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Protein

Synaptotagmin-11

Gene

Syt11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Calcium 1By similarity1
Metal bindingi187Calcium 2By similarity1
Metal bindingi194Calcium 1By similarity1
Metal bindingi248Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi249Calcium 1By similarity1
Metal bindingi249Calcium 2By similarity1
Metal bindingi249Calcium 3By similarity1
Metal bindingi252Calcium 3By similarity1
Metal bindingi255Calcium 2By similarity1
Metal bindingi255Calcium 3By similarity1

GO - Molecular functioni

  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • clathrin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central
  • translation initiation factor binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • calcium ion regulated lysosome exocytosis Source: ParkinsonsUK-UCL
  • negative regulation of interleukin-6 secretion Source: ParkinsonsUK-UCL
  • negative regulation of membrane invagination Source: Ensembl
  • negative regulation of phagocytosis Source: ParkinsonsUK-UCL
  • negative regulation of synaptic vesicle endocytosis Source: Ensembl
  • negative regulation of tumor necrosis factor secretion Source: ParkinsonsUK-UCL
  • plasma membrane repair Source: ParkinsonsUK-UCL
  • positive regulation of protein localization to phagocytic vesicle Source: ParkinsonsUK-UCL
  • protein homotetramerization Source: ParkinsonsUK-UCL
  • regulation of defense response to bacterium Source: ParkinsonsUK-UCL
  • regulation of phagosome maturation Source: ParkinsonsUK-UCL
  • response to wounding Source: ParkinsonsUK-UCL
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:Syt11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1859547. Syt11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15VesicularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 430CytoplasmicSequence analysisAdd BLAST394

GO - Cellular componenti

  • axon Source: Ensembl
  • cell body Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: ParkinsonsUK-UCL
  • dendritic spine Source: Ensembl
  • early phagosome Source: ParkinsonsUK-UCL
  • inhibitory synapse Source: Ensembl
  • integral component of plasma membrane Source: MGI
  • lysosome Source: ParkinsonsUK-UCL
  • neuron projection Source: MGI
  • phagocytic cup Source: ParkinsonsUK-UCL
  • phagocytic vesicle Source: ParkinsonsUK-UCL
  • postsynaptic density Source: Ensembl
  • presynaptic active zone membrane Source: Ensembl
  • recycling endosome Source: ParkinsonsUK-UCL
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839701 – 430Synaptotagmin-11Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9R0N3.
PaxDbiQ9R0N3.
PRIDEiQ9R0N3.

PTM databases

iPTMnetiQ9R0N3.
PhosphoSitePlusiQ9R0N3.
SwissPalmiQ9R0N3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068923.
CleanExiMM_SYT11.
ExpressionAtlasiQ9R0N3. baseline and differential.
GenevisibleiQ9R0N3. MM.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers. Interacts with PARK2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Vti1aQ9JI512EBI-647443,EBI-7573650From a different organism.

GO - Molecular functioni

  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • clathrin binding Source: GO_Central
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SNARE binding Source: ParkinsonsUK-UCL
  • syntaxin binding Source: GO_Central
  • translation initiation factor binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

IntActiQ9R0N3. 22 interactors.
MINTiMINT-4136545.
STRINGi10090.ENSMUSP00000088464.

Structurei

3D structure databases

ProteinModelPortaliQ9R0N3.
SMRiQ9R0N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 261C2 1PROSITE-ProRule annotationAdd BLAST89
Domaini303 – 396C2 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9R0N3.
KOiK19911.
OMAiIKVDYGD.
OrthoDBiEOG091G09ZN.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R0N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPRRESG RGNLLINAES
110 120 130 140 150
GLLSHDKDPR GPSPASCMDQ LPIKRDYGEE LRSPMTSLTP GESKATSPSS
160 170 180 190 200
PEEDVMLGSL TFSVDYNFPK KALVVTIQEA HGLPVMDDQT QGSDPYIKMT
210 220 230 240 250
ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV LHFLVLSFDR
260 270 280 290 300
FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY
310 320 330 340 350
QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK
360 370 380 390 400
KCTLNPVFNE SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH
410 420 430
SVTTSGAEHW REVCESPRKP IAKWHSLSEY
Length:430
Mass (Da):48,333
Last modified:July 27, 2011 - v2
Checksum:i4E989259BE4FB423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145A → P in BAA85780 (PubMed:10531343).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026808 mRNA. Translation: BAA85780.1.
AK144169 mRNA. Translation: BAE25745.1.
BC054526 mRNA. Translation: AAH54526.1.
CCDSiCCDS38484.1.
RefSeqiNP_061274.2. NM_018804.3.
XP_006501411.1. XM_006501348.1.
UniGeneiMm.379376.

Genome annotation databases

EnsembliENSMUST00000090945; ENSMUSP00000088464; ENSMUSG00000068923.
ENSMUST00000107505; ENSMUSP00000103129; ENSMUSG00000068923.
GeneIDi229521.
KEGGimmu:229521.
UCSCiuc008pwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026808 mRNA. Translation: BAA85780.1.
AK144169 mRNA. Translation: BAE25745.1.
BC054526 mRNA. Translation: AAH54526.1.
CCDSiCCDS38484.1.
RefSeqiNP_061274.2. NM_018804.3.
XP_006501411.1. XM_006501348.1.
UniGeneiMm.379376.

3D structure databases

ProteinModelPortaliQ9R0N3.
SMRiQ9R0N3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R0N3. 22 interactors.
MINTiMINT-4136545.
STRINGi10090.ENSMUSP00000088464.

PTM databases

iPTMnetiQ9R0N3.
PhosphoSitePlusiQ9R0N3.
SwissPalmiQ9R0N3.

Proteomic databases

MaxQBiQ9R0N3.
PaxDbiQ9R0N3.
PRIDEiQ9R0N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090945; ENSMUSP00000088464; ENSMUSG00000068923.
ENSMUST00000107505; ENSMUSP00000103129; ENSMUSG00000068923.
GeneIDi229521.
KEGGimmu:229521.
UCSCiuc008pwk.1. mouse.

Organism-specific databases

CTDi23208.
MGIiMGI:1859547. Syt11.

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9R0N3.
KOiK19911.
OMAiIKVDYGD.
OrthoDBiEOG091G09ZN.
TreeFamiTF315600.

Miscellaneous databases

ChiTaRSiSyt11. mouse.
PROiQ9R0N3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068923.
CleanExiMM_SYT11.
ExpressionAtlasiQ9R0N3. baseline and differential.
GenevisibleiQ9R0N3. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT11_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N3
Secondary accession number(s): Q7TQG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.