true2007-10-022024-03-27137YLAT1_RATTransport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition.Kanai Y.Fukasawa Y.Cha S.H.Segawa H.Chairoungdua A.Kim D.K.Matsuo H.Kim J.Y.Miyamoto K.Takeda E.Endou H.doi:10.1074/jbc.m0006342002000J. Biol. Chem.27520787-20793NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONTRANSPORTER ACTIVITYBIOPHYSICOCHEMICAL PROPERTIESKidneycDNA encoding rat jejunal amino acid transporter y+LAT1.Ng A.M.L.Yao S.Y.M.Cheeseman C.I.Young J.D.1999-11EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [MRNA]Sprague-DawleyThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.Pfeiffer R.Rossier G.Spindler B.Meier C.Kuehn L.C.Verrey F.doi:10.1093/emboj/18.1.491999EMBO J.1849-57TISSUE SPECIFICITYQuantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.Lundby A.Secher A.Lage K.Nordsborg N.B.Dmytriyev A.Lundby C.Olsen J.V.doi:10.1038/ncomms18712012Nat. Commun.3876PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]the amino acid-polyamine-organocation (apc) family1 site, No reported glycans1 siteratSlc7a7EukaryotaAmino acid transport across the plasma membraneExpressed in adult mammalian kidney and 18 other cell types or tissuesAmino acid/polyamine transporter IAA/rel_permease1AMINO ACID TRANSPORTERY+L AMINO ACID TRANSPORTER 1AA_permease_2AA_transporterRNY+L amino acid transporter 1Solute carrier family 7 member 7y(+)L-type amino acid transporter 1Y+LAT1y+LAT-1Slc7a7Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10777485). Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10777485). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (PubMed:10777485).44 uM for L-leucine (in presence of 100 mM Na(+))423 uM for L-leucine (in absence of Na(+))68 uM for L-lysine (in presence of 100 mM Na(+))50 uM for L-lysine (in absence of Na(+))383 uM for L-leucine (in absence of Na(+) and pH 7.5)119 uM for L-leucine (in absence of Na(+) and pH 5.5)74 uM for L-lysine (in absence of Na(+) and pH 7.5)81 uM for L-lysine (in absence of Na(+) and pH 5.5)71.8 uM for sodium ion (in absence of Na(+) and pH 7.5)105.9 uM for L-leucine (in absence of Na(+) and pH 5.5)Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.Expressed in kidney cortex and intestine.Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.Y+L amino acid transporter 1556411512Helical4060Helical7292Helical110130Helical136156Helical163183Helical189209Helical225245Helical262282Helical307327Helical386406Helical419439Helical444464Phosphoserine21N-linked (GlcNAc...) asparagine328N32000-05-01155641e09e62225c36682fd7f3bcc1f517968dMVASTKYEVAAQNEADEADGSAQGDGAGPAAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATTNFEDSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYLLTNVAYYSVLDIKDILASDAVAVTFADQIFGIFNWTIPLAVALSCFGGLNASIVAASRLLFVGSREGHLPDAICMIHVERFTPVPSLLFNGILALVYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSLFFPIVFCLCTIFLVAVPLYSDTINSLIGIGIALSGLPFYFLIIRVPEHKRPLCLRRIVASTTRYLQIICMSVAAEMDLEDGELPKQGPKSKtruetruetruetruetruetruetruetruetruetruetrue