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UniProtKB - Q9R0Q7 (TEBP_MOUSE)

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Protein

Prostaglandin E synthase 3

Gene

Ptges3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.By similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.By similarity

Pathwayi: prostaglandin biosynthesis

This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • cell proliferation Source: MGI
  • chaperone cofactor-dependent protein refolding Source: MGI
  • chaperone-mediated protein complex assembly Source: MGI
  • glucocorticoid receptor signaling pathway Source: MGI
  • glycogen biosynthetic process Source: MGI
  • lung saccule development Source: MGI
  • positive regulation of phosphorylation Source: MGI
  • positive regulation of telomerase activity Source: BHF-UCL
  • prostaglandin biosynthetic process Source: MGI
  • protein stabilization Source: MGI
  • skin development Source: MGI
  • telomerase holoenzyme complex assembly Source: BHF-UCL
  • telomere maintenance via telomerase Source: BHF-UCL
Complete GO annotation...

Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

ReactomeiR-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-3371511. HSF1 activation.
R-MMU-3371568. Attenuation phase.
R-MMU-8937144. Aryl hydrocarbon receptor signalling.
UniPathwayiUPA00662.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase 3 (EC:5.3.99.3By similarity)
Alternative name(s):
Cytosolic prostaglandin E2 synthase
Short name:
cPGES
Hsp90 co-chaperone
Progesterone receptor complex p23
Sid 3177
Telomerase-binding protein p23
Gene namesi
Name:Ptges3
Synonyms:Sid3177, Tebp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1929282. Ptges3.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189531 – 160Prostaglandin E synthase 3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei85PhosphoserineBy similarity1
Modified residuei100PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1 Publication1
Modified residuei118PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9R0Q7.
MaxQBiQ9R0Q7.
PaxDbiQ9R0Q7.
PRIDEiQ9R0Q7.

PTM databases

iPTMnetiQ9R0Q7.
PhosphoSitePlusiQ9R0Q7.

Expressioni

Tissue specificityi

Expressed in testis, kidney, bladder and ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000071072.
CleanExiMM_PTGES3.
ExpressionAtlasiQ9R0Q7. baseline and differential.
GenevisibleiQ9R0Q7. MM.

Interactioni

Subunit structurei

Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.By similarity

GO - Molecular functioni

  • DNA polymerase binding Source: BHF-UCL
  • Hsp90 protein binding Source: MGI
  • unfolded protein binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi207917. 12 interactors.
IntActiQ9R0Q7. 3 interactors.
MINTiMINT-3289867.
STRINGi10090.ENSMUSP00000050292.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q7.
SMRiQ9R0Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90CSPROSITE-ProRule annotationAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi157 – 160PXLE motifBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 160Asp/Glu-richAdd BLAST53

Sequence similaritiesi

Belongs to the p23/wos2 family.Curated

Phylogenomic databases

eggNOGiKOG3158. Eukaryota.
ENOG41121RT. LUCA.
GeneTreeiENSGT00510000046493.
HOGENOMiHOG000177563.
HOVERGENiHBG002143.
InParanoidiQ9R0Q7.
KOiK15730.
OMAiKAAGPYW.
OrthoDBiEOG091G0XLQ.
PhylomeDBiQ9R0Q7.
TreeFamiTF315077.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
PfamiView protein in Pfam
PF04969. CS. 1 hit.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS51203. CS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R0Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL 
        60         70         80         90        100
NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS 
       110        120        130        140        150
VDFNNWKDWE DDSDEDMSNF DRFSEMMDHM GGDEDVDLPE VDGADDDSQD 
       160
SDDEKMPDLE
Length:160
Mass (Da):18,721
Last modified:May 1, 2000 - v1
Checksum:i7702CB59D7AFD739
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87 – 88PR → LG in AAD39543 (Ref. 3) Curated2
Sequence conflicti108D → N in AAP34198 (PubMed:14563409).Curated1
Sequence conflicti108D → N in BAB25906 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY281130 mRNA. Translation: AAP34198.1.
AB024935 mRNA. Translation: BAA84684.1.
AF153479 mRNA. Translation: AAD39543.1.
AK008805 mRNA. Translation: BAB25906.1.
AK075932 mRNA. Translation: BAC36062.1.
AK075987 mRNA. Translation: BAC36099.1.
AK077538 mRNA. Translation: BAC36854.1.
AK168073 mRNA. Translation: BAE40047.1.
AK168210 mRNA. Translation: BAE40169.1.
AK168721 mRNA. Translation: BAE40563.1.
BC003708 mRNA. Translation: AAH03708.1.
BC085264 mRNA. Translation: AAH85264.1.
CCDSiCCDS36087.1.
RefSeqiNP_062740.1. NM_019766.4.
UniGeneiMm.305816.

Genome annotation databases

EnsembliENSMUST00000052798; ENSMUSP00000050292; ENSMUSG00000071072.
GeneIDi56351.
KEGGimmu:56351.
UCSCiuc007hld.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTEBP_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q7
Secondary accession number(s): Q542V4, Q9D7V0, Q9WV83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families