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Protein

Melanotransferrin

Gene

Meltf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Iron 1PROSITE-ProRule annotation1
Metal bindingi107Iron 1PROSITE-ProRule annotation1
Binding sitei132Carbonate 1PROSITE-ProRule annotation1
Binding sitei136Carbonate 1PROSITE-ProRule annotation1
Binding sitei138Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei139Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi210Iron 1PROSITE-ProRule annotation1
Metal bindingi279Iron 1PROSITE-ProRule annotation1
Metal bindingi451Iron 2PROSITE-ProRule annotation1
Metal bindingi556Iron 2PROSITE-ProRule annotation1
Metal bindingi625Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiS60.976

Names & Taxonomyi

Protein namesi
Recommended name:
MelanotransferrinBy similarity
Alternative name(s):
Membrane-bound transferrin-like protein p97
Short name:
MTf
CD_antigen: CD228
Gene namesi
Name:Meltf
Synonyms:Mfi2, Mtf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1353421 Meltf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003574120 – 709MelanotransferrinAdd BLAST690
PropeptideiPRO_0000035742710 – 738Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 63PROSITE-ProRule annotation
Disulfide bondi36 ↔ 54PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 189PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Modified residuei462PhosphoserineBy similarity1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi709GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R0R1
PaxDbiQ9R0R1
PRIDEiQ9R0R1

PTM databases

PhosphoSitePlusiQ9R0R1

Expressioni

Gene expression databases

BgeeiENSMUSG00000022780
ExpressionAtlasiQ9R0R1 baseline and differential
GenevisibleiQ9R0R1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023464

Structurei

3D structure databases

ProteinModelPortaliQ9R0R1
SMRiQ9R0R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 357Transferrin-like 1PROSITE-ProRule annotationAdd BLAST335
Domaini366 – 706Transferrin-like 2PROSITE-ProRule annotationAdd BLAST341

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
GeneTreeiENSGT00390000001619
HOGENOMiHOG000043759
HOVERGENiHBG000055
InParanoidiQ9R0R1
KOiK06569
OMAiGRNKCVG
OrthoDBiEOG091G0242
PhylomeDBiQ9R0R1
TreeFamiTF324013

Family and domain databases

InterProiView protein in InterPro
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405 Transferrin, 2 hits
PIRSFiPIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 2 hits
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSVTFWL LLSLRTVVCV MEVQWCTISD AEQQKCKDMS EAFQGAGIRP
60 70 80 90 100
SLLCVQGNSA DHCVQLIKEQ KADAITLDGG AIYEAGKEHG LKPVVGEVYD
110 120 130 140 150
QDIGTSYYAV AVVRRNSNVT INTLKGVKSC HTGINRTVGW NVPVGYLVES
160 170 180 190 200
GHLSVMGCDV LKAVGDYFGG SCVPGTGETS HSESLCRLCR GDSSGHNVCD
210 220 230 240 250
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGNT LPSWGKSLMS
260 270 280 290 300
EDFQLLCRDG SRADITEWRR CHLAKVPAHA VVVRGDMDGG LIFQLLNEGQ
310 320 330 340 350
LLFSHEDSSF QMFSSKAYSQ KNLLFKDSTL ELVPIATQNY EAWLGQEYLQ
360 370 380 390 400
AMKGLLCDPN RLPHYLRWCV LSAPEIQKCG DMAVAFSRQN LKPEIQCVSA
410 420 430 440 450
ESPEHCMEQI QAGHTDAVTL RGEDIYRAGK VYGLVPAAGE LYAEEDRSNS
460 470 480 490 500
YFVVAVARRD SSYSFTLDEL RGKRSCHPYL GSPAGWEVPI GSLIQRGFIR
510 520 530 540 550
PKDCDVLTAV SQFFNASCVP VNNPKNYPSA LCALCVGDEK GRNKCVGSSQ
560 570 580 590 600
ERYYGYSGAF RCLVEHAGDV AFVKHTTVFE NTNGHNPEPW ASHLRWQDYE
610 620 630 640 650
LLCPNGARAE VDQFQACNLA QMPSHAVMVR PDTNIFTVYG LLDKAQDLFG
660 670 680 690 700
DDHNKNGFQM FDSSKYHSQD LLFKDATVRA VPVREKTTYL DWLGPDYVVA
710 720 730
LEGMLSQQCS GAGAAVQRVP LLALLLLTLA AGLLPRVL
Length:738
Mass (Da):81,293
Last modified:May 1, 2000 - v1
Checksum:iB5D9BFAB30F4B8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024336 mRNA Translation: BAA86655.1
AB047799 Genomic DNA Translation: BAB41139.1
BC040347 mRNA Translation: AAH40347.1
CCDSiCCDS28108.1
RefSeqiNP_038928.1, NM_013900.2
UniGeneiMm.30988

Genome annotation databases

EnsembliENSMUST00000023464; ENSMUSP00000023464; ENSMUSG00000022780
GeneIDi30060
KEGGimmu:30060
UCSCiuc007yxv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome