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Protein

Destrin

Gene

Dstn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • actin filament fragmentation Source: UniProtKB
  • actin filament severing Source: InterPro
  • positive regulation of actin filament depolymerization Source: MGI

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Sid 23
Gene namesi
Name:Dstn
Synonyms:Dsn, Sid23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929270 Dstn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149192 – 165DestrinAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei19N6-acetyllysineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9R0P5
MaxQBiQ9R0P5
PaxDbiQ9R0P5
PRIDEiQ9R0P5

2D gel databases

REPRODUCTION-2DPAGEiIPI00127942
Q9R0P5

PTM databases

iPTMnetiQ9R0P5
PhosphoSitePlusiQ9R0P5
SwissPalmiQ9R0P5

Expressioni

Tissue specificityi

Widely expressed. Not found in skeletal muscle.1 Publication

Developmental stagei

In E10.5 embryo somites is expressed in a superficial patch of cells (adaxial region).1 Publication

Gene expression databases

BgeeiENSMUSG00000015932
CleanExiMM_DSTN
ExpressionAtlasiQ9R0P5 baseline and differential
GenevisibleiQ9R0P5 MM

Interactioni

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi207975, 8 interactors
IntActiQ9R0P5, 10 interactors
MINTiQ9R0P5
STRINGi10090.ENSMUSP00000099461

Structurei

3D structure databases

ProteinModelPortaliQ9R0P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
GeneTreeiENSGT00440000033289
HOGENOMiHOG000039697
HOVERGENiHBG000381
InParanoidiQ9R0P5
KOiK10363
OMAiQMLPEKD
OrthoDBiEOG091G0PWC
PhylomeDBiQ9R0P5
TreeFamiTF328601

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
IPR029924 Dstn
PANTHERiPTHR11913 PTHR11913, 1 hit
PTHR11913:SF18 PTHR11913:SF18, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIVVE
60 70 80 90 100
EGKEILVGDV GATITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM
110 120 130 140 150
FFLWAPEQAP LKSKMIYASS KDAIKKKFPG IKHEYQANGP EDLNRTCIAE
160
KLGGSLIVAF EGSPV
Length:165
Mass (Da):18,522
Last modified:January 23, 2007 - v3
Checksum:i42BD07984C9B3667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025406 mRNA Translation: BAA84691.1
AK078898 mRNA Translation: BAC37447.1
CCDSiCCDS16812.1
RefSeqiNP_062745.1, NM_019771.2
UniGeneiMm.28919

Genome annotation databases

EnsembliENSMUST00000103172; ENSMUSP00000099461; ENSMUSG00000015932
GeneIDi56431
KEGGimmu:56431
UCSCiuc008mqi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDEST_MOUSE
AccessioniPrimary (citable) accession number: Q9R0P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health