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Q9R0N7

- SYT7_MOUSE

UniProt

Q9R0N7 - SYT7_MOUSE

Protein

Synaptotagmin-7

Gene

Syt7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi166 – 1661Calcium 1By similarity
    Metal bindingi166 – 1661Calcium 2By similarity
    Metal bindingi172 – 1721Calcium 1By similarity
    Metal bindingi225 – 2251Calcium 1By similarity
    Metal bindingi225 – 2251Calcium 2By similarity
    Metal bindingi227 – 2271Calcium 1By similarity
    Metal bindingi227 – 2271Calcium 2By similarity
    Metal bindingi227 – 2271Calcium 3By similarity
    Metal bindingi230 – 2301Calcium 3By similarity
    Metal bindingi233 – 2331Calcium 2By similarity
    Metal bindingi233 – 2331Calcium 3By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. exocytosis Source: InterPro
    2. plasma membrane repair Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-7
    Alternative name(s):
    Synaptotagmin VII
    Short name:
    SytVII
    Gene namesi
    Name:Syt7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1859545. Syt7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosome Source: MGI
    4. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Synaptotagmin-7PRO_0000183958Add
    BLAST

    Proteomic databases

    MaxQBiQ9R0N7.
    PaxDbiQ9R0N7.
    PRIDEiQ9R0N7.

    PTM databases

    PhosphoSiteiQ9R0N7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0N7.
    BgeeiQ9R0N7.
    CleanExiMM_SYT7.
    GenevestigatoriQ9R0N7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9R0N7. 1 interaction.
    MINTiMINT-4998417.

    Structurei

    Secondary structure

    1
    403
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi269 – 2779
    Turni278 – 2814
    Beta strandi282 – 29211
    Turni298 – 3003
    Beta strandi304 – 3129
    Beta strandi315 – 3217
    Beta strandi332 – 3409
    Helixi343 – 3486
    Beta strandi349 – 3579
    Beta strandi360 – 3623
    Beta strandi365 – 37612
    Helixi378 – 38912
    Beta strandi395 – 4006

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3N5AX-ray1.44A266-403[»]
    ProteinModelPortaliQ9R0N7.
    SMRiQ9R0N7. Positions 133-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616VesicularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 403366CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini137 – 239103C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 371104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5038.
    GeneTreeiENSGT00750000117274.
    HOGENOMiHOG000232126.
    HOVERGENiHBG005010.
    PhylomeDBiQ9R0N7.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015427. Synaptotagmin7.
    [Graphical view]
    PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0N7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK    50
    NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTET 100
    RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 150
    TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 200
    NETFLFEGFP YEKVVQRVLY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 250
    QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 300
    TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT 350
    IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 400
    LKA 403
    Length:403
    Mass (Da):45,472
    Last modified:May 1, 2000 - v1
    Checksum:i4E63C5779C2ED43E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026804 mRNA. Translation: BAA85776.1.
    BC139806 mRNA. Translation: AAI39807.1.
    CCDSiCCDS29575.1.
    RefSeqiNP_061271.1. NM_018801.3.
    UniGeneiMm.182654.

    Genome annotation databases

    EnsembliENSMUST00000073899; ENSMUSP00000073560; ENSMUSG00000024743.
    GeneIDi54525.
    KEGGimmu:54525.
    UCSCiuc008gpq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026804 mRNA. Translation: BAA85776.1 .
    BC139806 mRNA. Translation: AAI39807.1 .
    CCDSi CCDS29575.1.
    RefSeqi NP_061271.1. NM_018801.3.
    UniGenei Mm.182654.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3N5A X-ray 1.44 A 266-403 [» ]
    ProteinModelPortali Q9R0N7.
    SMRi Q9R0N7. Positions 133-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0N7. 1 interaction.
    MINTi MINT-4998417.

    PTM databases

    PhosphoSitei Q9R0N7.

    Proteomic databases

    MaxQBi Q9R0N7.
    PaxDbi Q9R0N7.
    PRIDEi Q9R0N7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073899 ; ENSMUSP00000073560 ; ENSMUSG00000024743 .
    GeneIDi 54525.
    KEGGi mmu:54525.
    UCSCi uc008gpq.2. mouse.

    Organism-specific databases

    CTDi 9066.
    MGIi MGI:1859545. Syt7.

    Phylogenomic databases

    eggNOGi COG5038.
    GeneTreei ENSGT00750000117274.
    HOGENOMi HOG000232126.
    HOVERGENi HBG005010.
    PhylomeDBi Q9R0N7.

    Miscellaneous databases

    NextBioi 311364.
    PROi Q9R0N7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0N7.
    Bgeei Q9R0N7.
    CleanExi MM_SYT7.
    Genevestigatori Q9R0N7.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015427. Synaptotagmin7.
    [Graphical view ]
    PANTHERi PTHR10024:SF97. PTHR10024:SF97. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
      Fukuda M., Kanno E., Mikoshiba K.
      J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSYT7_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0N7
    Secondary accession number(s): A4QPF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3