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Protein

Apelin

Gene

Apln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Endogenous ligand for APJ. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking. The oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin
Alternative name(s):
APJ endogenous ligand
Cleaved into the following 4 chains:
Gene namesi
Name:Apln
Synonyms:Apel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1353624. Apln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 4119By similarityPRO_0000001764Add
BLAST
Peptidei42 – 7736Apelin-36By similarityPRO_0000001765Add
BLAST
Peptidei47 – 7731Apelin-31By similarityPRO_0000001766Add
BLAST
Peptidei50 – 7728Apelin-28By similarityPRO_0000001767Add
BLAST
Peptidei65 – 7713Apelin-13By similarityPRO_0000001768Add
BLAST

Post-translational modificationi

Several active peptides may be produced by proteolytic processing of the peptide precursor.

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9R0R4.
PRIDEiQ9R0R4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037010.
CleanExiMM_APLN.
ExpressionAtlasiQ9R0R4. baseline and differential.
GenevisibleiQ9R0R4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046012.

Family & Domainsi

Sequence similaritiesi

Belongs to the apelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9R0R4.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG091G19F6.
PhylomeDBiQ9R0R4.
TreeFamiTF339660.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PfamiPF15360. Apelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRLCVQAL LLLWLSLTAV CGVPLMLPPD GTGLEEGSMR YLVKPRTSRT
60 70
GPGAWQGGRR KFRRQRPRLS HKGPMPF
Length:77
Mass (Da):8,658
Last modified:May 1, 2000 - v1
Checksum:iD71E0D58E47D2376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023494 mRNA. Translation: BAA84976.1.
BC020015 mRNA. Translation: AAH20015.1.
CCDSiCCDS40958.1.
RefSeqiNP_038940.1. NM_013912.3.
UniGeneiMm.29262.

Genome annotation databases

EnsembliENSMUST00000039026; ENSMUSP00000046012; ENSMUSG00000037010.
GeneIDi30878.
KEGGimmu:30878.
UCSCiuc009tbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023494 mRNA. Translation: BAA84976.1.
BC020015 mRNA. Translation: AAH20015.1.
CCDSiCCDS40958.1.
RefSeqiNP_038940.1. NM_013912.3.
UniGeneiMm.29262.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046012.

Proteomic databases

PaxDbiQ9R0R4.
PRIDEiQ9R0R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039026; ENSMUSP00000046012; ENSMUSG00000037010.
GeneIDi30878.
KEGGimmu:30878.
UCSCiuc009tbu.1. mouse.

Organism-specific databases

CTDi8862.
MGIiMGI:1353624. Apln.

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9R0R4.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG091G19F6.
PhylomeDBiQ9R0R4.
TreeFamiTF339660.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9R0R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037010.
CleanExiMM_APLN.
ExpressionAtlasiQ9R0R4. baseline and differential.
GenevisibleiQ9R0R4. MM.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PfamiPF15360. Apelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPEL_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.