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Protein

Caspase

Gene

Casp9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei275 – 2751UniRule annotation
Active sitei325 – 3251UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiC14.010.

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp9Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1277950. Casp9.

PTM / Processingi

Proteomic databases

PaxDbiQ9R0S9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030747.

Structurei

3D structure databases

ProteinModelPortaliQ9R0S9.
SMRiQ9R0S9. Positions 1-96, 183-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292CARDInterPro annotationAdd
BLAST
Domaini197 – 329133CASPASE_P20InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG059022.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR033171. Caspase-9.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PANTHERiPTHR10454:SF157. PTHR10454:SF157. 1 hit.
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEADRQLLR RCRVRLVSEL QVAELWDALL SRELFTRDMI EDIQQAGSGS
60 70 80 90 100
RRDQARQLVT DLETRGRQAL PLFISCLEDT GQGTLASLLQ SGRQAAKQDP
110 120 130 140 150
EAVKPLDHLV PVVLGPMGLT AKEQRVVKLE PSQPAVGNLT PVVLGPEELW
160 170 180 190 200
PARLKPEVLR PETPRPVDIG SGGAHDVCVP GKIRGHADMA YTLDSDPCGH
210 220 230 240 250
CLIINNVNFC PSSGLGTRTG SNLDRDKLEH RFRWLRFMVE VKNDLTAKKM
260 270 280 290 300
VTALMEMAHR NHRALDCFVV VILSHGCQAS HLQFPGAVYG TDGCSVSIEK
310 320 330 340 350
IVNIFNGSGC PSLGGKPKLF FIQACGGEQK DHGFEVACTS SQGRTLDSDS
360 370 380 390
EPDAVPYQEG PRPLDQLDAV SSLPTPSDIL VSYSTFPGRQ CCF
Length:393
Mass (Da):42,975
Last modified:May 1, 2000 - v1
Checksum:iCA889475E50DD632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019601 mRNA. Translation: BAA86896.1.
UniGeneiMm.88829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019601 mRNA. Translation: BAA86896.1.
UniGeneiMm.88829.

3D structure databases

ProteinModelPortaliQ9R0S9.
SMRiQ9R0S9. Positions 1-96, 183-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030747.

Protein family/group databases

MEROPSiC14.010.

Proteomic databases

PaxDbiQ9R0S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1277950. Casp9.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG059022.

Miscellaneous databases

ChiTaRSiCasp9. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR033171. Caspase-9.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PANTHERiPTHR10454:SF157. PTHR10454:SF157. 1 hit.
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9."
    Fujita E., Jinbo A., Matuzaki H., Konishi H., Kikkawa U., Momoi T.
    Biochem. Biophys. Res. Commun. 264:550-555(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9R0S9_MOUSE
AccessioniPrimary (citable) accession number: Q9R0S9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.