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Q9R0P1

- Q9R0P1_MOUSE

UniProt

Q9R0P1 - Q9R0P1_MOUSE

Protein
Submitted name:

LKB1 serine/threonin kinase

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. magnesium ion binding Source: Ensembl
    3. protein kinase activator activity Source: Ensembl
    4. protein serine/threonine kinase activity Source: Ensembl

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. anoikis Source: Ensembl
    3. axonogenesis Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
    6. negative regulation of cell proliferation Source: Ensembl
    7. positive regulation of gluconeogenesis Source: Ensembl
    8. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    9. protein autophosphorylation Source: Ensembl
    10. protein heterooligomerization Source: Ensembl
    11. response to glucagon Source: Ensembl
    12. response to lipid Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    LKB1 serine/threonin kinaseImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: Ensembl
    3. protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0P1.
    BgeeiQ9R0P1.
    GenevestigatoriQ9R0P1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG054467.
    InParanoidiQ9R0P1.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9R0P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    EIQLLRRLRH RNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR    50
    FPVCQAHGYF RQLIDGLEYL HSQGIVHKDI KPGNLLLTTN GTLKISDLGV 100
    AEALHPFAVD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN 150
    ITTGLYPFEG DNIYKLFENI GRGDFTIPCD CGPPLSDLLR GMLEYEPAKR 200
    FSIRQIRQHS WFRKKHPLAE ALVPIPPSPD TKDRWRSMTV VPYLEDLHGR 250
    AEEEEEEDLF DIEDGIIYTQ DFTVPGQVLE EEVGQNGQSH SLPKAVCVNG 300
    TEPQLSSKVK PEGRPGTANP ARKVCSSNKI RRLSACKQQ 339
    Length:339
    Mass (Da):38,308
    Last modified:May 1, 2000 - v1
    Checksum:i73F4DB9438443A6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026255 Genomic DNA. Translation: BAA86229.1.
    UniGeneiMm.44231.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026255 Genomic DNA. Translation: BAA86229.1 .
    UniGenei Mm.44231.

    3D structure databases

    ProteinModelPortali Q9R0P1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG054467.
    InParanoidi Q9R0P1.

    Gene expression databases

    ArrayExpressi Q9R0P1.
    Bgeei Q9R0P1.
    Genevestigatori Q9R0P1.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129OlaImported.

    Entry informationi

    Entry nameiQ9R0P1_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0P1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)