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Protein

ADAM DEC1

Gene

Adamdec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in the control of the immune response and during pregnancy.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi351 – 3511Zinc; catalyticBy similarity
Active sitei352 – 3521PROSITE-ProRule annotation
Metal bindingi355 – 3551Zinc; catalyticBy similarity
Metal bindingi361 – 3611Zinc; catalyticSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.219.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAM DEC1 (EC:3.4.24.-)
Alternative name(s):
A disintegrin and metalloproteinase domain-like protein decysin-1
Short name:
ADAM-like protein decysin-1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917650. Adamdec1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Propeptidei34 – 208175Sequence analysisPRO_0000029148Add
BLAST
Chaini209 – 467259ADAM DEC1PRO_0000029149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi327 ↔ 406By similarity
Disulfide bondi368 ↔ 373By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9R0X2.
PaxDbiQ9R0X2.
PeptideAtlasiQ9R0X2.
PRIDEiQ9R0X2.

PTM databases

iPTMnetiQ9R0X2.
PhosphoSiteiQ9R0X2.

Expressioni

Tissue specificityi

Expressed highly in uterus during pregnancy.

Developmental stagei

From the prepubertal period to day 5.5 of pregnancy is weakly expressed. From day 5.5 of pregnancy, an increase of expression is observed. At day 12.5 expression is higher.1 Publication

Inductioni

Induced by immunization in mature dendritic cells (DC), in marginal zone (MZ) metallophils, in follicular DC (FDC) and tingible body macrophages of germinal center. Down-regulated by steroid hormones and PRL.1 Publication

Gene expression databases

BgeeiENSMUSG00000022057.
CleanExiMM_ADAMDEC1.
ExpressionAtlasiQ9R0X2. baseline and differential.
GenevisibleiQ9R0X2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022641.

Structurei

3D structure databases

ProteinModelPortaliQ9R0X2.
SMRiQ9R0X2. Positions 217-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 411195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini418 – 46750DisintegrinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00800000124044.
HOGENOMiHOG000230883.
HOVERGENiHBG106501.
InParanoidiQ9R0X2.
KOiK08634.
OMAiLRGYFTH.
OrthoDBiEOG091G07X4.
PhylomeDBiQ9R0X2.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR033613. ADAMDEC1.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PANTHERiPTHR11905:SF125. PTHR11905:SF125. 1 hit.
PfamiPF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGTSRLPT EASMSWVLLS VLWLIIQIQV IDATLTPELK PHEIVRPKKL
60 70 80 90 100
PISQKRGLEN NQTERYGKEE KYAPEVQYQI ILNGEEIVFH LKRTKHLLGP
110 120 130 140 150
DYTETSYSPR GEESTRHSQD VKPCYYEGHI QNARGSLARI STCDGLRGYF
160 170 180 190 200
THRDQRYQIK PLQSTDEGEH AVLPYSWKGQ DTVHDKDAEK QVVRKRSHLR
210 220 230 240 250
TSRSLKNPNE DLLQGQKYIG LFLVLDNAYY KLYNGNVTQM RTFLFKVLNL
260 270 280 290 300
LNMIYKTINI QVSLVGMEIW SDQDKIKVEP NLGATFTHFM RWHYSNLGKR
310 320 330 340 350
IHNHAQLLSG ASFRHGRVGM AAGNSFCTTS SVSVIEAKKK NNVALVALMS
360 370 380 390 400
HELGHALGMK DVPYYTKCPS GSCVMNQYLS SKFPKDFSTV SRSHFQGFLS
410 420 430 440 450
SRNARCLLLA PDPKNIIKPT CGNQVLDVGE ECDCGSPEEC TNLCCEPLTC
460
RLKSQPDCSE ASNHITE
Length:467
Mass (Da):52,956
Last modified:May 1, 2000 - v1
Checksum:i12A0FF346BAD70E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242912 mRNA. Translation: CAB54557.1.
BC046324 mRNA. Translation: AAH46324.1.
CCDSiCCDS49532.1.
RefSeqiNP_067450.1. NM_021475.2.
UniGeneiMm.36742.

Genome annotation databases

EnsembliENSMUST00000022641; ENSMUSP00000022641; ENSMUSG00000022057.
GeneIDi58860.
KEGGimmu:58860.
UCSCiuc007uls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242912 mRNA. Translation: CAB54557.1.
BC046324 mRNA. Translation: AAH46324.1.
CCDSiCCDS49532.1.
RefSeqiNP_067450.1. NM_021475.2.
UniGeneiMm.36742.

3D structure databases

ProteinModelPortaliQ9R0X2.
SMRiQ9R0X2. Positions 217-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022641.

Protein family/group databases

MEROPSiM12.219.

PTM databases

iPTMnetiQ9R0X2.
PhosphoSiteiQ9R0X2.

Proteomic databases

MaxQBiQ9R0X2.
PaxDbiQ9R0X2.
PeptideAtlasiQ9R0X2.
PRIDEiQ9R0X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022641; ENSMUSP00000022641; ENSMUSG00000022057.
GeneIDi58860.
KEGGimmu:58860.
UCSCiuc007uls.1. mouse.

Organism-specific databases

CTDi27299.
MGIiMGI:1917650. Adamdec1.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00800000124044.
HOGENOMiHOG000230883.
HOVERGENiHBG106501.
InParanoidiQ9R0X2.
KOiK08634.
OMAiLRGYFTH.
OrthoDBiEOG091G07X4.
PhylomeDBiQ9R0X2.
TreeFamiTF314733.

Miscellaneous databases

PROiQ9R0X2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022057.
CleanExiMM_ADAMDEC1.
ExpressionAtlasiQ9R0X2. baseline and differential.
GenevisibleiQ9R0X2. MM.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR033613. ADAMDEC1.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PANTHERiPTHR11905:SF125. PTHR11905:SF125. 1 hit.
PfamiPF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADEC1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.