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Protein

Apelin

Gene

Apln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Endogenous ligand for APJ. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking. The oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin
Alternative name(s):
APJ endogenous ligand
Cleaved into the following 4 chains:
Gene namesi
Name:Apln
Synonyms:Apel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1353624. Apln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 4119By similarityPRO_0000001764Add
BLAST
Peptidei42 – 7736Apelin-36By similarityPRO_0000001765Add
BLAST
Peptidei47 – 7731Apelin-31By similarityPRO_0000001766Add
BLAST
Peptidei50 – 7728Apelin-28By similarityPRO_0000001767Add
BLAST
Peptidei65 – 7713Apelin-13By similarityPRO_0000001768Add
BLAST

Post-translational modificationi

Several active peptides may be produced by proteolytic processing of the peptide precursor.

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9R0R4.
PRIDEiQ9R0R4.

Expressioni

Gene expression databases

BgeeiQ9R0R4.
CleanExiMM_APLN.
ExpressionAtlasiQ9R0R4. baseline and differential.
GenevisibleiQ9R0R4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046012.

Family & Domainsi

Sequence similaritiesi

Belongs to the apelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9R0R4.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG78SQN2.
PhylomeDBiQ9R0R4.
TreeFamiTF339660.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PfamiPF15360. Apelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRLCVQAL LLLWLSLTAV CGVPLMLPPD GTGLEEGSMR YLVKPRTSRT
60 70
GPGAWQGGRR KFRRQRPRLS HKGPMPF
Length:77
Mass (Da):8,658
Last modified:May 1, 2000 - v1
Checksum:iD71E0D58E47D2376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023494 mRNA. Translation: BAA84976.1.
BC020015 mRNA. Translation: AAH20015.1.
CCDSiCCDS40958.1.
RefSeqiNP_038940.1. NM_013912.3.
UniGeneiMm.29262.

Genome annotation databases

EnsembliENSMUST00000039026; ENSMUSP00000046012; ENSMUSG00000037010.
GeneIDi30878.
KEGGimmu:30878.
UCSCiuc009tbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023494 mRNA. Translation: BAA84976.1.
BC020015 mRNA. Translation: AAH20015.1.
CCDSiCCDS40958.1.
RefSeqiNP_038940.1. NM_013912.3.
UniGeneiMm.29262.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046012.

Proteomic databases

PaxDbiQ9R0R4.
PRIDEiQ9R0R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039026; ENSMUSP00000046012; ENSMUSG00000037010.
GeneIDi30878.
KEGGimmu:30878.
UCSCiuc009tbu.1. mouse.

Organism-specific databases

CTDi8862.
MGIiMGI:1353624. Apln.

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9R0R4.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG78SQN2.
PhylomeDBiQ9R0R4.
TreeFamiTF339660.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi307292.
PROiQ9R0R4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0R4.
CleanExiMM_APLN.
ExpressionAtlasiQ9R0R4. baseline and differential.
GenevisibleiQ9R0R4. MM.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PfamiPF15360. Apelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum."
    Habata Y., Fujii R., Hosoya M., Fukusumi S., Kawamata Y., Hinuma S., Kitada C., Nishizawa N., Murosaki S., Kurokawa T., Onda H., Tatemoto K., Fujino M.
    Biochim. Biophys. Acta 1452:25-35(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAPEL_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.