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Protein

Pituitary homeobox 2

Gene

Pitx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi92 – 151HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox 2
Alternative name(s):
Homeobox protein PITX2
Paired-like homeodomain transcription factor 2
rPtx2
Gene namesi
Name:Pitx2
Synonyms:Ptx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3331 Pitx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492251 – 324Pituitary homeobox 2Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97Phosphothreonine; by PKB/AKT2By similarity1

Post-translational modificationi

Phosphorylation at Thr-97 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R0W1
PRIDEiQ9R0W1

Expressioni

Tissue specificityi

Expressed in the brain.

Gene expression databases

BgeeiENSRNOG00000010681
GenevisibleiQ9R0W1 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046259

Structurei

3D structure databases

ProteinModelPortaliQ9R0W1
SMRiQ9R0W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi286 – 299OARPROSITE-ProRule annotationAdd BLAST14
Motifi292 – 296Nuclear localization signalSequence analysis5

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000273886
HOVERGENiHBG068770
InParanoidiQ9R0W1
KOiK04686
OMAiPLNIDHH
OrthoDBiEOG091G0H7U
PhylomeDBiQ9R0W1
TreeFamiTF351940

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PTX2A (identifier: Q9R0W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNCMKGPLPL EHRAAGTKLS AASSPFCHHT QALAMASVLA PGQPRSLDAS
60 70 80 90 100
KHRLEVHTIS DTSSPEVAEK DKGQQGKNED VGAEDPSKKK RQRRQRTHFT
110 120 130 140 150
SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR
160 170 180 190 200
ERNQQAELCK NGFGPQFNGL MQPYDDMYPG YSYNNWAAKG LTSASLSTKS
210 220 230 240 250
FPFFNSMNVN PLSSQSMFSP PNSISSMSMS SSMVPSAVTG VPGSSLNSLN
260 270 280 290 300
NLNNLSSPSL NSAVPTPACP YAPPTPPYVY RDTCNSSLAS LRLKAKQHSS
310 320
FGYASVQNPA SNLSACQYAV DRPV
Length:324
Mass (Da):35,758
Last modified:May 1, 2000 - v1
Checksum:i0FAB2ABA8CF180E3
GO
Isoform PTX2B (identifier: Q9R0W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     54-68: LEVHTISDTSSPEVA → METNCRKLVSACVQL

Show »
Length:271
Mass (Da):30,306
Checksum:iF1D2ADA39B03FF6C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022641 – 53Missing in isoform PTX2B. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_00226554 – 68LEVHT…SPEVA → METNCRKLVSACVQL in isoform PTX2B. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039832 mRNA Translation: AAC70909.1
AJ222971 mRNA Translation: CAB52283.1
AJ222972 mRNA Translation: CAB52284.1
RefSeqiNP_001035970.1, NM_001042505.1 [Q9R0W1-1]
NP_062207.1, NM_019334.2 [Q9R0W1-2]
XP_017446543.1, XM_017591054.1 [Q9R0W1-2]
UniGeneiRn.17591

Genome annotation databases

EnsembliENSRNOT00000044232; ENSRNOP00000043402; ENSRNOG00000010681 [Q9R0W1-2]
ENSRNOT00000051009; ENSRNOP00000046259; ENSRNOG00000010681 [Q9R0W1-1]
GeneIDi54284
KEGGirno:54284
UCSCiRGD:3331 rat [Q9R0W1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPITX2_RAT
AccessioniPrimary (citable) accession number: Q9R0W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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