Non-receptor tyrosine-protein kinase TYK2

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Q9R117 (TYK2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Non-receptor tyrosine-protein kinase TYK2
EC=2.7.10.2

Gene names

Name:

Tyk2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1180 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Interacts with JAKMIP1 By similarity.
Domain	The FERM domain mediates interaction with JAKMIP1 By similarity.
Miscellaneous	Tyk2 deficient mice display reduced responses to interferon-alpha/beta and IL-12 and a selective deficiency in STAT3 activation in these pathways. Interferon-gamma signaling is also impaired.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 2 protein kinase domains. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	Repeat SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein kinase cascade Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1180

1180

Non-receptor tyrosine-protein kinase TYK2

PRO_0000088178

Regions

Domain

29 – 426

398

FERM

Domain

445 – 525

SH2; atypical

Domain

585 – 862

278

Protein kinase 1

Domain

890 – 1162

273

Protein kinase 2

Nucleotide binding

896 – 904

ATP By similarity

Sites

Active site

1016

Proton acceptor By similarity

Binding site

923

ATP By similarity

Amino acid modifications

Modified residue

291

Phosphotyrosine By similarity

Modified residue

600

Phosphotyrosine Ref.4

Modified residue

877

Phosphoserine By similarity

Modified residue

1047

Phosphotyrosine; by autocatalysis By similarity

Experimental info

Sequence conflict

191

C → F in AAC34580. Ref.1

Sequence conflict

234

H → R in AAC34580. Ref.1

Sequence conflict

355

K → E in AAC34580. Ref.1

Sequence conflict

831

C → S in AAD49423. Ref.1

Sequence conflict

1099

T → M in AAD49423. Ref.1

Secondary structure

1180

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9R117 [UniParc].

Last modified August 15, 2003. Version 2.
Checksum: 65E060079F08B1C9
Show »

FASTA

1,180

132,861

        10         20         30         40         50         60 
MPLCGRRAIL EDSKADGTEA QPLVPTGCLM VLLHWPGPEG GEPWVTFSQT SLTAEEVCIH 

        70         80         90        100        110        120 
IAHKVGITPP CLNLFALYNA QAKVWLPPNH ILDTSQDMNL YFRMRFYFRN WHGMNPQEPA 

       130        140        150        160        170        180 
VYRCGFPGAE TSSDRAEQGV QLLDSASFEY LFEQGKHEFM NDVVSLRDLS SEEEIHHFKN 

       190        200        210        220        230        240 
ESLGMAFLHL CHLALSRGVP LEEMAREISF KNCIPHSFRQ HIRQHNVLTR LRLHRVFRRF 

       250        260        270        280        290        300 
LRAFRPGHLS QQVVMVKYLA TLERLAPRFG SERIPVCHLE VLAQPERDPC YIQNSGQTAG 

       310        320        330        340        350        360 
DPGPELPSGP PTHEVLVTGT GGIQWHPLQT QESERGNSRG NPHGSRSGKK PKAPKAGEHL 

       370        380        390        400        410        420 
TESPQEPPWT YFCDFQDISH VVLKERRVHI HLQDNKCLLL CLCSQAEALS FVALVDGYFR 

       430        440        450        460        470        480 
LTADSSHYLC HEVAPPRLVT SIQNGIHGPL MDPFVQAKLW PEDGLYLIQW STSHLHRLIL 

       490        500        510        520        530        540 
TVAHRNPAXS NGPRGLRLRK FPITQQPGAF VLDGWGRSFA SLGDLRLALQ GCSLRAGDDC 

       550        560        570        580        590        600 
FPLHXCCLPR PREISNLVIM RGSRAHTRPL NLSQLSFHRV HQDEITQLSH LGQGTRTNVY 

       610        620        630        640        650        660 
EGLLRVGGPD EGKVDNGCPP EPGGTSGQQL RVVLKVLDPS HHDIALAFYE XASLMSQVSH 

       670        680        690        700        710        720 
MHLAFLHGVC VRGSENIIVT EFVEHGPLDV WLRRQRGQVP MTWKMVVAQQ LASALSYLED 

       730        740        750        760        770        780 
KNLVHGNVCG RNILLARLGL EEGTNPFIKL SDPGVGQGAL SREERVERIP WTAPECLSGG 

       790        800        810        820        830        840 
TSSLGTATDM WGFGATLLEI CFDGEAPLQG RGPSEKERFY TKKHQLPEPS CPELATLTRQ 

       850        860        870        880        890        900 
CLTYEPAQRP SFRTILRDLT RLQPQNLVGT SAVNSDSPAS DPTVFHKRYL KKIRDLGEGH 

       910        920        930        940        950        960 
FGKVSLYCYD PTNDGTGEMV AVKALKEGCG PQLRSGWQRE IEILRTLYHE HIVKYKGCCE 

       970        980        990       1000       1010       1020 
DQGEKSVQLV MEYVPLGSLR DYLPRHCVGL AQLLLFAQQI CEGMAYLHAQ HYIHRDLAAR 

      1030       1040       1050       1060       1070       1080 
NVLLDNDRLV KIGDFGLAKA VPEGHEYYRV REDGDSPVFW YAPECLKECK FYYASDVWSF 

      1090       1100       1110       1120       1130       1140 
GVTLYELLTY CDSNQSPHTK FTELIGHTQG QMTVLRLTEL LERGERLPRP DRCPCEIYHL 

      1150       1160       1170       1180 
MKNCWETEAS FRPTFQNLVP ILQTAQEKYQ GQVPSVFSVC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Partial impairment of cytokine responses in Tyk2-deficient mice." Karaghiosoff M., Neubauer H., Lassnig C., Kovarik P., Schindler H., Pircher H., McCoy B., Bogdan C., Decker T., Brem G., Pfeffer K., Mueller M. Immunity 13:549-560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv. Tissue: Liver.
[2]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 732-737, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1180.
[4]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600, MASS SPECTROMETRY. Tissue: Mast cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF173032 mRNA. Translation: AAD49423.1.
AF052607 Genomic DNA. Translation: AAC34580.2.
BC019789 mRNA. Translation: AAH19789.1.

IPI

IPI00653270.

UniGene

Mm.20249.
Mm.450004.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4E1Z	X-ray	2.50	A	880-1170	[»]
4E20	X-ray	2.60	A	881-1170	[»]

ProteinModelPortal

Q9R117.

SMR

Q9R117. Positions 577-1170.

ModBase

Search...

PTM databases

PhosphoSite

Q9R117.

Proteomic databases

PaxDb

Q9R117.

PRIDE

Q9R117.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:1929470. Tyk2.

Phylogenomic databases

eggNOG

COG0515.

HOVERGEN

HBG006195.

InParanoid

Q9R117.

OrthoDB

EOG4FXR6W.

Enzyme and pathway databases

BRENDA

2.7.10.2. 3474.

Gene expression databases

CleanEx

MM_TYK2.

Genevestigator

Q9R117.

GermOnline

ENSMUSG00000032175. Mus musculus.

Family and domain databases

InterPro

IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]

Pfam

PF07714. Pkinase_Tyr. 2 hits.
[Graphical view]

PIRSF

PIRSF000636. TyrPK_Jak. 1 hit.

PRINTS

PR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.

SMART

SM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]

SUPFAM

SSF47031. FERM_3-hlx. 1 hit.
SSF56112. Kinase_like. 2 hits.

PROSITE

PS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

TYK2. mouse.

SOURCE

Search...

Entry information

Entry name

TYK2_MOUSE

Accession

Primary (citable) accession number: Q9R117
Secondary accession number(s): O88431, Q8VE41

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	August 15, 2003
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents