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Q9R0N7 (SYT7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-7
Alternative name(s):
Synaptotagmin VII
Short name=SytVII
Gene names
Name:Syt7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Synaptotagmin-7
PRO_0000183958

Regions

Topological domain1 – 1616Vesicular Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 403366Cytoplasmic Potential
Domain137 – 239103C2 1
Domain268 – 371104C2 2

Sites

Metal binding1661Calcium 1 By similarity
Metal binding1661Calcium 2 By similarity
Metal binding1721Calcium 1 By similarity
Metal binding2251Calcium 1 By similarity
Metal binding2251Calcium 2 By similarity
Metal binding2271Calcium 1 By similarity
Metal binding2271Calcium 2 By similarity
Metal binding2271Calcium 3 By similarity
Metal binding2301Calcium 3 By similarity
Metal binding2331Calcium 2 By similarity
Metal binding2331Calcium 3 By similarity

Secondary structure

........................ 403
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9R0N7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4E63C5779C2ED43E

FASTA40345,472
        10         20         30         40         50         60 
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK NSLETVGTPD 

        70         80         90        100        110        120 
SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTET RSSVSDLVNS LTSEMLMLSP 

       130        140        150        160        170        180 
GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL 

       190        200        210        220        230        240 
PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRVLY LQVLDYDRFS RNDPIGEVSI 

       250        260        270        280        290        300 
PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 

       310        320        330        340        350        360 
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK 

       370        380        390        400 
LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA 

« Hide

References

« Hide 'large scale' references
[1]"Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
Fukuda M., Kanno E., Mikoshiba K.
J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026804 mRNA. Translation: BAA85776.1.
BC139806 mRNA. Translation: AAI39807.1.
RefSeqNP_061271.1. NM_018801.3.
UniGeneMm.182654.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3N5AX-ray1.44A266-403[»]
ProteinModelPortalQ9R0N7.
SMRQ9R0N7. Positions 133-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9R0N7. 1 interaction.
MINTMINT-4998417.

PTM databases

PhosphoSiteQ9R0N7.

Proteomic databases

PaxDbQ9R0N7.
PRIDEQ9R0N7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073899; ENSMUSP00000073560; ENSMUSG00000024743.
GeneID54525.
KEGGmmu:54525.
UCSCuc008gpq.2. mouse.

Organism-specific databases

CTD9066.
MGIMGI:1859545. Syt7.

Phylogenomic databases

eggNOGCOG5038.
GeneTreeENSGT00750000117274.
HOGENOMHOG000232126.
HOVERGENHBG005010.
PhylomeDBQ9R0N7.

Gene expression databases

ArrayExpressQ9R0N7.
BgeeQ9R0N7.
CleanExMM_SYT7.
GenevestigatorQ9R0N7.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERPTHR10024:SF29. PTHR10024:SF29. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio311364.
PROQ9R0N7.
SOURCESearch...

Entry information

Entry nameSYT7_MOUSE
AccessionPrimary (citable) accession number: Q9R0N7
Secondary accession number(s): A4QPF1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot