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Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906 Leukotriene receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:Ltb4r
Synonyms:Blt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620410 Ltb4r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini45 – 56CytoplasmicSequence analysisAdd BLAST12
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 93ExtracellularSequence analysisAdd BLAST16
Transmembranei94 – 115Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini116 – 140CytoplasmicSequence analysisAdd BLAST25
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 179ExtracellularSequence analysisAdd BLAST18
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 222CytoplasmicSequence analysisAdd BLAST22
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 268ExtracellularSequence analysisAdd BLAST25
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 351CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2126
GuidetoPHARMACOLOGYi267

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697101 – 351Leukotriene B4 receptor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R0Q2
PRIDEiQ9R0Q2

PTM databases

PhosphoSitePlusiQ9R0Q2

Expressioni

Tissue specificityi

Exclusively expressed in polymorphonuclear leukocytes.1 Publication

Gene expression databases

BgeeiENSRNOG00000020399
GenevisibleiQ9R0Q2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027647

Chemistry databases

BindingDBiQ9R0Q2

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000008594
HOVERGENiHBG104134
InParanoidiQ9R0Q2
KOiK04296
OMAiYHVVNLA
OrthoDBiEOG091G0FBQ
PhylomeDBiQ9R0Q2
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003981 Leukotriene_B4_rcpt
IPR003983 Leukotriene_B4_typ-1_rcpt
PANTHERiPTHR24230:SF51 PTHR24230:SF51, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01477 LTB1RECEPTOR
PR01476 LTBRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R0Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANTTSTAA TSSPGGMSLS LLPIVLLSVA LVVGLPGNSF VVWSILKRMQ
60 70 80 90 100
KRSVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFEVT GCRLCHYVCG
110 120 130 140 150
VSMYASVLLI TIMSLDRSLA VARPFVSQKV RTKAFARWVL AGIWVVSFLL
160 170 180 190 200
AIPVLVYRTV TPKNKTLICD SRYPSDGHKV FHLLFEAITG FLLPFLAVVA
210 220 230 240 250
SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTL
260 270 280 290 300
AGWDKNSPAG QRLKLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VVKLLEGTGS EVSSTRRGGT LVQTPKATPT CPEPGPTDSF MTSSTPPESS

K
Length:351
Mass (Da):37,931
Last modified:May 1, 2000 - v1
Checksum:i6B1660C021221994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025230 Genomic DNA Translation: BAA84578.1
PIRiJC7096
RefSeqiNP_067688.1, NM_021656.1
XP_006252073.1, XM_006252011.3
XP_006252074.1, XM_006252012.1
XP_017455280.1, XM_017599791.1
UniGeneiRn.41003

Genome annotation databases

EnsembliENSRNOT00000027647; ENSRNOP00000027647; ENSRNOG00000020399
GeneIDi59264
KEGGirno:59264
UCSCiRGD:620410 rat

Similar proteinsi

Entry informationi

Entry nameiLT4R1_RAT
AccessioniPrimary (citable) accession number: Q9R0Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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