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Q9R0N3

- SYT11_MOUSE

UniProt

Q9R0N3 - SYT11_MOUSE

Protein

Synaptotagmin-11

Gene

Syt11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Calcium 1By similarity
    Metal bindingi187 – 1871Calcium 2By similarity
    Metal bindingi194 – 1941Calcium 1By similarity
    Metal bindingi248 – 2481Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi249 – 2491Calcium 1By similarity
    Metal bindingi249 – 2491Calcium 2By similarity
    Metal bindingi249 – 2491Calcium 3By similarity
    Metal bindingi252 – 2521Calcium 3By similarity
    Metal bindingi255 – 2551Calcium 2By similarity
    Metal bindingi255 – 2551Calcium 3By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. transporter activity Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-11
    Alternative name(s):
    Synaptotagmin XI
    Short name:
    SytXI
    Gene namesi
    Name:Syt11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1859547. Syt11.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: MGI
    3. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Synaptotagmin-11PRO_0000183970Add
    BLAST

    Post-translational modificationi

    Ubiquitinated and targeted to the proteasome complex for degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ9R0N3.
    PRIDEiQ9R0N3.

    PTM databases

    PhosphoSiteiQ9R0N3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R0N3.
    BgeeiQ9R0N3.
    CleanExiMM_SYT11.
    GenevestigatoriQ9R0N3.

    Interactioni

    Subunit structurei

    Homodimer. Can also form heterodimers. Interacts with PARK2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Vti1aQ9JI512EBI-647443,EBI-7573650From a different organism.

    Protein-protein interaction databases

    IntActiQ9R0N3. 22 interactions.
    MINTiMINT-4136545.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R0N3.
    SMRiQ9R0N3. Positions 157-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515VesicularSequence AnalysisAdd
    BLAST
    Topological domaini37 – 430394CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 26189C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 39694C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292488.
    GeneTreeiENSGT00750000117274.
    HOGENOMiHOG000232126.
    HOVERGENiHBG005010.
    InParanoidiQ7TQG8.
    OMAiIKVDYGD.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028699. SYT11.
    [Graphical view]
    PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R0N3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT    50
    PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPRRESG RGNLLINAES 100
    GLLSHDKDPR GPSPASCMDQ LPIKRDYGEE LRSPMTSLTP GESKATSPSS 150
    PEEDVMLGSL TFSVDYNFPK KALVVTIQEA HGLPVMDDQT QGSDPYIKMT 200
    ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV LHFLVLSFDR 250
    FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY 300
    QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK 350
    KCTLNPVFNE SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH 400
    SVTTSGAEHW REVCESPRKP IAKWHSLSEY 430
    Length:430
    Mass (Da):48,333
    Last modified:July 27, 2011 - v2
    Checksum:i4E989259BE4FB423
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451A → P in BAA85780. (PubMed:10531343)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026808 mRNA. Translation: BAA85780.1.
    AK144169 mRNA. Translation: BAE25745.1.
    BC054526 mRNA. Translation: AAH54526.1.
    CCDSiCCDS38484.1.
    RefSeqiNP_061274.2. NM_018804.3.
    XP_006501411.1. XM_006501348.1.
    XP_006501412.1. XM_006501349.1.
    UniGeneiMm.379376.

    Genome annotation databases

    EnsembliENSMUST00000090945; ENSMUSP00000088464; ENSMUSG00000068923.
    ENSMUST00000107505; ENSMUSP00000103129; ENSMUSG00000068923.
    GeneIDi229521.
    KEGGimmu:229521.
    UCSCiuc008pwk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026808 mRNA. Translation: BAA85780.1 .
    AK144169 mRNA. Translation: BAE25745.1 .
    BC054526 mRNA. Translation: AAH54526.1 .
    CCDSi CCDS38484.1.
    RefSeqi NP_061274.2. NM_018804.3.
    XP_006501411.1. XM_006501348.1.
    XP_006501412.1. XM_006501349.1.
    UniGenei Mm.379376.

    3D structure databases

    ProteinModelPortali Q9R0N3.
    SMRi Q9R0N3. Positions 157-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R0N3. 22 interactions.
    MINTi MINT-4136545.

    PTM databases

    PhosphoSitei Q9R0N3.

    Proteomic databases

    PaxDbi Q9R0N3.
    PRIDEi Q9R0N3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090945 ; ENSMUSP00000088464 ; ENSMUSG00000068923 .
    ENSMUST00000107505 ; ENSMUSP00000103129 ; ENSMUSG00000068923 .
    GeneIDi 229521.
    KEGGi mmu:229521.
    UCSCi uc008pwk.1. mouse.

    Organism-specific databases

    CTDi 23208.
    MGIi MGI:1859547. Syt11.

    Phylogenomic databases

    eggNOGi NOG292488.
    GeneTreei ENSGT00750000117274.
    HOGENOMi HOG000232126.
    HOVERGENi HBG005010.
    InParanoidi Q7TQG8.
    OMAi IKVDYGD.
    TreeFami TF315600.

    Miscellaneous databases

    ChiTaRSi SYT11. mouse.
    NextBioi 379479.
    PROi Q9R0N3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R0N3.
    Bgeei Q9R0N3.
    CleanExi MM_SYT11.
    Genevestigatori Q9R0N3.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028699. SYT11.
    [Graphical view ]
    PANTHERi PTHR10024:SF115. PTHR10024:SF115. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
      Fukuda M., Kanno E., Mikoshiba K.
      J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Cerebellum.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiSYT11_MOUSE
    AccessioniPrimary (citable) accession number: Q9R0N3
    Secondary accession number(s): Q7TQG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3