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Protein

Acid-sensing ion channel 5

Gene

Asic5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride (By similarity).By similarity

GO - Molecular functioni

  • hydrogen ion channel activity Source: MGI
  • ligand-gated sodium channel activity Source: MGI
  • sodium channel activity Source: MGI

GO - Biological processi

  • sodium ion transmembrane transport Source: MGI

Keywordsi

Molecular functionIon channel, Sodium channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 5
Short name:
ASIC5
Alternative name(s):
Amiloride-sensitive cation channel 5
Brain-liver-intestine amiloride-sensitive Na(+) channel
Short name:
BLINaC
Gene namesi
Name:Asic5
Synonyms:Accn5, Blinac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929259. Asic5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 459ExtracellularSequence analysisAdd BLAST377
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 495CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003355981 – 495Acid-sensing ion channel 5Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 207By similarity
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 192By similarity
Disulfide bondi298 ↔ 377By similarity
Disulfide bondi315 ↔ 373By similarity
Disulfide bondi319 ↔ 364By similarity
Disulfide bondi328 ↔ 350By similarity
Disulfide bondi330 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0Y1.
PRIDEiQ9R0Y1.

PTM databases

PhosphoSitePlusiQ9R0Y1.

Expressioni

Tissue specificityi

Detected in cerebellum, brainstem, kidney, liver, hepatocytes, lung, intestine and embryo. In the cerebellum. restricted to interneurons in the granular layer, specifically in GRM1-expressing unipolar brush cells of the vestibulocerebellum.2 Publications

Gene expression databases

BgeeiENSMUSG00000028008.
ExpressionAtlasiQ9R0Y1. baseline and differential.
GenevisibleiQ9R0Y1. MM.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029641.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Y1.
SMRiQ9R0Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9R0Y1.
KOiK04832.
OMAiGIECDLQ.
OrthoDBiEOG091G053J.
PhylomeDBiQ9R0Y1.
TreeFamiTF330663.

Family and domain databases

InterProiView protein in InterPro
IPR001873. ENaC.
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiView protein in Pfam
PF00858. ASC. 1 hit.
PRINTSiPR01078. AMINACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9R0Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTEKSQVH AEKGLLGKIK RYLSKRPLPS PTDRKKFDQD FAMSTSFHGI
60 70 80 90 100
HNIAQNQNKV RKVIWLAVVL GSVSLLVWQI YSRLVNYFTW PTTTSIEVQY
110 120 130 140 150
VEKIEFPAVT LCNLNRFQTE AVSRFGIIFF LWDIVSKVLR LQEISANNTG
160 170 180 190 200
SPETLDFVTN HQNFSITEFV KNNGFYLNND TLVHCEFFGK TCSPKDFKHV
210 220 230 240 250
FTEYGNCFTF NYGENIQNKN KVSVSGRGLK LLLDVHQEEF TDNPVPGFAD
260 270 280 290 300
AGVIFVIHSP KKEPQFDGLG LSSPVGMHAR VTIRQLKTVH QEYPWGECNP
310 320 330 340 350
NIKLRNFITY STYGCLKECK ARHIQRLCGC LPFLLPGNGV ECDLLEYYNC
360 370 380 390 400
VSPILDHIER KGLCTMGTHN SSCPVSCEET EYPATVSYST FPSQRATRFL
410 420 430 440 450
AKKLNQSQEY IRENLVNIEI NYSDLNYKIT QQQKAVSVPE LLADVGGQLG
460 470 480 490
LFCGASLITI IEIIEYFFTN FYWVLIFFLL KILETIQRTS PPQAV
Length:495
Mass (Da):56,523
Last modified:May 1, 2000 - v1
Checksum:iBE710FD1B415A9F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19035 mRNA. Translation: CAB54040.1.
CCDSiCCDS17428.1.
RefSeqiNP_067345.1. NM_021370.2.
XP_006501884.1. XM_006501821.1.
XP_006501886.1. XM_006501823.2.
UniGeneiMm.88839.

Genome annotation databases

EnsembliENSMUST00000029641; ENSMUSP00000029641; ENSMUSG00000028008.
GeneIDi58170.
KEGGimmu:58170.
UCSCiuc008pop.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiASIC5_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families