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Protein

Synaptotagmin-7

Gene

Syt7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi166 – 1661Calcium 1By similarity
Metal bindingi166 – 1661Calcium 2By similarity
Metal bindingi172 – 1721Calcium 1By similarity
Metal bindingi225 – 2251Calcium 1By similarity
Metal bindingi225 – 2251Calcium 2By similarity
Metal bindingi227 – 2271Calcium 1By similarity
Metal bindingi227 – 2271Calcium 2By similarity
Metal bindingi227 – 2271Calcium 3By similarity
Metal bindingi230 – 2301Calcium 3By similarity
Metal bindingi233 – 2331Calcium 2By similarity
Metal bindingi233 – 2331Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-7
Alternative name(s):
Synaptotagmin VII
Short name:
SytVII
Gene namesi
Name:Syt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1859545. Syt7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616VesicularSequence AnalysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Topological domaini38 – 403366CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Synaptotagmin-7PRO_0000183958Add
BLAST

Proteomic databases

MaxQBiQ9R0N7.
PaxDbiQ9R0N7.
PRIDEiQ9R0N7.

PTM databases

PhosphoSiteiQ9R0N7.

Expressioni

Gene expression databases

BgeeiQ9R0N7.
CleanExiMM_SYT7.
ExpressionAtlasiQ9R0N7. baseline and differential.
GenevisibleiQ9R0N7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9R0N7. 1 interaction.
MINTiMINT-4998417.
STRINGi10090.ENSMUSP00000127973.

Structurei

Secondary structure

1
403
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi269 – 2779Combined sources
Turni278 – 2814Combined sources
Beta strandi282 – 29211Combined sources
Turni298 – 3003Combined sources
Beta strandi304 – 3129Combined sources
Beta strandi315 – 3217Combined sources
Beta strandi332 – 3409Combined sources
Helixi343 – 3486Combined sources
Beta strandi349 – 3579Combined sources
Beta strandi360 – 3623Combined sources
Beta strandi365 – 37612Combined sources
Helixi378 – 38912Combined sources
Beta strandi395 – 4006Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N5AX-ray1.44A266-403[»]
ProteinModelPortaliQ9R0N7.
SMRiQ9R0N7. Positions 133-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 239103C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 371104C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9R0N7.
PhylomeDBiQ9R0N7.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK
60 70 80 90 100
NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTET
110 120 130 140 150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES
160 170 180 190 200
TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW
210 220 230 240 250
NETFLFEGFP YEKVVQRVLY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM
260 270 280 290 300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG
310 320 330 340 350
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT
360 370 380 390 400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ

LKA
Length:403
Mass (Da):45,472
Last modified:May 1, 2000 - v1
Checksum:i4E63C5779C2ED43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026804 mRNA. Translation: BAA85776.1.
BC139806 mRNA. Translation: AAI39807.1.
CCDSiCCDS29575.1.
RefSeqiNP_061271.1. NM_018801.3.
UniGeneiMm.182654.

Genome annotation databases

EnsembliENSMUST00000073899; ENSMUSP00000073560; ENSMUSG00000024743.
GeneIDi54525.
KEGGimmu:54525.
UCSCiuc008gpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026804 mRNA. Translation: BAA85776.1.
BC139806 mRNA. Translation: AAI39807.1.
CCDSiCCDS29575.1.
RefSeqiNP_061271.1. NM_018801.3.
UniGeneiMm.182654.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N5AX-ray1.44A266-403[»]
ProteinModelPortaliQ9R0N7.
SMRiQ9R0N7. Positions 133-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R0N7. 1 interaction.
MINTiMINT-4998417.
STRINGi10090.ENSMUSP00000127973.

PTM databases

PhosphoSiteiQ9R0N7.

Proteomic databases

MaxQBiQ9R0N7.
PaxDbiQ9R0N7.
PRIDEiQ9R0N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073899; ENSMUSP00000073560; ENSMUSG00000024743.
GeneIDi54525.
KEGGimmu:54525.
UCSCiuc008gpq.2. mouse.

Organism-specific databases

CTDi9066.
MGIiMGI:1859545. Syt7.

Phylogenomic databases

eggNOGiCOG5038.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9R0N7.
PhylomeDBiQ9R0N7.

Miscellaneous databases

ChiTaRSiSyt7. mouse.
NextBioi311364.
PROiQ9R0N7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R0N7.
CleanExiMM_SYT7.
ExpressionAtlasiQ9R0N7. baseline and differential.
GenevisibleiQ9R0N7. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
    Fukuda M., Kanno E., Mikoshiba K.
    J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSYT7_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N7
Secondary accession number(s): A4QPF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.