Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9R0N3

- SYT11_MOUSE

UniProt

Q9R0N3 - SYT11_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Synaptotagmin-11

Gene

Syt11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Calcium 1By similarity
Metal bindingi187 – 1871Calcium 2By similarity
Metal bindingi194 – 1941Calcium 1By similarity
Metal bindingi248 – 2481Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi249 – 2491Calcium 1By similarity
Metal bindingi249 – 2491Calcium 2By similarity
Metal bindingi249 – 2491Calcium 3By similarity
Metal bindingi252 – 2521Calcium 3By similarity
Metal bindingi255 – 2551Calcium 2By similarity
Metal bindingi255 – 2551Calcium 3By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:Syt11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1859547. Syt11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515VesicularSequence AnalysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 430394CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: MGI
  3. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Synaptotagmin-11PRO_0000183970Add
BLAST

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9R0N3.
PaxDbiQ9R0N3.
PRIDEiQ9R0N3.

PTM databases

PhosphoSiteiQ9R0N3.

Expressioni

Gene expression databases

BgeeiQ9R0N3.
CleanExiMM_SYT11.
ExpressionAtlasiQ9R0N3. baseline and differential.
GenevestigatoriQ9R0N3.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers. Interacts with PARK2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Vti1aQ9JI512EBI-647443,EBI-7573650From a different organism.

Protein-protein interaction databases

IntActiQ9R0N3. 22 interactions.
MINTiMINT-4136545.

Structurei

3D structure databases

ProteinModelPortaliQ9R0N3.
SMRiQ9R0N3. Positions 157-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 26189C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini303 – 39694C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292488.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9R0N3.
OMAiIKVDYGD.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0N3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPRRESG RGNLLINAES
110 120 130 140 150
GLLSHDKDPR GPSPASCMDQ LPIKRDYGEE LRSPMTSLTP GESKATSPSS
160 170 180 190 200
PEEDVMLGSL TFSVDYNFPK KALVVTIQEA HGLPVMDDQT QGSDPYIKMT
210 220 230 240 250
ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV LHFLVLSFDR
260 270 280 290 300
FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY
310 320 330 340 350
QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK
360 370 380 390 400
KCTLNPVFNE SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH
410 420 430
SVTTSGAEHW REVCESPRKP IAKWHSLSEY
Length:430
Mass (Da):48,333
Last modified:July 27, 2011 - v2
Checksum:i4E989259BE4FB423
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451A → P in BAA85780. (PubMed:10531343)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026808 mRNA. Translation: BAA85780.1.
AK144169 mRNA. Translation: BAE25745.1.
BC054526 mRNA. Translation: AAH54526.1.
CCDSiCCDS38484.1.
RefSeqiNP_061274.2. NM_018804.3.
XP_006501411.1. XM_006501348.1.
XP_006501412.1. XM_006501349.1.
UniGeneiMm.379376.

Genome annotation databases

EnsembliENSMUST00000090945; ENSMUSP00000088464; ENSMUSG00000068923.
ENSMUST00000107505; ENSMUSP00000103129; ENSMUSG00000068923.
GeneIDi229521.
KEGGimmu:229521.
UCSCiuc008pwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026808 mRNA. Translation: BAA85780.1 .
AK144169 mRNA. Translation: BAE25745.1 .
BC054526 mRNA. Translation: AAH54526.1 .
CCDSi CCDS38484.1.
RefSeqi NP_061274.2. NM_018804.3.
XP_006501411.1. XM_006501348.1.
XP_006501412.1. XM_006501349.1.
UniGenei Mm.379376.

3D structure databases

ProteinModelPortali Q9R0N3.
SMRi Q9R0N3. Positions 157-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R0N3. 22 interactions.
MINTi MINT-4136545.

PTM databases

PhosphoSitei Q9R0N3.

Proteomic databases

MaxQBi Q9R0N3.
PaxDbi Q9R0N3.
PRIDEi Q9R0N3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090945 ; ENSMUSP00000088464 ; ENSMUSG00000068923 .
ENSMUST00000107505 ; ENSMUSP00000103129 ; ENSMUSG00000068923 .
GeneIDi 229521.
KEGGi mmu:229521.
UCSCi uc008pwk.1. mouse.

Organism-specific databases

CTDi 23208.
MGIi MGI:1859547. Syt11.

Phylogenomic databases

eggNOGi NOG292488.
GeneTreei ENSGT00760000118973.
HOGENOMi HOG000232126.
HOVERGENi HBG005010.
InParanoidi Q9R0N3.
OMAi IKVDYGD.
TreeFami TF315600.

Miscellaneous databases

ChiTaRSi Syt11. mouse.
NextBioi 379479.
PROi Q9R0N3.
SOURCEi Search...

Gene expression databases

Bgeei Q9R0N3.
CleanExi MM_SYT11.
ExpressionAtlasi Q9R0N3. baseline and differential.
Genevestigatori Q9R0N3.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view ]
PANTHERi PTHR10024:SF115. PTHR10024:SF115. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
    Fukuda M., Kanno E., Mikoshiba K.
    J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Cerebellum.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiSYT11_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N3
Secondary accession number(s): Q7TQG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3