ID   Q9R0S0_MOUSE            Unreviewed;       159 AA.
AC   Q9R0S0;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   SubName: Full=GADD45G {ECO:0000313|EMBL:AAP79506.1};
DE   SubName: Full=Growth arrest and DNA-damage-inducible 45 gamma {ECO:0000313|Ensembl:ENSMUSP00000021903.3};
DE   SubName: Full=OIG37 {ECO:0000313|EMBL:BAA78538.1};
GN   Name=Gadd45g {ECO:0000313|Ensembl:ENSMUSP00000021903.3,
GN   ECO:0000313|MGI:MGI:1346325};
GN   Synonyms=oig37 {ECO:0000313|EMBL:BAA78538.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAA78538.1};
RN   [1] {ECO:0000313|EMBL:BAA78538.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10455148; DOI=10.1074/jbc.274.35.24766;
RA   Nakayama K., Hara T., Hibi M., Hirano T., Miyajima A.;
RT   "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118
RT   and GADD45 and negatively regulates cell growth.";
RL   J. Biol. Chem. 274:24766-24772(1999).
RN   [2] {ECO:0000313|EMBL:AAP79506.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAP79506.1};
RA   Balliet A.G., Hollander M.C., Fornace A.J. Jr., Hoffman B.,
RA   Liebermann D.A.;
RT   "Comparative Analysis of the Genetic Structure and Chromosomal Mapping of
RT   the Murine Gadd45g/CR6 Gene.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000021903.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000021903.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000021903.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000021903.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GADD45 family.
CC       {ECO:0000256|ARBA:ARBA00007361}.
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DR   EMBL; AY258502; AAP79506.1; -; Genomic_DNA.
DR   EMBL; AB021884; BAA78538.1; -; mRNA.
DR   RefSeq; NP_035947.2; NM_011817.2.
DR   Antibodypedia; 13541; 989 antibodies from 35 providers.
DR   DNASU; 23882; -.
DR   Ensembl; ENSMUST00000021903.3; ENSMUSP00000021903.3; ENSMUSG00000021453.3.
DR   GeneID; 23882; -.
DR   KEGG; mmu:23882; -.
DR   UCSC; uc007qmq.2; mouse.
DR   AGR; MGI:1346325; -.
DR   CTD; 10912; -.
DR   MGI; MGI:1346325; Gadd45g.
DR   VEuPathDB; HostDB:ENSMUSG00000021453; -.
DR   GeneTree; ENSGT00950000182964; -.
DR   HOGENOM; CLU_118164_0_0_1; -.
DR   OMA; EDTWKDP; -.
DR   OrthoDB; 4103218at2759; -.
DR   TreeFam; TF300196; -.
DR   BioGRID-ORCS; 23882; 1 hit in 79 CRISPR screens.
DR   ChiTaRS; Gadd45g; mouse.
DR   Proteomes; UP000000589; Chromosome 13.
DR   Bgee; ENSMUSG00000021453; Expressed in ventricular zone and 269 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR024824; GADD45.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR   PANTHER; PTHR10411; GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45; 1.
DR   PANTHER; PTHR10411:SF4; GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          25..107
FT                   /note="Ribosomal protein eL8/eL30/eS12/Gadd45"
FT                   /evidence="ECO:0000259|Pfam:PF01248"
SQ   SEQUENCE   159 AA;  17301 MW;  4B598AF54529BD96 CRC64;
     MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC
     VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGADEE GGAPGDLHCI
     LISNPNEDTW KDPALEKLSL FCEESRSFND WVPSITLPE
//