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Q9R0U1

- IP6K2_RAT

UniProt

Q9R0U1 - IP6K2_RAT

Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.By similarity1 Publication

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of cell growth Source: Ensembl
    2. phosphate ion transport Source: RGD
    3. phosphatidylinositol phosphorylation Source: Ensembl
    4. positive regulation of apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198650. Synthesis of IPs in the nucleus.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 2
    Alternative name(s):
    P(i)-uptake stimulator
    Short name:
    PiUS
    Gene namesi
    Name:Ip6k2
    Synonyms:Ihpk2, Pius
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi620529. Ip6k2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. intermediate filament cytoskeleton Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Inositol hexakisphosphate kinase 2PRO_0000066880Add
    BLAST

    Proteomic databases

    PaxDbiQ9R0U1.
    PRIDEiQ9R0U1.

    PTM databases

    PhosphoSiteiQ9R0U1.

    Expressioni

    Tissue specificityi

    Highly expressed in small intestine.1 Publication

    Gene expression databases

    GenevestigatoriQ9R0U1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0U1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 2239Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    GeneTreeiENSGT00390000014381.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    KOiK07756.
    OMAiKEWVRQH.
    OrthoDBiEOG747PHX.
    PhylomeDBiQ9R0U1.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0U1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ    50
    FYETLPAEMR RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD 100
    NSDCEPKSKL LRWTNKKHHV LETEKSPKDW VRQHRKEEKM KSHKLEEEFE 150
    WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY 200
    KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV 250
    IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 300
    ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED 350
    LEDLSEESAD ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG 400
    QDAGYIFGLQ SLIDIVTEIS EESGE 425
    Length:425
    Mass (Da):49,164
    Last modified:November 13, 2007 - v2
    Checksum:i6E44C1D3D6EA7FD8
    GO

    Sequence cautioni

    The sequence BAA87611.1 differs from that shown. Reason: Chimeric cDNA.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015723 mRNA. Translation: BAA87611.1. Sequence problems.
    BC083574 mRNA. Translation: AAH83574.1.
    RefSeqiNP_067692.2. NM_021660.2.
    XP_006243914.1. XM_006243852.1.
    UniGeneiRn.112574.

    Genome annotation databases

    EnsembliENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361.
    GeneIDi59268.
    KEGGirno:59268.
    UCSCiRGD:620529. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015723 mRNA. Translation: BAA87611.1 . Sequence problems.
    BC083574 mRNA. Translation: AAH83574.1 .
    RefSeqi NP_067692.2. NM_021660.2.
    XP_006243914.1. XM_006243852.1.
    UniGenei Rn.112574.

    3D structure databases

    ProteinModelPortali Q9R0U1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9R0U1.

    Proteomic databases

    PaxDbi Q9R0U1.
    PRIDEi Q9R0U1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027584 ; ENSRNOP00000027584 ; ENSRNOG00000020361 .
    GeneIDi 59268.
    KEGGi rno:59268.
    UCSCi RGD:620529. rat.

    Organism-specific databases

    CTDi 51447.
    RGDi 620529. Ip6k2.

    Phylogenomic databases

    eggNOGi NOG274869.
    GeneTreei ENSGT00390000014381.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    KOi K07756.
    OMAi KEWVRQH.
    OrthoDBi EOG747PHX.
    PhylomeDBi Q9R0U1.

    Enzyme and pathway databases

    Reactomei REACT_198650. Synthesis of IPs in the nucleus.

    Miscellaneous databases

    NextBioi 611797.

    Gene expression databases

    Genevestigatori Q9R0U1.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3."
      Katai K., Miyamoto K., Kishida S., Segawa H., Nii T., Tanaka H., Tani Y., Arai H., Tatsumi S., Morita K., Taketani Y., Takeda E.
      Biochem. J. 343:705-712(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiIP6K2_RAT
    AccessioniPrimary (citable) accession number: Q9R0U1
    Secondary accession number(s): Q5XIU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3