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Q9R117

- TYK2_MOUSE

UniProt

Q9R117 - TYK2_MOUSE

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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene
Tyk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei923 – 9231ATP By similarity
Active sitei1016 – 10161Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi896 – 9049ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
Gene namesi
Name:Tyk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1929470. Tyk2.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11801180Non-receptor tyrosine-protein kinase TYK2PRO_0000088178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei291 – 2911Phosphotyrosine By similarity
Modified residuei600 – 6001Phosphotyrosine1 Publication
Modified residuei877 – 8771Phosphoserine By similarity
Modified residuei1047 – 10471Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R117.
PRIDEiQ9R117.

PTM databases

PhosphoSiteiQ9R117.

Expressioni

Gene expression databases

CleanExiMM_TYK2.
GenevestigatoriQ9R117.

Interactioni

Subunit structurei

Interacts with JAKMIP1 By similarity.

Protein-protein interaction databases

MINTiMINT-1513145.

Structurei

Secondary structure

1
1180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi887 – 8893
Beta strandi890 – 8989
Beta strandi900 – 90910
Beta strandi913 – 9153
Beta strandi918 – 9258
Helixi931 – 94616
Beta strandi955 – 9606
Beta strandi967 – 9726
Helixi979 – 9824
Helixi983 – 9853
Helixi990 – 100920
Helixi1019 – 10213
Beta strandi1022 – 10243
Helixi1026 – 10283
Beta strandi1030 – 10323
Beta strandi1046 – 10494
Beta strandi1054 – 10563
Helixi1058 – 10603
Helixi1063 – 10675
Beta strandi1070 – 10723
Helixi1073 – 108816
Turni1089 – 10913
Helixi1093 – 10953
Helixi1097 – 11059
Helixi1110 – 112314
Helixi1135 – 114410
Helixi1149 – 11513
Helixi1155 – 116814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E1ZX-ray2.50A880-1170[»]
4E20X-ray2.60A881-1170[»]
ProteinModelPortaliQ9R117.
SMRiQ9R117. Positions 27-562, 573-863, 880-1170.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 426398FERMAdd
BLAST
Domaini445 – 52581SH2; atypicalAdd
BLAST
Domaini585 – 862278Protein kinase 1Add
BLAST
Domaini890 – 1162273Protein kinase 2Add
BLAST

Domaini

The FERM domain mediates interaction with JAKMIP1 By similarity.

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 SH2 domain.

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG006195.
InParanoidiQ9R117.

Family and domain databases

InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R117-1 [UniParc]FASTAAdd to Basket

« Hide

MPLCGRRAIL EDSKADGTEA QPLVPTGCLM VLLHWPGPEG GEPWVTFSQT     50
SLTAEEVCIH IAHKVGITPP CLNLFALYNA QAKVWLPPNH ILDTSQDMNL 100
YFRMRFYFRN WHGMNPQEPA VYRCGFPGAE TSSDRAEQGV QLLDSASFEY 150
LFEQGKHEFM NDVVSLRDLS SEEEIHHFKN ESLGMAFLHL CHLALSRGVP 200
LEEMAREISF KNCIPHSFRQ HIRQHNVLTR LRLHRVFRRF LRAFRPGHLS 250
QQVVMVKYLA TLERLAPRFG SERIPVCHLE VLAQPERDPC YIQNSGQTAG 300
DPGPELPSGP PTHEVLVTGT GGIQWHPLQT QESERGNSRG NPHGSRSGKK 350
PKAPKAGEHL TESPQEPPWT YFCDFQDISH VVLKERRVHI HLQDNKCLLL 400
CLCSQAEALS FVALVDGYFR LTADSSHYLC HEVAPPRLVT SIQNGIHGPL 450
MDPFVQAKLW PEDGLYLIQW STSHLHRLIL TVAHRNPAXS NGPRGLRLRK 500
FPITQQPGAF VLDGWGRSFA SLGDLRLALQ GCSLRAGDDC FPLHXCCLPR 550
PREISNLVIM RGSRAHTRPL NLSQLSFHRV HQDEITQLSH LGQGTRTNVY 600
EGLLRVGGPD EGKVDNGCPP EPGGTSGQQL RVVLKVLDPS HHDIALAFYE 650
XASLMSQVSH MHLAFLHGVC VRGSENIIVT EFVEHGPLDV WLRRQRGQVP 700
MTWKMVVAQQ LASALSYLED KNLVHGNVCG RNILLARLGL EEGTNPFIKL 750
SDPGVGQGAL SREERVERIP WTAPECLSGG TSSLGTATDM WGFGATLLEI 800
CFDGEAPLQG RGPSEKERFY TKKHQLPEPS CPELATLTRQ CLTYEPAQRP 850
SFRTILRDLT RLQPQNLVGT SAVNSDSPAS DPTVFHKRYL KKIRDLGEGH 900
FGKVSLYCYD PTNDGTGEMV AVKALKEGCG PQLRSGWQRE IEILRTLYHE 950
HIVKYKGCCE DQGEKSVQLV MEYVPLGSLR DYLPRHCVGL AQLLLFAQQI 1000
CEGMAYLHAQ HYIHRDLAAR NVLLDNDRLV KIGDFGLAKA VPEGHEYYRV 1050
REDGDSPVFW YAPECLKECK FYYASDVWSF GVTLYELLTY CDSNQSPHTK 1100
FTELIGHTQG QMTVLRLTEL LERGERLPRP DRCPCEIYHL MKNCWETEAS 1150
FRPTFQNLVP ILQTAQEKYQ GQVPSVFSVC 1180
Length:1,180
Mass (Da):132,861
Last modified:August 15, 2003 - v2
Checksum:i65E060079F08B1C9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911C → F in AAC34580. 1 Publication
Sequence conflicti234 – 2341H → R in AAC34580. 1 Publication
Sequence conflicti355 – 3551K → E in AAC34580. 1 Publication
Sequence conflicti831 – 8311C → S in AAD49423. 1 Publication
Sequence conflicti1099 – 10991T → M in AAD49423. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173032 mRNA. Translation: AAD49423.1.
AF052607 Genomic DNA. Translation: AAC34580.2.
BC019789 mRNA. Translation: AAH19789.1.
UniGeneiMm.20249.
Mm.450004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173032 mRNA. Translation: AAD49423.1 .
AF052607 Genomic DNA. Translation: AAC34580.2 .
BC019789 mRNA. Translation: AAH19789.1 .
UniGenei Mm.20249.
Mm.450004.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E1Z X-ray 2.50 A 880-1170 [» ]
4E20 X-ray 2.60 A 881-1170 [» ]
ProteinModelPortali Q9R117.
SMRi Q9R117. Positions 27-562, 573-863, 880-1170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1513145.

PTM databases

PhosphoSitei Q9R117.

Proteomic databases

PaxDbi Q9R117.
PRIDEi Q9R117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1929470. Tyk2.

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG006195.
InParanoidi Q9R117.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.

Miscellaneous databases

ChiTaRSi TYK2. mouse.
PROi Q9R117.
SOURCEi Search...

Gene expression databases

CleanExi MM_TYK2.
Genevestigatori Q9R117.

Family and domain databases

InterProi IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
[Graphical view ]
PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
PRINTSi PR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTi SM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Liver.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 732-737, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1180.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 880-1170 IN COMPLEX WITH INHIBITOR.

Entry informationi

Entry nameiTYK2_MOUSE
AccessioniPrimary (citable) accession number: Q9R117
Secondary accession number(s): O88431, Q8VE41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 15, 2003
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Tyk2 deficient mice display reduced responses to interferon-alpha/beta and IL-12 and a selective deficiency in STAT3 activation in these pathways. Interferon-gamma signaling is also impaired.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi