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Protein

Acid-sensing ion channel 5

Gene

Asic5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride.1 Publication

GO - Molecular functioni

  • hydrogen ion channel activity Source: Ensembl
  • ligand-gated sodium channel activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.6.1.3. the epithelial na(+) channel (enac) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 5
Short name:
ASIC5
Alternative name(s):
Amiloride-sensitive cation channel 5
Brain-liver-intestine amiloride-sensitive Na(+) channel
Short name:
BLINaC
Gene namesi
Name:Asic5
Synonyms:Accn5, Blinac
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi69295. Asic5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 459377ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 49515CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi443 – 4431A → C or S: Minimal channel activation. 1 Publication
Mutagenesisi443 – 4431A → F, T or V: Activates the channel. 1 Publication
Mutagenesisi443 – 4431A → K: Partial channel activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Acid-sensing ion channel 5PRO_0000335599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 207By similarity
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi185 ↔ 192By similarity
Disulfide bondi298 ↔ 377By similarity
Disulfide bondi315 ↔ 373By similarity
Disulfide bondi319 ↔ 364By similarity
Disulfide bondi328 ↔ 350By similarity
Disulfide bondi330 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R0W5.
PRIDEiQ9R0W5.

Expressioni

Tissue specificityi

Detected in brain, liver, duodenum, jejunum, ileum and testis.1 Publication

Gene expression databases

GenevisibleiQ9R0W5. RN.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016039.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9R0W5.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9R0W5.
TreeFamiTF330663.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9R0W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTEKSKGP AEKGLLGKIR RYLSKRPLPS PTDRKKFDHD FAISTSFHGI
60 70 80 90 100
HNIAQNQNKV RKVIWLSVVL GSVSLLVWQI YSRLVNYFMW PTTTSIEVQY
110 120 130 140 150
VEKIEFPAVT FCNLNRFQTE AVSRFGIIFF LWDIVSKVLR LQEISGNNTG
160 170 180 190 200
SPEALDFVAS HRNFSITEFV KNNGFYLNHD TLVHCEFFGK TCDPKDFKHV
210 220 230 240 250
FTEYGNCFTF NYGENVQSKN KVSVSGRGLK LLLDVHQEEF TDNPVPGFAD
260 270 280 290 300
AGVIFVIHSP KKEPQFDGLG LSSPVGMHAR VTIRQLKTIH QEYPWGECNP
310 320 330 340 350
DIKLRNFTTY STYGCLKECK AKHIQRLCGC LPFLLPGNGV ECDLLKYYNC
360 370 380 390 400
VSPILDHIER KGLCTMGTHN SSCPVPCEET EYPATIAYST FPSQRATKFL
410 420 430 440 450
AKKLNQSQEY IRENLVNIEI NYSDLNYKIT QQQKAVSVPE LLADVGGQLG
460 470 480 490
LFCGASLITI IEIIEYLFTS FYWVFIFFLL KILEMIQRTS PPQTV
Length:495
Mass (Da):56,464
Last modified:May 1, 2000 - v1
Checksum:iFAB265F495EA02AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19034 mRNA. Translation: CAB54072.1.
RefSeqiNP_071563.1. NM_022227.1.
UniGeneiRn.44631.

Genome annotation databases

EnsembliENSRNOT00000016039; ENSRNOP00000016039; ENSRNOG00000011842.
GeneIDi63866.
KEGGirno:63866.
UCSCiRGD:69295. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19034 mRNA. Translation: CAB54072.1.
RefSeqiNP_071563.1. NM_022227.1.
UniGeneiRn.44631.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016039.

Protein family/group databases

TCDBi1.A.6.1.3. the epithelial na(+) channel (enac) family.

Proteomic databases

PaxDbiQ9R0W5.
PRIDEiQ9R0W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016039; ENSRNOP00000016039; ENSRNOG00000011842.
GeneIDi63866.
KEGGirno:63866.
UCSCiRGD:69295. rat.

Organism-specific databases

CTDi51802.
RGDi69295. Asic5.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00760000119120.
HOGENOMiHOG000033777.
HOVERGENiHBG095680.
InParanoidiQ9R0W5.
KOiK04832.
OMAiTERKKFD.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9R0W5.
TreeFamiTF330663.

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.

Miscellaneous databases

NextBioi612480.
PROiQ9R0W5.

Gene expression databases

GenevisibleiQ9R0W5. RN.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals."
    Sakai H., Lingueglia E., Champigny G., Mattei M.-G., Lazdunski M.
    J. Physiol. (Lond.) 519:323-333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ALA-443, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Brain, Intestine and Liver.

Entry informationi

Entry nameiASIC5_RAT
AccessioniPrimary (citable) accession number: Q9R0W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.