Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hemochromatosis gene product HFE splice variant delE2

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Hemochromatosis gene product HFE splice variant delE2Imported
Submitted name:
Hemochromatosis, isoform CRA_bImported
Submitted name:
Hereditary hemochromatosis protein homologImported
Gene namesi
Name:HfeImported
ORF Names:rCG_45141Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2793. Hfe.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei230 – 25324HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 272245Sequence analysisPRO_5007929059Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000016967.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 22190Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFNV. Eukaryota.
ENOG4111CQR. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF172. PTHR16675:SF172. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP VTKLRVVPES HILQVILGCE
60 70 80 90 100
VHEDNSTSGF WKYGYDGQDH LEFCPKTLNW SAAEPRAWAT KMEWEEHRIR
110 120 130 140 150
ARQSRDYLQR DCPQQLKQVL ELQRGVLGQQ VPTLVKVTRH WASTGTSLRC
160 170 180 190 200
QALNFFPQNI TMRWLKDSQP LDAKDVNPEN VLPNGDGTYQ GWLTLAVAPG
210 220 230 240 250
EETRFSCQVE HPGLDQPLTA TWEPSRSQDM IIGIISGITI CAIFFVGILI
260 270
LVLRKRKVSG GTMGDYVLTE CE
Length:272
Mass (Da):30,757
Last modified:May 1, 2000 - v1
Checksum:i1D91063CCBEF5502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130391 Genomic DNA. No translation available.
AF176534 mRNA. Translation: AAD49965.1.
CH474064 Genomic DNA. Translation: EDL86570.1.
RefSeqiNP_001166905.1. NM_001173434.1.
UniGeneiRn.42931.

Genome annotation databases

EnsembliENSRNOT00000022809; ENSRNOP00000022809; ENSRNOG00000016967.
GeneIDi29199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130391 Genomic DNA. No translation available.
AF176534 mRNA. Translation: AAD49965.1.
CH474064 Genomic DNA. Translation: EDL86570.1.
RefSeqiNP_001166905.1. NM_001173434.1.
UniGeneiRn.42931.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022809; ENSRNOP00000022809; ENSRNOG00000016967.
GeneIDi29199.

Organism-specific databases

CTDi3077.
RGDi2793. Hfe.

Phylogenomic databases

eggNOGiENOG410IFNV. Eukaryota.
ENOG4111CQR. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.

Gene expression databases

BgeeiENSRNOG00000016967.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF172. PTHR16675:SF172. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R105_RAT
AccessioniPrimary (citable) accession number: Q9R105
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.