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Protein
Submitted name:

Hemochromatosis gene product HFE splice variant delE2

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Hemochromatosis gene product HFE splice variant delE2Imported
Submitted name:
Hemochromatosis, isoform CRA_bImported
Submitted name:
Hereditary hemochromatosis protein homologImported
Gene namesi
Name:HfeImported
ORF Names:rCG_45141Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2793. Hfe.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei230 – 253HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501084814828 – 272Sequence analysisAdd BLAST245

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000016967.
ExpressionAtlasiQ9R105. baseline.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 221Ig-likeInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFNV. Eukaryota.
ENOG4111CQR. LUCA.
GeneTreeiENSGT00740000114936.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR031092. HFE.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
PANTHERiPTHR16675:SF172. PTHR16675:SF172. 2 hits.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP VTKLRVVPES HILQVILGCE
60 70 80 90 100
VHEDNSTSGF WKYGYDGQDH LEFCPKTLNW SAAEPRAWAT KMEWEEHRIR
110 120 130 140 150
ARQSRDYLQR DCPQQLKQVL ELQRGVLGQQ VPTLVKVTRH WASTGTSLRC
160 170 180 190 200
QALNFFPQNI TMRWLKDSQP LDAKDVNPEN VLPNGDGTYQ GWLTLAVAPG
210 220 230 240 250
EETRFSCQVE HPGLDQPLTA TWEPSRSQDM IIGIISGITI CAIFFVGILI
260 270
LVLRKRKVSG GTMGDYVLTE CE
Length:272
Mass (Da):30,757
Last modified:May 1, 2000 - v1
Checksum:i1D91063CCBEF5502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130391 Genomic DNA. No translation available.
AF176534 mRNA. Translation: AAD49965.1.
CH474064 Genomic DNA. Translation: EDL86570.1.
RefSeqiNP_001166905.1. NM_001173434.1.
UniGeneiRn.42931.

Genome annotation databases

EnsembliENSRNOT00000022809; ENSRNOP00000022809; ENSRNOG00000016967.
GeneIDi29199.

Similar proteinsi

Entry informationi

Entry nameiQ9R105_RAT
AccessioniPrimary (citable) accession number: Q9R105
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported