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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

Chrna6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: MGI

GO - Biological processi

  • membrane depolarization Source: MGI
  • neuromuscular synaptic transmission Source: GO_Central
  • regulation of dopamine secretion Source: MGI
  • response to nicotine Source: GO_Central
  • signal transduction Source: GOC
  • synaptic transmission, cholinergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-MMU-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:Chrna6
Synonyms:Nica6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106213. Chrna6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 240ExtracellularSequence analysisAdd BLAST210
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 465CytoplasmicSequence analysisAdd BLAST138
Transmembranei466 – 485HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: MGI
  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000000036131 – 494Neuronal acetylcholine receptor subunit alpha-6Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0W9.
PRIDEiQ9R0W9.

PTM databases

PhosphoSitePlusiQ9R0W9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031491.
GenevisibleiQ9R0W9. MM.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033882.

Structurei

3D structure databases

ProteinModelPortaliQ9R0W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9R0W9.
KOiK04808.
OMAiKFANRVE.
OrthoDBiEOG091G0R20.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSRDQGNL HSGLCLWLCG FLALFKGSTG CESEEQLFHR LFAHYNRFIR
60 70 80 90 100
PVENVSDPVT VHFELAITQL ANVDEVNQIM ETNLWLRHIW KDYRLRWDPT
110 120 130 140 150
EYDGIETLRV PADNIWKPDI VLYNNAVGDF QVEGKTKALL KYDGVITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPATHTMPKW VKTIFLQAFP
360 370 380 390 400
SILMMRKPLD KTKEAGGVKD PKSHTKRPAK VKFTHRGESK LLKECHHCQK
410 420 430 440 450
SSDIAPGKRR SSQQPARWVA ENSEHSSDVE DVIESVQFIA ENMKSHNETN
460 470 480 490
EVEDDWKYMA MVVDRVFLWV FIIVCVFGTV GLFLQPLLGN TGKS
Length:494
Mass (Da):56,856
Last modified:July 27, 2011 - v2
Checksum:iA4655895692E2530
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63F → L in CAB53472 (Ref. 1) Curated1
Sequence conflicti493K → N in CAB53472 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245706 mRNA. Translation: CAB53472.1.
AK149262 mRNA. Translation: BAE28777.1.
CH466580 Genomic DNA. Translation: EDL32787.1.
BC031985 mRNA. Translation: AAH31985.1.
CCDSiCCDS40312.1.
RefSeqiNP_067344.2. NM_021369.2.
UniGeneiMm.283137.

Genome annotation databases

EnsembliENSMUST00000033882; ENSMUSP00000033882; ENSMUSG00000031491.
GeneIDi11440.
KEGGimmu:11440.
UCSCiuc009liv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245706 mRNA. Translation: CAB53472.1.
AK149262 mRNA. Translation: BAE28777.1.
CH466580 Genomic DNA. Translation: EDL32787.1.
BC031985 mRNA. Translation: AAH31985.1.
CCDSiCCDS40312.1.
RefSeqiNP_067344.2. NM_021369.2.
UniGeneiMm.283137.

3D structure databases

ProteinModelPortaliQ9R0W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033882.

Chemistry databases

ChEMBLiCHEMBL6183.

PTM databases

PhosphoSitePlusiQ9R0W9.

Proteomic databases

PaxDbiQ9R0W9.
PRIDEiQ9R0W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033882; ENSMUSP00000033882; ENSMUSG00000031491.
GeneIDi11440.
KEGGimmu:11440.
UCSCiuc009liv.1. mouse.

Organism-specific databases

CTDi8973.
MGIiMGI:106213. Chrna6.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9R0W9.
KOiK04808.
OMAiKFANRVE.
OrthoDBiEOG091G0R20.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiR-MMU-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-MMU-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

PROiQ9R0W9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031491.
GenevisibleiQ9R0W9. MM.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA6_MOUSE
AccessioniPrimary (citable) accession number: Q9R0W9
Secondary accession number(s): Q3UEY4, Q8K0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.