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Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

  • leukotriene B4 receptor activity Source: Ensembl
  • leukotriene receptor activity Source: RGD

GO - Biological processi

  • inflammatory response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:Ltb4r
Synonyms:Blt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620410. Ltb4r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 5612CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9316ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 14025CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 17918ExtracellularSequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini201 – 22222CytoplasmicSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini244 – 26825ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 35162CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2126.
GuidetoPHARMACOLOGYi267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Leukotriene B4 receptor 1PRO_0000069710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R0Q2.
PRIDEiQ9R0Q2.

PTM databases

PhosphoSiteiQ9R0Q2.

Expressioni

Tissue specificityi

Exclusively expressed in polymorphonuclear leukocytes.1 Publication

Gene expression databases

GenevisibleiQ9R0Q2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027647.

Chemistry

BindingDBiQ9R0Q2.

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ9R0Q2.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG738056.
PhylomeDBiQ9R0Q2.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANTTSTAA TSSPGGMSLS LLPIVLLSVA LVVGLPGNSF VVWSILKRMQ
60 70 80 90 100
KRSVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFEVT GCRLCHYVCG
110 120 130 140 150
VSMYASVLLI TIMSLDRSLA VARPFVSQKV RTKAFARWVL AGIWVVSFLL
160 170 180 190 200
AIPVLVYRTV TPKNKTLICD SRYPSDGHKV FHLLFEAITG FLLPFLAVVA
210 220 230 240 250
SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTL
260 270 280 290 300
AGWDKNSPAG QRLKLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VVKLLEGTGS EVSSTRRGGT LVQTPKATPT CPEPGPTDSF MTSSTPPESS

K
Length:351
Mass (Da):37,931
Last modified:May 1, 2000 - v1
Checksum:i6B1660C021221994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025230 Genomic DNA. Translation: BAA84578.1.
PIRiJC7096.
RefSeqiNP_067688.1. NM_021656.1.
XP_006252073.1. XM_006252011.2.
XP_006252074.1. XM_006252012.1.
UniGeneiRn.41003.

Genome annotation databases

EnsembliENSRNOT00000027647; ENSRNOP00000027647; ENSRNOG00000020399.
GeneIDi59264.
KEGGirno:59264.
UCSCiRGD:620410. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025230 Genomic DNA. Translation: BAA84578.1.
PIRiJC7096.
RefSeqiNP_067688.1. NM_021656.1.
XP_006252073.1. XM_006252011.2.
XP_006252074.1. XM_006252012.1.
UniGeneiRn.41003.

3D structure databases

ProteinModelPortaliQ9R0Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027647.

Chemistry

BindingDBiQ9R0Q2.
ChEMBLiCHEMBL2126.
GuidetoPHARMACOLOGYi267.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9R0Q2.

Proteomic databases

PaxDbiQ9R0Q2.
PRIDEiQ9R0Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027647; ENSRNOP00000027647; ENSRNOG00000020399.
GeneIDi59264.
KEGGirno:59264.
UCSCiRGD:620410. rat.

Organism-specific databases

CTDi1241.
RGDi620410. Ltb4r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ9R0Q2.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG738056.
PhylomeDBiQ9R0Q2.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9R0Q2.

Gene expression databases

GenevisibleiQ9R0Q2. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLT4R1_RAT
AccessioniPrimary (citable) accession number: Q9R0Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.