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Protein

Melanotransferrin

Gene

Meltf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Iron 1PROSITE-ProRule annotation1
Metal bindingi107Iron 1PROSITE-ProRule annotation1
Binding sitei132Carbonate 1PROSITE-ProRule annotation1
Binding sitei136Carbonate 1PROSITE-ProRule annotation1
Binding sitei138Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei139Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi210Iron 1PROSITE-ProRule annotation1
Metal bindingi279Iron 1PROSITE-ProRule annotation1
Metal bindingi451Iron 2PROSITE-ProRule annotation1
Metal bindingi556Iron 2PROSITE-ProRule annotation1
Metal bindingi625Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding, Zinc

Protein family/group databases

MEROPSiS60.976.

Names & Taxonomyi

Protein namesi
Recommended name:
MelanotransferrinBy similarity
Alternative name(s):
Membrane-bound transferrin-like protein p97
Short name:
MTf
CD_antigen: CD228
Gene namesi
Name:Meltf
Synonyms:Mfi2, Mtf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1353421. Mfi2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003574120 – 709MelanotransferrinAdd BLAST690
PropeptideiPRO_0000035742710 – 738Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 63PROSITE-ProRule annotation
Disulfide bondi36 ↔ 54PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi172 ↔ 189PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Modified residuei462PhosphoserineBy similarity1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Lipidationi709GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R0R1.
PaxDbiQ9R0R1.
PRIDEiQ9R0R1.

PTM databases

PhosphoSitePlusiQ9R0R1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022780.
ExpressionAtlasiQ9R0R1. baseline and differential.
GenevisibleiQ9R0R1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023464.

Structurei

3D structure databases

ProteinModelPortaliQ9R0R1.
SMRiQ9R0R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 357Transferrin-like 1PROSITE-ProRule annotationAdd BLAST335
Domaini366 – 706Transferrin-like 2PROSITE-ProRule annotationAdd BLAST341

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiQ9R0R1.
KOiK06569.
OMAiFDNTNGH.
OrthoDBiEOG091G0242.
PhylomeDBiQ9R0R1.
TreeFamiTF324013.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSVTFWL LLSLRTVVCV MEVQWCTISD AEQQKCKDMS EAFQGAGIRP
60 70 80 90 100
SLLCVQGNSA DHCVQLIKEQ KADAITLDGG AIYEAGKEHG LKPVVGEVYD
110 120 130 140 150
QDIGTSYYAV AVVRRNSNVT INTLKGVKSC HTGINRTVGW NVPVGYLVES
160 170 180 190 200
GHLSVMGCDV LKAVGDYFGG SCVPGTGETS HSESLCRLCR GDSSGHNVCD
210 220 230 240 250
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGNT LPSWGKSLMS
260 270 280 290 300
EDFQLLCRDG SRADITEWRR CHLAKVPAHA VVVRGDMDGG LIFQLLNEGQ
310 320 330 340 350
LLFSHEDSSF QMFSSKAYSQ KNLLFKDSTL ELVPIATQNY EAWLGQEYLQ
360 370 380 390 400
AMKGLLCDPN RLPHYLRWCV LSAPEIQKCG DMAVAFSRQN LKPEIQCVSA
410 420 430 440 450
ESPEHCMEQI QAGHTDAVTL RGEDIYRAGK VYGLVPAAGE LYAEEDRSNS
460 470 480 490 500
YFVVAVARRD SSYSFTLDEL RGKRSCHPYL GSPAGWEVPI GSLIQRGFIR
510 520 530 540 550
PKDCDVLTAV SQFFNASCVP VNNPKNYPSA LCALCVGDEK GRNKCVGSSQ
560 570 580 590 600
ERYYGYSGAF RCLVEHAGDV AFVKHTTVFE NTNGHNPEPW ASHLRWQDYE
610 620 630 640 650
LLCPNGARAE VDQFQACNLA QMPSHAVMVR PDTNIFTVYG LLDKAQDLFG
660 670 680 690 700
DDHNKNGFQM FDSSKYHSQD LLFKDATVRA VPVREKTTYL DWLGPDYVVA
710 720 730
LEGMLSQQCS GAGAAVQRVP LLALLLLTLA AGLLPRVL
Length:738
Mass (Da):81,293
Last modified:May 1, 2000 - v1
Checksum:iB5D9BFAB30F4B8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024336 mRNA. Translation: BAA86655.1.
AB047799 Genomic DNA. Translation: BAB41139.1.
BC040347 mRNA. Translation: AAH40347.1.
CCDSiCCDS28108.1.
RefSeqiNP_038928.1. NM_013900.2.
UniGeneiMm.30988.

Genome annotation databases

EnsembliENSMUST00000023464; ENSMUSP00000023464; ENSMUSG00000022780.
GeneIDi30060.
KEGGimmu:30060.
UCSCiuc007yxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024336 mRNA. Translation: BAA86655.1.
AB047799 Genomic DNA. Translation: BAB41139.1.
BC040347 mRNA. Translation: AAH40347.1.
CCDSiCCDS28108.1.
RefSeqiNP_038928.1. NM_013900.2.
UniGeneiMm.30988.

3D structure databases

ProteinModelPortaliQ9R0R1.
SMRiQ9R0R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023464.

Protein family/group databases

MEROPSiS60.976.

PTM databases

PhosphoSitePlusiQ9R0R1.

Proteomic databases

MaxQBiQ9R0R1.
PaxDbiQ9R0R1.
PRIDEiQ9R0R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023464; ENSMUSP00000023464; ENSMUSG00000022780.
GeneIDi30060.
KEGGimmu:30060.
UCSCiuc007yxv.1. mouse.

Organism-specific databases

CTDi30060.
MGIiMGI:1353421. Mfi2.

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiQ9R0R1.
KOiK06569.
OMAiFDNTNGH.
OrthoDBiEOG091G0242.
PhylomeDBiQ9R0R1.
TreeFamiTF324013.

Miscellaneous databases

PROiQ9R0R1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022780.
ExpressionAtlasiQ9R0R1. baseline and differential.
GenevisibleiQ9R0R1. MM.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.