Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine deaminase

Gene

Gda

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Catalytic activityi

Guanine + H2O = xanthine + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: guanine degradation

This protein is involved in step 1 of the subpathway that synthesizes xanthine from guanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Guanine deaminase (Gda)
This subpathway is part of the pathway guanine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes xanthine from guanine, the pathway guanine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Zinc; via tele nitrogenBy similarity1
Metal bindingi84Zinc; via tele nitrogenBy similarity1
Metal bindingi240Zinc; via tele nitrogenBy similarity1
Metal bindingi330ZincBy similarity1
Binding sitei330SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-74259 Purine catabolism
SABIO-RKQ9R111
UniPathwayiUPA00603; UER00660

Protein family/group databases

MEROPSiM38.981

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine deaminase (EC:3.5.4.3)
Short name:
Guanase
Short name:
Guanine aminase
Alternative name(s):
Guanine aminohydrolase
Short name:
GAH
Gene namesi
Name:Gda
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95678 Gda

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222991 – 454Guanine deaminaseAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei453PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9R111
PaxDbiQ9R111
PRIDEiQ9R111

2D gel databases

REPRODUCTION-2DPAGEIPI00469987
Q9R111

PTM databases

iPTMnetiQ9R111
PhosphoSitePlusiQ9R111
SwissPalmiQ9R111

Expressioni

Gene expression databases

BgeeiENSMUSG00000058624
CleanExiMM_GDA
ExpressionAtlasiQ9R111 baseline and differential
GenevisibleiQ9R111 MM

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621086EBI-2308876,EBI-300895

Protein-protein interaction databases

BioGridi199872, 3 interactors
IntActiQ9R111, 3 interactors
MINTiQ9R111
STRINGi10090.ENSMUSP00000084882

Structurei

3D structure databases

ProteinModelPortaliQ9R111
SMRiQ9R111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Substrate bindingBy similarity4
Regioni213 – 214Substrate bindingBy similarity2
Regioni240 – 243Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3968 Eukaryota
COG0402 LUCA
GeneTreeiENSGT00390000017130
HOVERGENiHBG005930
InParanoidiQ9R111
KOiK01487
OMAiWCFKPCE
OrthoDBiEOG091G07AM
TreeFamiTF324539

Family and domain databases

CDDicd01303 GDEase, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR014311 Guanine_deaminase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11271:SF6 PTHR11271:SF6, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02967 guan_deamin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAARTPPLA LVFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEESSQ
60 70 80 90 100
QEKLAKEWCF KPCEIRELSH HEFFMPGLVD THIHAPQYAF AGSNVDLPLL
110 120 130 140 150
EWLNKYTFPT EQRFRSTDVA EEVYTRVVRR TLKNGTTTAC YFGTIHTDSS
160 170 180 190 200
LILAEITDKF GQRAFVGKVC MDLNDTVPEY KETTEESVKE TERFVSEMLQ
210 220 230 240 250
KNYPRVKPIV TPRFTLSCTE TLMSELGNIA KTHDLYIQSH ISENREEIEA
260 270 280 290 300
VKSLYPSYKN YTDVYDKNNL LTNKTVMAHG CYLSEEELNI FSERGASIAH
310 320 330 340 350
CPNSNLSLSS GLLNVLEVLK HKVKIGLGTD VAGGYSYSML DAIRRAVMVS
360 370 380 390 400
NVLLINKVNE KNLTLKEVFR LATLGGSQAL GLDSEIGNFE VGKEFDALLI
410 420 430 440 450
NPRASDSPID LFYGDFVGDI SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF

SSSV
Length:454
Mass (Da):51,013
Last modified:May 1, 2000 - v1
Checksum:i7711573C8C93D64E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174583 mRNA Translation: AAD50297.1
CCDSiCCDS29698.1
RefSeqiNP_034396.1, NM_010266.2
UniGeneiMm.45054

Genome annotation databases

EnsembliENSMUST00000087600; ENSMUSP00000084882; ENSMUSG00000058624
GeneIDi14544
KEGGimmu:14544
UCSCiuc008gyx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGUAD_MOUSE
AccessioniPrimary (citable) accession number: Q9R111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health