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Q9R0Q4

- MO4L2_MOUSE

UniProt

Q9R0Q4 - MO4L2_MOUSE

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Protein

Mortality factor 4-like protein 2

Gene

Morf4l2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).By similarity

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. positive regulation of striated muscle cell differentiation Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. regulation of growth Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 2
Alternative name(s):
MORF-related gene X protein
Sid 393
Transcription factor-like protein MRGX
Gene namesi
Name:Morf4l2
Synonyms:Kiaa0026, Sid393
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1927167. Morf4l2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Mortality factor 4-like protein 2PRO_0000088769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9R0Q4.
PaxDbiQ9R0Q4.
PRIDEiQ9R0Q4.

PTM databases

PhosphoSiteiQ9R0Q4.

Expressioni

Gene expression databases

BgeeiQ9R0Q4.
CleanExiMM_MORF4L2.
ExpressionAtlasiQ9R0Q4. baseline and differential.
GenevestigatoriQ9R0Q4.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108722.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q4.
SMRiQ9R0Q4. Positions 117-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 288172MRGPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MRG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317973.
GeneTreeiENSGT00530000063018.
HOVERGENiHBG052487.
InParanoidiQ9R0Q4.
KOiK11342.
OMAiRGNMQRS.
OrthoDBiEOG7ZPNK7.
PhylomeDBiQ9R0Q4.
TreeFamiTF323400.

Family and domain databases

InterProiIPR008676. MRG.
IPR026541. MRG_dom.
[Graphical view]
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiPF05712. MRG. 1 hit.
[Graphical view]
PROSITEiPS51640. MRG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0Q4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRKQASQT RGQQSAEEDN FKKPTRSNMQ RSKMRGAASG KKSAGSQPKN
60 70 80 90 100
LDPALPGRWG GRSAENPPSG SVRKTRKNKQ KAPGNGDGGS TSEVPQPPRK
110 120 130 140 150
KRARADPTVE SEEAFKSRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP
160 170 180 190 200
AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVGGIKEYF NVMLGTQLLY
210 220 230 240 250
KFERPQYAEI LLAHPDAPMS QIYGAPHLLR LFVRIGAMLA YTPLDEKSLA
260 270 280
LLLGYLHDFL KYLAKNSASL FTASDYKVAS ADYHRKAL
Length:288
Mass (Da):32,184
Last modified:May 1, 2000 - v1
Checksum:iDE371EDD3D4DF4E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → S in AAH75653. (PubMed:15489334)Curated
Sequence conflicti145 – 1451Q → P in BAC36075. (PubMed:16141072)Curated
Sequence conflicti176 – 1761E → D in BAC97848. (PubMed:14621295)Curated
Sequence conflicti186 – 1861I → T in BAC41017. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025049 mRNA. Translation: BAA84687.1.
AK075946 mRNA. Translation: BAC36075.1.
AK088849 mRNA. Translation: BAC40611.1.
AK089963 mRNA. Translation: BAC41017.1.
AK129038 mRNA. Translation: BAC97848.1.
AK131944 mRNA. Translation: BAE20890.1.
AK145686 mRNA. Translation: BAE26588.1.
AK150401 mRNA. Translation: BAE29527.1.
AK150670 mRNA. Translation: BAE29752.1.
AK151570 mRNA. Translation: BAE30512.1.
AK160012 mRNA. Translation: BAE35559.1.
AK161610 mRNA. Translation: BAE36491.1.
AK164433 mRNA. Translation: BAE37786.1.
AK166637 mRNA. Translation: BAE38909.1.
AL671887 Genomic DNA. Translation: CAM17215.1.
BC075653 mRNA. Translation: AAH75653.1.
BC088731 mRNA. Translation: AAH88731.1.
CCDSiCCDS30422.1.
RefSeqiNP_001161697.1. NM_001168225.1.
NP_001161698.1. NM_001168226.1.
NP_001161699.1. NM_001168227.1.
NP_001161700.1. NM_001168228.1.
NP_001161701.1. NM_001168229.1.
NP_001161702.1. NM_001168230.1.
NP_062742.4. NM_019768.4.
XP_006528647.1. XM_006528584.1.
UniGeneiMm.27218.

Genome annotation databases

EnsembliENSMUST00000033797; ENSMUSP00000033797; ENSMUSG00000031422.
ENSMUST00000080411; ENSMUSP00000108722; ENSMUSG00000031422.
ENSMUST00000113097; ENSMUSP00000108720; ENSMUSG00000031422.
ENSMUST00000164609; ENSMUSP00000129774; ENSMUSG00000031422.
ENSMUST00000166478; ENSMUSP00000131909; ENSMUSG00000031422.
ENSMUST00000166930; ENSMUSP00000126363; ENSMUSG00000031422.
ENSMUST00000169418; ENSMUSP00000132643; ENSMUSG00000031422.
GeneIDi56397.
KEGGimmu:56397.
UCSCiuc009uiu.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025049 mRNA. Translation: BAA84687.1 .
AK075946 mRNA. Translation: BAC36075.1 .
AK088849 mRNA. Translation: BAC40611.1 .
AK089963 mRNA. Translation: BAC41017.1 .
AK129038 mRNA. Translation: BAC97848.1 .
AK131944 mRNA. Translation: BAE20890.1 .
AK145686 mRNA. Translation: BAE26588.1 .
AK150401 mRNA. Translation: BAE29527.1 .
AK150670 mRNA. Translation: BAE29752.1 .
AK151570 mRNA. Translation: BAE30512.1 .
AK160012 mRNA. Translation: BAE35559.1 .
AK161610 mRNA. Translation: BAE36491.1 .
AK164433 mRNA. Translation: BAE37786.1 .
AK166637 mRNA. Translation: BAE38909.1 .
AL671887 Genomic DNA. Translation: CAM17215.1 .
BC075653 mRNA. Translation: AAH75653.1 .
BC088731 mRNA. Translation: AAH88731.1 .
CCDSi CCDS30422.1.
RefSeqi NP_001161697.1. NM_001168225.1.
NP_001161698.1. NM_001168226.1.
NP_001161699.1. NM_001168227.1.
NP_001161700.1. NM_001168228.1.
NP_001161701.1. NM_001168229.1.
NP_001161702.1. NM_001168230.1.
NP_062742.4. NM_019768.4.
XP_006528647.1. XM_006528584.1.
UniGenei Mm.27218.

3D structure databases

ProteinModelPortali Q9R0Q4.
SMRi Q9R0Q4. Positions 117-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000108722.

PTM databases

PhosphoSitei Q9R0Q4.

Proteomic databases

MaxQBi Q9R0Q4.
PaxDbi Q9R0Q4.
PRIDEi Q9R0Q4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033797 ; ENSMUSP00000033797 ; ENSMUSG00000031422 .
ENSMUST00000080411 ; ENSMUSP00000108722 ; ENSMUSG00000031422 .
ENSMUST00000113097 ; ENSMUSP00000108720 ; ENSMUSG00000031422 .
ENSMUST00000164609 ; ENSMUSP00000129774 ; ENSMUSG00000031422 .
ENSMUST00000166478 ; ENSMUSP00000131909 ; ENSMUSG00000031422 .
ENSMUST00000166930 ; ENSMUSP00000126363 ; ENSMUSG00000031422 .
ENSMUST00000169418 ; ENSMUSP00000132643 ; ENSMUSG00000031422 .
GeneIDi 56397.
KEGGi mmu:56397.
UCSCi uc009uiu.3. mouse.

Organism-specific databases

CTDi 9643.
MGIi MGI:1927167. Morf4l2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG317973.
GeneTreei ENSGT00530000063018.
HOVERGENi HBG052487.
InParanoidi Q9R0Q4.
KOi K11342.
OMAi RGNMQRS.
OrthoDBi EOG7ZPNK7.
PhylomeDBi Q9R0Q4.
TreeFami TF323400.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi MORF4L2. mouse.
NextBioi 312500.
PROi Q9R0Q4.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0Q4.
CleanExi MM_MORF4L2.
ExpressionAtlasi Q9R0Q4. baseline and differential.
Genevestigatori Q9R0Q4.

Family and domain databases

InterProi IPR008676. MRG.
IPR026541. MRG_dom.
[Graphical view ]
PANTHERi PTHR10880. PTHR10880. 1 hit.
Pfami PF05712. MRG. 1 hit.
[Graphical view ]
PROSITEi PS51640. MRG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homolog of KIAA0026."
    Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeJ, C57BL/6J and NOD.
    Tissue: Bone marrow, Embryonic stem cell, Eye and Thymus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and C57BL/6.
    Tissue: Eye and Mammary tumor.

Entry informationi

Entry nameiMO4L2_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q4
Secondary accession number(s): A2AEB2
, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3