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Protein

Synaptotagmin-5

Gene

Syt5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.1 Publication

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi139Calcium 1By similarity1
Metal bindingi139Calcium 2By similarity1
Metal bindingi145Calcium 1By similarity1
Metal bindingi197Calcium 1By similarity1
Metal bindingi197Calcium 2By similarity1
Metal bindingi198Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi199Calcium 1By similarity1
Metal bindingi199Calcium 2By similarity1
Metal bindingi199Calcium 3By similarity1
Metal bindingi202Calcium 3By similarity1
Metal bindingi205Calcium 2By similarity1
Metal bindingi205Calcium 3By similarity1

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: ParkinsonsUK-UCL
  • calcium ion binding Source: GO_Central
  • clathrin binding Source: GO_Central
  • phosphatidylinositol-4,5-bisphosphate binding Source: ParkinsonsUK-UCL
  • phosphatidylserine binding Source: ParkinsonsUK-UCL
  • protein heterodimerization activity Source: UniProtKB
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-5
Alternative name(s):
Synaptotagmin IX1 Publication
Synaptotagmin V
Short name:
SytV
Gene namesi
Name:Syt5
Synonyms:Syt91 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1926368. Syt5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24VesicularSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 386CytoplasmicSequence analysisAdd BLAST341

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dense core granule Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
  • perinuclear region of cytoplasm Source: ParkinsonsUK-UCL
  • plasma membrane Source: GO_Central
  • proximal neuron projection Source: ParkinsonsUK-UCL
  • recycling endosome membrane Source: UniProtKB-SubCell
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839521 – 386Synaptotagmin-5Add BLAST386

Proteomic databases

MaxQBiQ9R0N5.
PaxDbiQ9R0N5.
PeptideAtlasiQ9R0N5.
PRIDEiQ9R0N5.

PTM databases

iPTMnetiQ9R0N5.
PhosphoSitePlusiQ9R0N5.
SwissPalmiQ9R0N5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000004961.
CleanExiMM_SYT5.
MM_SYT9.
ExpressionAtlasiQ9R0N5. baseline and differential.
GenevisibleiQ9R0N5. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).By similarity

GO - Molecular functioni

  • clathrin binding Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central

Protein-protein interaction databases

BioGridi207314. 1 interactor.
IntActiQ9R0N5. 2 interactors.
MINTiMINT-4998411.
STRINGi10090.ENSMUSP00000070322.

Structurei

3D structure databases

ProteinModelPortaliQ9R0N5.
SMRiQ9R0N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 211C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini253 – 344C2 2PROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232127.
HOVERGENiHBG005010.
InParanoidiQ9R0N5.
KOiK19905.
OMAiCRRRMGK.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ9R0N5.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
[Graphical view]
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPEPPTLGS PAPKTPPDSS RIRQGAVPAW VLATIVLGSG LLVFSSCFCL
60 70 80 90 100
YRKRCRRRMG KKSQAQAQVH LQEVKELGRS YIDKVQPEIE ELDRSPSMPG
110 120 130 140 150
QQVSDKHQLG RLQYSLDYDF QTGQLLVGIL QAQGLAALDL GGSSDPYVSV
160 170 180 190 200
YLLPDKRRRH ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR
210 220 230 240 250
FSRNDAIGEV RVPMSSVNLG RPVQAWRELQ VAPKEEQEKL GDICFSLRYV
260 270 280 290 300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
310 320 330 340 350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAVG
360 370 380
GAGLRHWADM LANPRRPIAQ WHSLRPPDRA RPIPAP
Length:386
Mass (Da):43,130
Last modified:May 1, 2000 - v1
Checksum:iF884902E032082F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026806 mRNA. Translation: BAA85778.1.
BC047148 mRNA. Translation: AAH47148.1.
CCDSiCCDS20738.1.
RefSeqiNP_058604.1. NM_016908.2.
XP_006540252.1. XM_006540189.3.
XP_006540253.1. XM_006540190.3.
UniGeneiMm.358663.

Genome annotation databases

EnsembliENSMUST00000065957; ENSMUSP00000070322; ENSMUSG00000004961.
GeneIDi53420.
KEGGimmu:53420.
UCSCiuc009exy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026806 mRNA. Translation: BAA85778.1.
BC047148 mRNA. Translation: AAH47148.1.
CCDSiCCDS20738.1.
RefSeqiNP_058604.1. NM_016908.2.
XP_006540252.1. XM_006540189.3.
XP_006540253.1. XM_006540190.3.
UniGeneiMm.358663.

3D structure databases

ProteinModelPortaliQ9R0N5.
SMRiQ9R0N5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207314. 1 interactor.
IntActiQ9R0N5. 2 interactors.
MINTiMINT-4998411.
STRINGi10090.ENSMUSP00000070322.

PTM databases

iPTMnetiQ9R0N5.
PhosphoSitePlusiQ9R0N5.
SwissPalmiQ9R0N5.

Proteomic databases

MaxQBiQ9R0N5.
PaxDbiQ9R0N5.
PeptideAtlasiQ9R0N5.
PRIDEiQ9R0N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065957; ENSMUSP00000070322; ENSMUSG00000004961.
GeneIDi53420.
KEGGimmu:53420.
UCSCiuc009exy.1. mouse.

Organism-specific databases

CTDi6861.
MGIiMGI:1926368. Syt5.

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232127.
HOVERGENiHBG005010.
InParanoidiQ9R0N5.
KOiK19905.
OMAiCRRRMGK.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ9R0N5.
TreeFamiTF315600.

Enzyme and pathway databases

ReactomeiR-MMU-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ9R0N5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004961.
CleanExiMM_SYT5.
MM_SYT9.
ExpressionAtlasiQ9R0N5. baseline and differential.
GenevisibleiQ9R0N5. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
[Graphical view]
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT5_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.