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Protein
Submitted name:

LKB1 serine/threonin kinase

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. magnesium ion binding Source: Ensembl
  3. protein kinase activator activity Source: Ensembl
  4. protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase activity Source: Ensembl
  2. anoikis Source: Ensembl
  3. axonogenesis Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  6. negative regulation of cell proliferation Source: Ensembl
  7. positive regulation of gluconeogenesis Source: Ensembl
  8. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  9. protein autophosphorylation Source: Ensembl
  10. protein heterooligomerization Source: Ensembl
  11. response to glucagon Source: Ensembl
  12. response to lipid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
LKB1 serine/threonin kinaseImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9R0P1.
ExpressionAtlasiQ9R0P1. baseline and differential.
GenevestigatoriQ9R0P1.

Structurei

3D structure databases

ProteinModelPortaliQ9R0P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG054467.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R0P1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EIQLLRRLRH RNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR
60 70 80 90 100
FPVCQAHGYF RQLIDGLEYL HSQGIVHKDI KPGNLLLTTN GTLKISDLGV
110 120 130 140 150
AEALHPFAVD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN
160 170 180 190 200
ITTGLYPFEG DNIYKLFENI GRGDFTIPCD CGPPLSDLLR GMLEYEPAKR
210 220 230 240 250
FSIRQIRQHS WFRKKHPLAE ALVPIPPSPD TKDRWRSMTV VPYLEDLHGR
260 270 280 290 300
AEEEEEEDLF DIEDGIIYTQ DFTVPGQVLE EEVGQNGQSH SLPKAVCVNG
310 320 330
TEPQLSSKVK PEGRPGTANP ARKVCSSNKI RRLSACKQQ
Length:339
Mass (Da):38,308
Last modified:May 1, 2000 - v1
Checksum:i73F4DB9438443A6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026255 Genomic DNA. Translation: BAA86229.1.
UniGeneiMm.44231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026255 Genomic DNA. Translation: BAA86229.1.
UniGeneiMm.44231.

3D structure databases

ProteinModelPortaliQ9R0P1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG054467.

Gene expression databases

BgeeiQ9R0P1.
ExpressionAtlasiQ9R0P1. baseline and differential.
GenevestigatoriQ9R0P1.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129OlaImported.

Entry informationi

Entry nameiQ9R0P1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0P1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.