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Protein

UDP-glucuronosyltransferase 2A3

Gene

UGT2A3

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
Short name:
UDPGT 2A3
Gene namesi
Name:UGT2A3
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 494471ExtracellularSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST
Topological domaini516 – 53015CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2A3PRO_0000299145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Specifically expressed in liver and small intestine.1 Publication

Inductioni

Up-regulated in kidney and liver following in utero morphine treatment.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019647.

Structurei

3D structure databases

ProteinModelPortaliQ9R110.
SMRiQ9R110. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ9R110.
OMAiHTMERIC.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGKLASAV LLLLLCCAGS GFCGKVLVWP CEMSHWLNLK TLLEELVKRG
60 70 80 90 100
HEVTVLTLSN NLFIDYNRHP AFNFEVIPVP TDKNMSENIL NEFIELAVNV
110 120 130 140 150
MPTMPLWQSG KLLQQFFVQI TEDLGLNCRN TVYNQSLMKK LRDSKYDVLV
160 170 180 190 200
TDPVIPCGEL VAEMLGVPFV NMLKFSMGHT IEKYCGQLPA PPSYVPVPLG
210 220 230 240 250
GLTTRMTFME RVKNMVFSVL FDFWIQQYDY KFWDQFYSEA LGRPTTLCEI
260 270 280 290 300
MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GEDGVVVFSL GSMVKNLTEE KANLIASALA QIPQKVLWRY KGKKPATLGP
360 370 380 390 400
NTRLFDWIPQ NDLLGHPKTK AFITHGGSNG IYEAIYHGVP MVGMPIFSDQ
410 420 430 440 450
PDNLAGMKAK GAAVEVNMNT MTSADLLGAL RTVINDPTYK ENAMKLSRIH
460 470 480 490 500
HDQPVKPLDR AAFWVEFVMH HKGAKHLRVA AHDLSWFQYH SLDVIGFLLA
510 520 530
CVASAILLVT KCCLFSFQNF IKIGKRIKKE
Length:530
Mass (Da):59,895
Last modified:May 1, 2000 - v1
Checksum:iEE2F394D3FD484E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175221 mRNA. Translation: AAD51732.1.
RefSeqiNP_001166497.1. NM_001173026.1.

Genome annotation databases

EnsembliENSCPOT00000023420; ENSCPOP00000019647; ENSCPOG00000010848.
GeneIDi100135631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175221 mRNA. Translation: AAD51732.1.
RefSeqiNP_001166497.1. NM_001173026.1.

3D structure databases

ProteinModelPortaliQ9R110.
SMRiQ9R110. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019647.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000023420; ENSCPOP00000019647; ENSCPOG00000010848.
GeneIDi100135631.

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ9R110.
OMAiHTMERIC.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Morphine regulation of a novel uridine diphosphate glucuronosyl-transferase in guinea pig pups following in utero exposure."
    Smith S.A., Nagalla S.R., Andrews D.P., Olsen G.D.
    Mol. Genet. Metab. 68:68-77(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiUD2A3_CAVPO
AccessioniPrimary (citable) accession number: Q9R110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.