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Q9R0R1

- TRFM_MOUSE

UniProt

Q9R0R1 - TRFM_MOUSE

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Protein

Melanotransferrin

Gene

Mfi2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
Binding sitei132 – 1321Carbonate 1PROSITE-ProRule annotation
Binding sitei136 – 1361Carbonate 1PROSITE-ProRule annotation
Binding sitei138 – 1381Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Binding sitei139 – 1391Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi210 – 2101Iron 1PROSITE-ProRule annotation
Metal bindingi279 – 2791Iron 1PROSITE-ProRule annotation
Metal bindingi451 – 4511Iron 2PROSITE-ProRule annotation
Metal bindingi556 – 5561Iron 2PROSITE-ProRule annotation
Metal bindingi625 – 6251Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
  2. iron ion import Source: Ensembl
  3. negative regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  4. positive regulation of extracellular matrix disassembly Source: Ensembl
  5. positive regulation of plasminogen activation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding, Zinc

Protein family/group databases

MEROPSiS60.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanotransferrin
Alternative name(s):
Membrane-bound transferrin-like protein p97
Short name:
MTf
CD_antigen: CD228
Gene namesi
Name:Mfi2
Synonyms:Mtf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1353421. Mfi2.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of plasma membrane Source: Ensembl
  2. cell surface Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 709690MelanotransferrinPRO_0000035741Add
BLAST
Propeptidei710 – 73829Removed in mature formSequence AnalysisPRO_0000035742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 63PROSITE-ProRule annotation
Disulfide bondi36 ↔ 54PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi172 ↔ 189PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Lipidationi709 – 7091GPI-anchor amidated cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9R0R1.
PRIDEiQ9R0R1.

PTM databases

PhosphoSiteiQ9R0R1.

Expressioni

Gene expression databases

BgeeiQ9R0R1.
ExpressionAtlasiQ9R0R1. baseline and differential.
GenevestigatoriQ9R0R1.

Structurei

3D structure databases

ProteinModelPortaliQ9R0R1.
SMRiQ9R0R1. Positions 23-710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 357335Transferrin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 706341Transferrin-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG87503.
GeneTreeiENSGT00390000001619.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiQ9R0R1.
KOiK06569.
OMAiTAVSEFF.
OrthoDBiEOG7D59N7.
PhylomeDBiQ9R0R1.
TreeFamiTF324013.

Family and domain databases

InterProiIPR029773. MTF.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PANTHERiPTHR11485:SF5. PTHR11485:SF5. 1 hit.
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0R1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLSVTFWL LLSLRTVVCV MEVQWCTISD AEQQKCKDMS EAFQGAGIRP
60 70 80 90 100
SLLCVQGNSA DHCVQLIKEQ KADAITLDGG AIYEAGKEHG LKPVVGEVYD
110 120 130 140 150
QDIGTSYYAV AVVRRNSNVT INTLKGVKSC HTGINRTVGW NVPVGYLVES
160 170 180 190 200
GHLSVMGCDV LKAVGDYFGG SCVPGTGETS HSESLCRLCR GDSSGHNVCD
210 220 230 240 250
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGNT LPSWGKSLMS
260 270 280 290 300
EDFQLLCRDG SRADITEWRR CHLAKVPAHA VVVRGDMDGG LIFQLLNEGQ
310 320 330 340 350
LLFSHEDSSF QMFSSKAYSQ KNLLFKDSTL ELVPIATQNY EAWLGQEYLQ
360 370 380 390 400
AMKGLLCDPN RLPHYLRWCV LSAPEIQKCG DMAVAFSRQN LKPEIQCVSA
410 420 430 440 450
ESPEHCMEQI QAGHTDAVTL RGEDIYRAGK VYGLVPAAGE LYAEEDRSNS
460 470 480 490 500
YFVVAVARRD SSYSFTLDEL RGKRSCHPYL GSPAGWEVPI GSLIQRGFIR
510 520 530 540 550
PKDCDVLTAV SQFFNASCVP VNNPKNYPSA LCALCVGDEK GRNKCVGSSQ
560 570 580 590 600
ERYYGYSGAF RCLVEHAGDV AFVKHTTVFE NTNGHNPEPW ASHLRWQDYE
610 620 630 640 650
LLCPNGARAE VDQFQACNLA QMPSHAVMVR PDTNIFTVYG LLDKAQDLFG
660 670 680 690 700
DDHNKNGFQM FDSSKYHSQD LLFKDATVRA VPVREKTTYL DWLGPDYVVA
710 720 730
LEGMLSQQCS GAGAAVQRVP LLALLLLTLA AGLLPRVL
Length:738
Mass (Da):81,293
Last modified:May 1, 2000 - v1
Checksum:iB5D9BFAB30F4B8B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024336 mRNA. Translation: BAA86655.1.
AB047799 Genomic DNA. Translation: BAB41139.1.
BC040347 mRNA. Translation: AAH40347.1.
CCDSiCCDS28108.1.
RefSeqiNP_038928.1. NM_013900.2.
UniGeneiMm.30988.

Genome annotation databases

EnsembliENSMUST00000023464; ENSMUSP00000023464; ENSMUSG00000022780.
GeneIDi30060.
KEGGimmu:30060.
UCSCiuc007yxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024336 mRNA. Translation: BAA86655.1 .
AB047799 Genomic DNA. Translation: BAB41139.1 .
BC040347 mRNA. Translation: AAH40347.1 .
CCDSi CCDS28108.1.
RefSeqi NP_038928.1. NM_013900.2.
UniGenei Mm.30988.

3D structure databases

ProteinModelPortali Q9R0R1.
SMRi Q9R0R1. Positions 23-710.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S60.973.

PTM databases

PhosphoSitei Q9R0R1.

Proteomic databases

PaxDbi Q9R0R1.
PRIDEi Q9R0R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023464 ; ENSMUSP00000023464 ; ENSMUSG00000022780 .
GeneIDi 30060.
KEGGi mmu:30060.
UCSCi uc007yxv.1. mouse.

Organism-specific databases

CTDi 4241.
MGIi MGI:1353421. Mfi2.

Phylogenomic databases

eggNOGi NOG87503.
GeneTreei ENSGT00390000001619.
HOGENOMi HOG000043759.
HOVERGENi HBG000055.
InParanoidi Q9R0R1.
KOi K06569.
OMAi TAVSEFF.
OrthoDBi EOG7D59N7.
PhylomeDBi Q9R0R1.
TreeFami TF324013.

Miscellaneous databases

NextBioi 307198.
PROi Q9R0R1.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0R1.
ExpressionAtlasi Q9R0R1. baseline and differential.
Genevestigatori Q9R0R1.

Family and domain databases

InterProi IPR029773. MTF.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view ]
PANTHERi PTHR11485:SF5. PTHR11485:SF5. 1 hit.
Pfami PF00405. Transferrin. 2 hits.
[Graphical view ]
PIRSFi PIRSF002549. Transferrin. 1 hit.
PRINTSi PR00422. TRANSFERRIN.
SMARTi SM00094. TR_FER. 2 hits.
[Graphical view ]
PROSITEi PS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells."
    Nakamasu K., Kawamoto T., Shen M., Gotoh O., Teramoto M., Noshiro M., Kato Y.
    Biochim. Biophys. Acta 1447:258-264(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and promoter analysis of the mouse membrane-bound transferrin-like protein (MTf) gene."
    Nakamasu K., Kawamoto T., Yoshida E., Noshiro M., Matsuda Y., Kato Y.
    Eur. J. Biochem. 268:1468-1476(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9R0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3