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Q9R0S5

- YLAT1_RAT

UniProt

Q9R0S5 - YLAT1_RAT

Protein

Y+L amino acid transporter 1

Gene

Slc7a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes By similarity.By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Y+L amino acid transporter 1
    Alternative name(s):
    Solute carrier family 7 member 7
    y(+)L-type amino acid transporter 1
    Short name:
    Y+LAT1
    Short name:
    y+LAT-1
    Gene namesi
    Name:Slc7a7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi619902. Slc7a7.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Y+L amino acid transporter 1PRO_0000304936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211PhosphoserineBy similarity
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9R0S5.

    Expressioni

    Tissue specificityi

    Expressed in kidney cortex and intestine.1 Publication

    Gene expression databases

    GenevestigatoriQ9R0S5.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0S5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei419 – 43921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110280.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ9R0S5.
    KOiK13867.
    OMAiCLAPYAA.
    OrthoDBiEOG73BVCR.
    PhylomeDBiQ9R0S5.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9R0S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV    50
    GNMIGSGIFV SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI 100
    KKSGASYAYI LEAFGGFLAF IRLWTSLLII EPTSQAVIAI TFANYMVQPL 150
    FPSCGAPYAA GRLLAAACIC LLTFINCAYV KWGTLVQDIF TYAKVLALIA 200
    VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF SYSGWDTLNY 250
    VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA 300
    VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA 350
    ICMIHVERFT PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI 400
    VGQLYLRWKE PDRPRPLKLS LFFPIVFCLC TIFLVAVPLY SDTINSLIGI 450
    GIALSGLPFY FLIIRVPEHK RPLCLRRIVA STTRYLQIIC MSVAAEMDLE 500
    DGELPKQGPK SK 512
    Length:512
    Mass (Da):55,641
    Last modified:May 1, 2000 - v1
    Checksum:i708905B2ACB0A824
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31A → N in AAF07216. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020520 mRNA. Translation: BAA87325.1.
    AF200684 mRNA. Translation: AAF07216.1.
    BC091142 mRNA. Translation: AAH91142.1.
    RefSeqiNP_112631.1. NM_031341.1.
    XP_006252082.1. XM_006252020.1.
    XP_006252083.1. XM_006252021.1.
    XP_006252084.1. XM_006252022.1.
    XP_006252085.1. XM_006252023.1.
    XP_006252086.1. XM_006252024.1.
    UniGeneiRn.163294.

    Genome annotation databases

    EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
    GeneIDi83509.
    KEGGirno:83509.
    UCSCiRGD:619902. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020520 mRNA. Translation: BAA87325.1 .
    AF200684 mRNA. Translation: AAF07216.1 .
    BC091142 mRNA. Translation: AAH91142.1 .
    RefSeqi NP_112631.1. NM_031341.1.
    XP_006252082.1. XM_006252020.1.
    XP_006252083.1. XM_006252021.1.
    XP_006252084.1. XM_006252022.1.
    XP_006252085.1. XM_006252023.1.
    XP_006252086.1. XM_006252024.1.
    UniGenei Rn.163294.

    3D structure databases

    ProteinModelPortali Q9R0S5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

    Proteomic databases

    PRIDEi Q9R0S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014391 ; ENSRNOP00000014391 ; ENSRNOG00000010296 .
    GeneIDi 83509.
    KEGGi rno:83509.
    UCSCi RGD:619902. rat.

    Organism-specific databases

    CTDi 9056.
    RGDi 619902. Slc7a7.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110280.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q9R0S5.
    KOi K13867.
    OMAi CLAPYAA.
    OrthoDBi EOG73BVCR.
    PhylomeDBi Q9R0S5.
    TreeFami TF313355.

    Miscellaneous databases

    NextBioi 615950.
    PROi Q9R0S5.

    Gene expression databases

    Genevestigatori Q9R0S5.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a system y+L amino acid transporter."
      Kanai Y., Fukasawa Y., Segawa H., Endou H.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "cDNA encoding rat jejunal amino acid transporter y+LAT1."
      Ng A.M.L., Yao S.Y.M., Cheeseman C.I., Young J.D.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."
      Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.
      EMBO J. 18:49-57(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiYLAT1_RAT
    AccessioniPrimary (citable) accession number: Q9R0S5
    Secondary accession number(s): Q9QZ66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3