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Q9R0N7

- SYT7_MOUSE

UniProt

Q9R0N7 - SYT7_MOUSE

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Protein
Synaptotagmin-7
Gene
Syt7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi166 – 1661Calcium 1 By similarity
Metal bindingi166 – 1661Calcium 2 By similarity
Metal bindingi172 – 1721Calcium 1 By similarity
Metal bindingi225 – 2251Calcium 1 By similarity
Metal bindingi225 – 2251Calcium 2 By similarity
Metal bindingi227 – 2271Calcium 1 By similarity
Metal bindingi227 – 2271Calcium 2 By similarity
Metal bindingi227 – 2271Calcium 3 By similarity
Metal bindingi230 – 2301Calcium 3 By similarity
Metal bindingi233 – 2331Calcium 2 By similarity
Metal bindingi233 – 2331Calcium 3 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro

GO - Biological processi

  1. exocytosis Source: InterPro
  2. plasma membrane repair Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-7
Alternative name(s):
Synaptotagmin VII
Short name:
SytVII
Gene namesi
Name:Syt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1859545. Syt7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Vesicular Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 403366Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Synaptotagmin-7
PRO_0000183958Add
BLAST

Proteomic databases

MaxQBiQ9R0N7.
PaxDbiQ9R0N7.
PRIDEiQ9R0N7.

PTM databases

PhosphoSiteiQ9R0N7.

Expressioni

Gene expression databases

ArrayExpressiQ9R0N7.
BgeeiQ9R0N7.
CleanExiMM_SYT7.
GenevestigatoriQ9R0N7.

Interactioni

Protein-protein interaction databases

IntActiQ9R0N7. 1 interaction.
MINTiMINT-4998417.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi269 – 2779
Turni278 – 2814
Beta strandi282 – 29211
Turni298 – 3003
Beta strandi304 – 3129
Beta strandi315 – 3217
Beta strandi332 – 3409
Helixi343 – 3486
Beta strandi349 – 3579
Beta strandi360 – 3623
Beta strandi365 – 37612
Helixi378 – 38912
Beta strandi395 – 4006

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N5AX-ray1.44A266-403[»]
ProteinModelPortaliQ9R0N7.
SMRiQ9R0N7. Positions 133-403.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 239103C2 1
Add
BLAST
Domaini268 – 371104C2 2
Add
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
GeneTreeiENSGT00750000117274.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
PhylomeDBiQ9R0N7.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0N7-1 [UniParc]FASTAAdd to Basket

« Hide

MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK    50
NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTET 100
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 150
TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 200
NETFLFEGFP YEKVVQRVLY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 250
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 300
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT 350
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 400
LKA 403
Length:403
Mass (Da):45,472
Last modified:May 1, 2000 - v1
Checksum:i4E63C5779C2ED43E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026804 mRNA. Translation: BAA85776.1.
BC139806 mRNA. Translation: AAI39807.1.
CCDSiCCDS29575.1.
RefSeqiNP_061271.1. NM_018801.3.
UniGeneiMm.182654.

Genome annotation databases

EnsembliENSMUST00000073899; ENSMUSP00000073560; ENSMUSG00000024743.
GeneIDi54525.
KEGGimmu:54525.
UCSCiuc008gpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026804 mRNA. Translation: BAA85776.1 .
BC139806 mRNA. Translation: AAI39807.1 .
CCDSi CCDS29575.1.
RefSeqi NP_061271.1. NM_018801.3.
UniGenei Mm.182654.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3N5A X-ray 1.44 A 266-403 [» ]
ProteinModelPortali Q9R0N7.
SMRi Q9R0N7. Positions 133-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0N7. 1 interaction.
MINTi MINT-4998417.

PTM databases

PhosphoSitei Q9R0N7.

Proteomic databases

MaxQBi Q9R0N7.
PaxDbi Q9R0N7.
PRIDEi Q9R0N7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073899 ; ENSMUSP00000073560 ; ENSMUSG00000024743 .
GeneIDi 54525.
KEGGi mmu:54525.
UCSCi uc008gpq.2. mouse.

Organism-specific databases

CTDi 9066.
MGIi MGI:1859545. Syt7.

Phylogenomic databases

eggNOGi COG5038.
GeneTreei ENSGT00750000117274.
HOGENOMi HOG000232126.
HOVERGENi HBG005010.
PhylomeDBi Q9R0N7.

Miscellaneous databases

NextBioi 311364.
PROi Q9R0N7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R0N7.
Bgeei Q9R0N7.
CleanExi MM_SYT7.
Genevestigatori Q9R0N7.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view ]
PANTHERi PTHR10024:SF97. PTHR10024:SF97. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
    Fukuda M., Kanno E., Mikoshiba K.
    J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSYT7_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N7
Secondary accession number(s): A4QPF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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