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Q9R110 (UD2A3_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2A3

Short name=UDPGT 2A3
EC=2.4.1.17
Gene names
Name:UGT2A3
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Specifically expressed in liver and small intestine. Ref.1

Induction

Up-regulated in kidney and liver following in utero morphine treatment. Ref.1

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 530507UDP-glucuronosyltransferase 2A3
PRO_0000299145

Regions

Topological domain24 – 494471Extracellular Potential
Transmembrane495 – 51521Helical; Potential
Topological domain516 – 53015Cytoplasmic Potential

Amino acid modifications

Glycosylation3161N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9R110 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EE2F394D3FD484E1

FASTA53059,895
        10         20         30         40         50         60 
MAPGKLASAV LLLLLCCAGS GFCGKVLVWP CEMSHWLNLK TLLEELVKRG HEVTVLTLSN 

        70         80         90        100        110        120 
NLFIDYNRHP AFNFEVIPVP TDKNMSENIL NEFIELAVNV MPTMPLWQSG KLLQQFFVQI 

       130        140        150        160        170        180 
TEDLGLNCRN TVYNQSLMKK LRDSKYDVLV TDPVIPCGEL VAEMLGVPFV NMLKFSMGHT 

       190        200        210        220        230        240 
IEKYCGQLPA PPSYVPVPLG GLTTRMTFME RVKNMVFSVL FDFWIQQYDY KFWDQFYSEA 

       250        260        270        280        290        300 
LGRPTTLCEI MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG LHCKPAKPLP KEMEEFVQSS 

       310        320        330        340        350        360 
GEDGVVVFSL GSMVKNLTEE KANLIASALA QIPQKVLWRY KGKKPATLGP NTRLFDWIPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFITHGGSNG IYEAIYHGVP MVGMPIFSDQ PDNLAGMKAK GAAVEVNMNT 

       430        440        450        460        470        480 
MTSADLLGAL RTVINDPTYK ENAMKLSRIH HDQPVKPLDR AAFWVEFVMH HKGAKHLRVA 

       490        500        510        520        530 
AHDLSWFQYH SLDVIGFLLA CVASAILLVT KCCLFSFQNF IKIGKRIKKE 

« Hide

References

[1]"Morphine regulation of a novel uridine diphosphate glucuronosyl-transferase in guinea pig pups following in utero exposure."
Smith S.A., Nagalla S.R., Andrews D.P., Olsen G.D.
Mol. Genet. Metab. 68:68-77(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Strain: Hartley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF175221 mRNA. Translation: AAD51732.1.
RefSeqNP_001166497.1. NM_001173026.1.

3D structure databases

ProteinModelPortalQ9R110.
SMRQ9R110. Positions 286-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000019647.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000023420; ENSCPOP00000019647; ENSCPOG00000010848.
GeneID100135631.

Phylogenomic databases

eggNOGCOG1819.
GeneTreeENSGT00640000091260.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidQ9R110.
OMASHEDEYT.
OrthoDBEOG7GBFWS.
TreeFamTF315472.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD2A3_CAVPO
AccessionPrimary (citable) accession number: Q9R110
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families