Ptges3

Functionⁱ

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.By similarity

Catalytic activityⁱ

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.By similarity

Pathwayⁱ: prostaglandin biosynthesis

This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.

GO - Molecular functionⁱ

DNA polymerase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10197982
Hsp90 protein binding Source: MGI
p53 binding Source: Ensembl
prostaglandin-E synthase activity Source: UniProtKB
telomerase activity Source: MGI
unfolded protein binding Source: UniProtKB

Complete GO annotation...

GO - Biological processⁱ

cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
chaperone cofactor-dependent protein refolding Source: MGI
chaperone-mediated protein complex assembly Source: MGI
glucocorticoid receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
glycogen biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
lung saccule development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
negative regulation of cell death Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of phosphorylation Source: MGI
positive regulation of telomerase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10197982
prostaglandin biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
protein stabilization Source: MGI
sensory perception of pain Source: Ensembl
skin development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17438133
telomerase holoenzyme complex assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 10197982
telomere maintenance via telomerase
Source: BHF-UCL
Inferred from direct assayⁱ
- 10197982

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX). R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR). R-MMU-3371511. HSF1 activation. R-MMU-3371568. Attenuation phase. R-MMU-8937144. Aryl hydrocarbon receptor signalling.
UniPathwayⁱ	UPA00662.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostaglandin E synthase 3 (EC:5.3.99.3By similarity) Alternative name(s): Cytosolic prostaglandin E2 synthase Short name: cPGES Hsp90 co-chaperone Progesterone receptor complex p23 Sid 3177 Telomerase-binding protein p23
Gene namesⁱ	Name:Ptges3 Synonyms:Sid3177, Tebp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1929282. Ptges3.

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q3ZBF7 (TEBP_BOVIN)

GO - Cellular componentⁱ

actin filament Source: Ensembl
cytosol Source: MGI
extracellular exosome Source: MGI
neuronal cell body Source: Ensembl
neuron projection Source: Ensembl
nucleoplasm Source: MGI
nucleus Source: MGI
perinuclear region of cytoplasm Source: Ensembl
protein complex Source: MGI
telomerase holoenzyme complex Source: MGI

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218953	1 – 160	Prostaglandin E synthase 3Add BLAST		160

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	33	N6-acetyllysineCombined sources	1
Modified residueⁱ	44	PhosphoserineCombined sources	1
Modified residueⁱ	85	PhosphoserineBy similarity	1
Modified residueⁱ	100	PhosphoserineCombined sources	1
Modified residueⁱ	113	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	118	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphoserineCombined sources	1
Modified residueⁱ	151	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9R0Q7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9R0Q7.
PaxDbⁱ	Q9R0Q7.
PRIDEⁱ	Q9R0Q7.

PTM databases

iPTMnetⁱ	Q9R0Q7.
PhosphoSitePlusⁱ	Q9R0Q7.

Expressionⁱ

Tissue specificityⁱ

Expressed in testis, kidney, bladder and ovary.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000071072.
CleanExⁱ	MM_PTGES3.
ExpressionAtlasⁱ	Q9R0Q7. baseline and differential.
Genevisibleⁱ	Q9R0Q7. MM.

Interactionⁱ

Subunit structureⁱ

Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.By similarity

GO - Molecular functionⁱ

DNA polymerase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10197982
Hsp90 protein binding Source: MGI
p53 binding Source: Ensembl
unfolded protein binding Source: UniProtKB

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	207917. 12 interactors.
IntActⁱ	Q9R0Q7. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3289867.
STRINGⁱ	10090.ENSMUSP00000050292.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R0Q7.
SMRⁱ	Q9R0Q7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 90	CSPROSITE-ProRule annotationAdd BLAST		90

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	157 – 160	PXLE motifBy similarity		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	108 – 160	Asp/Glu-richAdd BLAST		53

Sequence similaritiesⁱ

Belongs to the p23/wos2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3158. Eukaryota. ENOG41121RT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046493.
HOGENOMⁱ	HOG000177563.
HOVERGENⁱ	HBG002143.
InParanoidⁱ	Q9R0Q7.
KEGG Orthology (KO) More...KOⁱ	K15730.
OMAⁱ	KAAGPYW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XLQ.
PhylomeDBⁱ	Q9R0Q7.
TreeFamⁱ	TF315077.

Family and domain databases

Gene3Dⁱ	2.60.40.790. 1 hit.
InterProⁱ	View protein in InterPro IPR007052. CS_dom. IPR008978. HSP20-like_chaperone.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04969. CS. 1 hit.
SUPFAMⁱ	SSF49764. SSF49764. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51203. CS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9R0Q7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL 
        60         70         80         90        100
NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS 
       110        120        130        140        150
VDFNNWKDWE DDSDEDMSNF DRFSEMMDHM GGDEDVDLPE VDGADDDSQD 
       160
SDDEKMPDLE

Length:160

Mass (Da):18,721

Last modified:May 1, 2000 - v1

Checksum:ⁱ7702CB59D7AFD739

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	87 – 88	PR → LG in AAD39543 (Ref. 3) Curated	2
Sequence conflictⁱ	108	D → N in AAP34198 (PubMed:14563409).Curated	1
Sequence conflictⁱ	108	D → N in BAB25906 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY281130 mRNA. Translation: AAP34198.1. AB024935 mRNA. Translation: BAA84684.1. AF153479 mRNA. Translation: AAD39543.1. AK008805 mRNA. Translation: BAB25906.1. AK075932 mRNA. Translation: BAC36062.1. AK075987 mRNA. Translation: BAC36099.1. AK077538 mRNA. Translation: BAC36854.1. AK168073 mRNA. Translation: BAE40047.1. AK168210 mRNA. Translation: BAE40169.1. AK168721 mRNA. Translation: BAE40563.1. BC003708 mRNA. Translation: AAH03708.1. BC085264 mRNA. Translation: AAH85264.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36087.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_062740.1. NM_019766.4.
UniGeneⁱ	Mm.305816.

Genome annotation databases

Ensemblⁱ	ENSMUST00000052798; ENSMUSP00000050292; ENSMUSG00000071072.
GeneIDⁱ	56351.
KEGGⁱ	mmu:56351.
UCSC genome browser More...UCSCⁱ	uc007hld.1. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY281130 mRNA. Translation: AAP34198.1. AB024935 mRNA. Translation: BAA84684.1. AF153479 mRNA. Translation: AAD39543.1. AK008805 mRNA. Translation: BAB25906.1. AK075932 mRNA. Translation: BAC36062.1. AK075987 mRNA. Translation: BAC36099.1. AK077538 mRNA. Translation: BAC36854.1. AK168073 mRNA. Translation: BAE40047.1. AK168210 mRNA. Translation: BAE40169.1. AK168721 mRNA. Translation: BAE40563.1. BC003708 mRNA. Translation: AAH03708.1. BC085264 mRNA. Translation: AAH85264.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36087.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_062740.1. NM_019766.4.
UniGeneⁱ	Mm.305816.

3D structure databases

ProteinModelPortalⁱ	Q9R0Q7.
SMRⁱ	Q9R0Q7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207917. 12 interactors.
IntActⁱ	Q9R0Q7. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3289867.
STRINGⁱ	10090.ENSMUSP00000050292.

PTM databases

iPTMnetⁱ	Q9R0Q7.
PhosphoSitePlusⁱ	Q9R0Q7.

Proteomic databases

EPDⁱ	Q9R0Q7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9R0Q7.
PaxDbⁱ	Q9R0Q7.
PRIDEⁱ	Q9R0Q7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000052798; ENSMUSP00000050292; ENSMUSG00000071072.
GeneIDⁱ	56351.
KEGGⁱ	mmu:56351.
UCSC genome browser More...UCSCⁱ	uc007hld.1. mouse.

Organism-specific databases

CTDⁱ	10728.
MGIⁱ	MGI:1929282. Ptges3.

Phylogenomic databases

eggNOGⁱ	KOG3158. Eukaryota. ENOG41121RT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046493.
HOGENOMⁱ	HOG000177563.
HOVERGENⁱ	HBG002143.
InParanoidⁱ	Q9R0Q7.
KEGG Orthology (KO) More...KOⁱ	K15730.
OMAⁱ	KAAGPYW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XLQ.
PhylomeDBⁱ	Q9R0Q7.
TreeFamⁱ	TF315077.

Enzyme and pathway databases

UniPathwayⁱ	UPA00662.
Reactomeⁱ	R-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX). R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR). R-MMU-3371511. HSF1 activation. R-MMU-3371568. Attenuation phase. R-MMU-8937144. Aryl hydrocarbon receptor signalling.

Miscellaneous databases

ChiTaRSⁱ	Ptges3. mouse.
Protein Ontology More...PROⁱ	PR:Q9R0Q7.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000071072.
CleanExⁱ	MM_PTGES3.
ExpressionAtlasⁱ	Q9R0Q7. baseline and differential.
Genevisibleⁱ	Q9R0Q7. MM.

Family and domain databases

Gene3Dⁱ	2.60.40.790. 1 hit.
InterProⁱ	View protein in InterPro IPR007052. CS_dom. IPR008978. HSP20-like_chaperone.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04969. CS. 1 hit.
SUPFAMⁱ	SSF49764. SSF49764. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51203. CS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TEBP_MOUSE
Accessionⁱ	Q9R0Q7Primary (citable) accession number: Q9R0Q7 Secondary accession number(s): Q542V4, Q9D7V0, Q9WV83
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	June 7, 2017
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R0Q7 (TEBP_MOUSE)

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Prostaglandin E synthase 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: prostaglandin biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: prostaglandin biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ