Q9R0P1 (Q9R0P1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LKB1 serine/threonin kinase EMBL BAA86229.1

Gene names

Name:

Stk11 MGI 1341870

Organism

Mus musculus (Mouse) EMBL BAA86229.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	339 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 protein kinase domain. SAAS SAAS020636

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020636 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS020636 Transferase
Gene Ontology (GO)
Biological_process	anoikis Inferred from electronic annotation. Source: Compara axonogenesis Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway by p53 class mediator Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of gluconeogenesis Inferred from electronic annotation. Source: Compara positive regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from electronic annotation. Source: Compara response to glucagon stimulus Inferred from electronic annotation. Source: Compara response to lipid Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: Compara protein kinase activator activity Inferred from electronic annotation. Source: Compara protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAA86229.1

Sequences

	Sequence		Length	Mass (Da)
	Q9R0P1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 73F4DB9438443A6C	FASTA	339	38,308
	10 20 30 40 50 60 EIQLLRRLRH RNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF 70 80 90 100 110 120 RQLIDGLEYL HSQGIVHKDI KPGNLLLTTN GTLKISDLGV AEALHPFAVD DTCRTSQGSP 130 140 150 160 170 180 AFQPPEIANG LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GRGDFTIPCD 190 200 210 220 230 240 CGPPLSDLLR GMLEYEPAKR FSIRQIRQHS WFRKKHPLAE ALVPIPPSPD TKDRWRSMTV 250 260 270 280 290 300 VPYLEDLHGR AEEEEEEDLF DIEDGIIYTQ DFTVPGQVLE EEVGQNGQSH SLPKAVCVNG 310 320 330 TEPQLSSKVK PEGRPGTANP ARKVCSSNKI RRLSACKQQ

References

[1]

"Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis." Jishage K., Nezu J., Kawase Y., Iwata T., Watanabe M., Miyoshi A., Ose A., Habu K., Kake T., Kamada N., Ueda O., Kinoshita M., Jenne D.E., Shimane M., Suzuki H. Proc. Natl. Acad. Sci. U.S.A. 99:8903-8908(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129Ola EMBL BAA86229.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026255 Genomic DNA. Translation: BAA86229.1.
IPI	IPI00123476.
UniGene	Mm.44231.
3D structure databases
ProteinModelPortal	Q9R0P1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9R0P1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG054467.
InParanoid	Q9R0P1.
Gene expression databases
ArrayExpress	Q9R0P1.
Bgee	Q9R0P1.
Genevestigator	Q9R0P1.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR24347. PTHR24347. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9R0P1_MOUSE

Accession

Primary (citable) accession number: Q9R0P1

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)