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Q9R0Z6

- Q9R0Z6_MOUSE

UniProt

Q9R0Z6 - Q9R0Z6_MOUSE

Protein
Submitted name:

Protein kinase c-alpha

Gene

Pkca

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. histone kinase activity (H3-T6 specific) Source: Ensembl

    GO - Biological processi

    1. desmosome assembly Source: Ensembl
    2. intracellular signal transduction Source: InterPro
    3. negative regulation of glial cell apoptotic process Source: Ensembl
    4. positive regulation of angiogenesis Source: Ensembl
    5. positive regulation of blood vessel endothelial cell migration Source: Ensembl
    6. positive regulation of cell adhesion Source: Ensembl
    7. positive regulation of endothelial cell proliferation Source: Ensembl
    8. positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
    9. positive regulation of mitotic cell cycle Source: Ensembl
    10. regulation of platelet aggregation Source: Ensembl
    11. response to interleukin-1 Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196644. Syndecan interactions.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_198691. HuR stabilizes mRNA.
    REACT_206166. Response to elevated platelet cytosolic Ca2+.
    REACT_208718. Depolymerisation of the Nuclear Lamina.
    REACT_215302. Disinhibition of SNARE formation.
    REACT_215587. Calmodulin induced events.
    REACT_221970. Ca2+ pathway.
    REACT_222404. WNT5A-dependent internalization of FZD4.
    REACT_227425. Regulation of KIT signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein kinase c-alphaImported
    Gene namesi
    Name:PkcaImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0Z6.
    BgeeiQ9R0Z6.
    GenevestigatoriQ9R0Z6.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9R0Z6.

    Family and domain databases

    InterProiIPR020454. DAG/PE-bd.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PRINTSiPR00008. DAGPEDOMAIN.
    PROSITEiPS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9R0Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC   50
    SHCTDFIW 58
    Length:58
    Mass (Da):6,746
    Last modified:May 1, 2000 - v1
    Checksum:i63EB1B8CBA4B5171
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei58 – 581Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178928 Genomic DNA. Translation: AAD51851.1.
    UniGeneiMm.222178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178928 Genomic DNA. Translation: AAD51851.1 .
    UniGenei Mm.222178.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    InParanoidi Q9R0Z6.

    Enzyme and pathway databases

    Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_188578. Signaling by SCF-KIT.
    REACT_196644. Syndecan interactions.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_198691. HuR stabilizes mRNA.
    REACT_206166. Response to elevated platelet cytosolic Ca2+.
    REACT_208718. Depolymerisation of the Nuclear Lamina.
    REACT_215302. Disinhibition of SNARE formation.
    REACT_215587. Calmodulin induced events.
    REACT_221970. Ca2+ pathway.
    REACT_222404. WNT5A-dependent internalization of FZD4.
    REACT_227425. Regulation of KIT signaling.

    Miscellaneous databases

    ChiTaRSi PRKCA. mouse.

    Gene expression databases

    ArrayExpressi Q9R0Z6.
    Bgeei Q9R0Z6.
    Genevestigatori Q9R0Z6.

    Family and domain databases

    InterProi IPR020454. DAG/PE-bd.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    PRINTSi PR00008. DAGPEDOMAIN.
    PROSITEi PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element."
      Desai D.S., Hirai S., Karnes W.E. Jr, Niles R.M., Ohno S.
      Biochem. Biophys. Res. Commun. 263:28-34(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJImported.

    Entry informationi

    Entry nameiQ9R0Z6_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0Z6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)