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Protein

Y+L amino acid transporter 1

Gene

Slc7a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes (By similarity).By similarity

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_243822. Amino acid transport across the plasma membrane.
REACT_245266. Basigin interactions.

Protein family/group databases

TCDBi2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 1
Alternative name(s):
Solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
Short name:
Y+LAT1
Short name:
y+LAT-1
Gene namesi
Name:Slc7a7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi619902. Slc7a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Y+L amino acid transporter 1PRO_0000304936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9R0S5.

Expressioni

Tissue specificityi

Expressed in kidney cortex and intestine.1 Publication

Gene expression databases

GenevestigatoriQ9R0S5.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9R0S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9R0S5.
KOiK13867.
OMAiCIAPYVA.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9R0S5.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0S5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV
60 70 80 90 100
GNMIGSGIFV SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI
110 120 130 140 150
KKSGASYAYI LEAFGGFLAF IRLWTSLLII EPTSQAVIAI TFANYMVQPL
160 170 180 190 200
FPSCGAPYAA GRLLAAACIC LLTFINCAYV KWGTLVQDIF TYAKVLALIA
210 220 230 240 250
VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF SYSGWDTLNY
260 270 280 290 300
VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA
310 320 330 340 350
VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA
360 370 380 390 400
ICMIHVERFT PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI
410 420 430 440 450
VGQLYLRWKE PDRPRPLKLS LFFPIVFCLC TIFLVAVPLY SDTINSLIGI
460 470 480 490 500
GIALSGLPFY FLIIRVPEHK RPLCLRRIVA STTRYLQIIC MSVAAEMDLE
510
DGELPKQGPK SK
Length:512
Mass (Da):55,641
Last modified:May 1, 2000 - v1
Checksum:i708905B2ACB0A824
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31A → N in AAF07216. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020520 mRNA. Translation: BAA87325.1.
AF200684 mRNA. Translation: AAF07216.1.
BC091142 mRNA. Translation: AAH91142.1.
RefSeqiNP_112631.1. NM_031341.1.
XP_006252082.1. XM_006252020.2.
XP_006252083.1. XM_006252021.2.
XP_006252085.1. XM_006252023.2.
XP_006252086.1. XM_006252024.2.
XP_008768927.1. XM_008770705.1.
UniGeneiRn.163294.

Genome annotation databases

EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
GeneIDi83509.
KEGGirno:83509.
UCSCiRGD:619902. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020520 mRNA. Translation: BAA87325.1.
AF200684 mRNA. Translation: AAF07216.1.
BC091142 mRNA. Translation: AAH91142.1.
RefSeqiNP_112631.1. NM_031341.1.
XP_006252082.1. XM_006252020.2.
XP_006252083.1. XM_006252021.2.
XP_006252085.1. XM_006252023.2.
XP_006252086.1. XM_006252024.2.
XP_008768927.1. XM_008770705.1.
UniGeneiRn.163294.

3D structure databases

ProteinModelPortaliQ9R0S5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEiQ9R0S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
GeneIDi83509.
KEGGirno:83509.
UCSCiRGD:619902. rat.

Organism-specific databases

CTDi9056.
RGDi619902. Slc7a7.

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9R0S5.
KOiK13867.
OMAiCIAPYVA.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9R0S5.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiREACT_243822. Amino acid transport across the plasma membrane.
REACT_245266. Basigin interactions.

Miscellaneous databases

NextBioi615950.
PROiQ9R0S5.

Gene expression databases

GenevestigatoriQ9R0S5.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a system y+L amino acid transporter."
    Kanai Y., Fukasawa Y., Segawa H., Endou H.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "cDNA encoding rat jejunal amino acid transporter y+LAT1."
    Ng A.M.L., Yao S.Y.M., Cheeseman C.I., Young J.D.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."
    Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.
    EMBO J. 18:49-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiYLAT1_RAT
AccessioniPrimary (citable) accession number: Q9R0S5
Secondary accession number(s): Q9QZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.