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Q9R0S0

- Q9R0S0_MOUSE

UniProt

Q9R0S0 - Q9R0S0_MOUSE

Protein
Submitted name:

GADD45G

Gene

Gadd45g

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPKK activity Source: MGI
    2. activation of MAPKKK activity Source: Ensembl
    3. interferon-gamma biosynthetic process Source: MGI
    4. negative regulation of protein kinase activity Source: MGI
    5. positive regulation of apoptotic process Source: Ensembl
    6. positive regulation of JNK cascade Source: Ensembl
    7. positive regulation of p38MAPK cascade Source: Ensembl
    8. regulation of cell cycle Source: MGI
    9. response to stress Source: InterPro
    10. T-helper 1 cell differentiation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GADD45GImported
    Submitted name:
    Growth arrest and DNA damage-inducible protein GADD45 gammaImported
    Submitted name:
    Growth arrest and DNA-damage-inducible 45 gamma, isoform CRA_bImported
    Submitted name:
    OIG37Imported
    Gene namesi
    Name:Gadd45gImported
    Synonyms:oig37Imported
    ORF Names:mCG_3413Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1346325. Gadd45g.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R0S0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000021903.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000016506.
    HOVERGENiHBG051684.
    InParanoidiQ9R0S0.
    KOiK04402.
    OMAiDWVPTIT.
    OrthoDBiEOG7J1819.
    TreeFamiTF300196.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    InterProiIPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view]
    PANTHERiPTHR10411. PTHR10411. 1 hit.
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9R0S0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL    50
    NVDPDNVTFC VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR 100
    LAAIVGADEE GGAPGDLHCI LISNPNEDTW KDPALEKLSL FCEESRSFND 150
    WVPSITLPE 159
    Length:159
    Mass (Da):17,301
    Last modified:May 1, 2000 - v1
    Checksum:i4B598AF54529BD96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126247 Genomic DNA. No translation available.
    AY258502 Genomic DNA. Translation: AAP79506.1.
    AB021884 mRNA. Translation: BAA78538.1.
    CH466546 Genomic DNA. Translation: EDL41110.1.
    RefSeqiNP_035947.2. NM_011817.2.
    UniGeneiMm.281298.

    Genome annotation databases

    EnsembliENSMUST00000021903; ENSMUSP00000021903; ENSMUSG00000021453.
    GeneIDi23882.
    KEGGimmu:23882.
    UCSCiuc007qmq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126247 Genomic DNA. No translation available.
    AY258502 Genomic DNA. Translation: AAP79506.1 .
    AB021884 mRNA. Translation: BAA78538.1 .
    CH466546 Genomic DNA. Translation: EDL41110.1 .
    RefSeqi NP_035947.2. NM_011817.2.
    UniGenei Mm.281298.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000021903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021903 ; ENSMUSP00000021903 ; ENSMUSG00000021453 .
    GeneIDi 23882.
    KEGGi mmu:23882.
    UCSCi uc007qmq.2. mouse.

    Organism-specific databases

    CTDi 10912.
    MGIi MGI:1346325. Gadd45g.

    Phylogenomic databases

    GeneTreei ENSGT00390000016506.
    HOVERGENi HBG051684.
    InParanoidi Q9R0S0.
    KOi K04402.
    OMAi DWVPTIT.
    OrthoDBi EOG7J1819.
    TreeFami TF300196.

    Miscellaneous databases

    ChiTaRSi GADD45G. mouse.
    NextBioi 303623.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9R0S0.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    InterProi IPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view ]
    PANTHERi PTHR10411. PTHR10411. 1 hit.
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth."
      Nakayama K., Hara T., Hibi M., Hirano T., Miyajima A.
      J. Biol. Chem. 274:24766-24772(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. "Comparative Analysis of the Genetic Structure and Chromosomal Mapping of the Murine Gadd45g/CR6 Gene."
      Balliet A.G., Hollander M.C., Fornace A.J. Jr., Hoffman B., Liebermann D.A.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9R0S0_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0S0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3