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Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.By similarity1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of cell growth Source: Ensembl
  2. phosphate ion transport Source: RGD
  3. phosphatidylinositol phosphorylation Source: Ensembl
  4. positive regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_309272. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2, Pius
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620529. Ip6k2.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Inositol hexakisphosphate kinase 2PRO_0000066880Add
BLAST

Proteomic databases

PaxDbiQ9R0U1.
PRIDEiQ9R0U1.

PTM databases

PhosphoSiteiQ9R0U1.

Expressioni

Tissue specificityi

Highly expressed in small intestine.1 Publication

Gene expression databases

GenevestigatoriQ9R0U1.

Structurei

3D structure databases

ProteinModelPortaliQ9R0U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2239Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ9R0U1.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
PhylomeDBiQ9R0U1.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ
60 70 80 90 100
FYETLPAEMR RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD
110 120 130 140 150
NSDCEPKSKL LRWTNKKHHV LETEKSPKDW VRQHRKEEKM KSHKLEEEFE
160 170 180 190 200
WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY
210 220 230 240 250
KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV
260 270 280 290 300
IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR
310 320 330 340 350
ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED
360 370 380 390 400
LEDLSEESAD ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG
410 420
QDAGYIFGLQ SLIDIVTEIS EESGE
Length:425
Mass (Da):49,164
Last modified:November 13, 2007 - v2
Checksum:i6E44C1D3D6EA7FD8
GO

Sequence cautioni

The sequence BAA87611.1 differs from that shown.Chimeric cDNA.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015723 mRNA. Translation: BAA87611.1. Sequence problems.
BC083574 mRNA. Translation: AAH83574.1.
RefSeqiNP_067692.2. NM_021660.2.
XP_008764786.1. XM_008766564.1.
UniGeneiRn.112574.

Genome annotation databases

EnsembliENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361.
GeneIDi59268.
KEGGirno:59268.
UCSCiRGD:620529. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015723 mRNA. Translation: BAA87611.1. Sequence problems.
BC083574 mRNA. Translation: AAH83574.1.
RefSeqiNP_067692.2. NM_021660.2.
XP_008764786.1. XM_008766564.1.
UniGeneiRn.112574.

3D structure databases

ProteinModelPortaliQ9R0U1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9R0U1.

Proteomic databases

PaxDbiQ9R0U1.
PRIDEiQ9R0U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361.
GeneIDi59268.
KEGGirno:59268.
UCSCiRGD:620529. rat.

Organism-specific databases

CTDi51447.
RGDi620529. Ip6k2.

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ9R0U1.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
PhylomeDBiQ9R0U1.

Enzyme and pathway databases

ReactomeiREACT_309272. Synthesis of IPs in the nucleus.

Miscellaneous databases

NextBioi611797.
PROiQ9R0U1.

Gene expression databases

GenevestigatoriQ9R0U1.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3."
    Katai K., Miyamoto K., Kishida S., Segawa H., Nii T., Tanaka H., Tani Y., Arai H., Tatsumi S., Morita K., Taketani Y., Takeda E.
    Biochem. J. 343:705-712(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIP6K2_RAT
AccessioniPrimary (citable) accession number: Q9R0U1
Secondary accession number(s): Q5XIU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 13, 2007
Last modified: April 29, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.