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Q9R0Z6

- Q9R0Z6_MOUSE

UniProt

Q9R0Z6 - Q9R0Z6_MOUSE

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Protein
Submitted name:

Protein kinase c-alpha

Gene

Pkca

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. histone kinase activity (H3-T6 specific) Source: Ensembl

GO - Biological processi

  1. desmosome assembly Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. negative regulation of glial cell apoptotic process Source: Ensembl
  4. positive regulation of angiogenesis Source: Ensembl
  5. positive regulation of blood vessel endothelial cell migration Source: Ensembl
  6. positive regulation of cell adhesion Source: Ensembl
  7. positive regulation of endothelial cell proliferation Source: Ensembl
  8. positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
  9. positive regulation of mitotic cell cycle Source: Ensembl
  10. regulation of platelet aggregation Source: Ensembl
  11. response to interleukin-1 Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_188578. Signaling by SCF-KIT.
REACT_196644. Syndecan interactions.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_198691. HuR stabilizes mRNA.
REACT_206166. Response to elevated platelet cytosolic Ca2+.
REACT_208718. Depolymerisation of the Nuclear Lamina.
REACT_215302. Disinhibition of SNARE formation.
REACT_215587. Calmodulin induced events.
REACT_221970. Ca2+ pathway.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_227425. Regulation of KIT signaling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_247495. Acetylcholine regulates insulin secretion.
REACT_253367. Trafficking of GluR2-containing AMPA receptors.
REACT_258013. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase c-alphaImported
Gene namesi
Name:PkcaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9R0Z6.
ExpressionAtlasiQ9R0Z6. baseline and differential.
GenevestigatoriQ9R0Z6.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
PROSITEiPS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R0Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC

SHCTDFIW
Length:58
Mass (Da):6,746
Last modified:May 1, 2000 - v1
Checksum:i63EB1B8CBA4B5171
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei58 – 581Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178928 Genomic DNA. Translation: AAD51851.1.
UniGeneiMm.222178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178928 Genomic DNA. Translation: AAD51851.1 .
UniGenei Mm.222178.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9R0Z6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_188578. Signaling by SCF-KIT.
REACT_196644. Syndecan interactions.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_198691. HuR stabilizes mRNA.
REACT_206166. Response to elevated platelet cytosolic Ca2+.
REACT_208718. Depolymerisation of the Nuclear Lamina.
REACT_215302. Disinhibition of SNARE formation.
REACT_215587. Calmodulin induced events.
REACT_221970. Ca2+ pathway.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_227425. Regulation of KIT signaling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_247495. Acetylcholine regulates insulin secretion.
REACT_253367. Trafficking of GluR2-containing AMPA receptors.
REACT_258013. G alpha (z) signalling events.

Miscellaneous databases

ChiTaRSi Prkca. mouse.

Gene expression databases

Bgeei Q9R0Z6.
ExpressionAtlasi Q9R0Z6. baseline and differential.
Genevestigatori Q9R0Z6.

Family and domain databases

InterProi IPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view ]
PRINTSi PR00008. DAGPEDOMAIN.
PROSITEi PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element."
    Desai D.S., Hirai S., Karnes W.E. Jr, Niles R.M., Ohno S.
    Biochem. Biophys. Res. Commun. 263:28-34(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.

Entry informationi

Entry nameiQ9R0Z6_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)