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Protein

Interleukin-12 subunit alpha

Gene

Il12a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alpha
Short name:
IL-12A
Alternative name(s):
Cytotoxic lymphocyte maturation factor 35 kDa subunit
Short name:
CLMF p35
IL-12 subunit p35
Gene namesi
Name:Il12a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620562. Il12a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 215193Interleukin-12 subunit alphaPRO_0000015611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi60 ↔ 192By similarity
Disulfide bondi81 ↔ 119By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 – 92InterchainCurated
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R103.
PRIDEiQ9R103.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012832.

Structurei

3D structure databases

ProteinModelPortaliQ9R103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
HOGENOMiHOG000113026.
HOVERGENiHBG063691.
InParanoidiQ9R103.
KOiK05406.
PhylomeDBiQ9R103.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
[Graphical view]
PANTHERiPTHR10523. PTHR10523. 1 hit.
PfamiPF03039. IL12. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT
60 70 80 90 100
AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS
110 120 130 140 150
IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT
160 170 180 190 200
LDRNMLMAID ELMRSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST
210
RVMTINRVMN YLSSS
Length:215
Mass (Da):24,246
Last modified:May 1, 2000 - v1
Checksum:i60EDC00C70F0E005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177031 mRNA. Translation: AAD51364.1.
RefSeqiNP_445842.1. NM_053390.1.
UniGeneiRn.207199.

Genome annotation databases

GeneIDi84405.
KEGGirno:84405.
UCSCiRGD:620562. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177031 mRNA. Translation: AAD51364.1.
RefSeqiNP_445842.1. NM_053390.1.
UniGeneiRn.207199.

3D structure databases

ProteinModelPortaliQ9R103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012832.

Proteomic databases

PaxDbiQ9R103.
PRIDEiQ9R103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84405.
KEGGirno:84405.
UCSCiRGD:620562. rat.

Organism-specific databases

CTDi3592.
RGDi620562. Il12a.

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
HOGENOMiHOG000113026.
HOVERGENiHBG063691.
InParanoidiQ9R103.
KOiK05406.
PhylomeDBiQ9R103.

Miscellaneous databases

NextBioi616856.
PROiQ9R103.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
[Graphical view]
PANTHERiPTHR10523. PTHR10523. 1 hit.
PfamiPF03039. IL12. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the rat interleukin 12 p35 subunit."
    Verma N.D., He X.Y., Hall B.M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DA.

Entry informationi

Entry nameiIL12A_RAT
AccessioniPrimary (citable) accession number: Q9R103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.