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Protein

Pituitary homeobox 2

Gene

Pitx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi92 – 151HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox 2
Alternative name(s):
Homeobox protein PITX2
Paired-like homeodomain transcription factor 2
rPtx2
Gene namesi
Name:Pitx2
Synonyms:Ptx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3331. Pitx2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleus Source: RGD
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492251 – 324Pituitary homeobox 2Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97Phosphothreonine; by PKB/AKT2By similarity1

Post-translational modificationi

Phosphorylation at Thr-97 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R0W1.
PRIDEiQ9R0W1.

Expressioni

Tissue specificityi

Expressed in the brain.

Gene expression databases

BgeeiENSRNOG00000010681.
GenevisibleiQ9R0W1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046259.

Structurei

3D structure databases

ProteinModelPortaliQ9R0W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi286 – 299OARPROSITE-ProRule annotationAdd BLAST14
Motifi292 – 296Nuclear localization signalSequence analysis5

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000273886.
HOVERGENiHBG068770.
InParanoidiQ9R0W1.
KOiK04686.
OMAiPLNIDHH.
OrthoDBiEOG091G0H7U.
PhylomeDBiQ9R0W1.
TreeFamiTF351940.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR016233. Homeobox_Pitx/unc30.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PIRSFiPIRSF000563. Homeobox_protein_Pitx/Unc30. 1 hit.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PTX2A (identifier: Q9R0W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNCMKGPLPL EHRAAGTKLS AASSPFCHHT QALAMASVLA PGQPRSLDAS
60 70 80 90 100
KHRLEVHTIS DTSSPEVAEK DKGQQGKNED VGAEDPSKKK RQRRQRTHFT
110 120 130 140 150
SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR
160 170 180 190 200
ERNQQAELCK NGFGPQFNGL MQPYDDMYPG YSYNNWAAKG LTSASLSTKS
210 220 230 240 250
FPFFNSMNVN PLSSQSMFSP PNSISSMSMS SSMVPSAVTG VPGSSLNSLN
260 270 280 290 300
NLNNLSSPSL NSAVPTPACP YAPPTPPYVY RDTCNSSLAS LRLKAKQHSS
310 320
FGYASVQNPA SNLSACQYAV DRPV
Length:324
Mass (Da):35,758
Last modified:May 1, 2000 - v1
Checksum:i0FAB2ABA8CF180E3
GO
Isoform PTX2B (identifier: Q9R0W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     54-68: LEVHTISDTSSPEVA → METNCRKLVSACVQL

Show »
Length:271
Mass (Da):30,306
Checksum:iF1D2ADA39B03FF6C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022641 – 53Missing in isoform PTX2B. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_00226554 – 68LEVHT…SPEVA → METNCRKLVSACVQL in isoform PTX2B. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039832 mRNA. Translation: AAC70909.1.
AJ222971 mRNA. Translation: CAB52283.1.
AJ222972 mRNA. Translation: CAB52284.1.
RefSeqiNP_001035970.1. NM_001042505.1. [Q9R0W1-1]
NP_062207.1. NM_019334.2. [Q9R0W1-2]
XP_017446543.1. XM_017591054.1. [Q9R0W1-2]
UniGeneiRn.17591.

Genome annotation databases

EnsembliENSRNOT00000044232; ENSRNOP00000043402; ENSRNOG00000010681. [Q9R0W1-2]
ENSRNOT00000051009; ENSRNOP00000046259; ENSRNOG00000010681. [Q9R0W1-1]
GeneIDi54284.
KEGGirno:54284.
UCSCiRGD:3331. rat. [Q9R0W1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039832 mRNA. Translation: AAC70909.1.
AJ222971 mRNA. Translation: CAB52283.1.
AJ222972 mRNA. Translation: CAB52284.1.
RefSeqiNP_001035970.1. NM_001042505.1. [Q9R0W1-1]
NP_062207.1. NM_019334.2. [Q9R0W1-2]
XP_017446543.1. XM_017591054.1. [Q9R0W1-2]
UniGeneiRn.17591.

3D structure databases

ProteinModelPortaliQ9R0W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046259.

Proteomic databases

PaxDbiQ9R0W1.
PRIDEiQ9R0W1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044232; ENSRNOP00000043402; ENSRNOG00000010681. [Q9R0W1-2]
ENSRNOT00000051009; ENSRNOP00000046259; ENSRNOG00000010681. [Q9R0W1-1]
GeneIDi54284.
KEGGirno:54284.
UCSCiRGD:3331. rat. [Q9R0W1-1]

Organism-specific databases

CTDi5308.
RGDi3331. Pitx2.

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000273886.
HOVERGENiHBG068770.
InParanoidiQ9R0W1.
KOiK04686.
OMAiPLNIDHH.
OrthoDBiEOG091G0H7U.
PhylomeDBiQ9R0W1.
TreeFamiTF351940.

Miscellaneous databases

PROiQ9R0W1.

Gene expression databases

BgeeiENSRNOG00000010681.
GenevisibleiQ9R0W1. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR016233. Homeobox_Pitx/unc30.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PIRSFiPIRSF000563. Homeobox_protein_Pitx/Unc30. 1 hit.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPITX2_RAT
AccessioniPrimary (citable) accession number: Q9R0W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.