Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-formylglutathione hydrolase

Gene

Esd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine hydrolase involved in the detoxification of formaldehyde.By similarity

Catalytic activityi

S-formylglutathione + H2O = glutathione + formate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Charge relay systemBy similarity1
Active sitei226Charge relay systemBy similarity1
Active sitei260Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Protein family/group databases

ESTHERimouse-ES10 A85-EsteraseD-FGH

Names & Taxonomyi

Protein namesi
Recommended name:
S-formylglutathione hydrolase (EC:3.1.2.12)
Short name:
FGH
Alternative name(s):
Esterase 10
Esterase D
Sid 478
Gene namesi
Name:Esd
Synonyms:Es10, Sid478
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95421 Esd

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002103402 – 282S-formylglutathione hydrolaseAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4N6-succinyllysineCombined sources1
Modified residuei200N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R0P3
MaxQBiQ9R0P3
PaxDbiQ9R0P3
PRIDEiQ9R0P3

PTM databases

iPTMnetiQ9R0P3
PhosphoSitePlusiQ9R0P3
SwissPalmiQ9R0P3

Expressioni

Gene expression databases

BgeeiENSMUSG00000021996
CleanExiMM_ESD
ExpressionAtlasiQ9R0P3 baseline and differential
GenevisibleiQ9R0P3 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199507, 2 interactors
IntActiQ9R0P3, 4 interactors
MINTiQ9R0P3
STRINGi10090.ENSMUSP00000022573

Structurei

3D structure databases

ProteinModelPortaliQ9R0P3
SMRiQ9R0P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGiKOG3101 Eukaryota
COG0627 LUCA
GeneTreeiENSGT00390000011864
HOGENOMiHOG000263929
HOVERGENiHBG001326
InParanoidiQ9R0P3
KOiK01070
PhylomeDBiQ9R0P3
TreeFamiTF300793

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000801 Esterase_put
IPR014186 S-formylglutathione_hydrol
PANTHERiPTHR10061 PTHR10061, 1 hit
PfamiView protein in Pfam
PF00756 Esterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR02821 fghA_ester_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKQISSNR CFGGLQKVFE HSSVELKCKM RFAVYLPPQA ESGKCPALYW
60 70 80 90 100
LSGLTCTEQN FISKSGYQQA ASEHGLVVIA PDTSPRGCNI KGEDDSWDFG
110 120 130 140 150
TGAGFYVNAT EDPWKANYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM
160 170 180 190 200
GGHGALICAL KNPGKYRSVS AFAPICNPVL CSWGKKAFSG YLGPDESKWK
210 220 230 240 250
AYDATCLVKA YSGSQIDILI DQGKDDEFLS NGQLLPDNFI AACTEKKIPV
260 270 280
VFRLQEGYDH SYYFIATFIA DHIRHHAKYL NA
Length:282
Mass (Da):31,320
Last modified:May 1, 2000 - v1
Checksum:i9151D328FBB460A6
GO

Sequence cautioni

The sequence BAB27115 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAB27115 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025408 mRNA Translation: BAA84693.1
AK007527 mRNA Translation: BAB25090.1
AK010683 mRNA Translation: BAB27115.1 Different initiation.
AK021209 mRNA Translation: BAB32330.1
AK079131 mRNA Translation: BAC37555.1
AK088115 mRNA Translation: BAC40154.1
BC046766 mRNA Translation: AAH46766.2
CCDSiCCDS36975.1
RefSeqiNP_058599.1, NM_016903.5
UniGeneiMm.38055

Genome annotation databases

EnsembliENSMUST00000022573; ENSMUSP00000022573; ENSMUSG00000021996
GeneIDi13885
KEGGimmu:13885
UCSCiuc007uqd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiESTD_MOUSE
AccessioniPrimary (citable) accession number: Q9R0P3
Secondary accession number(s): Q80ZX4, Q9CWI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health