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Q9R0U1 (IP6K2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 2

Short name=InsP6 kinase 2
EC=2.7.4.21
Alternative name(s):
P(i)-uptake stimulator
Short name=PiUS
Gene names
Name:Ip6k2
Synonyms:Ihpk2, Pius
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport. Ref.1

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in small intestine. Ref.1

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence caution

The sequence BAA87611.1 differs from that shown. Reason: Chimeric cDNA.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Inositol hexakisphosphate kinase 2
PRO_0000066880

Regions

Region215 – 2239Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R0U1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 6E44C1D3D6EA7FD8

FASTA42549,164
        10         20         30         40         50         60 
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 

        70         80         90        100        110        120 
RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD NSDCEPKSKL LRWTNKKHHV 

       130        140        150        160        170        180 
LETEKSPKDW VRQHRKEEKM KSHKLEEEFE WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM 

       190        200        210        220        230        240 
KCHQQQLQRM KENAKHRNQY KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI 

       250        260        270        280        290        300 
RKCQQSTSAV IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 

       310        320        330        340        350        360 
ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED LEDLSEESAD 

       370        380        390        400        410        420 
ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG QDAGYIFGLQ SLIDIVTEIS 


EESGE 

« Hide

References

« Hide 'large scale' references
[1]"Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3."
Katai K., Miyamoto K., Kishida S., Segawa H., Nii T., Tanaka H., Tani Y., Arai H., Tatsumi S., Morita K., Taketani Y., Takeda E.
Biochem. J. 343:705-712(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015723 mRNA. Translation: BAA87611.1. Sequence problems.
BC083574 mRNA. Translation: AAH83574.1.
RefSeqNP_067692.2. NM_021660.2.
XP_006243914.1. XM_006243852.1.
UniGeneRn.112574.

3D structure databases

ProteinModelPortalQ9R0U1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9R0U1.

Proteomic databases

PaxDbQ9R0U1.
PRIDEQ9R0U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361.
GeneID59268.
KEGGrno:59268.
UCSCRGD:620529. rat.

Organism-specific databases

CTD51447.
RGD620529. Ip6k2.

Phylogenomic databases

eggNOGNOG274869.
GeneTreeENSGT00390000014381.
HOGENOMHOG000007418.
HOVERGENHBG052140.
KOK07756.
OMAKEWVRQH.
OrthoDBEOG747PHX.
PhylomeDBQ9R0U1.

Gene expression databases

GenevestigatorQ9R0U1.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611797.

Entry information

Entry nameIP6K2_RAT
AccessionPrimary (citable) accession number: Q9R0U1
Secondary accession number(s): Q5XIU6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families