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Q9R0R1

- TRFM_MOUSE

UniProt

Q9R0R1 - TRFM_MOUSE

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Protein

Melanotransferrin

Gene
Mfi2, Mtf
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1 By similarity
Metal bindingi107 – 1071Iron 1 By similarity
Binding sitei132 – 1321Carbonate 1 By similarity
Binding sitei136 – 1361Carbonate 1 By similarity
Binding sitei138 – 1381Carbonate 1; via amide nitrogen By similarity
Binding sitei139 – 1391Carbonate 1; via amide nitrogen By similarity
Metal bindingi210 – 2101Iron 1 By similarity
Metal bindingi279 – 2791Iron 1 By similarity
Metal bindingi451 – 4511Iron 2 By similarity
Metal bindingi556 – 5561Iron 2 By similarity
Metal bindingi625 – 6251Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding, Zinc

Protein family/group databases

MEROPSiS60.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanotransferrin
Alternative name(s):
Membrane-bound transferrin-like protein p97
Short name:
MTf
CD_antigen: CD228
Gene namesi
Name:Mfi2
Synonyms:Mtf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1353421. Mfi2.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 709690MelanotransferrinPRO_0000035741Add
BLAST
Propeptidei710 – 73829Removed in mature form Reviewed predictionPRO_0000035742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 63 By similarity
Disulfide bondi36 ↔ 54 By similarity
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 216 By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi172 ↔ 189 By similarity
Disulfide bondi186 ↔ 199 By similarity
Disulfide bondi257 ↔ 271 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Lipidationi709 – 7091GPI-anchor amidated cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9R0R1.
PRIDEiQ9R0R1.

PTM databases

PhosphoSiteiQ9R0R1.

Expressioni

Gene expression databases

BgeeiQ9R0R1.
GenevestigatoriQ9R0R1.

Structurei

3D structure databases

ProteinModelPortaliQ9R0R1.
SMRiQ9R0R1. Positions 23-710.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 357335Transferrin-like 1Add
BLAST
Domaini366 – 706341Transferrin-like 2Add
BLAST

Sequence similaritiesi

Belongs to the transferrin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG87503.
GeneTreeiENSGT00390000001619.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiQ9R0R1.
KOiK06569.
OMAiTAVSEFF.
OrthoDBiEOG7D59N7.
PhylomeDBiQ9R0R1.
TreeFamiTF324013.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R1-1 [UniParc]FASTAAdd to Basket

« Hide

MRLLSVTFWL LLSLRTVVCV MEVQWCTISD AEQQKCKDMS EAFQGAGIRP    50
SLLCVQGNSA DHCVQLIKEQ KADAITLDGG AIYEAGKEHG LKPVVGEVYD 100
QDIGTSYYAV AVVRRNSNVT INTLKGVKSC HTGINRTVGW NVPVGYLVES 150
GHLSVMGCDV LKAVGDYFGG SCVPGTGETS HSESLCRLCR GDSSGHNVCD 200
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGNT LPSWGKSLMS 250
EDFQLLCRDG SRADITEWRR CHLAKVPAHA VVVRGDMDGG LIFQLLNEGQ 300
LLFSHEDSSF QMFSSKAYSQ KNLLFKDSTL ELVPIATQNY EAWLGQEYLQ 350
AMKGLLCDPN RLPHYLRWCV LSAPEIQKCG DMAVAFSRQN LKPEIQCVSA 400
ESPEHCMEQI QAGHTDAVTL RGEDIYRAGK VYGLVPAAGE LYAEEDRSNS 450
YFVVAVARRD SSYSFTLDEL RGKRSCHPYL GSPAGWEVPI GSLIQRGFIR 500
PKDCDVLTAV SQFFNASCVP VNNPKNYPSA LCALCVGDEK GRNKCVGSSQ 550
ERYYGYSGAF RCLVEHAGDV AFVKHTTVFE NTNGHNPEPW ASHLRWQDYE 600
LLCPNGARAE VDQFQACNLA QMPSHAVMVR PDTNIFTVYG LLDKAQDLFG 650
DDHNKNGFQM FDSSKYHSQD LLFKDATVRA VPVREKTTYL DWLGPDYVVA 700
LEGMLSQQCS GAGAAVQRVP LLALLLLTLA AGLLPRVL 738
Length:738
Mass (Da):81,293
Last modified:May 1, 2000 - v1
Checksum:iB5D9BFAB30F4B8B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024336 mRNA. Translation: BAA86655.1.
AB047799 Genomic DNA. Translation: BAB41139.1.
BC040347 mRNA. Translation: AAH40347.1.
CCDSiCCDS28108.1.
RefSeqiNP_038928.1. NM_013900.2.
UniGeneiMm.30988.

Genome annotation databases

EnsembliENSMUST00000023464; ENSMUSP00000023464; ENSMUSG00000022780.
GeneIDi30060.
KEGGimmu:30060.
UCSCiuc007yxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024336 mRNA. Translation: BAA86655.1 .
AB047799 Genomic DNA. Translation: BAB41139.1 .
BC040347 mRNA. Translation: AAH40347.1 .
CCDSi CCDS28108.1.
RefSeqi NP_038928.1. NM_013900.2.
UniGenei Mm.30988.

3D structure databases

ProteinModelPortali Q9R0R1.
SMRi Q9R0R1. Positions 23-710.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S60.973.

PTM databases

PhosphoSitei Q9R0R1.

Proteomic databases

PaxDbi Q9R0R1.
PRIDEi Q9R0R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023464 ; ENSMUSP00000023464 ; ENSMUSG00000022780 .
GeneIDi 30060.
KEGGi mmu:30060.
UCSCi uc007yxv.1. mouse.

Organism-specific databases

CTDi 4241.
MGIi MGI:1353421. Mfi2.

Phylogenomic databases

eggNOGi NOG87503.
GeneTreei ENSGT00390000001619.
HOGENOMi HOG000043759.
HOVERGENi HBG000055.
InParanoidi Q9R0R1.
KOi K06569.
OMAi TAVSEFF.
OrthoDBi EOG7D59N7.
PhylomeDBi Q9R0R1.
TreeFami TF324013.

Miscellaneous databases

NextBioi 307198.
PROi Q9R0R1.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0R1.
Genevestigatori Q9R0R1.

Family and domain databases

InterProi IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view ]
Pfami PF00405. Transferrin. 2 hits.
[Graphical view ]
PIRSFi PIRSF002549. Transferrin. 1 hit.
PRINTSi PR00422. TRANSFERRIN.
SMARTi SM00094. TR_FER. 2 hits.
[Graphical view ]
PROSITEi PS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells."
    Nakamasu K., Kawamoto T., Shen M., Gotoh O., Teramoto M., Noshiro M., Kato Y.
    Biochim. Biophys. Acta 1447:258-264(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and promoter analysis of the mouse membrane-bound transferrin-like protein (MTf) gene."
    Nakamasu K., Kawamoto T., Yoshida E., Noshiro M., Matsuda Y., Kato Y.
    Eur. J. Biochem. 268:1468-1476(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi