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Protein
Submitted name:

Protein kinase c-alpha

Gene

Pkca

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_274491. HuR stabilizes mRNA.
REACT_296380. G alpha (z) signalling events.
REACT_299462. WNT5A-dependent internalization of FZD4.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_306601. Acetylcholine regulates insulin secretion.
REACT_311545. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_318580. Response to elevated platelet cytosolic Ca2+.
REACT_322343. Trafficking of GluR2-containing AMPA receptors.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326610. Syndecan interactions.
REACT_327841. Signaling by SCF-KIT.
REACT_331940. Ca2+ pathway.
REACT_332567. Calmodulin induced events.
REACT_342156. Disinhibition of SNARE formation.
REACT_352955. Depolymerisation of the Nuclear Lamina.
REACT_354765. Regulation of KIT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase c-alphaImported
Gene namesi
Name:PkcaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9R0Z6.
ExpressionAtlasiQ9R0Z6. baseline and differential.
GenevestigatoriQ9R0Z6.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
PROSITEiPS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R0Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC

SHCTDFIW
Length:58
Mass (Da):6,746
Last modified:May 1, 2000 - v1
Checksum:i63EB1B8CBA4B5171
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei58 – 581Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178928 Genomic DNA. Translation: AAD51851.1.
UniGeneiMm.222178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178928 Genomic DNA. Translation: AAD51851.1.
UniGeneiMm.222178.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9R0Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

ReactomeiREACT_274491. HuR stabilizes mRNA.
REACT_296380. G alpha (z) signalling events.
REACT_299462. WNT5A-dependent internalization of FZD4.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_306601. Acetylcholine regulates insulin secretion.
REACT_311545. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_318580. Response to elevated platelet cytosolic Ca2+.
REACT_322343. Trafficking of GluR2-containing AMPA receptors.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326610. Syndecan interactions.
REACT_327841. Signaling by SCF-KIT.
REACT_331940. Ca2+ pathway.
REACT_332567. Calmodulin induced events.
REACT_342156. Disinhibition of SNARE formation.
REACT_352955. Depolymerisation of the Nuclear Lamina.
REACT_354765. Regulation of KIT signaling.

Miscellaneous databases

ChiTaRSiPrkca. mouse.

Gene expression databases

BgeeiQ9R0Z6.
ExpressionAtlasiQ9R0Z6. baseline and differential.
GenevestigatoriQ9R0Z6.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
PROSITEiPS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element."
    Desai D.S., Hirai S., Karnes W.E. Jr, Niles R.M., Ohno S.
    Biochem. Biophys. Res. Commun. 263:28-34(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.

Entry informationi

Entry nameiQ9R0Z6_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.