Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-formylglutathione hydrolase

Gene

Esd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine hydrolase involved in the detoxification of formaldehyde.By similarity

Catalytic activityi

S-formylglutathione + H2O = glutathione + formate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Charge relay systemBy similarity1
Active sitei226Charge relay systemBy similarity1
Active sitei260Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Protein family/group databases

ESTHERimouse-ES10. A85-EsteraseD-FGH.

Names & Taxonomyi

Protein namesi
Recommended name:
S-formylglutathione hydrolase (EC:3.1.2.12)
Short name:
FGH
Alternative name(s):
Esterase 10
Esterase D
Sid 478
Gene namesi
Name:Esd
Synonyms:Es10, Sid478
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95421. Esd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002103402 – 282S-formylglutathione hydrolaseAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4N6-succinyllysineCombined sources1
Modified residuei200N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R0P3.
MaxQBiQ9R0P3.
PaxDbiQ9R0P3.
PRIDEiQ9R0P3.

PTM databases

iPTMnetiQ9R0P3.
PhosphoSitePlusiQ9R0P3.
SwissPalmiQ9R0P3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021996.
CleanExiMM_ESD.
ExpressionAtlasiQ9R0P3. baseline and differential.
GenevisibleiQ9R0P3. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi199507. 1 interactor.
IntActiQ9R0P3. 4 interactors.
MINTiMINT-1854442.
STRINGi10090.ENSMUSP00000022573.

Structurei

3D structure databases

ProteinModelPortaliQ9R0P3.
SMRiQ9R0P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGiKOG3101. Eukaryota.
COG0627. LUCA.
GeneTreeiENSGT00390000011864.
HOGENOMiHOG000263929.
HOVERGENiHBG001326.
InParanoidiQ9R0P3.
KOiK01070.
PhylomeDBiQ9R0P3.
TreeFamiTF300793.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKQISSNR CFGGLQKVFE HSSVELKCKM RFAVYLPPQA ESGKCPALYW
60 70 80 90 100
LSGLTCTEQN FISKSGYQQA ASEHGLVVIA PDTSPRGCNI KGEDDSWDFG
110 120 130 140 150
TGAGFYVNAT EDPWKANYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM
160 170 180 190 200
GGHGALICAL KNPGKYRSVS AFAPICNPVL CSWGKKAFSG YLGPDESKWK
210 220 230 240 250
AYDATCLVKA YSGSQIDILI DQGKDDEFLS NGQLLPDNFI AACTEKKIPV
260 270 280
VFRLQEGYDH SYYFIATFIA DHIRHHAKYL NA
Length:282
Mass (Da):31,320
Last modified:May 1, 2000 - v1
Checksum:i9151D328FBB460A6
GO

Sequence cautioni

The sequence BAB27115 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAB27115 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025408 mRNA. Translation: BAA84693.1.
AK007527 mRNA. Translation: BAB25090.1.
AK010683 mRNA. Translation: BAB27115.1. Different initiation.
AK021209 mRNA. Translation: BAB32330.1.
AK079131 mRNA. Translation: BAC37555.1.
AK088115 mRNA. Translation: BAC40154.1.
BC046766 mRNA. Translation: AAH46766.2.
CCDSiCCDS36975.1.
RefSeqiNP_058599.1. NM_016903.5.
UniGeneiMm.38055.

Genome annotation databases

EnsembliENSMUST00000022573; ENSMUSP00000022573; ENSMUSG00000021996.
GeneIDi13885.
KEGGimmu:13885.
UCSCiuc007uqd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025408 mRNA. Translation: BAA84693.1.
AK007527 mRNA. Translation: BAB25090.1.
AK010683 mRNA. Translation: BAB27115.1. Different initiation.
AK021209 mRNA. Translation: BAB32330.1.
AK079131 mRNA. Translation: BAC37555.1.
AK088115 mRNA. Translation: BAC40154.1.
BC046766 mRNA. Translation: AAH46766.2.
CCDSiCCDS36975.1.
RefSeqiNP_058599.1. NM_016903.5.
UniGeneiMm.38055.

3D structure databases

ProteinModelPortaliQ9R0P3.
SMRiQ9R0P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199507. 1 interactor.
IntActiQ9R0P3. 4 interactors.
MINTiMINT-1854442.
STRINGi10090.ENSMUSP00000022573.

Chemistry databases

ChEMBLiCHEMBL3259483.

Protein family/group databases

ESTHERimouse-ES10. A85-EsteraseD-FGH.

PTM databases

iPTMnetiQ9R0P3.
PhosphoSitePlusiQ9R0P3.
SwissPalmiQ9R0P3.

Proteomic databases

EPDiQ9R0P3.
MaxQBiQ9R0P3.
PaxDbiQ9R0P3.
PRIDEiQ9R0P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022573; ENSMUSP00000022573; ENSMUSG00000021996.
GeneIDi13885.
KEGGimmu:13885.
UCSCiuc007uqd.2. mouse.

Organism-specific databases

CTDi2098.
MGIiMGI:95421. Esd.

Phylogenomic databases

eggNOGiKOG3101. Eukaryota.
COG0627. LUCA.
GeneTreeiENSGT00390000011864.
HOGENOMiHOG000263929.
HOVERGENiHBG001326.
InParanoidiQ9R0P3.
KOiK01070.
PhylomeDBiQ9R0P3.
TreeFamiTF300793.

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Miscellaneous databases

PROiQ9R0P3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021996.
CleanExiMM_ESD.
ExpressionAtlasiQ9R0P3. baseline and differential.
GenevisibleiQ9R0P3. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000801. Esterase_put.
IPR014186. S-formylglutathione_hydrol.
[Graphical view]
PANTHERiPTHR10061. PTHR10061. 1 hit.
PfamiPF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02821. fghA_ester_D. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiESTD_MOUSE
AccessioniPrimary (citable) accession number: Q9R0P3
Secondary accession number(s): Q80ZX4, Q9CWI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.