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Protein

Sulfide:quinone oxidoreductase, mitochondrial

Gene

Sqrdl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011Cysteine persulfide intermediateBy similarity
Active sitei379 – 3791Cysteine persulfide intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 545FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-1614517. Sulfide oxidation to sulfate.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide:quinone oxidoreductase, mitochondrial (EC:1.8.5.-By similarity)
Short name:
SQOR
Gene namesi
Name:Sqrdl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929899. Sqrdl.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 450Sulfide:quinone oxidoreductase, mitochondrialPRO_0000022409
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei134 – 1341N6-acetyllysineCombined sources
Modified residuei173 – 1731N6-acetyllysineCombined sources
Modified residuei343 – 3431PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein, Quinone

Proteomic databases

MaxQBiQ9R112.
PaxDbiQ9R112.
PeptideAtlasiQ9R112.
PRIDEiQ9R112.

PTM databases

iPTMnetiQ9R112.
PhosphoSiteiQ9R112.
SwissPalmiQ9R112.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005803.
CleanExiMM_SQRDL.
ExpressionAtlasiQ9R112. baseline and differential.
GenevisibleiQ9R112. MM.

Interactioni

Protein-protein interaction databases

BioGridi208481. 1 interaction.
IntActiQ9R112. 3 interactions.
MINTiMINT-4112946.
STRINGi10090.ENSMUSP00000005953.

Structurei

3D structure databases

ProteinModelPortaliQ9R112.
SMRiQ9R112. Positions 41-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3851. Eukaryota.
COG0446. LUCA.
GeneTreeiENSGT00390000019406.
HOGENOMiHOG000249874.
HOVERGENiHBG029110.
InParanoidiQ9R112.
KOiK17218.
OMAiWMAWDRY.
OrthoDBiEOG091G08RU.
TreeFamiTF314384.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLVTVVSS PRARLFACFL RLGTQQAGPL QLHTGACCTA KNHYEVLVLG
60 70 80 90 100
GGAGGITMAT RMKRRVGAEN VAIVEPSERH FYQPIWTLVG AGAKELSLSV
110 120 130 140 150
RSTLSVIPSG VQWIQDRVAE LNPDENCIRT DSGKEISYRY LIIALGIQLD
160 170 180 190 200
YEKIKGLPEG FAYPKIGSNY SVKTVEKTWK ALQGFKEGNA LFTFPNTPVK
210 220 230 240 250
CAGAPQKIMY LSEAYFRKTG KRPKANIIFN TALGTIFGVK KYADALQEII
260 270 280 290 300
RERDVSVNYK HNLIEVRPDK QEAVFEILDK PGETHVIPYE MLHVTPPMSA
310 320 330 340 350
PDVLKRSPVA DSAGWVDVDK ETLQHKKYPN VFGIGDCTNL PTSKTAAAVA
360 370 380 390 400
AQSGILDRTM CLIMKNQRPI KKYDGYTSCP LVTGYNRVIL AEFDYTAQPL
410 420 430 440 450
ETFPFDQSKE RITMYLMKAD MMPFLYWNMM LRGYWGGPAF LRKLFHLGMN
Length:450
Mass (Da):50,282
Last modified:July 27, 2011 - v3
Checksum:iCBA500CE60803C8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61T → A in AAH11153 (PubMed:15489334).Curated
Sequence conflicti99 – 991S → T in BAB25580 (PubMed:16141072).Curated
Sequence conflicti184 – 1841G → D in AAD50300 (Ref. 1) Curated
Sequence conflicti184 – 1841G → D in AAH11153 (PubMed:15489334).Curated
Sequence conflicti185 – 1851F → L in AAD50300 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174535 mRNA. Translation: AAD50300.1.
AK008290 mRNA. Translation: BAB25580.1.
AK075598 mRNA. Translation: BAC35847.1.
AL928950 Genomic DNA. Translation: CAM26699.1.
BC011153 mRNA. Translation: AAH11153.1.
CCDSiCCDS16669.1.
RefSeqiNP_001155975.1. NM_001162503.1.
NP_067482.4. NM_021507.5.
XP_006500029.1. XM_006499966.1.
UniGeneiMm.28986.

Genome annotation databases

EnsembliENSMUST00000005953; ENSMUSP00000005953; ENSMUSG00000005803.
ENSMUST00000110506; ENSMUSP00000106133; ENSMUSG00000005803.
GeneIDi59010.
KEGGimmu:59010.
UCSCiuc008mbh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174535 mRNA. Translation: AAD50300.1.
AK008290 mRNA. Translation: BAB25580.1.
AK075598 mRNA. Translation: BAC35847.1.
AL928950 Genomic DNA. Translation: CAM26699.1.
BC011153 mRNA. Translation: AAH11153.1.
CCDSiCCDS16669.1.
RefSeqiNP_001155975.1. NM_001162503.1.
NP_067482.4. NM_021507.5.
XP_006500029.1. XM_006499966.1.
UniGeneiMm.28986.

3D structure databases

ProteinModelPortaliQ9R112.
SMRiQ9R112. Positions 41-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208481. 1 interaction.
IntActiQ9R112. 3 interactions.
MINTiMINT-4112946.
STRINGi10090.ENSMUSP00000005953.

PTM databases

iPTMnetiQ9R112.
PhosphoSiteiQ9R112.
SwissPalmiQ9R112.

Proteomic databases

MaxQBiQ9R112.
PaxDbiQ9R112.
PeptideAtlasiQ9R112.
PRIDEiQ9R112.

Protocols and materials databases

DNASUi59010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005953; ENSMUSP00000005953; ENSMUSG00000005803.
ENSMUST00000110506; ENSMUSP00000106133; ENSMUSG00000005803.
GeneIDi59010.
KEGGimmu:59010.
UCSCiuc008mbh.2. mouse.

Organism-specific databases

CTDi58472.
MGIiMGI:1929899. Sqrdl.

Phylogenomic databases

eggNOGiKOG3851. Eukaryota.
COG0446. LUCA.
GeneTreeiENSGT00390000019406.
HOGENOMiHOG000249874.
HOVERGENiHBG029110.
InParanoidiQ9R112.
KOiK17218.
OMAiWMAWDRY.
OrthoDBiEOG091G08RU.
TreeFamiTF314384.

Enzyme and pathway databases

ReactomeiR-MMU-1614517. Sulfide oxidation to sulfate.

Miscellaneous databases

PROiQ9R112.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005803.
CleanExiMM_SQRDL.
ExpressionAtlasiQ9R112. baseline and differential.
GenevisibleiQ9R112. MM.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSQRD_MOUSE
AccessioniPrimary (citable) accession number: Q9R112
Secondary accession number(s): Q8BW20, Q91XA1, Q9D891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.