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Protein

Gamma-aminobutyric acid receptor subunit gamma-1

Gene

Gabrg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-1
Alternative name(s):
GABA(A) receptor subunit gamma-1
Gene namesi
Name:Gabrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103156. Gabrg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 272ExtracellularCuratedAdd BLAST237
Transmembranei273 – 294HelicalCuratedAdd BLAST22
Transmembranei299 – 320HelicalCuratedAdd BLAST22
Transmembranei332 – 354HelicalCuratedAdd BLAST23
Topological domaini355 – 444CytoplasmicCuratedAdd BLAST90
Transmembranei445 – 465HelicalCuratedAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000047436 – 465Gamma-aminobutyric acid receptor subunit gamma-1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi188 ↔ 202By similarity
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

May be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9R0Y8.
PaxDbiQ9R0Y8.
PRIDEiQ9R0Y8.

PTM databases

iPTMnetiQ9R0Y8.
PhosphoSitePlusiQ9R0Y8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001260.
ExpressionAtlasiQ9R0Y8. baseline and differential.
GenevisibleiQ9R0Y8. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031119.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ9R0Y8.
KOiK05186.
OMAiVRLMFLL.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005438. GABBAg1_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01621. GABAARGAMMA1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGKAFLFS PSLLWSQTRG VRLIFLLLTL HLGNCVDKAD DEDDEDLTMN
60 70 80 90 100
KTWVLAPKIH EGDITQILNS LLQGYDNKLR PDIGVRPTVI ETDVYVNSIG
110 120 130 140 150
PVDPINMEYT IDIIFAQTWF DSRLKFNSTM KVLMLNSNMV GKIWIPDTFF
160 170 180 190 200
RNSRKSDAHW ITTPNRLLRI WSDGRVLYTL RLTINAECYL QLHNFPMDEH
210 220 230 240 250
SCPLEFSSYG YPKNEIEYKW KKPSVEVADP KYWRLYQFAF VGLRNSTEIS
260 270 280 290 300
HTISGDYIIM TIFFDLSRRM GYFTIQTYIP CILTVVLSWV SFWINKDAVP
310 320 330 340 350
ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFAALME
360 370 380 390 400
YGTLHYFTSN NKGKTTRGRK LKNKTSASPG LHAGSTLIPM NSISLPQGED
410 420 430 440 450
DYGYQCLEGK DCTSFFCCFD DCRTGSWREG RIHIRIAKID SYSRIFFPTA
460
FALFNLVYWV GYLYL
Length:465
Mass (Da):53,407
Last modified:October 3, 2012 - v2
Checksum:i02E341E690EA6529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti421 – 431DCRTGSWREGR → RLQNWVLEGRA in CAA38992 (PubMed:9527017).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55272 mRNA. Translation: CAA38992.1.
AK034332 mRNA. Translation: BAC28677.1.
AK047752 mRNA. Translation: BAC33146.1.
AK049956 mRNA. Translation: BAC34006.1.
AK038468 mRNA. Translation: BAE43302.1.
AC068252 Genomic DNA. No translation available.
AC092716 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37806.1.
BC099939 mRNA. Translation: AAH99939.1.
CCDSiCCDS19326.1.
RefSeqiNP_034382.2. NM_010252.4.
UniGeneiMm.255292.

Genome annotation databases

EnsembliENSMUST00000031119; ENSMUSP00000031119; ENSMUSG00000001260.
GeneIDi14405.
KEGGimmu:14405.
UCSCiuc008xqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55272 mRNA. Translation: CAA38992.1.
AK034332 mRNA. Translation: BAC28677.1.
AK047752 mRNA. Translation: BAC33146.1.
AK049956 mRNA. Translation: BAC34006.1.
AK038468 mRNA. Translation: BAE43302.1.
AC068252 Genomic DNA. No translation available.
AC092716 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37806.1.
BC099939 mRNA. Translation: AAH99939.1.
CCDSiCCDS19326.1.
RefSeqiNP_034382.2. NM_010252.4.
UniGeneiMm.255292.

3D structure databases

ProteinModelPortaliQ9R0Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031119.

Chemistry databases

ChEMBLiCHEMBL2094133.

PTM databases

iPTMnetiQ9R0Y8.
PhosphoSitePlusiQ9R0Y8.

Proteomic databases

MaxQBiQ9R0Y8.
PaxDbiQ9R0Y8.
PRIDEiQ9R0Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031119; ENSMUSP00000031119; ENSMUSG00000001260.
GeneIDi14405.
KEGGimmu:14405.
UCSCiuc008xqr.1. mouse.

Organism-specific databases

CTDi2565.
MGIiMGI:103156. Gabrg1.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ9R0Y8.
KOiK05186.
OMAiVRLMFLL.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Miscellaneous databases

PROiQ9R0Y8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001260.
ExpressionAtlasiQ9R0Y8. baseline and differential.
GenevisibleiQ9R0Y8. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005438. GABBAg1_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01621. GABAARGAMMA1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRG1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Y8
Secondary accession number(s): Q8BHM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This subunit carries the benzodiazepine binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.