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Protein

Synaptotagmin-11

Gene

Syt11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Calcium 1By similarity1
Metal bindingi187Calcium 2By similarity1
Metal bindingi194Calcium 1By similarity1
Metal bindingi248Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi249Calcium 1By similarity1
Metal bindingi249Calcium 2By similarity1
Metal bindingi249Calcium 3By similarity1
Metal bindingi252Calcium 3By similarity1
Metal bindingi255Calcium 2By similarity1
Metal bindingi255Calcium 3By similarity1

GO - Molecular functioni

  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • clathrin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central
  • translation initiation factor binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • calcium ion regulated lysosome exocytosis Source: ParkinsonsUK-UCL
  • negative regulation of clathrin-coated pit assembly Source: Ensembl
  • negative regulation of clathrin-dependent endocytosis Source: Ensembl
  • negative regulation of interleukin-6 secretion Source: ParkinsonsUK-UCL
  • negative regulation of membrane invagination Source: Ensembl
  • negative regulation of phagocytosis Source: ParkinsonsUK-UCL
  • negative regulation of synaptic vesicle endocytosis Source: Ensembl
  • negative regulation of tumor necrosis factor secretion Source: ParkinsonsUK-UCL
  • plasma membrane repair Source: ParkinsonsUK-UCL
  • positive regulation of protein localization to phagocytic vesicle Source: ParkinsonsUK-UCL
  • protein homotetramerization Source: ParkinsonsUK-UCL
  • regulation of defense response to bacterium Source: ParkinsonsUK-UCL
  • regulation of phagosome maturation Source: ParkinsonsUK-UCL
  • response to wounding Source: ParkinsonsUK-UCL
  • vesicle fusion Source: GO_Central

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:Syt11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1859547 Syt11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15VesicularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 430CytoplasmicSequence analysisAdd BLAST394

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839701 – 430Synaptotagmin-11Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9R0N3
PaxDbiQ9R0N3
PRIDEiQ9R0N3

PTM databases

iPTMnetiQ9R0N3
PhosphoSitePlusiQ9R0N3
SwissPalmiQ9R0N3

Expressioni

Gene expression databases

BgeeiENSMUSG00000068923
CleanExiMM_SYT11
ExpressionAtlasiQ9R0N3 baseline and differential
GenevisibleiQ9R0N3 MM

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers. Interacts with PRKN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Vti1aQ9JI512EBI-647443,EBI-7573650From Rattus norvegicus.

GO - Molecular functioni

  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • clathrin binding Source: GO_Central
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central
  • translation initiation factor binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

IntActiQ9R0N3, 22 interactors
MINTiQ9R0N3
STRINGi10090.ENSMUSP00000088464

Structurei

3D structure databases

ProteinModelPortaliQ9R0N3
SMRiQ9R0N3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 261C2 1PROSITE-ProRule annotationAdd BLAST89
Domaini303 – 396C2 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232126
HOVERGENiHBG005010
InParanoidiQ9R0N3
KOiK19911
OMAiIKVDYGD
OrthoDBiEOG091G09ZN
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028699 SYT11
PANTHERiPTHR10024:SF115 PTHR10024:SF115, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9R0N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPRRESG RGNLLINAES
110 120 130 140 150
GLLSHDKDPR GPSPASCMDQ LPIKRDYGEE LRSPMTSLTP GESKATSPSS
160 170 180 190 200
PEEDVMLGSL TFSVDYNFPK KALVVTIQEA HGLPVMDDQT QGSDPYIKMT
210 220 230 240 250
ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV LHFLVLSFDR
260 270 280 290 300
FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY
310 320 330 340 350
QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK
360 370 380 390 400
KCTLNPVFNE SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH
410 420 430
SVTTSGAEHW REVCESPRKP IAKWHSLSEY
Length:430
Mass (Da):48,333
Last modified:July 27, 2011 - v2
Checksum:i4E989259BE4FB423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145A → P in BAA85780 (PubMed:10531343).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026808 mRNA Translation: BAA85780.1
AK144169 mRNA Translation: BAE25745.1
BC054526 mRNA Translation: AAH54526.1
CCDSiCCDS38484.1
RefSeqiNP_061274.2, NM_018804.3
XP_006501411.1, XM_006501348.1
UniGeneiMm.379376

Genome annotation databases

EnsembliENSMUST00000090945; ENSMUSP00000088464; ENSMUSG00000068923
ENSMUST00000107505; ENSMUSP00000103129; ENSMUSG00000068923
GeneIDi229521
KEGGimmu:229521
UCSCiuc008pwk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSYT11_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N3
Secondary accession number(s): Q7TQG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health