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Q9R110

- UD2A3_CAVPO

UniProt

Q9R110 - UD2A3_CAVPO

Protein

UDP-glucuronosyltransferase 2A3

Gene

UGT2A3

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2A3 (EC:2.4.1.17)
    Short name:
    UDPGT 2A3
    Gene namesi
    Name:UGT2A3
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2A3PRO_0000299145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Specifically expressed in liver and small intestine.1 Publication

    Inductioni

    Up-regulated in kidney and liver following in utero morphine treatment.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000019647.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R110.
    SMRiQ9R110. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 494471ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini516 – 53015CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00640000091260.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiQ9R110.
    OMAiHWAANIL.
    OrthoDBiEOG7GBFWS.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R110-1 [UniParc]FASTAAdd to Basket

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    MAPGKLASAV LLLLLCCAGS GFCGKVLVWP CEMSHWLNLK TLLEELVKRG    50
    HEVTVLTLSN NLFIDYNRHP AFNFEVIPVP TDKNMSENIL NEFIELAVNV 100
    MPTMPLWQSG KLLQQFFVQI TEDLGLNCRN TVYNQSLMKK LRDSKYDVLV 150
    TDPVIPCGEL VAEMLGVPFV NMLKFSMGHT IEKYCGQLPA PPSYVPVPLG 200
    GLTTRMTFME RVKNMVFSVL FDFWIQQYDY KFWDQFYSEA LGRPTTLCEI 250
    MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG LHCKPAKPLP KEMEEFVQSS 300
    GEDGVVVFSL GSMVKNLTEE KANLIASALA QIPQKVLWRY KGKKPATLGP 350
    NTRLFDWIPQ NDLLGHPKTK AFITHGGSNG IYEAIYHGVP MVGMPIFSDQ 400
    PDNLAGMKAK GAAVEVNMNT MTSADLLGAL RTVINDPTYK ENAMKLSRIH 450
    HDQPVKPLDR AAFWVEFVMH HKGAKHLRVA AHDLSWFQYH SLDVIGFLLA 500
    CVASAILLVT KCCLFSFQNF IKIGKRIKKE 530
    Length:530
    Mass (Da):59,895
    Last modified:May 1, 2000 - v1
    Checksum:iEE2F394D3FD484E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175221 mRNA. Translation: AAD51732.1.
    RefSeqiNP_001166497.1. NM_001173026.1.

    Genome annotation databases

    EnsembliENSCPOT00000023420; ENSCPOP00000019647; ENSCPOG00000010848.
    GeneIDi100135631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175221 mRNA. Translation: AAD51732.1 .
    RefSeqi NP_001166497.1. NM_001173026.1.

    3D structure databases

    ProteinModelPortali Q9R110.
    SMRi Q9R110. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000019647.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000023420 ; ENSCPOP00000019647 ; ENSCPOG00000010848 .
    GeneIDi 100135631.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00640000091260.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi Q9R110.
    OMAi HWAANIL.
    OrthoDBi EOG7GBFWS.
    TreeFami TF315472.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Morphine regulation of a novel uridine diphosphate glucuronosyl-transferase in guinea pig pups following in utero exposure."
      Smith S.A., Nagalla S.R., Andrews D.P., Olsen G.D.
      Mol. Genet. Metab. 68:68-77(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiUD2A3_CAVPO
    AccessioniPrimary (citable) accession number: Q9R110
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3