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Protein

Cadherin-17

Gene

Cdh17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • germinal center B cell differentiation Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  • integrin-mediated signaling pathway Source: MGI
  • marginal zone B cell differentiation Source: UniProtKB
  • oligopeptide transport Source: MGI
  • positive regulation of integrin activation by cell surface receptor linked signal transduction Source: MGI
  • spleen development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
BILL-cadherin
Liver-intestine cadherin
Short name:
LI-cadherin
P130
Gene namesi
Name:Cdh17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1095414. Cdh17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 786761ExtracellularSequence analysisAdd
BLAST
Transmembranei787 – 80721HelicalSequence analysisAdd
BLAST
Topological domaini808 – 82720CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 827802Cadherin-17PRO_0000003813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9R100.
PaxDbiQ9R100.
PRIDEiQ9R100.

PTM databases

iPTMnetiQ9R100.
PhosphoSiteiQ9R100.

Expressioni

Tissue specificityi

Highest expression is found in intestine with lower expression in spleen, bone marrow, lung and testis. No expression detected in liver, kidney, heart, brain or skeletal muscle. Expressed in precursor B-cells and myeloid cells.1 Publication

Developmental stagei

Expression increases in pro- and pre-B-I cells, decreases in large and small pre-B-II cells, and increases again in immature and mature B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000028217.
CleanExiMM_CDH17.
ExpressionAtlasiQ9R100. baseline and differential.
GenevisibleiQ9R100. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198636. 4 interactions.
IntActiQ9R100. 1 interaction.
STRINGi10090.ENSMUSP00000029871.

Structurei

3D structure databases

ProteinModelPortaliQ9R100.
SMRiQ9R100. Positions 29-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12799Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 243116Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 33996Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini340 – 448109Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini449 – 565117Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini566 – 666101Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini667 – 776110Cadherin 7PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiQ9R100.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG091G033T.
PhylomeDBiQ9R100.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAQLHFLC LLTLYLTCGY GEEGKFSGPL KPMTFSIFEG QEPSQVIFQF
60 70 80 90 100
KTNPPAVTFE LTGETDGIFK IEKDGLLYHT RALDRETRAV HHLQLAALDS
110 120 130 140 150
HGAIVDGPVP ITIEVKDIND NRPTFLQSKY EGSVRQNSRP GKPFMYVNAT
160 170 180 190 200
DLDDPATPNG QLFYQIVIQL PQINDVMYFQ IDSKTGAISL TPEGSQELDP
210 220 230 240 250
VKNPSYNLVV SVKDMGGQSE NSFSDTTYVD ISIRENIWKA PEPVEIRENS
260 270 280 290 300
TDPHPIKITQ VQWNDPGAQY SLVNKEKLSP FPFSIDQEGN IYVTQALDRE
310 320 330 340 350
EKNSHVFFAT AKDENGKPLA YPLEIYVKVI DINDNPPTCL SPVTVFEVQE
360 370 380 390 400
NEPLGNSIGI FEAHDMDEAN NINSILKYKL VDQTPKVPSD GLFLIGEYEG
410 420 430 440 450
KVQLSKQSLK KQDSPQYNLS IEVSDVDFKT LCYIQVNVID INDQIPIFET
460 470 480 490 500
SNYGSKTLSE DTAIGSTILI IQATDADEPF TGSSKILYKI VQGDTEGRLE
510 520 530 540 550
VVTDPTTNAG YVKIKKPLDF ETQPVSSIVF QAENPEPLVK GIEYNASSFA
560 570 580 590 600
SFELIVTDVN EVPVFPQRIF QANVSEDAAV GSRVGNVTAR DPEGLTVSYS
610 620 630 640 650
LKGNMRGWLK IDSVTGEIFS AAPLDRETES VYRVQVVATE VGGSSLSSTA
660 670 680 690 700
DFHLVLTDVN DNPPRLAKDY TGLFFCHPLS APGSLIFEVT DDDQQSLRRP
710 720 730 740 750
KFTFALGREG LQSDWEVSKI NGTHARLSTR HTRFEEQVYN IPIRINDGGQ
760 770 780 790 800
PPMEGTVFLP VTFCQCVEGS CFRPAGRQDG IPTVGMAVGI LLTTFLVIGI
810 820
ILAVVFIRMR KDKVENPQSP ENKPLRS
Length:827
Mass (Da):91,645
Last modified:May 1, 2000 - v1
Checksum:iCDCECEA5A76E2B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177669 mRNA. Translation: AAD51125.1.
D87912 mRNA. Translation: BAB03264.1.
BC042891 mRNA. Translation: AAH42891.1.
CCDSiCCDS17972.1.
RefSeqiNP_062727.1. NM_019753.4.
XP_006537646.1. XM_006537583.1.
XP_006537647.1. XM_006537584.2.
UniGeneiMm.33402.

Genome annotation databases

EnsembliENSMUST00000029871; ENSMUSP00000029871; ENSMUSG00000028217.
GeneIDi12557.
KEGGimmu:12557.
UCSCiuc008rzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177669 mRNA. Translation: AAD51125.1.
D87912 mRNA. Translation: BAB03264.1.
BC042891 mRNA. Translation: AAH42891.1.
CCDSiCCDS17972.1.
RefSeqiNP_062727.1. NM_019753.4.
XP_006537646.1. XM_006537583.1.
XP_006537647.1. XM_006537584.2.
UniGeneiMm.33402.

3D structure databases

ProteinModelPortaliQ9R100.
SMRiQ9R100. Positions 29-764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198636. 4 interactions.
IntActiQ9R100. 1 interaction.
STRINGi10090.ENSMUSP00000029871.

PTM databases

iPTMnetiQ9R100.
PhosphoSiteiQ9R100.

Proteomic databases

MaxQBiQ9R100.
PaxDbiQ9R100.
PRIDEiQ9R100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029871; ENSMUSP00000029871; ENSMUSG00000028217.
GeneIDi12557.
KEGGimmu:12557.
UCSCiuc008rzy.2. mouse.

Organism-specific databases

CTDi1015.
MGIiMGI:1095414. Cdh17.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiQ9R100.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG091G033T.
PhylomeDBiQ9R100.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiQ9R100.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028217.
CleanExiMM_CDH17.
ExpressionAtlasiQ9R100. baseline and differential.
GenevisibleiQ9R100. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD17_MOUSE
AccessioniPrimary (citable) accession number: Q9R100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.