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Q9R0S5

- YLAT1_RAT

UniProt

Q9R0S5 - YLAT1_RAT

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Protein

Y+L amino acid transporter 1

Gene

Slc7a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes (By similarity).By similarity

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 1
Alternative name(s):
Solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
Short name:
Y+LAT1
Short name:
y+LAT-1
Gene namesi
Name:Slc7a7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi619902. Slc7a7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Y+L amino acid transporter 1PRO_0000304936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9R0S5.

Expressioni

Tissue specificityi

Expressed in kidney cortex and intestine.1 Publication

Gene expression databases

GenevestigatoriQ9R0S5.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9R0S5.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9R0S5.
KOiK13867.
OMAiCLAPYAA.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9R0S5.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0S5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV
60 70 80 90 100
GNMIGSGIFV SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI
110 120 130 140 150
KKSGASYAYI LEAFGGFLAF IRLWTSLLII EPTSQAVIAI TFANYMVQPL
160 170 180 190 200
FPSCGAPYAA GRLLAAACIC LLTFINCAYV KWGTLVQDIF TYAKVLALIA
210 220 230 240 250
VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF SYSGWDTLNY
260 270 280 290 300
VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA
310 320 330 340 350
VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA
360 370 380 390 400
ICMIHVERFT PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI
410 420 430 440 450
VGQLYLRWKE PDRPRPLKLS LFFPIVFCLC TIFLVAVPLY SDTINSLIGI
460 470 480 490 500
GIALSGLPFY FLIIRVPEHK RPLCLRRIVA STTRYLQIIC MSVAAEMDLE
510
DGELPKQGPK SK
Length:512
Mass (Da):55,641
Last modified:May 1, 2000 - v1
Checksum:i708905B2ACB0A824
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31A → N in AAF07216. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020520 mRNA. Translation: BAA87325.1.
AF200684 mRNA. Translation: AAF07216.1.
BC091142 mRNA. Translation: AAH91142.1.
RefSeqiNP_112631.1. NM_031341.1.
XP_006252082.1. XM_006252020.2.
XP_006252083.1. XM_006252021.2.
XP_006252085.1. XM_006252023.2.
XP_006252086.1. XM_006252024.2.
UniGeneiRn.163294.

Genome annotation databases

EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
GeneIDi83509.
KEGGirno:83509.
UCSCiRGD:619902. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020520 mRNA. Translation: BAA87325.1 .
AF200684 mRNA. Translation: AAF07216.1 .
BC091142 mRNA. Translation: AAH91142.1 .
RefSeqi NP_112631.1. NM_031341.1.
XP_006252082.1. XM_006252020.2.
XP_006252083.1. XM_006252021.2.
XP_006252085.1. XM_006252023.2.
XP_006252086.1. XM_006252024.2.
UniGenei Rn.163294.

3D structure databases

ProteinModelPortali Q9R0S5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEi Q9R0S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014391 ; ENSRNOP00000014391 ; ENSRNOG00000010296 .
GeneIDi 83509.
KEGGi rno:83509.
UCSCi RGD:619902. rat.

Organism-specific databases

CTDi 9056.
RGDi 619902. Slc7a7.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119037.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi Q9R0S5.
KOi K13867.
OMAi CLAPYAA.
OrthoDBi EOG73BVCR.
PhylomeDBi Q9R0S5.
TreeFami TF313355.

Miscellaneous databases

NextBioi 615950.
PROi Q9R0S5.

Gene expression databases

Genevestigatori Q9R0S5.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a system y+L amino acid transporter."
    Kanai Y., Fukasawa Y., Segawa H., Endou H.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "cDNA encoding rat jejunal amino acid transporter y+LAT1."
    Ng A.M.L., Yao S.Y.M., Cheeseman C.I., Young J.D.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."
    Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.
    EMBO J. 18:49-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiYLAT1_RAT
AccessioniPrimary (citable) accession number: Q9R0S5
Secondary accession number(s): Q9QZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3