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Protein

Mortality factor 4-like protein 2

Gene

Morf4l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 2
Alternative name(s):
MORF-related gene X protein
Sid 393
Transcription factor-like protein MRGX
Gene namesi
Name:Morf4l2
Synonyms:Kiaa0026, Sid393
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1927167 Morf4l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887691 – 288Mortality factor 4-like protein 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R0Q4
MaxQBiQ9R0Q4
PaxDbiQ9R0Q4
PeptideAtlasiQ9R0Q4
PRIDEiQ9R0Q4

PTM databases

iPTMnetiQ9R0Q4
PhosphoSitePlusiQ9R0Q4

Expressioni

Gene expression databases

BgeeiENSMUSG00000031422
CleanExiMM_MORF4L2
ExpressionAtlasiQ9R0Q4 baseline and differential
GenevisibleiQ9R0Q4 MM

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors (By similarity).By similarity

Protein-protein interaction databases

BioGridi207951, 1 interactor
IntActiQ9R0Q4, 1 interactor
STRINGi10090.ENSMUSP00000033797

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q4
SMRiQ9R0Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 288MRGPROSITE-ProRule annotationAdd BLAST172

Phylogenomic databases

eggNOGiKOG3001 Eukaryota
ENOG410XR9F LUCA
GeneTreeiENSGT00530000063018
HOVERGENiHBG052487
InParanoidiQ9R0Q4
KOiK11342
OMAiRGNMQRS
OrthoDBiEOG091G0J32
PhylomeDBiQ9R0Q4
TreeFamiTF323400

Family and domain databases

Gene3Di1.10.274.30, 1 hit
InterProiView protein in InterPro
IPR008676 MRG
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR038012 MRGX
PANTHERiPTHR10880 PTHR10880, 1 hit
PTHR10880:SF25 PTHR10880:SF25, 1 hit
PfamiView protein in Pfam
PF05712 MRG, 1 hit
PIRSFiPIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit
PROSITEiView protein in PROSITE
PS51640 MRG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R0Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKQASQT RGQQSAEEDN FKKPTRSNMQ RSKMRGAASG KKSAGSQPKN
60 70 80 90 100
LDPALPGRWG GRSAENPPSG SVRKTRKNKQ KAPGNGDGGS TSEVPQPPRK
110 120 130 140 150
KRARADPTVE SEEAFKSRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP
160 170 180 190 200
AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVGGIKEYF NVMLGTQLLY
210 220 230 240 250
KFERPQYAEI LLAHPDAPMS QIYGAPHLLR LFVRIGAMLA YTPLDEKSLA
260 270 280
LLLGYLHDFL KYLAKNSASL FTASDYKVAS ADYHRKAL
Length:288
Mass (Da):32,184
Last modified:May 1, 2000 - v1
Checksum:iDE371EDD3D4DF4E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → S in AAH75653 (PubMed:15489334).Curated1
Sequence conflicti145Q → P in BAC36075 (PubMed:16141072).Curated1
Sequence conflicti176E → D in BAC97848 (PubMed:14621295).Curated1
Sequence conflicti186I → T in BAC41017 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025049 mRNA Translation: BAA84687.1
AK075946 mRNA Translation: BAC36075.1
AK088849 mRNA Translation: BAC40611.1
AK089963 mRNA Translation: BAC41017.1
AK129038 mRNA Translation: BAC97848.1
AK131944 mRNA Translation: BAE20890.1
AK145686 mRNA Translation: BAE26588.1
AK150401 mRNA Translation: BAE29527.1
AK150670 mRNA Translation: BAE29752.1
AK151570 mRNA Translation: BAE30512.1
AK160012 mRNA Translation: BAE35559.1
AK161610 mRNA Translation: BAE36491.1
AK164433 mRNA Translation: BAE37786.1
AK166637 mRNA Translation: BAE38909.1
AL671887 Genomic DNA No translation available.
BC075653 mRNA Translation: AAH75653.1
BC088731 mRNA Translation: AAH88731.1
CCDSiCCDS30422.1
RefSeqiNP_001161697.1, NM_001168225.1
NP_001161698.1, NM_001168226.1
NP_001161699.1, NM_001168227.1
NP_001161700.1, NM_001168228.1
NP_001161701.1, NM_001168229.1
NP_001161702.1, NM_001168230.1
NP_062742.4, NM_019768.4
XP_006528647.1, XM_006528584.1
UniGeneiMm.27218

Genome annotation databases

EnsembliENSMUST00000033797; ENSMUSP00000033797; ENSMUSG00000031422
ENSMUST00000080411; ENSMUSP00000108722; ENSMUSG00000031422
ENSMUST00000113097; ENSMUSP00000108720; ENSMUSG00000031422
ENSMUST00000164609; ENSMUSP00000129774; ENSMUSG00000031422
ENSMUST00000166478; ENSMUSP00000131909; ENSMUSG00000031422
ENSMUST00000166930; ENSMUSP00000126363; ENSMUSG00000031422
ENSMUST00000169418; ENSMUSP00000132643; ENSMUSG00000031422
GeneIDi56397
KEGGimmu:56397
UCSCiuc009uiu.3 mouse

Similar proteinsi

Entry informationi

Entry nameiMO4L2_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q4
Secondary accession number(s): A2AEB2
, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health