Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inositol hexakisphosphate kinase 2

Gene

Ip6k2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.By similarity1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1855191 Synthesis of IPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:Ip6k2
Synonyms:Ihpk2, Pius
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620529 Ip6k2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668801 – 425Inositol hexakisphosphate kinase 2Add BLAST425

Proteomic databases

PaxDbiQ9R0U1
PRIDEiQ9R0U1

PTM databases

PhosphoSitePlusiQ9R0U1

Expressioni

Tissue specificityi

Highly expressed in small intestine.1 Publication

Gene expression databases

BgeeiENSRNOG00000020361
GenevisibleiQ9R0U1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027584

Structurei

3D structure databases

ProteinModelPortaliQ9R0U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 223Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YB60 LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000007418
HOVERGENiHBG052140
InParanoidiQ9R0U1
KOiK07756
OMAiLRWTNKK
OrthoDBiEOG091G0JK2
PhylomeDBiQ9R0U1

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ
60 70 80 90 100
FYETLPAEMR RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD
110 120 130 140 150
NSDCEPKSKL LRWTNKKHHV LETEKSPKDW VRQHRKEEKM KSHKLEEEFE
160 170 180 190 200
WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY
210 220 230 240 250
KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV
260 270 280 290 300
IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR
310 320 330 340 350
ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED
360 370 380 390 400
LEDLSEESAD ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG
410 420
QDAGYIFGLQ SLIDIVTEIS EESGE
Length:425
Mass (Da):49,164
Last modified:November 13, 2007 - v2
Checksum:i6E44C1D3D6EA7FD8
GO

Sequence cautioni

The sequence BAA87611 differs from that shown. Chimeric cDNA.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015723 mRNA Translation: BAA87611.1 Sequence problems.
BC083574 mRNA Translation: AAH83574.1
RefSeqiNP_067692.2, NM_021660.2
XP_008764786.1, XM_008766564.2
UniGeneiRn.112574

Genome annotation databases

EnsembliENSRNOT00000027584; ENSRNOP00000027584; ENSRNOG00000020361
ENSRNOT00000077078; ENSRNOP00000071056; ENSRNOG00000020361
GeneIDi59268
KEGGirno:59268
UCSCiRGD:620529 rat

Similar proteinsi

Entry informationi

Entry nameiIP6K2_RAT
AccessioniPrimary (citable) accession number: Q9R0U1
Secondary accession number(s): Q5XIU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health