Reviewed,
UniProtKB/Swiss-Prot Q9R0Y5 (KAD1_MOUSE)
Last modified
November 3, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenylate kinase isoenzyme 1 Short name=AK 1 EC=2.7.4.3 Alternative name(s): ATP-AMP transphosphorylase 1 Myokinase | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 194 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth By similarity. May provide a mechanism to buffer the adenylate energy charge for sperm motility. |
| Catalytic activity | ATP + AMP = 2 ADP. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Developmental stage | Up-regulated during late spermiogenesis, when the flagellum is being assembled. Ref.2 |
| Sequence similarities | Belongs to the adenylate kinase family. |
| Sequence caution | The sequence CAM16612.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | ATP metabolic process Inferred from electronic annotation. Source: InterPro cell cycle arrest Ref.1Inferred from direct assay. Source: MGI |
| Cellular component | mitochondrion Inferred from direct assay. Source: MGI plasma membrane Ref.1Inferred from direct assay. Source: MGI |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activityInferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9R0Y5-1) Also known as: Ak1a; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9R0Y5-2) Also known as: Ak1b; The sequence of this isoform differs from the canonical sequence as follows: 1-2: ME → MGCCVSSEPQEEGGRKTG |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 194 | 194 | Adenylate kinase isoenzyme 1 | PRO_0000158911 | |||||
Regions | |||||||||
| Nucleotide binding | 15 – 23 | 9 | ATP By similarity | ||||||
| Nucleotide binding | 94 – 101 | 8 | AMP By similarity | ||||||
Sites | |||||||||
| Binding site | 39 | 1 | AMP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 2 | 2 | ME → MGCCVSSEPQEEGGRKTG in isoform 2. | VSP_024843 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "wt p53 dependent expression of a membrane-associated isoform of adenylate kinase." Collavin L., Lazarevic D., Utrera R., Marzinotto S., Monte M., Schneider C. Oncogene 18:5879-5888(1999) [PubMed: 10557075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). |
| [2] | "Adenylate kinases 1 and 2 are part of the accessory structures in the mouse sperm flagellum." Cao W., Haig-Ladewig L., Gerton G.L., Moss S.B. Biol. Reprod. 75:492-500(2006) [PubMed: 16790685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE. Strain: CD-1. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J and NOD. Tissue: Adipose tissue. |
| [4] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6 and FVB/N. Tissue: Mammary tumor and Retina. |
| [6] | Lubec G., Klug S. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 32-44; 64-77; 84-97 AND 150-166, MASS SPECTROMETRY. Tissue: Hippocampus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ010108 mRNA. Translation: CAB52407.1. AJ010109 mRNA. Translation: CAB52408.1. DQ486026 mRNA. Translation: ABF46940.1. AK046613 mRNA. Translation: BAC32808.1. AK089270 mRNA. Translation: BAC40822.1. AL772271 Genomic DNA. Translation: CAM16612.1. Sequence problems. AL772271 Genomic DNA. Translation: CAM16613.1. AL772271 Genomic DNA. Translation: CAM16614.1. BC014802 mRNA. Translation: AAH14802.1. BC054366 mRNA. Translation: AAH54366.1. | |
| IPI | IPI00128209. IPI00750256. |
| RefSeq | NP_067490.1. |
| UniGene | Mm.29189 |
3D structure databases | |
| HSSP | HSSP built from PDB template 3ADK based on UniProtKB P00571. |
| SMR | Q9R0Y5. Positions 1-193. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9R0Y5. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | Q9R0Y5. |
Proteomic databases | |
| PRIDE | Q9R0Y5. |
Genome annotation databases | |
| Ensembl | ENSMUST00000068271; ENSMUSP00000068479; ENSMUSG00000026817; Mus musculus. [Genome view] ENSMUST00000113277; ENSMUSP00000108902; ENSMUSG00000026817; Mus musculus. [Genome view] ENSMUST00000113278; ENSMUSP00000108903; ENSMUSG00000026817; Mus musculus. [Genome view] |
| GeneID | 11636. |
| KEGG | mmu:11636. |
| NMPDR | fig|10090.3.peg.5814. |
| UCSC | uc008jgh.1. mouse. uc008jgj.1. mouse. |
Organism-specific databases | |
| MGI | MGI:87977. Ak1. |
Phylogenomic databases | |
| HOGENOM | Q9R0Y5. |
| HOVERGEN | Q9R0Y5. |
| OMA | GPETMTQ. |
Enzyme and pathway databases | |
| BRENDA | 2.7.4.3. 244. |
Gene expression databases | |
| ArrayExpress | Q9R0Y5. |
| Bgee | Q9R0Y5. |
| CleanEx | MM_AK1. |
| Genevestigator | Q9R0Y5. |
| GermOnline | ENSMUSG00000026817. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000850. Adenylate_kin. IPR006267. Adenylate_kin1. [Graphical view] |
| PANTHER | PTHR23359. Adenylate_kin. 1 hit. |
| Pfam | PF00406. ADK. 1 hit. [Graphical view] |
| PRINTS | PR00094. ADENYLTKNASE. |
| ProDom | PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01360. aden_kin_iso1. 1 hit. |
| PROSITE | PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | KAD1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9R0Y5 Secondary accession number(s): A2AK80, Q542C5, Q9R0Y4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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