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Q9R0S5 (YLAT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Y+L amino acid transporter 1
Alternative name(s):
Solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
Short name=Y+LAT1
Short name=y+LAT-1
Gene names
Name:Slc7a7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes By similarity.

Subunit structure

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc By similarity.

Subcellular location

Basolateral cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in kidney cortex and intestine. Ref.4

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Y+L amino acid transporter 1
PRO_0000304936

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane307 – 32721Helical; Potential
Transmembrane386 – 40621Helical; Potential
Transmembrane419 – 43921Helical; Potential
Transmembrane444 – 46421Helical; Potential

Amino acid modifications

Modified residue211Phosphoserine By similarity
Glycosylation3281N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict31A → N in AAF07216. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9R0S5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 708905B2ACB0A824

FASTA51255,641
        10         20         30         40         50         60 
MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV GNMIGSGIFV 

        70         80         90        100        110        120 
SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI KKSGASYAYI LEAFGGFLAF 

       130        140        150        160        170        180 
IRLWTSLLII EPTSQAVIAI TFANYMVQPL FPSCGAPYAA GRLLAAACIC LLTFINCAYV 

       190        200        210        220        230        240 
KWGTLVQDIF TYAKVLALIA VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF 

       250        260        270        280        290        300 
SYSGWDTLNY VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA 

       310        320        330        340        350        360 
VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA ICMIHVERFT 

       370        380        390        400        410        420 
PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI VGQLYLRWKE PDRPRPLKLS 

       430        440        450        460        470        480 
LFFPIVFCLC TIFLVAVPLY SDTINSLIGI GIALSGLPFY FLIIRVPEHK RPLCLRRIVA 

       490        500        510 
STTRYLQIIC MSVAAEMDLE DGELPKQGPK SK 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a system y+L amino acid transporter."
Kanai Y., Fukasawa Y., Segawa H., Endou H.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"cDNA encoding rat jejunal amino acid transporter y+LAT1."
Ng A.M.L., Yao S.Y.M., Cheeseman C.I., Young J.D.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]"Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."
Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.
EMBO J. 18:49-57(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020520 mRNA. Translation: BAA87325.1.
AF200684 mRNA. Translation: AAF07216.1.
BC091142 mRNA. Translation: AAH91142.1.
RefSeqNP_112631.1. NM_031341.1.
XP_006252082.1. XM_006252020.1.
XP_006252083.1. XM_006252021.1.
XP_006252084.1. XM_006252022.1.
XP_006252085.1. XM_006252023.1.
XP_006252086.1. XM_006252024.1.
UniGeneRn.163294.

3D structure databases

ProteinModelPortalQ9R0S5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.3.8.7. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEQ9R0S5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
GeneID83509.
KEGGrno:83509.
UCSCRGD:619902. rat.

Organism-specific databases

CTD9056.
RGD619902. Slc7a7.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00730000110280.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidQ9R0S5.
KOK13867.
OMACLAPYAA.
OrthoDBEOG73BVCR.
PhylomeDBQ9R0S5.
TreeFamTF313355.

Gene expression databases

GenevestigatorQ9R0S5.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio615950.
PROQ9R0S5.

Entry information

Entry nameYLAT1_RAT
AccessionPrimary (citable) accession number: Q9R0S5
Secondary accession number(s): Q9QZ66
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families