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Protein

Actin-related protein 2/3 complex subunit 1A

Gene

Arpc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1A
Alternative name(s):
SOP2-like protein
Sid 329
Gene namesi
Name:Arpc1a
Synonyms:Sid329
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928896. Arpc1a.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • muscle cell projection membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 370369Actin-related protein 2/3 complex subunit 1APRO_0000050853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R0Q6.
MaxQBiQ9R0Q6.
PaxDbiQ9R0Q6.
PRIDEiQ9R0Q6.

PTM databases

iPTMnetiQ9R0Q6.
PhosphoSiteiQ9R0Q6.
SwissPalmiQ9R0Q6.

Expressioni

Gene expression databases

BgeeiQ9R0Q6.
CleanExiMM_ARPC1A.
ExpressionAtlasiQ9R0Q6. baseline and differential.
GenevisibleiQ9R0Q6. MM.

Interactioni

Subunit structurei

Probable component of the Arp2/3 complex in which it may replace ARPC1B.

Protein-protein interaction databases

BioGridi207984. 1 interaction.
IntActiQ9R0Q6. 5 interactions.
MINTiMINT-4088193.
STRINGi10090.ENSMUSP00000031625.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q6.
SMRiQ9R0Q6. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1Add
BLAST
Repeati50 – 8940WD 2Add
BLAST
Repeati140 – 17940WD 3Add
BLAST
Repeati202 – 24140WD 4Add
BLAST
Repeati244 – 28441WD 5Add
BLAST
Repeati322 – 36544WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ9R0Q6.
KOiK05757.
OMAiNCDDRGS.
OrthoDBiEOG77DJ62.
PhylomeDBiQ9R0Q6.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030140. ARC1A.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF11. PTHR10709:SF11. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWTKAHELKE
60 70 80 90 100
HNGHITGIDW APKSDRIVTC GADRNAYVWS QKDGIWKPTL VILRINRAAT
110 120 130 140 150
FVKWSPLENK FAVGSGARLI SVCYFESEND WWVSKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP ASTPWGSKMP FGQLMSEFGG
210 220 230 240 250
SGTGGWVHGV SFSASGNRLA WVSHDSTVSV ADASKSVQVS TLRTEFLPLL
260 270 280 290 300
SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDVPK QSIQRNMSAM
310 320 330 340 350
ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG
360 370
AMTIWDFKTL ESSIQGLRIM
Length:370
Mass (Da):41,626
Last modified:May 1, 2000 - v1
Checksum:iB47F0151B27211B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024984 mRNA. Translation: BAA84685.1.
AK076107 mRNA. Translation: BAC36187.1.
AK145663 mRNA. Translation: BAE26575.1.
BC001988 mRNA. Translation: AAH01988.1.
CCDSiCCDS19855.1.
RefSeqiNP_062741.1. NM_019767.2.
UniGeneiMm.371610.

Genome annotation databases

EnsembliENSMUST00000031625; ENSMUSP00000031625; ENSMUSG00000029621.
GeneIDi56443.
KEGGimmu:56443.
UCSCiuc009ama.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024984 mRNA. Translation: BAA84685.1.
AK076107 mRNA. Translation: BAC36187.1.
AK145663 mRNA. Translation: BAE26575.1.
BC001988 mRNA. Translation: AAH01988.1.
CCDSiCCDS19855.1.
RefSeqiNP_062741.1. NM_019767.2.
UniGeneiMm.371610.

3D structure databases

ProteinModelPortaliQ9R0Q6.
SMRiQ9R0Q6. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207984. 1 interaction.
IntActiQ9R0Q6. 5 interactions.
MINTiMINT-4088193.
STRINGi10090.ENSMUSP00000031625.

PTM databases

iPTMnetiQ9R0Q6.
PhosphoSiteiQ9R0Q6.
SwissPalmiQ9R0Q6.

Proteomic databases

EPDiQ9R0Q6.
MaxQBiQ9R0Q6.
PaxDbiQ9R0Q6.
PRIDEiQ9R0Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031625; ENSMUSP00000031625; ENSMUSG00000029621.
GeneIDi56443.
KEGGimmu:56443.
UCSCiuc009ama.1. mouse.

Organism-specific databases

CTDi10552.
MGIiMGI:1928896. Arpc1a.

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ9R0Q6.
KOiK05757.
OMAiNCDDRGS.
OrthoDBiEOG77DJ62.
PhylomeDBiQ9R0Q6.
TreeFamiTF315041.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

ChiTaRSiArpc1a. mouse.
PROiQ9R0Q6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0Q6.
CleanExiMM_ARPC1A.
ExpressionAtlasiQ9R0Q6. baseline and differential.
GenevisibleiQ9R0Q6. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030140. ARC1A.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF11. PTHR10709:SF11. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homolog of Sop2p-like protein."
    Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 236-243 AND 359-368, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiARC1A_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q6
Secondary accession number(s): Q3UL75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.