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Q9R0U1

- IP6K2_RAT

UniProt

Q9R0U1 - IP6K2_RAT

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Protein

Inositol hexakisphosphate kinase 2

Gene
Ip6k2, Ihpk2, Pius
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of cell growth Source: Ensembl
  2. phosphate ion transport Source: RGD
  3. phosphatidylinositol phosphorylation Source: Ensembl
  4. positive regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198650. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2, Pius
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620529. Ip6k2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Inositol hexakisphosphate kinase 2PRO_0000066880Add
BLAST

Proteomic databases

PaxDbiQ9R0U1.
PRIDEiQ9R0U1.

PTM databases

PhosphoSiteiQ9R0U1.

Expressioni

Tissue specificityi

Highly expressed in small intestine.1 Publication

Gene expression databases

GenevestigatoriQ9R0U1.

Structurei

3D structure databases

ProteinModelPortaliQ9R0U1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2239Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
KOiK07756.
OMAiKEWVRQH.
OrthoDBiEOG747PHX.
PhylomeDBiQ9R0U1.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0U1-1 [UniParc]FASTAAdd to Basket

« Hide

MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ    50
FYETLPAEMR RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD 100
NSDCEPKSKL LRWTNKKHHV LETEKSPKDW VRQHRKEEKM KSHKLEEEFE 150
WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY 200
KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV 250
IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 300
ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED 350
LEDLSEESAD ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG 400
QDAGYIFGLQ SLIDIVTEIS EESGE 425
Length:425
Mass (Da):49,164
Last modified:November 13, 2007 - v2
Checksum:i6E44C1D3D6EA7FD8
GO

Sequence cautioni

The sequence BAA87611.1 differs from that shown. Reason: Chimeric cDNA.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015723 mRNA. Translation: BAA87611.1. Sequence problems.
BC083574 mRNA. Translation: AAH83574.1.
RefSeqiNP_067692.2. NM_021660.2.
XP_006243914.1. XM_006243852.1.
UniGeneiRn.112574.

Genome annotation databases

EnsembliENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361.
GeneIDi59268.
KEGGirno:59268.
UCSCiRGD:620529. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015723 mRNA. Translation: BAA87611.1 . Sequence problems.
BC083574 mRNA. Translation: AAH83574.1 .
RefSeqi NP_067692.2. NM_021660.2.
XP_006243914.1. XM_006243852.1.
UniGenei Rn.112574.

3D structure databases

ProteinModelPortali Q9R0U1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9R0U1.

Proteomic databases

PaxDbi Q9R0U1.
PRIDEi Q9R0U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027584 ; ENSRNOP00000027584 ; ENSRNOG00000020361 .
GeneIDi 59268.
KEGGi rno:59268.
UCSCi RGD:620529. rat.

Organism-specific databases

CTDi 51447.
RGDi 620529. Ip6k2.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOGENOMi HOG000007418.
HOVERGENi HBG052140.
KOi K07756.
OMAi KEWVRQH.
OrthoDBi EOG747PHX.
PhylomeDBi Q9R0U1.

Enzyme and pathway databases

Reactomei REACT_198650. Synthesis of IPs in the nucleus.

Miscellaneous databases

NextBioi 611797.

Gene expression databases

Genevestigatori Q9R0U1.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3."
    Katai K., Miyamoto K., Kishida S., Segawa H., Nii T., Tanaka H., Tani Y., Arai H., Tatsumi S., Morita K., Taketani Y., Takeda E.
    Biochem. J. 343:705-712(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIP6K2_RAT
AccessioniPrimary (citable) accession number: Q9R0U1
Secondary accession number(s): Q5XIU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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