequence conflicti234 – 2341H → R in AAC34580. (PubMed:11070173)Curated
    Sequence conflicti355 – 3551K → E in AAC34580. (PubMed:11070173)Curated
    Sequence conflicti831 – 8311C → S in AAD49423. (PubMed:11070173)Curated
    Sequence conflicti1099 – 10991T → M in AAD49423. (PubMed:11070173)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173032 mRNA. Translation: AAD49423.1.
    AF052607 Genomic DNA. Translation: AAC34580.2.
    BC019789 mRNA. Translation: AAH19789.1.
    UniGeneiMm.20249.
    Mm.450004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173032 mRNA. Translation: AAD49423.1 .
    AF052607 Genomic DNA. Translation: AAC34580.2 .
    BC019789 mRNA. Translation: AAH19789.1 .
    UniGenei Mm.20249.
    Mm.450004.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E1Z X-ray 2.50 A 880-1170 [» ]
    4E20 X-ray 2.60 A 881-1170 [» ]
    ProteinModelPortali Q9R117.
    SMRi Q9R117. Positions 27-562, 573-863, 880-1170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1513145.

    PTM databases

    PhosphoSitei Q9R117.

    Proteomic databases

    PaxDbi Q9R117.
    PRIDEi Q9R117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1929470. Tyk2.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG006195.
    InParanoidi Q9R117.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.

    Miscellaneous databases

    ChiTaRSi TYK2. mouse.
    PROi Q9R117.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TYK2.
    Genevestigatori Q9R117.

    Family and domain databases

    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
      Tissue: Liver.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 732-737, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1180.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 880-1170 IN COMPLEX WITH INHIBITOR.

    Entry informationi

    Entry nameiTYK2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R117
    Secondary accession number(s): O88431, Q8VE41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Tyk2 deficient mice display reduced responses to interferon-alpha/beta and IL-12 and a selective deficiency in STAT3 activation in these pathways. Interferon-gamma signaling is also impaired.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3