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Protein

Acid-sensing ion channel 5

Gene

Asic5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride (By similarity).By similarity

GO - Molecular functioni

  • hydrogen ion channel activity Source: MGI
  • ligand-gated sodium channel activity Source: MGI
  • sodium channel activity Source: MGI

GO - Biological processi

  • proton transport Source: GOC
  • sodium ion transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 5
Short name:
ASIC5
Alternative name(s):
Amiloride-sensitive cation channel 5
Brain-liver-intestine amiloride-sensitive Na(+) channel
Short name:
BLINaC
Gene namesi
Name:Asic5
Synonyms:Accn5, Blinac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929259. Asic5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 459377ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 49515CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Acid-sensing ion channel 5PRO_0000335598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 207By similarity
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi185 ↔ 192By similarity
Disulfide bondi298 ↔ 377By similarity
Disulfide bondi315 ↔ 373By similarity
Disulfide bondi319 ↔ 364By similarity
Disulfide bondi328 ↔ 350By similarity
Disulfide bondi330 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0Y1.
PRIDEiQ9R0Y1.

PTM databases

PhosphoSiteiQ9R0Y1.

Expressioni

Tissue specificityi

Detected in cerebellum, brainstem, kidney, liver, hepatocytes, lung, intestine and embryo. In the cerebellum. restricted to interneurons in the granular layer, specifically in GRM1-expressing unipolar brush cells of the vestibulocerebellum.2 Publications

Gene expression databases

BgeeiQ9R0Y1.
ExpressionAtlasiQ9R0Y1. baseline and differential.
GenevisibleiQ9R0Y1. MM.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029641.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Y1.
SMRiQ9R0Y1. Positions 63-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9R0Y1.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9R0Y1.
TreeFamiTF330663.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9R0Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTEKSQVH AEKGLLGKIK RYLSKRPLPS PTDRKKFDQD FAMSTSFHGI
60 70 80 90 100
HNIAQNQNKV RKVIWLAVVL GSVSLLVWQI YSRLVNYFTW PTTTSIEVQY
110 120 130 140 150
VEKIEFPAVT LCNLNRFQTE AVSRFGIIFF LWDIVSKVLR LQEISANNTG
160 170 180 190 200
SPETLDFVTN HQNFSITEFV KNNGFYLNND TLVHCEFFGK TCSPKDFKHV
210 220 230 240 250
FTEYGNCFTF NYGENIQNKN KVSVSGRGLK LLLDVHQEEF TDNPVPGFAD
260 270 280 290 300
AGVIFVIHSP KKEPQFDGLG LSSPVGMHAR VTIRQLKTVH QEYPWGECNP
310 320 330 340 350
NIKLRNFITY STYGCLKECK ARHIQRLCGC LPFLLPGNGV ECDLLEYYNC
360 370 380 390 400
VSPILDHIER KGLCTMGTHN SSCPVSCEET EYPATVSYST FPSQRATRFL
410 420 430 440 450
AKKLNQSQEY IRENLVNIEI NYSDLNYKIT QQQKAVSVPE LLADVGGQLG
460 470 480 490
LFCGASLITI IEIIEYFFTN FYWVLIFFLL KILETIQRTS PPQAV
Length:495
Mass (Da):56,523
Last modified:May 1, 2000 - v1
Checksum:iBE710FD1B415A9F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19035 mRNA. Translation: CAB54040.1.
CCDSiCCDS17428.1.
RefSeqiNP_067345.1. NM_021370.2.
XP_006501884.1. XM_006501821.1.
XP_006501885.1. XM_006501822.1.
XP_006501886.1. XM_006501823.2.
XP_006501887.1. XM_006501824.2.
XP_011238478.1. XM_011240176.1.
UniGeneiMm.88839.

Genome annotation databases

EnsembliENSMUST00000029641; ENSMUSP00000029641; ENSMUSG00000028008.
GeneIDi58170.
KEGGimmu:58170.
UCSCiuc008pop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19035 mRNA. Translation: CAB54040.1.
CCDSiCCDS17428.1.
RefSeqiNP_067345.1. NM_021370.2.
XP_006501884.1. XM_006501821.1.
XP_006501885.1. XM_006501822.1.
XP_006501886.1. XM_006501823.2.
XP_006501887.1. XM_006501824.2.
XP_011238478.1. XM_011240176.1.
UniGeneiMm.88839.

3D structure databases

ProteinModelPortaliQ9R0Y1.
SMRiQ9R0Y1. Positions 63-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029641.

PTM databases

PhosphoSiteiQ9R0Y1.

Proteomic databases

PaxDbiQ9R0Y1.
PRIDEiQ9R0Y1.

Protocols and materials databases

DNASUi58170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029641; ENSMUSP00000029641; ENSMUSG00000028008.
GeneIDi58170.
KEGGimmu:58170.
UCSCiuc008pop.1. mouse.

Organism-specific databases

CTDi51802.
MGIiMGI:1929259. Asic5.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9R0Y1.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9R0Y1.
TreeFamiTF330663.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

NextBioi314105.
PROiQ9R0Y1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0Y1.
ExpressionAtlasiQ9R0Y1. baseline and differential.
GenevisibleiQ9R0Y1. MM.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals."
    Sakai H., Lingueglia E., Champigny G., Mattei M.-G., Lazdunski M.
    J. Physiol. (Lond.) 519:323-333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Brain, Intestine and Liver.
  2. "Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum."
    Boiko N., Kucher V., Wang B., Stockand J.D.
    PLoS ONE 9:E91326-E91326(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiASIC5_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.