Reviewed, UniProtKB/Swiss-Prot Q9R110 (UD2A3_CAVPO)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2A3
      Short name=UDPGT 2A3
    EC=2.4.1.17

Gene names

Name:

UGT2A3

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Specifically expressed in liver and small intestine. Ref.1
Induction	Up-regulated in kidney and liver following in utero morphine treatment. Ref.1
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 530	507	UDP-glucuronosyltransferase 2A3		PRO_0000299145
Regions
	Topological domain	24 – 494	471	Extracellular Potential
	Transmembrane	495 – 515	21	Potential
	Topological domain	516 – 530	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9R110-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: EE2F394D3FD484E1	FASTA	530	59,895
	10 20 30 40 50 60 MAPGKLASAV LLLLLCCAGS GFCGKVLVWP CEMSHWLNLK TLLEELVKRG HEVTVLTLSN 70 80 90 100 110 120 NLFIDYNRHP AFNFEVIPVP TDKNMSENIL NEFIELAVNV MPTMPLWQSG KLLQQFFVQI 130 140 150 160 170 180 TEDLGLNCRN TVYNQSLMKK LRDSKYDVLV TDPVIPCGEL VAEMLGVPFV NMLKFSMGHT 190 200 210 220 230 240 IEKYCGQLPA PPSYVPVPLG GLTTRMTFME RVKNMVFSVL FDFWIQQYDY KFWDQFYSEA 250 260 270 280 290 300 LGRPTTLCEI MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG LHCKPAKPLP KEMEEFVQSS 310 320 330 340 350 360 GEDGVVVFSL GSMVKNLTEE KANLIASALA QIPQKVLWRY KGKKPATLGP NTRLFDWIPQ 370 380 390 400 410 420 NDLLGHPKTK AFITHGGSNG IYEAIYHGVP MVGMPIFSDQ PDNLAGMKAK GAAVEVNMNT 430 440 450 460 470 480 MTSADLLGAL RTVINDPTYK ENAMKLSRIH HDQPVKPLDR AAFWVEFVMH HKGAKHLRVA 490 500 510 520 530 AHDLSWFQYH SLDVIGFLLA CVASAILLVT KCCLFSFQNF IKIGKRIKKE

References

[1]

"Morphine regulation of a novel uridine diphosphate glucuronosyl-transferase in guinea pig pups following in utero exposure." Smith S.A., Nagalla S.R., Andrews D.P., Olsen G.D. Mol. Genet. Metab. 68:68-77(1999) [PubMed: 10479484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION. Strain: Hartley. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF175221 mRNA. Translation: AAD51732.1.
3D structure databases
SMR	Q9R110. Positions 286-447.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSCPOG00000010848. Cavia porcellus. [Contig view]
Phylogenomic databases
HOVERGEN	Q9R110.
OMA	Q9R110. MSENILN.
Enzyme and pathway databases
BRENDA	2.4.1.17. 44.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD2A3_CAVPO

Accession

Primary (citable) accession number: Q9R110

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)